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The map label for this gene is mdtG [H]

Identifier: 157370579

GI number: 157370579

Start: 2551714

End: 2552934

Strand: Reverse

Name: mdtG [H]

Synonym: Spro_2339

Alternate gene names: 157370579

Gene position: 2552934-2551714 (Counterclockwise)

Preceding gene: 157370580

Following gene: 157370576

Centisome position: 46.85

GC content: 56.92

Gene sequence:

>1221_bases
ATGGAAGCGTGGAAACTCAATCTGATCTCAGTCTGGCTCGGCTGTTTCTTTACCGGGCTGGCGATGAGCCAAATCCTGCC
TTTTCTACCGCTGTACGTCGAACAGCTCGGCGTCAGTGGCCACCAGTCGCTGAGTATCTGGTCCGGATTGGTGTTCAGCG
GCACCTTTTTGGTTTCGGCGCTGGTATCACCGCTGTGGGGCAGCCTGGCAGACCGCAAGGGCCGCAAGCTCATGCTGCTG
CGTGCTTCGCTGGGAATGGCCGTCGTGATTGCGCTGCAGGGTATGGTCACCAACGTTTATCAGCTGTTTGCACTGCGCGC
ACTGATGGGGCTGACCTCCGGCTATATCCCCAATGCCATGGCGTTGGTCGCTTCGCAGGTACCGCGTGACAAAAGCGGCT
GGGCTTTGGGCACTTTGTCTACCGGCCCGGTGACCGGGGTGATCGTTGGCCCACTGTTGGGTGGCCTGATGGCCGACCAT
CTGGGGCTACGCGTGGTGTTCTTCGTCACCGCGGTGCTGATGTTTGTCAGTTTCCTGATTACCCTGTTCCTGATAAAAGA
ACGCCATATCGAGGTAAAAAAAGCCGATCGATTAAGCGGCAAAGCGGTATTCCAGTCGCTGCCCTATCCGACGCTGATTG
TGACGCTGTTTATCAGCACTCTGATGATCCAGCTGGCCAACTCATCGATCAGTCCGATACTGACGCTGTTTATCAAGGAT
TTGTCCGGTGATAGTGGCAATCTGGCCTTTATTAGCGGCATGATCGCCGCCGTTCCTGGCGTTGCCGCATTGATGTCTGC
CCCGCGTCTCGGTCGACTTGGCGACCGTATCGGCACCGCACGCATTTTGTTGGCCGCATTGGGATTGACTACGGTGCTAT
TTGCCATCATGGCCTGGGTGGAAACGCCGCTCCAGTTGGGGATCCTGCGTTTTCTGTTGGGGTTTGCCGATGGTGCCTTG
ATGCCTGCGGTGCAGACGCTGCTGCTGAAGTACTCTTCCGATCAGGTCACCGGACGCATCTTCGGCTATAACCAGTCATT
TATGTATCTCGGTAACGTGGTGGGTCCACTGATTGGTTCTGGCGTTTCGGCGCTGATGGGCTTCCGCTGGGTGTTTGTGG
TCACGGCGGTGCTGGTGCTGATTAACTGCCTGCAACTGCGCAGCCAGTTTAACAAGGTCGAAGCGAAGTCCTCTCCCTCC
GGCCAAGAGGGAGAGCGTTGA

Upstream 100 bases:

>100_bases
TACGTTTGCTCACCGATTTCGCCCAGCAACACCTGATAACCGGTGTTATTATTACTCTGCTCAATAAACTCCTCCCAATT
CAAAGTGGTACGACAAGCTG

Downstream 100 bases:

>100_bases
TTAATGGTTAATCACGTAACCAGGGGGTAAAGGTCACGCCGATCAACAGCCCTTCCGGGCTGAGCAACCGGGTGACGCTC
TGGCCCCAGGGTTCTTCACG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MEAWKLNLISVWLGCFFTGLAMSQILPFLPLYVEQLGVSGHQSLSIWSGLVFSGTFLVSALVSPLWGSLADRKGRKLMLL
RASLGMAVVIALQGMVTNVYQLFALRALMGLTSGYIPNAMALVASQVPRDKSGWALGTLSTGPVTGVIVGPLLGGLMADH
LGLRVVFFVTAVLMFVSFLITLFLIKERHIEVKKADRLSGKAVFQSLPYPTLIVTLFISTLMIQLANSSISPILTLFIKD
LSGDSGNLAFISGMIAAVPGVAALMSAPRLGRLGDRIGTARILLAALGLTTVLFAIMAWVETPLQLGILRFLLGFADGAL
MPAVQTLLLKYSSDQVTGRIFGYNQSFMYLGNVVGPLIGSGVSALMGFRWVFVVTAVLVLINCLQLRSQFNKVEAKSSPS
GQEGER

Sequences:

>Translated_406_residues
MEAWKLNLISVWLGCFFTGLAMSQILPFLPLYVEQLGVSGHQSLSIWSGLVFSGTFLVSALVSPLWGSLADRKGRKLMLL
RASLGMAVVIALQGMVTNVYQLFALRALMGLTSGYIPNAMALVASQVPRDKSGWALGTLSTGPVTGVIVGPLLGGLMADH
LGLRVVFFVTAVLMFVSFLITLFLIKERHIEVKKADRLSGKAVFQSLPYPTLIVTLFISTLMIQLANSSISPILTLFIKD
LSGDSGNLAFISGMIAAVPGVAALMSAPRLGRLGDRIGTARILLAALGLTTVLFAIMAWVETPLQLGILRFLLGFADGAL
MPAVQTLLLKYSSDQVTGRIFGYNQSFMYLGNVVGPLIGSGVSALMGFRWVFVVTAVLVLINCLQLRSQFNKVEAKSSPS
GQEGER
>Mature_406_residues
MEAWKLNLISVWLGCFFTGLAMSQILPFLPLYVEQLGVSGHQSLSIWSGLVFSGTFLVSALVSPLWGSLADRKGRKLMLL
RASLGMAVVIALQGMVTNVYQLFALRALMGLTSGYIPNAMALVASQVPRDKSGWALGTLSTGPVTGVIVGPLLGGLMADH
LGLRVVFFVTAVLMFVSFLITLFLIKERHIEVKKADRLSGKAVFQSLPYPTLIVTLFISTLMIQLANSSISPILTLFIKD
LSGDSGNLAFISGMIAAVPGVAALMSAPRLGRLGDRIGTARILLAALGLTTVLFAIMAWVETPLQLGILRFLLGFADGAL
MPAVQTLLLKYSSDQVTGRIFGYNQSFMYLGNVVGPLIGSGVSALMGFRWVFVVTAVLVLINCLQLRSQFNKVEAKSSPS
GQEGER

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=381, Percent_Identity=61.1548556430446, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI87082404, Length=369, Percent_Identity=23.8482384823848, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI62471713, Length=345, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62471717, Length=345, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62471715, Length=345, Percent_Identity=26.9565217391304, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43519; Mature: 43519

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA