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The map label for this gene is fepA [H]

Identifier: 157371667

GI number: 157371667

Start: 3798384

End: 3800663

Strand: Direct

Name: fepA [H]

Synonym: Spro_3430

Alternate gene names: 157371667

Gene position: 3798384-3800663 (Clockwise)

Preceding gene: 157371663

Following gene: 157371671

Centisome position: 69.71

GC content: 56.36

Gene sequence:

>2280_bases
ATGAACCGCAAATTATCTCGTTATTCCTTAGCCACACTCATCGGGTTAGGATTAGGCGCGTCCGCCTTTGCGCACGCCGC
ACAGCAAACAGAAACCACCGCAGAAACAGACTCCGTCGCCAAAAATAAAAAAGAAGCCGCCGAGGACACCATTGTTGTCA
CCGCCGCCAAGCAGAACCTGCAGGCGCCCGGGGTTTCGACCATTACCGCCGACGAAATCAAAAAACGCCCACCGGCGCGC
GATATTAGCGAACTGATCCGCACCATGCCGGGCGTTAACCTGACCGGTAACTCCACCAGCGGCCAGCGCGGCAACAACCG
CCAGATCGATATTCGCGGCATGGGCCCGGAAAATACCCTGATCCTGATCGACGGCAAACCCGCCACCAGCCGCAACTCTG
TACGTCAGGGTTGGCGTGGCGAACGTGATACCCGCGGCGATACCGCCTGGGTGCCACCGGAGATGATTGAACGCATCGAA
GTGCTGCGCGGCCCGGCAGCGGCACGCTACGGCAACGGCGCCGCCGGCGGCGTGGTCAATATCATCACCAAAAAGAACAC
CAAAGAGCTGCACGGCTCGTTAAATGCCTACTTCAACGTGCCGCAGCACAAGCAGGAAGGCTCTACCAAGCGCACCGACT
TTAGCCTGTCCGGCCCGTTGACCGACGAGTTGAGCTTCCGCCTGTTCGGTGGCTACAGCAAAACTCAGGCCGACGCCTGG
GATATCAACGAAGCGCATAAATCCGAGCGCGTAGGCATTTATGCCAACAGCACGCCTTCCGGGCGTGAGGGCGTAGAAGA
CAAAAACATCGATGCCATGCTGCATTGGGATTTTGCTCACCTGCAGTCACTGGAGTTTGAGTATGCCTACGGTCGTCAGG
GCAACCTGTATGCCGGGGATACTCAAAACACCAACTCCAACCCGCTGGTGCAAAGCAACTACGGCAAAGAAACTAACCGT
ATCTACCGCGAAACCTTCGGTCTTAACCACCGGGGCGCCTGGGATAGTGGCGTTAGTACCAACAACTATATTCAGTTCGA
ACGCACCCGTAATACCCGTCTGAACGAAGGCCTGGCCGGCGGTACCGAAGGCATCTTCGATACCAAAAACGAAGGGTTTG
GCACCACCAAACTGGACGATTTCCTGGCACACAGCGAAATCAGCGTTCCCTTTGAACTGGGCGTGACACAAACCGCGACG
CTGGGCACCGAATGGAACCAGCAGAAGATGAAAGACGGCTCCTCCACCAGCCAAACCCTGATGGGCGGCACCATTCCTGG
TCAGGCAAACGGTACCCGCAGTCCTTATGCCTCCGCGCATATCTTCTCGCTGTTTGCCGAAGACAACATGGAGCTGACCG
ACAGCACCATGCTGACGCCAGGCCTGCGTTACGACCTGCACTCCGAGGCCGGCAACAACTGGAGCCCGTCGCTGAATCTG
TCGCAGGAATTGGGTGACTTCTTCACCCTGAAGATGGGCATCGCCCGCGCCTACAAGGCACCGAACCTGTACCAGACCAA
CCCAAACTATTTGCTCTACAGCAAAGGCCAGGGTTGCTCATCCAGCGATGTCAAAAATGGCTGTTACCTGTTGGGTAACG
ACGATCTGAAGGCGGAAACCAGCGTCAACAAAGAGGTGGGTCTGGAGTTCCATAACGACGGCTGGCTGGCCGGCGTGACT
TATTTCCGCAACGACTACCACAACAAAATCGAAGCGGGTAACTCCCGAATCGGCACCAGCAGCACCGGTACCGCTATCTA
CCAATGGGAAAACGTACCTAAAGCGGTAGTACAGGGATTGGAAGGCACGTTGAACGTGCCGGTCAGCGAGACCGTTTCCT
GGACCAACAATGCTACCTATATGATTGAAAACAAGAATAAGACTACCGGTGACTACCTGTCGATTATTCCTGAATTCACC
ATAAACTCGACCCTGAGCTGGCAGGCCACCGAGGAGCTGTCGATGCAGTCGACCCTGACCTGGTACGGCCGTCAGAAGCC
GAAGAAGTACAACTATCAGGGCAAACCGGTTAGCGGCACCGAAACCAAGGAAGTCAGCCCTTACGCCGTCGTGGGCGCCA
GCGCCACCTATGATGTGACCAAGAACGTCAGCCTGACGGCCGGTATCGACAACCTGTTCGACAAACGCCAGTTCCGTGAA
GGTAACTCGCAGAACGTAGGTGACCCGACCACCGGCGCGATTAATATCGCCGGTGCAGGTGCAGCCACCTACAACGAACC
GGGCCGGACTTACTATATGAGCGTGAATACCCATTTCTAA

Upstream 100 bases:

>100_bases
ATTTTTATTTCCGAAAACACAAAAACTACAACCGCCCTTCTCTACTGCCGGAGGCCTGCTTTCGGTGCTCCGGGAAAGGC
AGCAAGGTAGGAACTCTCAC

Downstream 100 bases:

>100_bases
TCGTGGGATAAACCGGTAATGAAACGGGGGCTGCCATGCAGCCCCTTTTTAATTATTTCTCCAGCGAAACCTGTTTGAAG
ATGTGCTTGCCAAACGGGTC

Product: outer membrane receptor FepA

Products: NA

Alternate protein names: Enterobactin outer-membrane receptor [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MNRKLSRYSLATLIGLGLGASAFAHAAQQTETTAETDSVAKNKKEAAEDTIVVTAAKQNLQAPGVSTITADEIKKRPPAR
DISELIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPATSRNSVRQGWRGERDTRGDTAWVPPEMIERIE
VLRGPAAARYGNGAAGGVVNIITKKNTKELHGSLNAYFNVPQHKQEGSTKRTDFSLSGPLTDELSFRLFGGYSKTQADAW
DINEAHKSERVGIYANSTPSGREGVEDKNIDAMLHWDFAHLQSLEFEYAYGRQGNLYAGDTQNTNSNPLVQSNYGKETNR
IYRETFGLNHRGAWDSGVSTNNYIQFERTRNTRLNEGLAGGTEGIFDTKNEGFGTTKLDDFLAHSEISVPFELGVTQTAT
LGTEWNQQKMKDGSSTSQTLMGGTIPGQANGTRSPYASAHIFSLFAEDNMELTDSTMLTPGLRYDLHSEAGNNWSPSLNL
SQELGDFFTLKMGIARAYKAPNLYQTNPNYLLYSKGQGCSSSDVKNGCYLLGNDDLKAETSVNKEVGLEFHNDGWLAGVT
YFRNDYHNKIEAGNSRIGTSSTGTAIYQWENVPKAVVQGLEGTLNVPVSETVSWTNNATYMIENKNKTTGDYLSIIPEFT
INSTLSWQATEELSMQSTLTWYGRQKPKKYNYQGKPVSGTETKEVSPYAVVGASATYDVTKNVSLTAGIDNLFDKRQFRE
GNSQNVGDPTTGAINIAGAGAATYNEPGRTYYMSVNTHF

Sequences:

>Translated_759_residues
MNRKLSRYSLATLIGLGLGASAFAHAAQQTETTAETDSVAKNKKEAAEDTIVVTAAKQNLQAPGVSTITADEIKKRPPAR
DISELIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPATSRNSVRQGWRGERDTRGDTAWVPPEMIERIE
VLRGPAAARYGNGAAGGVVNIITKKNTKELHGSLNAYFNVPQHKQEGSTKRTDFSLSGPLTDELSFRLFGGYSKTQADAW
DINEAHKSERVGIYANSTPSGREGVEDKNIDAMLHWDFAHLQSLEFEYAYGRQGNLYAGDTQNTNSNPLVQSNYGKETNR
IYRETFGLNHRGAWDSGVSTNNYIQFERTRNTRLNEGLAGGTEGIFDTKNEGFGTTKLDDFLAHSEISVPFELGVTQTAT
LGTEWNQQKMKDGSSTSQTLMGGTIPGQANGTRSPYASAHIFSLFAEDNMELTDSTMLTPGLRYDLHSEAGNNWSPSLNL
SQELGDFFTLKMGIARAYKAPNLYQTNPNYLLYSKGQGCSSSDVKNGCYLLGNDDLKAETSVNKEVGLEFHNDGWLAGVT
YFRNDYHNKIEAGNSRIGTSSTGTAIYQWENVPKAVVQGLEGTLNVPVSETVSWTNNATYMIENKNKTTGDYLSIIPEFT
INSTLSWQATEELSMQSTLTWYGRQKPKKYNYQGKPVSGTETKEVSPYAVVGASATYDVTKNVSLTAGIDNLFDKRQFRE
GNSQNVGDPTTGAINIAGAGAATYNEPGRTYYMSVNTHF
>Mature_759_residues
MNRKLSRYSLATLIGLGLGASAFAHAAQQTETTAETDSVAKNKKEAAEDTIVVTAAKQNLQAPGVSTITADEIKKRPPAR
DISELIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPATSRNSVRQGWRGERDTRGDTAWVPPEMIERIE
VLRGPAAARYGNGAAGGVVNIITKKNTKELHGSLNAYFNVPQHKQEGSTKRTDFSLSGPLTDELSFRLFGGYSKTQADAW
DINEAHKSERVGIYANSTPSGREGVEDKNIDAMLHWDFAHLQSLEFEYAYGRQGNLYAGDTQNTNSNPLVQSNYGKETNR
IYRETFGLNHRGAWDSGVSTNNYIQFERTRNTRLNEGLAGGTEGIFDTKNEGFGTTKLDDFLAHSEISVPFELGVTQTAT
LGTEWNQQKMKDGSSTSQTLMGGTIPGQANGTRSPYASAHIFSLFAEDNMELTDSTMLTPGLRYDLHSEAGNNWSPSLNL
SQELGDFFTLKMGIARAYKAPNLYQTNPNYLLYSKGQGCSSSDVKNGCYLLGNDDLKAETSVNKEVGLEFHNDGWLAGVT
YFRNDYHNKIEAGNSRIGTSSTGTAIYQWENVPKAVVQGLEGTLNVPVSETVSWTNNATYMIENKNKTTGDYLSIIPEFT
INSTLSWQATEELSMQSTLTWYGRQKPKKYNYQGKPVSGTETKEVSPYAVVGASATYDVTKNVSLTAGIDNLFDKRQFRE
GNSQNVGDPTTGAINIAGAGAATYNEPGRTYYMSVNTHF

Specific function: This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1786798, Length=764, Percent_Identity=69.5026178010471, Blast_Score=1087, Evalue=0.0,
Organism=Escherichia coli, GI1788478, Length=740, Percent_Identity=29.8648648648649, Blast_Score=252, Evalue=6e-68,
Organism=Escherichia coli, GI1790405, Length=148, Percent_Identity=33.7837837837838, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787723, Length=149, Percent_Identity=32.2147651006711, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786344, Length=198, Percent_Identity=26.2626262626263, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917
- InterPro:   IPR010105 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 83093; Mature: 83093

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00107 PROTEIN_KINASE_ATP ; PS00430 TONB_DEPENDENT_REC_1 ; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKLSRYSLATLIGLGLGASAFAHAAQQTETTAETDSVAKNKKEAAEDTIVVTAAKQNL
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
QAPGVSTITADEIKKRPPARDISELIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTL
CCCCCCEEEHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCEE
ILIDGKPATSRNSVRQGWRGERDTRGDTAWVPPEMIERIEVLRGPAAARYGNGAAGGVVN
EEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCEEE
IITKKNTKELHGSLNAYFNVPQHKQEGSTKRTDFSLSGPLTDELSFRLFGGYSKTQADAW
EEECCCCHHHHCCCEEEECCCCHHHCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCC
DINEAHKSERVGIYANSTPSGREGVEDKNIDAMLHWDFAHLQSLEFEYAYGRQGNLYAGD
CCHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEECHHHHHHCCEEEEECCCCCEEECC
TQNTNSNPLVQSNYGKETNRIYRETFGLNHRGAWDSGVSTNNYIQFERTRNTRLNEGLAG
CCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
GTEGIFDTKNEGFGTTKLDDFLAHSEISVPFELGVTQTATLGTEWNQQKMKDGSSTSQTL
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCHHE
MGGTIPGQANGTRSPYASAHIFSLFAEDNMELTDSTMLTPGLRYDLHSEAGNNWSPSLNL
ECCCCCCCCCCCCCCCCCEEEEEEEECCCCEECCCEEECCCCCEEECCCCCCCCCCCCCC
SQELGDFFTLKMGIARAYKAPNLYQTNPNYLLYSKGQGCSSSDVKNGCYLLGNDDLKAET
HHHHHHHEEHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCC
SVNKEVGLEFHNDGWLAGVTYFRNDYHNKIEAGNSRIGTSSTGTAIYQWENVPKAVVQGL
CCCHHHCCEECCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHCC
EGTLNVPVSETVSWTNNATYMIENKNKTTGDYLSIIPEFTINSTLSWQATEELSMQSTLT
CCEEECCHHHCEEECCCEEEEEECCCCCCCCHHHCCCCCCCCCEEEECCHHHHHHHHHEE
WYGRQKPKKYNYQGKPVSGTETKEVSPYAVVGASATYDVTKNVSLTAGIDNLFDKRQFRE
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCEEEECHHHHHHHHHHHC
GNSQNVGDPTTGAINIAGAGAATYNEPGRTYYMSVNTHF
CCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MNRKLSRYSLATLIGLGLGASAFAHAAQQTETTAETDSVAKNKKEAAEDTIVVTAAKQNL
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
QAPGVSTITADEIKKRPPARDISELIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTL
CCCCCCEEEHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCEE
ILIDGKPATSRNSVRQGWRGERDTRGDTAWVPPEMIERIEVLRGPAAARYGNGAAGGVVN
EEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCEEE
IITKKNTKELHGSLNAYFNVPQHKQEGSTKRTDFSLSGPLTDELSFRLFGGYSKTQADAW
EEECCCCHHHHCCCEEEECCCCHHHCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCC
DINEAHKSERVGIYANSTPSGREGVEDKNIDAMLHWDFAHLQSLEFEYAYGRQGNLYAGD
CCHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEECHHHHHHCCEEEEECCCCCEEECC
TQNTNSNPLVQSNYGKETNRIYRETFGLNHRGAWDSGVSTNNYIQFERTRNTRLNEGLAG
CCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
GTEGIFDTKNEGFGTTKLDDFLAHSEISVPFELGVTQTATLGTEWNQQKMKDGSSTSQTL
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCHHE
MGGTIPGQANGTRSPYASAHIFSLFAEDNMELTDSTMLTPGLRYDLHSEAGNNWSPSLNL
ECCCCCCCCCCCCCCCCCEEEEEEEECCCCEECCCEEECCCCCEEECCCCCCCCCCCCCC
SQELGDFFTLKMGIARAYKAPNLYQTNPNYLLYSKGQGCSSSDVKNGCYLLGNDDLKAET
HHHHHHHEEHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCC
SVNKEVGLEFHNDGWLAGVTYFRNDYHNKIEAGNSRIGTSSTGTAIYQWENVPKAVVQGL
CCCHHHCCEECCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHCC
EGTLNVPVSETVSWTNNATYMIENKNKTTGDYLSIIPEFTINSTLSWQATEELSMQSTLT
CCEEECCHHHCEEECCCEEEEEECCCCCCCCHHHCCCCCCCCCEEEECCHHHHHHHHHEE
WYGRQKPKKYNYQGKPVSGTETKEVSPYAVVGASATYDVTKNVSLTAGIDNLFDKRQFRE
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCEEEECHHHHHHHHHHHC
GNSQNVGDPTTGAINIAGAGAATYNEPGRTYYMSVNTHF
CCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3015941; 8905232; 9278503; 2974033; 2526281; 2201687; 9886293 [H]