Click here to switch to the map view.

The map label for this gene is hisQ [H]

Identifier: 157370638

GI number: 157370638

Start: 2619610

End: 2620302

Strand: Direct

Name: hisQ [H]

Synonym: Spro_2398

Alternate gene names: 157370638

Gene position: 2619610-2620302 (Clockwise)

Preceding gene: 157370637

Following gene: 157370639

Centisome position: 48.08

GC content: 58.87

Gene sequence:

>693_bases
ATGGTCATAGAGTATTTGCCGTTGCTGGCTCATGGCGCGTTGCTGTCACTGTGCGTGATGCTGGTTTCACTGGCGGTGGC
GTTGACGCTTGGCATGATCAATGCGCTGATTAAACTCTTTGGTCCGCGCTGGTTGCGCTGGGTATCGACGGGTTACACCA
CGCTGGTGCGCGGCATTCCCGAGTTGGTGATCATGCTGTTGCTGTTCTTTGGCGGCGAAATGCTGGTCAACGGCTTGCTT
GGCCTGGTGGGATTGGGGCCGCTGCGCTTCAACACCTTTATCTCTGGGGTGCTGGCGATTGGTTTTGTGTTTGGCGCTTA
CTACACCGAAACCTTTCGCGGGGCGTTTCTCACCGTGGAGCGCGGTCAACTCGAGGCGGCAATGGCCTACGGCATGCGGC
CGGGCCAGGTGTTTCGCCGGGTGCTGCTGCCGCAGATGCTGAGCTTCGCCATTCCCGGCATCAACAACAACTGGCTTGGG
CTGATGAAAGCCTCGGCGCTGGTGTCGATCCTCGGTCTGGAGGATATGGTTTGGCTGGCAGAGCAGGCCGGGCGGGCCAC
GCAAAAGCCTTTCCTGTTTTATTTCCTGGTGGCGCTGATTTATATGGCGATTACCGCCGTCTCCAGTTGGGGTTTTAGCC
GGTTGGCGCGGCGTTACGCGTTGGCTTCCTCACATTCGGCAGGAGCACGCTGA

Upstream 100 bases:

>100_bases
TGCCGACGGGACTTATGAAGCCATCCAGAAAAAATATTTTAGCTTCGACATATATGGCAACTAAACCGGCTCGGATCCAG
TCATCCAGGGGAGGCCGGGA

Downstream 100 bases:

>100_bases
TGAATCTGCAAAATATGCTGGATGCGGCACCGAGCTTTTTGTGGAGCGACGGTTCCGACGTCACCGGGCTGGCGATGACC
GCCAAACTGTTCTTGTTATC

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MVIEYLPLLAHGALLSLCVMLVSLAVALTLGMINALIKLFGPRWLRWVSTGYTTLVRGIPELVIMLLLFFGGEMLVNGLL
GLVGLGPLRFNTFISGVLAIGFVFGAYYTETFRGAFLTVERGQLEAAMAYGMRPGQVFRRVLLPQMLSFAIPGINNNWLG
LMKASALVSILGLEDMVWLAEQAGRATQKPFLFYFLVALIYMAITAVSSWGFSRLARRYALASSHSAGAR

Sequences:

>Translated_230_residues
MVIEYLPLLAHGALLSLCVMLVSLAVALTLGMINALIKLFGPRWLRWVSTGYTTLVRGIPELVIMLLLFFGGEMLVNGLL
GLVGLGPLRFNTFISGVLAIGFVFGAYYTETFRGAFLTVERGQLEAAMAYGMRPGQVFRRVLLPQMLSFAIPGINNNWLG
LMKASALVSILGLEDMVWLAEQAGRATQKPFLFYFLVALIYMAITAVSSWGFSRLARRYALASSHSAGAR
>Mature_230_residues
MVIEYLPLLAHGALLSLCVMLVSLAVALTLGMINALIKLFGPRWLRWVSTGYTTLVRGIPELVIMLLLFFGGEMLVNGLL
GLVGLGPLRFNTFISGVLAIGFVFGAYYTETFRGAFLTVERGQLEAAMAYGMRPGQVFRRVLLPQMLSFAIPGINNNWLG
LMKASALVSILGLEDMVWLAEQAGRATQKPFLFYFLVALIYMAITAVSSWGFSRLARRYALASSHSAGAR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=216, Percent_Identity=42.5925925925926, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI1787087, Length=229, Percent_Identity=32.3144104803493, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788226, Length=210, Percent_Identity=29.5238095238095, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787030, Length=213, Percent_Identity=28.169014084507, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788645, Length=196, Percent_Identity=29.5918367346939, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786873, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786874, Length=173, Percent_Identity=30.0578034682081, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25176; Mature: 25176

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIEYLPLLAHGALLSLCVMLVSLAVALTLGMINALIKLFGPRWLRWVSTGYTTLVRGIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELVIMLLLFFGGEMLVNGLLGLVGLGPLRFNTFISGVLAIGFVFGAYYTETFRGAFLTVE
HHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEE
RGQLEAAMAYGMRPGQVFRRVLLPQMLSFAIPGINNNWLGLMKASALVSILGLEDMVWLA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQAGRATQKPFLFYFLVALIYMAITAVSSWGFSRLARRYALASSHSAGAR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVIEYLPLLAHGALLSLCVMLVSLAVALTLGMINALIKLFGPRWLRWVSTGYTTLVRGIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELVIMLLLFFGGEMLVNGLLGLVGLGPLRFNTFISGVLAIGFVFGAYYTETFRGAFLTVE
HHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEE
RGQLEAAMAYGMRPGQVFRRVLLPQMLSFAIPGINNNWLGLMKASALVSILGLEDMVWLA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EQAGRATQKPFLFYFLVALIYMAITAVSSWGFSRLARRYALASSHSAGAR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]