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The map label for this gene is srlD [H]

Identifier: 157371807

GI number: 157371807

Start: 3949174

End: 3949953

Strand: Direct

Name: srlD [H]

Synonym: Spro_3572

Alternate gene names: 157371807

Gene position: 3949174-3949953 (Clockwise)

Preceding gene: 157371806

Following gene: 157371808

Centisome position: 72.48

GC content: 57.05

Gene sequence:

>780_bases
ATGTCTGAAGTAGCTGTAGTGATTGGCGGAGGCCAAACATTAGGTGCATTTTTGTGCCTGGGACTGGCGCAGGCGGGTTA
CCGCGTGGCGGTAGCCGATTTAAACGCGGATAACGCCCGCCAGGTGGCGCAGCAGATTAACCACCAGTACGGCGCCGGCA
TCGCGCAGGGTTTCCTGGCCGATGCCACCGATGAACAAAGCGTCATTGCCCTGGCGGCTGCGGTGGATAGCAAATTTGGC
CAGGCCAATCTGTTGGTGTACAGCGCCGGTATCGCCAAGGCCGCACCGATCACCGATTTTCCATTAGGGGATTTTGATCG
CTCGCTGCAGGTCAATCTGGTGGGATATTTTCTCTGTGCCCGCGAATTTTCCCGCCTGATGATCCGTGACGGCCTTGCCG
GACGCATCATTCAGATCAACTCCAAGTCCGGCAAGGTCGGCAGCAAACACAACTCGGGCTACAGCGCCGCCAAGTTCGGC
GGGGTCGGGCTGACCCAGTCACTGGCGCTCGATCTGGCGGAATACGGTATTACCGTGCATTCGCTGATGCTCGGCAACCT
GCTGAAGTCGCCAATGTTCCAGTCGCTACTGCCGCAATACGCACAAAAACTGGGGATCGCGCCGGATGAAGTTGAAAAAT
ACTACACCGACAAGGTGCCGCTAAAACGCGGTTGCGACTACCAGGACGTGCTGAATACCCTGCTGTTTTACGCCAGCGAC
AAGGCGTCTTATTGCACGGGGCAGTCGATCAACATTACCGGCGGTCAGGTAATGTTCTGA

Upstream 100 bases:

>100_bases
AGTCAGGCCGAATTTCCCGGTTCTATCCACGTGGCCGGTACCACGCCGGTTGATATCCCGTTAGGCAGTACGCTGAAATT
TATCGCATAAGGAGTAGACC

Downstream 100 bases:

>100_bases
TTAGCGATACTTCCCTCTCCGTCCGGGGAGGGAAGATAAACAGGAGACACTATGACCCAGGCATTAATCATCTTCGCCGT
ACTGGCCTGGCTGCTGCAAA

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSEVAVVIGGGQTLGAFLCLGLAQAGYRVAVADLNADNARQVAQQINHQYGAGIAQGFLADATDEQSVIALAAAVDSKFG
QANLLVYSAGIAKAAPITDFPLGDFDRSLQVNLVGYFLCAREFSRLMIRDGLAGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYAQKLGIAPDEVEKYYTDKVPLKRGCDYQDVLNTLLFYASD
KASYCTGQSINITGGQVMF

Sequences:

>Translated_259_residues
MSEVAVVIGGGQTLGAFLCLGLAQAGYRVAVADLNADNARQVAQQINHQYGAGIAQGFLADATDEQSVIALAAAVDSKFG
QANLLVYSAGIAKAAPITDFPLGDFDRSLQVNLVGYFLCAREFSRLMIRDGLAGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYAQKLGIAPDEVEKYYTDKVPLKRGCDYQDVLNTLLFYASD
KASYCTGQSINITGGQVMF
>Mature_258_residues
SEVAVVIGGGQTLGAFLCLGLAQAGYRVAVADLNADNARQVAQQINHQYGAGIAQGFLADATDEQSVIALAAAVDSKFGQ
ANLLVYSAGIAKAAPITDFPLGDFDRSLQVNLVGYFLCAREFSRLMIRDGLAGRIIQINSKSGKVGSKHNSGYSAAKFGG
VGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYAQKLGIAPDEVEKYYTDKVPLKRGCDYQDVLNTLLFYASDK
ASYCTGQSINITGGQVMF

Specific function: Sorbitol metabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=266, Percent_Identity=30.0751879699248, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI40254992, Length=255, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI7705925, Length=176, Percent_Identity=26.1363636363636, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4504505, Length=218, Percent_Identity=28.4403669724771, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4758504, Length=231, Percent_Identity=30.3030303030303, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI310128830, Length=217, Percent_Identity=24.4239631336406, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI310115468, Length=217, Percent_Identity=24.4239631336406, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI40807363, Length=214, Percent_Identity=23.8317757009346, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=25.0950570342205, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=83.3976833976834, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=30.1960784313725, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=28.90625, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=31.9066147859922, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=27.6923076923077, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.4046692607004, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=23.3201581027668, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=25.5813953488372, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=30.3149606299213, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=29.5275590551181, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508895, Length=169, Percent_Identity=28.4023668639053, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=26.6932270916335, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=25, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=266, Percent_Identity=28.1954887218045, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=26.5625, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=206, Percent_Identity=28.6407766990291, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=244, Percent_Identity=24.1803278688525, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=244, Percent_Identity=24.1803278688525, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=273, Percent_Identity=25.2747252747253, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=26.0223048327138, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=272, Percent_Identity=25.3676470588235, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=217, Percent_Identity=29.9539170506912, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=28.6274509803922, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=28.2352941176471, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17737361, Length=232, Percent_Identity=29.3103448275862, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=26.7716535433071, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24581726, Length=219, Percent_Identity=22.3744292237443, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221510726, Length=157, Percent_Identity=28.0254777070064, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649181, Length=170, Percent_Identity=28.2352941176471, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=24.8062015503876, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI18859837, Length=216, Percent_Identity=30.0925925925926, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 27507; Mature: 27376

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVAVVIGGGQTLGAFLCLGLAQAGYRVAVADLNADNARQVAQQINHQYGAGIAQGFLA
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHC
DATDEQSVIALAAAVDSKFGQANLLVYSAGIAKAAPITDFPLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGLAGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYAQKLGIAPDEVEKYYTDKVPLKRGCDYQDVLNTLLFYASD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCC
KASYCTGQSINITGGQVMF
CCCCCCCCEEECCCCEEEC
>Mature Secondary Structure 
SEVAVVIGGGQTLGAFLCLGLAQAGYRVAVADLNADNARQVAQQINHQYGAGIAQGFLA
CCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHC
DATDEQSVIALAAAVDSKFGQANLLVYSAGIAKAAPITDFPLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGLAGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYAQKLGIAPDEVEKYYTDKVPLKRGCDYQDVLNTLLFYASD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCC
KASYCTGQSINITGGQVMF
CCCCCCCCEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]