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The map label for this gene is lrp [H]

Identifier: 157371751

GI number: 157371751

Start: 3889224

End: 3889685

Strand: Direct

Name: lrp [H]

Synonym: Spro_3514

Alternate gene names: 157371751

Gene position: 3889224-3889685 (Clockwise)

Preceding gene: 157371748

Following gene: 157371754

Centisome position: 71.38

GC content: 56.71

Gene sequence:

>462_bases
ATGGATAAGATAGACCGCAAAATTCTTGCCGAACTACAAACGGATGGGCGACTTTCTGTCACCGAACTGGCCGAACGTGT
CGGGCTTAGCGTTTCGCCCTGCCATCGTCGGGTGAAGGCTCTGGAAGAATCAGGGGTGATCAGGGGCTATCGCGCCCAGC
TTGAACCCACCAGCCTGGGGTTTAACTTTTCCGCATTGGTTTTCGTCACCATGAGAGAAGGCGATCGCCATGCCGTCGCC
GCCTTTGAGGATGCGATGACCGATATTCCTCAGGTGGTTCAGGCGCAAAGGCTGTTCGGTGACCCAGACTACCTGCTGCA
TGTGATCTCCCGCGATCTGCCCGCTTTCCAGCAGTTGTATGACGAGAAGCTCTCTGCCCTGCCCGGCGTTCAGCGCCTCA
GCTCCACGCTGGTGATGAAAACCGTGGTGCCGGAGCGCTCTTTCTTGCCGATGGGAAAATAA

Upstream 100 bases:

>100_bases
GGCCCCGGCCGCTTAATTATTGGAAAGAATATCTTTAGGGCGTTAAAATGTGCTGCCAATGACTTGCCTGAAAACCACAA
ATTCGGGGAAATTTTTCTAA

Downstream 100 bases:

>100_bases
CGGCGGGAGCGTTTCCGCTCCCGTGGGTAGTGACTTACGGCTTAAGGCACAATCACAAAATCTGGATTGGCGACGGCAAA
CAAAGCATCGCGATCCGCCG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MDKIDRKILAELQTDGRLSVTELAERVGLSVSPCHRRVKALEESGVIRGYRAQLEPTSLGFNFSALVFVTMREGDRHAVA
AFEDAMTDIPQVVQAQRLFGDPDYLLHVISRDLPAFQQLYDEKLSALPGVQRLSSTLVMKTVVPERSFLPMGK

Sequences:

>Translated_153_residues
MDKIDRKILAELQTDGRLSVTELAERVGLSVSPCHRRVKALEESGVIRGYRAQLEPTSLGFNFSALVFVTMREGDRHAVA
AFEDAMTDIPQVVQAQRLFGDPDYLLHVISRDLPAFQQLYDEKLSALPGVQRLSSTLVMKTVVPERSFLPMGK
>Mature_153_residues
MDKIDRKILAELQTDGRLSVTELAERVGLSVSPCHRRVKALEESGVIRGYRAQLEPTSLGFNFSALVFVTMREGDRHAVA
AFEDAMTDIPQVVQAQRLFGDPDYLLHVISRDLPAFQQLYDEKLSALPGVQRLSSTLVMKTVVPERSFLPMGK

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=142, Percent_Identity=40.1408450704225, Blast_Score=104, Evalue=3e-24,
Organism=Escherichia coli, GI87081742, Length=142, Percent_Identity=33.8028169014084, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1790182, Length=151, Percent_Identity=25.1655629139073, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17101; Mature: 17101

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIDRKILAELQTDGRLSVTELAERVGLSVSPCHRRVKALEESGVIRGYRAQLEPTSLG
CCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCC
FNFSALVFVTMREGDRHAVAAFEDAMTDIPQVVQAQRLFGDPDYLLHVISRDLPAFQQLY
CCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
DEKLSALPGVQRLSSTLVMKTVVPERSFLPMGK
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDKIDRKILAELQTDGRLSVTELAERVGLSVSPCHRRVKALEESGVIRGYRAQLEPTSLG
CCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCC
FNFSALVFVTMREGDRHAVAAFEDAMTDIPQVVQAQRLFGDPDYLLHVISRDLPAFQQLY
CCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
DEKLSALPGVQRLSSTLVMKTVVPERSFLPMGK
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]