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The map label for this gene is hisM [H]

Identifier: 157370639

GI number: 157370639

Start: 2620302

End: 2621024

Strand: Direct

Name: hisM [H]

Synonym: Spro_2399

Alternate gene names: 157370639

Gene position: 2620302-2621024 (Clockwise)

Preceding gene: 157370638

Following gene: 157370641

Centisome position: 48.09

GC content: 57.4

Gene sequence:

>723_bases
ATGAATCTGCAAAATATGCTGGATGCGGCACCGAGCTTTTTGTGGAGCGACGGTTCCGACGTCACCGGGCTGGCGATGAC
CGCCAAACTGTTCTTGTTATCGGTGGTGCCAGGATTACTGCTGGCAGCGCTGATGGCGATCGGCCAGGTATACGGCCCGC
GACCGCTGTCGTGGCTGATCCGCAGCGTGACTTACTTTTTCCGCAGCACGCCGCTCTACCTGCAATTAATGCTGATTTAC
TACGGCCTGTCACAGTTTGACGTGGTGCAATTGGGTTGGCAGAACGACCAGCCTTTCTGGCTGCTGTTTCGCGACGCCAC
TTTCTGTGCCACGCTGGCGTTGGTACTCAATACCAGCGCTTACGTTGCCCAACTGTTGGCCGGCATGATGGAAACCTTCC
CGCGTCAGGAGTGGATTGCCGGTGAGGCCTATGGCATGAGTCAGTGGCAGATTATCCGCCGTCTGGTGCTGCCGGCAACG
CTGCGGCGTGGCATTCCGGCGCTGAATAACGAGATGGTCTTCCTGCTGCATGCCACCTCGCTGGCCAGTACCGTCACGCT
GCTGGATATTACCGGTGTGGCACGCGCATTTTATGCCGCCACCTATTCACCCTTTATTCCGTTCCTGATGGCGGCGGCAC
TGTATTTGCTGTGCACTTTCCTGCTGATCTTCATGTTTTCACGGGCAGAGCGTCGCTGGCTGGCGTTTATCCGCCGCGAT
TGA

Upstream 100 bases:

>100_bases
CGCTGATTTATATGGCGATTACCGCCGTCTCCAGTTGGGGTTTTAGCCGGTTGGCGCGGCGTTACGCGTTGGCTTCCTCA
CATTCGGCAGGAGCACGCTG

Downstream 100 bases:

>100_bases
TGCAGTTCAGGAGCGTTTGATCGACTGCAGCTCGGTCAGGGTGACGATTTTATCCACCCGAAATTTCTTGCTGGTCAGCC
AGGTATCGGCCAGCAGCCGG

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MNLQNMLDAAPSFLWSDGSDVTGLAMTAKLFLLSVVPGLLLAALMAIGQVYGPRPLSWLIRSVTYFFRSTPLYLQLMLIY
YGLSQFDVVQLGWQNDQPFWLLFRDATFCATLALVLNTSAYVAQLLAGMMETFPRQEWIAGEAYGMSQWQIIRRLVLPAT
LRRGIPALNNEMVFLLHATSLASTVTLLDITGVARAFYAATYSPFIPFLMAAALYLLCTFLLIFMFSRAERRWLAFIRRD

Sequences:

>Translated_240_residues
MNLQNMLDAAPSFLWSDGSDVTGLAMTAKLFLLSVVPGLLLAALMAIGQVYGPRPLSWLIRSVTYFFRSTPLYLQLMLIY
YGLSQFDVVQLGWQNDQPFWLLFRDATFCATLALVLNTSAYVAQLLAGMMETFPRQEWIAGEAYGMSQWQIIRRLVLPAT
LRRGIPALNNEMVFLLHATSLASTVTLLDITGVARAFYAATYSPFIPFLMAAALYLLCTFLLIFMFSRAERRWLAFIRRD
>Mature_240_residues
MNLQNMLDAAPSFLWSDGSDVTGLAMTAKLFLLSVVPGLLLAALMAIGQVYGPRPLSWLIRSVTYFFRSTPLYLQLMLIY
YGLSQFDVVQLGWQNDQPFWLLFRDATFCATLALVLNTSAYVAQLLAGMMETFPRQEWIAGEAYGMSQWQIIRRLVLPAT
LRRGIPALNNEMVFLLHATSLASTVTLLDITGVARAFYAATYSPFIPFLMAAALYLLCTFLLIFMFSRAERRWLAFIRRD

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=225, Percent_Identity=42.6666666666667, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1787086, Length=219, Percent_Identity=34.703196347032, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787087, Length=233, Percent_Identity=30.0429184549356, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788226, Length=214, Percent_Identity=30.8411214953271, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787030, Length=217, Percent_Identity=26.7281105990783, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786873, Length=169, Percent_Identity=26.6272189349112, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788646, Length=224, Percent_Identity=23.2142857142857, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 27138; Mature: 27138

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQNMLDAAPSFLWSDGSDVTGLAMTAKLFLLSVVPGLLLAALMAIGQVYGPRPLSWLI
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RSVTYFFRSTPLYLQLMLIYYGLSQFDVVQLGWQNDQPFWLLFRDATFCATLALVLNTSA
HHHHHHHHCCHHHHHHHHHHHCCCHHHEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCHH
YVAQLLAGMMETFPRQEWIAGEAYGMSQWQIIRRLVLPATLRRGIPALNNEMVFLLHATS
HHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHH
LASTVTLLDITGVARAFYAATYSPFIPFLMAAALYLLCTFLLIFMFSRAERRWLAFIRRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLQNMLDAAPSFLWSDGSDVTGLAMTAKLFLLSVVPGLLLAALMAIGQVYGPRPLSWLI
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RSVTYFFRSTPLYLQLMLIYYGLSQFDVVQLGWQNDQPFWLLFRDATFCATLALVLNTSA
HHHHHHHHCCHHHHHHHHHHHCCCHHHEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCHH
YVAQLLAGMMETFPRQEWIAGEAYGMSQWQIIRRLVLPATLRRGIPALNNEMVFLLHATS
HHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHH
LASTVTLLDITGVARAFYAATYSPFIPFLMAAALYLLCTFLLIFMFSRAERRWLAFIRRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]