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The map label for this gene is paaX [H]

Identifier: 157371323

GI number: 157371323

Start: 3392758

End: 3393696

Strand: Direct

Name: paaX [H]

Synonym: Spro_3083

Alternate gene names: 157371323

Gene position: 3392758-3393696 (Clockwise)

Preceding gene: 157371322

Following gene: 157371324

Centisome position: 62.27

GC content: 59.21

Gene sequence:

>939_bases
ATGGAACATAAACTGGATGAGTTTATCCGCCATGCTATAGACGCCCAGCCGATCAGCGGCACTTCACTGATTATCTCCCT
GTACGGCGATGCGCTGAGTCATCGCGGTGGCGAAGTTTGGCTCGGCAGCCTGAGCGCACTGCTGGAAGCGCTGGGTTTCG
GAGACCGCTTTGTGCGCACTTCGGTATTTCGCCTGCAAAAAGAGGGCTGGCTGGAGGTCGAAAAAATCGGTCGTCGCAGC
TTCTATCGGGTGACCGAACAGGGTATGCGCCAGTTCCGCCACGCCGAGTCGAAAATCTACCTCAGCGAGCCACCGGCCTG
GGACGGAAAATGGGATCTGTTGTTGCTGGAAAGCGCGGAGAAAAGCGAGCGGGCACGGCTGAAAAAAGAGCTGGGCTGGC
TGGGTTTTGGTCAAATCGCCAATAACCTGATGGCGGCGCCAACCCATGCGCAAACCGACGTCACCGCGCTGCTCGGCGAG
CTTAACGCCAGCGAACAAGCGATCTATTTTCGTGCCGATTACCCCTATAACCGCTCCGAGCATACTCTGCAGCAGCTGGT
GGCCAACTGTTGGGCGCTGGGCGAGGTCGCCGCCGATTATCATGAGTTTATCGTCTCTTTCCGCCCGCTAATGGCGTTGC
TGCGCGAAACCGACGATGCCCTGCTGACGCCCCAGCGCTGTTTCCAGATTAAGCTATTATTGATCCACTTCTTCCGCCGC
GTGGTGCTTAAAGATCCGCTGCTGCCGGACGCCTTGTTGCCCGCCCAGTGGGAGGGGCAGATCGCCCGCAACCTGTGTAT
CAATATTTATCAGCGGGTGGACCGCGCCGCGACCGAGTATGTCAGCGCGCTGGCGGAAACCACTATCGGCACCCTGCCCG
CCCCGGCGGCCGGCTATTACCGGCGCTTTGGCGGCCTGCCGCGCGATCCTTCATTTTAA

Upstream 100 bases:

>100_bases
GGTCGACCTGCGCCCCCGTTGATTCCATTGGCGTCACGGATGACGCCTCAAGAATTTGTGGTAATGTTGTGTCTCACCGT
CGGCTAACCCATGGAAAAAT

Downstream 100 bases:

>100_bases
GGAGCTTTTGCTATGCCCGTGTATCAGATTGATGGCCTGACGCCAGTGGTAGACCCCAGCAGCTATGTGCACCCGACGGC
GGTATTGATTGGCGATGTGA

Product: PaaX family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEHKLDEFIRHAIDAQPISGTSLIISLYGDALSHRGGEVWLGSLSALLEALGFGDRFVRTSVFRLQKEGWLEVEKIGRRS
FYRVTEQGMRQFRHAESKIYLSEPPAWDGKWDLLLLESAEKSERARLKKELGWLGFGQIANNLMAAPTHAQTDVTALLGE
LNASEQAIYFRADYPYNRSEHTLQQLVANCWALGEVAADYHEFIVSFRPLMALLRETDDALLTPQRCFQIKLLLIHFFRR
VVLKDPLLPDALLPAQWEGQIARNLCINIYQRVDRAATEYVSALAETTIGTLPAPAAGYYRRFGGLPRDPSF

Sequences:

>Translated_312_residues
MEHKLDEFIRHAIDAQPISGTSLIISLYGDALSHRGGEVWLGSLSALLEALGFGDRFVRTSVFRLQKEGWLEVEKIGRRS
FYRVTEQGMRQFRHAESKIYLSEPPAWDGKWDLLLLESAEKSERARLKKELGWLGFGQIANNLMAAPTHAQTDVTALLGE
LNASEQAIYFRADYPYNRSEHTLQQLVANCWALGEVAADYHEFIVSFRPLMALLRETDDALLTPQRCFQIKLLLIHFFRR
VVLKDPLLPDALLPAQWEGQIARNLCINIYQRVDRAATEYVSALAETTIGTLPAPAAGYYRRFGGLPRDPSF
>Mature_312_residues
MEHKLDEFIRHAIDAQPISGTSLIISLYGDALSHRGGEVWLGSLSALLEALGFGDRFVRTSVFRLQKEGWLEVEKIGRRS
FYRVTEQGMRQFRHAESKIYLSEPPAWDGKWDLLLLESAEKSERARLKKELGWLGFGQIANNLMAAPTHAQTDVTALLGE
LNASEQAIYFRADYPYNRSEHTLQQLVANCWALGEVAADYHEFIVSFRPLMALLRETDDALLTPQRCFQIKLLLIHFFRR
VVLKDPLLPDALLPAQWEGQIARNLCINIYQRVDRAATEYVSALAETTIGTLPAPAAGYYRRFGGLPRDPSF

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=303, Percent_Identity=60.3960396039604, Blast_Score=368, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 35394; Mature: 35394

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKLDEFIRHAIDAQPISGTSLIISLYGDALSHRGGEVWLGSLSALLEALGFGDRFVRT
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
SVFRLQKEGWLEVEKIGRRSFYRVTEQGMRQFRHAESKIYLSEPPAWDGKWDLLLLESAE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEECCCC
KSERARLKKELGWLGFGQIANNLMAAPTHAQTDVTALLGELNASEQAIYFRADYPYNRSE
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
HTLQQLVANCWALGEVAADYHEFIVSFRPLMALLRETDDALLTPQRCFQIKLLLIHFFRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHH
VVLKDPLLPDALLPAQWEGQIARNLCINIYQRVDRAATEYVSALAETTIGTLPAPAAGYY
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RRFGGLPRDPSF
HHHCCCCCCCCC
>Mature Secondary Structure
MEHKLDEFIRHAIDAQPISGTSLIISLYGDALSHRGGEVWLGSLSALLEALGFGDRFVRT
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
SVFRLQKEGWLEVEKIGRRSFYRVTEQGMRQFRHAESKIYLSEPPAWDGKWDLLLLESAE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEECCCC
KSERARLKKELGWLGFGQIANNLMAAPTHAQTDVTALLGELNASEQAIYFRADYPYNRSE
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
HTLQQLVANCWALGEVAADYHEFIVSFRPLMALLRETDDALLTPQRCFQIKLLLIHFFRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHH
VVLKDPLLPDALLPAQWEGQIARNLCINIYQRVDRAATEYVSALAETTIGTLPAPAAGYY
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RRFGGLPRDPSF
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]