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The map label for this gene is yegS [C]

Identifier: 157371797

GI number: 157371797

Start: 3938636

End: 3939553

Strand: Direct

Name: yegS [C]

Synonym: Spro_3562

Alternate gene names: 157371797

Gene position: 3938636-3939553 (Clockwise)

Preceding gene: 157371796

Following gene: 157371798

Centisome position: 72.28

GC content: 57.84

Gene sequence:

>918_bases
ATGCATCCACCAGCACCAGCGCTGCTTATCATCAACGGCAAAGGCGCCGGCAACGAAGAAGTTCGCCTGGCGGTACAGAA
ATTGCGGGATGAGAACCAAACCCTGCACGTTCGCGTCACCTGGGAACAGGGTGACGCCGCGCGCTATGTGCAGGAGGCCT
GTCAACTTGGGGTGGCCACACTGATTGCCGGTGGTGGCGATGGCACCATCAATGAGGTGGCTGCAGCATTGGCCGCGTTA
CCGGCTAAAGGACGGCCGGTATTGGGCATTCTGCCGTTGGGCACTGCCAACGACTTCGCCATGGCCTGCAATATCCCGCT
GATACCGGAACAGGCGCTGCGGTTGGCGGTCAAAGGCCGCGCCGTCCCGATAGATCTGGCAAAAGTTAACGATCAACGCT
ATTTCATCAATATGGCGACCGGCGGTTTTGGTACCCGAATCACGACCGAAACGCCGGAAAAACTGAAGGCCGCGTTGGGC
GGCGTGTCCTACTTTATCCACGGCTTGCTCCGCATGGACACGCTCAAAGCCGATCGCTGCGAGATCCGCGGTCCGGATTT
CCATTGGTCCGGTGACGCTTTGGTGATTGGTATCGGTAATGGTAAGCAGGCCGGTGGCGGGCAGCAATTATGCCCGGATG
CCCTGATCAACGATGGCCTGCTGCAACTGCGGCTGCTGACTGCTGACGAACTGTTACCGACACTGATCGCCAGCCTGTTT
AACGATGAAGAAAACAAAAACGTGATCGGTGCTGCCCTGCCGTGGCTGGAAATCGATGCGCCCCATGAAATGACCTTTAA
TCTCGACGGCGAACCACTCAAAGGCAGGCATTTCCGCATTGAAGTGCTGCCGAACGCCATCGAATGCCGTCTGCCCCCCA
ACTGCGAGCTGCTTGGGCAAACCCAGTCTTCCCAATAA

Upstream 100 bases:

>100_bases
GACGGCAACCAGCCAGAATTAACTGAATATTCTGATGGATTGCCACTGATGGGTAGTTTATCGTTGCCCACTATCTGTTA
ACAGCCGGGAGATATTGGGA

Downstream 100 bases:

>100_bases
CCGCTGAATATAGGGCTCAGCCTGTGCGCTGAGCCCCCTGTTGGTCTTCTGTTCTGCCCCTCTTTTTCCACGACAAAATG
TGATCTTCCCCGGCAAATTC

Product: lipid kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MHPPAPALLIINGKGAGNEEVRLAVQKLRDENQTLHVRVTWEQGDAARYVQEACQLGVATLIAGGGDGTINEVAAALAAL
PAKGRPVLGILPLGTANDFAMACNIPLIPEQALRLAVKGRAVPIDLAKVNDQRYFINMATGGFGTRITTETPEKLKAALG
GVSYFIHGLLRMDTLKADRCEIRGPDFHWSGDALVIGIGNGKQAGGGQQLCPDALINDGLLQLRLLTADELLPTLIASLF
NDEENKNVIGAALPWLEIDAPHEMTFNLDGEPLKGRHFRIEVLPNAIECRLPPNCELLGQTQSSQ

Sequences:

>Translated_305_residues
MHPPAPALLIINGKGAGNEEVRLAVQKLRDENQTLHVRVTWEQGDAARYVQEACQLGVATLIAGGGDGTINEVAAALAAL
PAKGRPVLGILPLGTANDFAMACNIPLIPEQALRLAVKGRAVPIDLAKVNDQRYFINMATGGFGTRITTETPEKLKAALG
GVSYFIHGLLRMDTLKADRCEIRGPDFHWSGDALVIGIGNGKQAGGGQQLCPDALINDGLLQLRLLTADELLPTLIASLF
NDEENKNVIGAALPWLEIDAPHEMTFNLDGEPLKGRHFRIEVLPNAIECRLPPNCELLGQTQSSQ
>Mature_305_residues
MHPPAPALLIINGKGAGNEEVRLAVQKLRDENQTLHVRVTWEQGDAARYVQEACQLGVATLIAGGGDGTINEVAAALAAL
PAKGRPVLGILPLGTANDFAMACNIPLIPEQALRLAVKGRAVPIDLAKVNDQRYFINMATGGFGTRITTETPEKLKAALG
GVSYFIHGLLRMDTLKADRCEIRGPDFHWSGDALVIGIGNGKQAGGGQQLCPDALINDGLLQLRLLTADELLPTLIASLF
NDEENKNVIGAALPWLEIDAPHEMTFNLDGEPLKGRHFRIEVLPNAIECRLPPNCELLGQTQSSQ

Specific function: Probably phosphorylates lipids; the in vivo substrate is unknown

COG id: COG1597

COG function: function code IR; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DAGKc domain

Homologues:

Organism=Escherichia coli, GI1788402, Length=292, Percent_Identity=67.4657534246575, Blast_Score=409, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YEGS_SERP5 (A8GHR8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479786.1
- ProteinModelPortal:   A8GHR8
- SMR:   A8GHR8
- STRING:   A8GHR8
- GeneID:   5605491
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3562
- eggNOG:   COG1597
- HOGENOM:   HBG698136
- OMA:   FRIECVP
- ProtClustDB:   PRK13054
- BioCyc:   SPRO399741:SPRO_3562-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01377
- InterPro:   IPR005218
- InterPro:   IPR001206
- InterPro:   IPR022433
- InterPro:   IPR022862
- SMART:   SM00046
- TIGRFAMs:   TIGR00147
- TIGRFAMs:   TIGR03702

Pfam domain/function: PF00781 DAGK_cat

EC number: NA

Molecular weight: Translated: 32665; Mature: 32665

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50146 DAGK

Important sites: ACT_SITE 271-271 BINDING 40-40 BINDING 95-95

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPPAPALLIINGKGAGNEEVRLAVQKLRDENQTLHVRVTWEQGDAARYVQEACQLGVAT
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCEEE
LIAGGGDGTINEVAAALAALPAKGRPVLGILPLGTANDFAMACNIPLIPEQALRLAVKGR
EEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHEEECCC
AVPIDLAKVNDQRYFINMATGGFGTRITTETPEKLKAALGGVSYFIHGLLRMDTLKADRC
EEEEEEEEECCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EIRGPDFHWSGDALVIGIGNGKQAGGGQQLCPDALINDGLLQLRLLTADELLPTLIASLF
EECCCCCEECCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEEEEECHHHHHHHHHHHHH
NDEENKNVIGAALPWLEIDAPHEMTFNLDGEPLKGRHFRIEVLPNAIECRLPPNCELLGQ
CCCCCCEEEEEECCEEEECCCCCEEEECCCCCCCCCEEEEEECCCEEEECCCCCCEEECC
TQSSQ
CCCCC
>Mature Secondary Structure
MHPPAPALLIINGKGAGNEEVRLAVQKLRDENQTLHVRVTWEQGDAARYVQEACQLGVAT
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCEEE
LIAGGGDGTINEVAAALAALPAKGRPVLGILPLGTANDFAMACNIPLIPEQALRLAVKGR
EEECCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHEEECCC
AVPIDLAKVNDQRYFINMATGGFGTRITTETPEKLKAALGGVSYFIHGLLRMDTLKADRC
EEEEEEEEECCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EIRGPDFHWSGDALVIGIGNGKQAGGGQQLCPDALINDGLLQLRLLTADELLPTLIASLF
EECCCCCEECCCEEEEECCCCCCCCCCCCCCCHHHHCCCEEEEEEECHHHHHHHHHHHHH
NDEENKNVIGAALPWLEIDAPHEMTFNLDGEPLKGRHFRIEVLPNAIECRLPPNCELLGQ
CCCCCCEEEEEECCEEEECCCCCEEEECCCCCCCCCEEEEEECCCEEEECCCCCCEEECC
TQSSQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA