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The map label for this gene is 157371413

Identifier: 157371413

GI number: 157371413

Start: 3495050

End: 3495940

Strand: Direct

Name: 157371413

Synonym: Spro_3174

Alternate gene names: NA

Gene position: 3495050-3495940 (Clockwise)

Preceding gene: 157371412

Following gene: 157371414

Centisome position: 64.14

GC content: 57.46

Gene sequence:

>891_bases
ATGCCTGACTCCCCTACTATTGCTCTGATTGGTCCCGGTGCGATTGGTACCACTATCGCTGCTGCATTGCACGAAGTCGG
CCGCACGCCACTACTTTGCGGGCGCACCGCGCACCCACAATTAATTCTGCGTCACGATGAAGGTGAAGTGGTGGTTCCTG
GTCCGGTATTGAGCAGGCCGCCGACCAGCACCCAACCCTTCGATCTGGTCTTTGTGGCGGTGAAAACGACCCAGGTGGCT
GAGAGCGCCCATTGGCTTGCCGCGTTATGCGATGAAAACACTGTCGTGTGTGCGCTGCAAAACGGCGTCGAACAGAAAAC
TCTGTTGGAACCCTATGTTAACGGAGCAATGGTACTGCCTTCGGTCGTATGGTTCCCGGCACAGCGCGAACCAGATTCCT
CTGTCCGCCTGCGGGCTAAACCGCGTTTGACACTCCCGGATGTGCCGCAGGTAAAACGGGTCGTTGATGCGCTCAGCGGT
AGCCGCTGCAGCGTTGAGTTGTCATCCGATTTCCTCTCGATCGCCTGGCGCAAACTATTGCAAAATGCGGTCGCGGGCCT
GATGGTTCTTGCAAACCGCCGTGCGGGAATGTTCTCACGCGGGGATATCACGAAACTGGCACTGGCTTATCTGCATGAAT
GTCTGACTGTCGCACGTGCCGAAGGTGCGGTACTTAGCGATAACGTTCCCCAGGAGATCGTTGACGGTTTTCATCGTGCG
CCTGCGGATTTGGGTACCTCCATTCTCGCCGATCGCCAGGCCAATCGCCCGCTGGAATGGGAGATACGCAACGGCGTCGT
GCAGCGTTATGGTCATGCGCAGGGTATTCCTACCCCCATTAGTGACATCCTGGTTCCTTTGTTGGCAGCAGGAAGCGAGG
GGCCGGGTTGA

Upstream 100 bases:

>100_bases
TGTTTCTCGGTGAAATACTCACGTTCAGCAAAATACTGGCGAGCACGGTGAGTGCTACCGGCACGCTGTTGATGGATTGA
CGATAACAGGAGGACTTAAA

Downstream 100 bases:

>100_bases
AGCGCTAAACACCAACTGCGTTTGTAGGGGGCGTTTCTCAAAGCTTTTTGACCCGTCACTGCCCCCACTATCGACACTTC
CCCCCTCCGCACCCCAGATC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPDSPTIALIGPGAIGTTIAAALHEVGRTPLLCGRTAHPQLILRHDEGEVVVPGPVLSRPPTSTQPFDLVFVAVKTTQVA
ESAHWLAALCDENTVVCALQNGVEQKTLLEPYVNGAMVLPSVVWFPAQREPDSSVRLRAKPRLTLPDVPQVKRVVDALSG
SRCSVELSSDFLSIAWRKLLQNAVAGLMVLANRRAGMFSRGDITKLALAYLHECLTVARAEGAVLSDNVPQEIVDGFHRA
PADLGTSILADRQANRPLEWEIRNGVVQRYGHAQGIPTPISDILVPLLAAGSEGPG

Sequences:

>Translated_296_residues
MPDSPTIALIGPGAIGTTIAAALHEVGRTPLLCGRTAHPQLILRHDEGEVVVPGPVLSRPPTSTQPFDLVFVAVKTTQVA
ESAHWLAALCDENTVVCALQNGVEQKTLLEPYVNGAMVLPSVVWFPAQREPDSSVRLRAKPRLTLPDVPQVKRVVDALSG
SRCSVELSSDFLSIAWRKLLQNAVAGLMVLANRRAGMFSRGDITKLALAYLHECLTVARAEGAVLSDNVPQEIVDGFHRA
PADLGTSILADRQANRPLEWEIRNGVVQRYGHAQGIPTPISDILVPLLAAGSEGPG
>Mature_295_residues
PDSPTIALIGPGAIGTTIAAALHEVGRTPLLCGRTAHPQLILRHDEGEVVVPGPVLSRPPTSTQPFDLVFVAVKTTQVAE
SAHWLAALCDENTVVCALQNGVEQKTLLEPYVNGAMVLPSVVWFPAQREPDSSVRLRAKPRLTLPDVPQVKRVVDALSGS
RCSVELSSDFLSIAWRKLLQNAVAGLMVLANRRAGMFSRGDITKLALAYLHECLTVARAEGAVLSDNVPQEIVDGFHRAP
ADLGTSILADRQANRPLEWEIRNGVVQRYGHAQGIPTPISDILVPLLAAGSEGPG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 31649; Mature: 31518

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSPTIALIGPGAIGTTIAAALHEVGRTPLLCGRTAHPQLILRHDEGEVVVPGPVLSRP
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCEEECCCCCCCC
PTSTQPFDLVFVAVKTTQVAESAHWLAALCDENTVVCALQNGVEQKTLLEPYVNGAMVLP
CCCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHHH
SVVWFPAQREPDSSVRLRAKPRLTLPDVPQVKRVVDALSGSRCSVELSSDFLSIAWRKLL
HHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHH
QNAVAGLMVLANRRAGMFSRGDITKLALAYLHECLTVARAEGAVLSDNVPQEIVDGFHRA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCC
PADLGTSILADRQANRPLEWEIRNGVVQRYGHAQGIPTPISDILVPLLAAGSEGPG
CHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PDSPTIALIGPGAIGTTIAAALHEVGRTPLLCGRTAHPQLILRHDEGEVVVPGPVLSRP
CCCCEEEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCEEECCCCCCCC
PTSTQPFDLVFVAVKTTQVAESAHWLAALCDENTVVCALQNGVEQKTLLEPYVNGAMVLP
CCCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHHH
SVVWFPAQREPDSSVRLRAKPRLTLPDVPQVKRVVDALSGSRCSVELSSDFLSIAWRKLL
HHHCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHH
QNAVAGLMVLANRRAGMFSRGDITKLALAYLHECLTVARAEGAVLSDNVPQEIVDGFHRA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCC
PADLGTSILADRQANRPLEWEIRNGVVQRYGHAQGIPTPISDILVPLLAAGSEGPG
CHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]