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The map label for this gene is mtr [H]

Identifier: 157371473

GI number: 157371473

Start: 3568852

End: 3570096

Strand: Direct

Name: mtr [H]

Synonym: Spro_3236

Alternate gene names: 157371473

Gene position: 3568852-3570096 (Clockwise)

Preceding gene: 157371471

Following gene: 157371474

Centisome position: 65.5

GC content: 58.23

Gene sequence:

>1245_bases
ATGTCCGCGGACACTATCCAGAAGCTTTCCCGCCCTTCGGTCCTTGGCGGCGCGATGATCATTGCAGGCACCGCCGTCGG
CGCCGGTATGTTCTCCATTCCTATTGTGACTTCTGGCGTGTGGTTCAGCGGCTCGGTCGCGCTGCTGATTTATACCTGGG
CCTGTATGCTGATCTCTGGCCTGATGATCCTCGAAGCTGCACTGCATTACCCAAGCGGTGCCAGCTTCAATACCATCGTC
AAGGATCTGCTGGGTAAAAGCTGGAACGCCATTAACGGCATTTCCATCGCCTTTGTGCTGTACATTCTGACCTATGCCTA
TATTTCCGCCGGTGGCTCAATTATCGCCCACACGCTGGAAGGCATCGTCGGCGTCGGGCAGACCACCGCCGGGCTGGTGT
TTGCCATCGTGGTGGCGTTTATCGTTTGGTTGTCCACCCGCGCGGTCGATCGTCTGAGCACCATTTTGATCGGCGGTATG
GTGATCACCTTTGTGATGTCGGTGGGCGATATGTTCACTCATGTGCAACCGGCAGTGCTGTTCAACCGGGGCGACAGCCA
GGCCAGCTATCTGCCTTACGCCCTGGCGGCGCTGCCTTATCTGCTGACCTCGTTCGGCTATCACGGCAATGTGCCGGGAC
TGGTGAAGTATTATCACAAGGACAGCGGTGCCGTGGTGCGCAGCCTGGTATACGGCACGCTGCTGGCGTTGGCGATCTAT
ATCCTGTGGCAGTATGTGATCCAGGGCAACATCGCCCGCGATGCCTTCCGCCAGGTGATTGCCGAAGGCGGCAATATCGG
CAGCCTGCTGAAACAAATGGGCAACGTCTCCAGCAGCCAGTCCGTTGGCCAACTGCTGAACGCCTTCTCTTATATGGCAC
TGGCCAGTTCGTTCCTTGGGGTTTCGCTGGGCCTGTTTGATTATTTGGCTGACTTCTTCAAATTCAGTGATGACACCACC
GGGCGCAGTAAAACCGCGTTGGTGACCTTTGCACCACCGACCATAGCCGCCCTGCTGTTCCCGAACGGCTTCCTGTACGC
CATCGGCTTCGCCGGGCTGGCGGCCACCGTTTGGGCGGTGATCGTACCGGCCATGATGGCACGCGCCAGTCGTCGTCGCT
TTGCCCAGGCGCAATATCTCGCTCCCGGTGGCCGGGGGATGATCCTGTTTATCATTCTGTTCGGGGTGATCAACGCCGTC
GCACACGTGCTGGCATTGCTGGGTCTGTTGCCGGTCTTCAAGTAA

Upstream 100 bases:

>100_bases
TGAAACAAGCACCTTCACGGCTTTACATGCGTCGACCGCACCTGTACCATTGAGCTAGTACAAAAGAACTTACGGCCGCC
ATGGCCACTCAGGAGCAAAA

Downstream 100 bases:

>100_bases
TACCGCAGGGGATGGCGCTCGCCATCCCTTTTTCCGCCACTGTTTTTGCTTGATCTGCTTGCCTGAAATCATCGGCGCGA
GTAACTTGTCGCAACTTCCC

Product: aromatic amino acid transporter

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSADTIQKLSRPSVLGGAMIIAGTAVGAGMFSIPIVTSGVWFSGSVALLIYTWACMLISGLMILEAALHYPSGASFNTIV
KDLLGKSWNAINGISIAFVLYILTYAYISAGGSIIAHTLEGIVGVGQTTAGLVFAIVVAFIVWLSTRAVDRLSTILIGGM
VITFVMSVGDMFTHVQPAVLFNRGDSQASYLPYALAALPYLLTSFGYHGNVPGLVKYYHKDSGAVVRSLVYGTLLALAIY
ILWQYVIQGNIARDAFRQVIAEGGNIGSLLKQMGNVSSSQSVGQLLNAFSYMALASSFLGVSLGLFDYLADFFKFSDDTT
GRSKTALVTFAPPTIAALLFPNGFLYAIGFAGLAATVWAVIVPAMMARASRRRFAQAQYLAPGGRGMILFIILFGVINAV
AHVLALLGLLPVFK

Sequences:

>Translated_414_residues
MSADTIQKLSRPSVLGGAMIIAGTAVGAGMFSIPIVTSGVWFSGSVALLIYTWACMLISGLMILEAALHYPSGASFNTIV
KDLLGKSWNAINGISIAFVLYILTYAYISAGGSIIAHTLEGIVGVGQTTAGLVFAIVVAFIVWLSTRAVDRLSTILIGGM
VITFVMSVGDMFTHVQPAVLFNRGDSQASYLPYALAALPYLLTSFGYHGNVPGLVKYYHKDSGAVVRSLVYGTLLALAIY
ILWQYVIQGNIARDAFRQVIAEGGNIGSLLKQMGNVSSSQSVGQLLNAFSYMALASSFLGVSLGLFDYLADFFKFSDDTT
GRSKTALVTFAPPTIAALLFPNGFLYAIGFAGLAATVWAVIVPAMMARASRRRFAQAQYLAPGGRGMILFIILFGVINAV
AHVLALLGLLPVFK
>Mature_413_residues
SADTIQKLSRPSVLGGAMIIAGTAVGAGMFSIPIVTSGVWFSGSVALLIYTWACMLISGLMILEAALHYPSGASFNTIVK
DLLGKSWNAINGISIAFVLYILTYAYISAGGSIIAHTLEGIVGVGQTTAGLVFAIVVAFIVWLSTRAVDRLSTILIGGMV
ITFVMSVGDMFTHVQPAVLFNRGDSQASYLPYALAALPYLLTSFGYHGNVPGLVKYYHKDSGAVVRSLVYGTLLALAIYI
LWQYVIQGNIARDAFRQVIAEGGNIGSLLKQMGNVSSSQSVGQLLNAFSYMALASSFLGVSLGLFDYLADFFKFSDDTTG
RSKTALVTFAPPTIAALLFPNGFLYAIGFAGLAATVWAVIVPAMMARASRRRFAQAQYLAPGGRGMILFIILFGVINAVA
HVLALLGLLPVFK

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=406, Percent_Identity=59.35960591133, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1790145, Length=413, Percent_Identity=45.5205811138014, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=35.4838709677419, Blast_Score=230, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43909; Mature: 43778

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADTIQKLSRPSVLGGAMIIAGTAVGAGMFSIPIVTSGVWFSGSVALLIYTWACMLISG
CCHHHHHHHCCCCHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LMILEAALHYPSGASFNTIVKDLLGKSWNAINGISIAFVLYILTYAYISAGGSIIAHTLE
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GIVGVGQTTAGLVFAIVVAFIVWLSTRAVDRLSTILIGGMVITFVMSVGDMFTHVQPAVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHE
FNRGDSQASYLPYALAALPYLLTSFGYHGNVPGLVKYYHKDSGAVVRSLVYGTLLALAIY
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILWQYVIQGNIARDAFRQVIAEGGNIGSLLKQMGNVSSSQSVGQLLNAFSYMALASSFLG
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSLGLFDYLADFFKFSDDTTGRSKTALVTFAPPTIAALLFPNGFLYAIGFAGLAATVWAV
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IVPAMMARASRRRFAQAQYLAPGGRGMILFIILFGVINAVAHVLALLGLLPVFK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SADTIQKLSRPSVLGGAMIIAGTAVGAGMFSIPIVTSGVWFSGSVALLIYTWACMLISG
CHHHHHHHCCCCHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LMILEAALHYPSGASFNTIVKDLLGKSWNAINGISIAFVLYILTYAYISAGGSIIAHTLE
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GIVGVGQTTAGLVFAIVVAFIVWLSTRAVDRLSTILIGGMVITFVMSVGDMFTHVQPAVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHE
FNRGDSQASYLPYALAALPYLLTSFGYHGNVPGLVKYYHKDSGAVVRSLVYGTLLALAIY
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILWQYVIQGNIARDAFRQVIAEGGNIGSLLKQMGNVSSSQSVGQLLNAFSYMALASSFLG
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSLGLFDYLADFFKFSDDTTGRSKTALVTFAPPTIAALLFPNGFLYAIGFAGLAATVWAV
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IVPAMMARASRRRFAQAQYLAPGGRGMILFIILFGVINAVAHVLALLGLLPVFK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]