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The map label for this gene is cycA [H]

Identifier: 157370712

GI number: 157370712

Start: 2708142

End: 2709599

Strand: Reverse

Name: cycA [H]

Synonym: Spro_2472

Alternate gene names: 157370712

Gene position: 2709599-2708142 (Counterclockwise)

Preceding gene: 157370714

Following gene: 157370711

Centisome position: 49.73

GC content: 53.36

Gene sequence:

>1458_bases
ATGACAAAAAGTAAGCAACATCGGTTGAATACCCTTTCAACCGAGGGGCACGACTGCGCCCAAACATTGCAACGAGGTCT
GAGCGAACGCCATATTCAGCTTATTTCCATCGGCGGTGCCATTGGCACCGGGTTGTTTATGGGCTCGGGCAAAACCATCG
CGCTTTCCGGCACTTCCATTGTTTTGACCTACGTCATTGTCGGTTTCTTTATGTTTATGGTGATGCGGGCGATGGGCGAA
TTATTGCTGACCAAGCTCGACTATCGCTCATTTGCCGATTTCGTCTCTGAATACCTGGGGCCCAAAGCCAGTTTTTTTCT
CGGTTGGTCTTACTGGCTGAGTTGGGTGGTGACCTGCATTGCCGATGTGGTGGTCTGCGGGGGTTACGTGCAGTACTGGT
ACCCGGAAGTTTCGCCCTGGCTGCCGGCCTTGCTGACCCTGGGGCTGCTGTGCCTGTTCAATATGCTGTCGGTGAAGATG
TTTGGTGAAGCCGAGTTCTGGTTTGCCATCATTAAAGTGATTGCCATTATCGCGCTGATCCTGACCGGTGCCTGGATGGT
ATTTATTGGCTGGACCTCGCCGGATGGGGTTAAAGCCTCGGTGAGCAATATCACCGACCCTAATATCTTTATGCCACACG
GCATATTCGGCTTTTTTGCCGGCTTCCAGATTGCCATATTCTCCTGTACCGGCATTGAGCTGCTGGGCACCATGTCGGCC
GAGACCAAAAATCCGCAGAAAGTACTGCCCAAAGCGATCAACGTGATCCCGGTACGCATCATCATTTTCTATGTGTTTTC
GATGCTGGCGATTATCGCCGTGACCTCATGGAGCCACGTTTCGCCGGACAGTAGCCCGTTCGTTATGCTGTTCGACCAGG
CCGGTTTGCCTGCGGCAGCCGCGGTGATTAACTTTGTCGCCTTGACCTCGGCCATGTCCTCAGCCAACAGCGGGGTTTAT
TCCAGCACCCGCATGCTGTATGGCCTGTCGATGGAGAAACACGCGCACGGGCAGTTCAAAATACTGTCACGTACCACCGC
GATTCCAATCCGCAGCCTGATGTTCTCCTGCTTCTGTATGGTGGTGGGCACCATGCTGTTGATCCTGATGCCGAACGTGA
TGACGCTGTTTACCATTGTTTCTACCGTGGCGGCGATACTGGTGGTTTACAGCTGGGGCATGATCCTGGTGGCCTATCTG
GTTTATCGTAAGCAACGGCCCGAATTGCATGAGCGTTCTACCTTCAAGATGCCGGGTGGGGTGATCATGACCTGGCTGAC
GTTGGCGTTTTTCGCTTTCACGCTGGTGCTGATGGTATTTGACCGGGATACGCTGATAGCGCTGTGCAGTATGCCGCTGT
GGTTTATCGCCTTGGCGTTAGTTTGGCGCTTCAGAATCAAAAATAGCCTGGCCCGGGAAGGCTATGTGTATTACCAGGCT
GGTCAAGAGGCTGAGTAG

Upstream 100 bases:

>100_bases
GGCCTGAATTTCTTTTTTGCCGGTAGAACGCCAACGGCGTTTCACTCCTGCTGCAGCGGTAAAAGCTGCTTAATCGCCTT
AATGACGGACAGGTAACACC

Downstream 100 bases:

>100_bases
GTTCGGTGAGTAAAAAATGCCAGAACAGCTCAATACTGTTATAAACCCCAGTTTGAATTTCTGAATGGTTCCGATATAGT
TGCTTCGTACAACTATATCG

Product: amino acid permease-associated protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTKSKQHRLNTLSTEGHDCAQTLQRGLSERHIQLISIGGAIGTGLFMGSGKTIALSGTSIVLTYVIVGFFMFMVMRAMGE
LLLTKLDYRSFADFVSEYLGPKASFFLGWSYWLSWVVTCIADVVVCGGYVQYWYPEVSPWLPALLTLGLLCLFNMLSVKM
FGEAEFWFAIIKVIAIIALILTGAWMVFIGWTSPDGVKASVSNITDPNIFMPHGIFGFFAGFQIAIFSCTGIELLGTMSA
ETKNPQKVLPKAINVIPVRIIIFYVFSMLAIIAVTSWSHVSPDSSPFVMLFDQAGLPAAAAVINFVALTSAMSSANSGVY
SSTRMLYGLSMEKHAHGQFKILSRTTAIPIRSLMFSCFCMVVGTMLLILMPNVMTLFTIVSTVAAILVVYSWGMILVAYL
VYRKQRPELHERSTFKMPGGVIMTWLTLAFFAFTLVLMVFDRDTLIALCSMPLWFIALALVWRFRIKNSLAREGYVYYQA
GQEAE

Sequences:

>Translated_485_residues
MTKSKQHRLNTLSTEGHDCAQTLQRGLSERHIQLISIGGAIGTGLFMGSGKTIALSGTSIVLTYVIVGFFMFMVMRAMGE
LLLTKLDYRSFADFVSEYLGPKASFFLGWSYWLSWVVTCIADVVVCGGYVQYWYPEVSPWLPALLTLGLLCLFNMLSVKM
FGEAEFWFAIIKVIAIIALILTGAWMVFIGWTSPDGVKASVSNITDPNIFMPHGIFGFFAGFQIAIFSCTGIELLGTMSA
ETKNPQKVLPKAINVIPVRIIIFYVFSMLAIIAVTSWSHVSPDSSPFVMLFDQAGLPAAAAVINFVALTSAMSSANSGVY
SSTRMLYGLSMEKHAHGQFKILSRTTAIPIRSLMFSCFCMVVGTMLLILMPNVMTLFTIVSTVAAILVVYSWGMILVAYL
VYRKQRPELHERSTFKMPGGVIMTWLTLAFFAFTLVLMVFDRDTLIALCSMPLWFIALALVWRFRIKNSLAREGYVYYQA
GQEAE
>Mature_484_residues
TKSKQHRLNTLSTEGHDCAQTLQRGLSERHIQLISIGGAIGTGLFMGSGKTIALSGTSIVLTYVIVGFFMFMVMRAMGEL
LLTKLDYRSFADFVSEYLGPKASFFLGWSYWLSWVVTCIADVVVCGGYVQYWYPEVSPWLPALLTLGLLCLFNMLSVKMF
GEAEFWFAIIKVIAIIALILTGAWMVFIGWTSPDGVKASVSNITDPNIFMPHGIFGFFAGFQIAIFSCTGIELLGTMSAE
TKNPQKVLPKAINVIPVRIIIFYVFSMLAIIAVTSWSHVSPDSSPFVMLFDQAGLPAAAAVINFVALTSAMSSANSGVYS
STRMLYGLSMEKHAHGQFKILSRTTAIPIRSLMFSCFCMVVGTMLLILMPNVMTLFTIVSTVAAILVVYSWGMILVAYLV
YRKQRPELHERSTFKMPGGVIMTWLTLAFFAFTLVLMVFDRDTLIALCSMPLWFIALALVWRFRIKNSLAREGYVYYQAG
QEAE

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790653, Length=466, Percent_Identity=54.0772532188841, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1786302, Length=461, Percent_Identity=36.2255965292842, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1786789, Length=461, Percent_Identity=36.4425162689805, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI48994972, Length=449, Percent_Identity=35.6347438752784, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI87081915, Length=474, Percent_Identity=35.8649789029536, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=34.061135371179, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=32.5379609544469, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1788480, Length=446, Percent_Identity=34.5291479820628, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=31.002331002331, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17540018, Length=369, Percent_Identity=24.9322493224932, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324924, Length=446, Percent_Identity=29.1479820627803, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324990, Length=512, Percent_Identity=27.1484375, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6324061, Length=444, Percent_Identity=28.6036036036036, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6320772, Length=352, Percent_Identity=32.9545454545455, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=437, Percent_Identity=27.4599542334096, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322892, Length=422, Percent_Identity=28.436018957346, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324553, Length=325, Percent_Identity=30.1538461538462, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324059, Length=337, Percent_Identity=32.0474777448071, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319824, Length=422, Percent_Identity=23.696682464455, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6322967, Length=422, Percent_Identity=26.5402843601896, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319608, Length=420, Percent_Identity=25.2380952380952, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=23.3415233415233, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319542, Length=422, Percent_Identity=23.696682464455, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320251, Length=421, Percent_Identity=24.7030878859857, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321053, Length=415, Percent_Identity=23.6144578313253, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319543, Length=323, Percent_Identity=26.0061919504644, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324981, Length=422, Percent_Identity=26.5402843601896, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320364, Length=476, Percent_Identity=23.9495798319328, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550968, Length=432, Percent_Identity=26.1574074074074, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921172, Length=432, Percent_Identity=26.1574074074074, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221331183, Length=448, Percent_Identity=23.4375, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17647653, Length=448, Percent_Identity=23.4375, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24664379, Length=448, Percent_Identity=23.4375, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53829; Mature: 53698

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSKQHRLNTLSTEGHDCAQTLQRGLSERHIQLISIGGAIGTGLFMGSGKTIALSGTSI
CCCCHHHHHHHCCCCCHHHHHHHHHCHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHH
VLTYVIVGFFMFMVMRAMGELLLTKLDYRSFADFVSEYLGPKASFFLGWSYWLSWVVTCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ADVVVCGGYVQYWYPEVSPWLPALLTLGLLCLFNMLSVKMFGEAEFWFAIIKVIAIIALI
HHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTGAWMVFIGWTSPDGVKASVSNITDPNIFMPHGIFGFFAGFQIAIFSCTGIELLGTMSA
HHCCCEEEEECCCCCCCEEHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCHHHHHCCCC
ETKNPQKVLPKAINVIPVRIIIFYVFSMLAIIAVTSWSHVSPDSSPFVMLFDQAGLPAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHH
AVINFVALTSAMSSANSGVYSSTRMLYGLSMEKHAHGQFKILSRTTAIPIRSLMFSCFCM
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHHH
VVGTMLLILMPNVMTLFTIVSTVAAILVVYSWGMILVAYLVYRKQRPELHERSTFKMPGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCH
VIMTWLTLAFFAFTLVLMVFDRDTLIALCSMPLWFIALALVWRFRIKNSLAREGYVYYQA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
GQEAE
CCCCC
>Mature Secondary Structure 
TKSKQHRLNTLSTEGHDCAQTLQRGLSERHIQLISIGGAIGTGLFMGSGKTIALSGTSI
CCCHHHHHHHCCCCCHHHHHHHHHCHHHCCEEEEEECCHHHHHEEECCCCEEEECCHHH
VLTYVIVGFFMFMVMRAMGELLLTKLDYRSFADFVSEYLGPKASFFLGWSYWLSWVVTCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ADVVVCGGYVQYWYPEVSPWLPALLTLGLLCLFNMLSVKMFGEAEFWFAIIKVIAIIALI
HHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTGAWMVFIGWTSPDGVKASVSNITDPNIFMPHGIFGFFAGFQIAIFSCTGIELLGTMSA
HHCCCEEEEECCCCCCCEEHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCHHHHHCCCC
ETKNPQKVLPKAINVIPVRIIIFYVFSMLAIIAVTSWSHVSPDSSPFVMLFDQAGLPAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHH
AVINFVALTSAMSSANSGVYSSTRMLYGLSMEKHAHGQFKILSRTTAIPIRSLMFSCFCM
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHHH
VVGTMLLILMPNVMTLFTIVSTVAAILVVYSWGMILVAYLVYRKQRPELHERSTFKMPGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCH
VIMTWLTLAFFAFTLVLMVFDRDTLIALCSMPLWFIALALVWRFRIKNSLAREGYVYYQA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
GQEAE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]