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The map label for this gene is xdhD [H]

Identifier: 157370541

GI number: 157370541

Start: 2505505

End: 2507898

Strand: Direct

Name: xdhD [H]

Synonym: Spro_2301

Alternate gene names: 157370541

Gene position: 2505505-2507898 (Clockwise)

Preceding gene: 157370540

Following gene: 157370542

Centisome position: 45.98

GC content: 58.48

Gene sequence:

>2394_bases
ATGAGTAATAGCAAACGCACCGAATATACCCAGCAGCAGTTGGCCGAACGTTTCCGTCAGCCGCTGCCCAGCGGCGTGGG
GCGCAGTCGCAAACACGAGAGCGCCGACAAACACGTCAGCGGTGAAGCGCAATACATTGACGACCGGCTGGAGTTTCCCA
ACCAGTTGCATCTGGCGGCAAAACTGAGTGAGAAAGCGCATGCGCGCATCGAAAAACTGGATCTGTCCGCCTGTTACGAT
TTTCCCGGCGTAGTCAGGGTCATCACCTGGCAGGACGTGCCGGGCGAACTGGATATTGCTCCGTTAACCTACGGCGATCC
GCTGCTGGCGAAGGACGTGGTCGAATACGTCGGGCAGGTGATTGCGGTGGTGGCGGCGGAGGATCCGGAGATCGCCTGGC
GGGCCGCGCAGGCCATTAAAGTGAGCTATCAGGAGCTGCCTGCGCAACTGGACGTCACCCAATCGTTGCGGGAAGGCTTC
GTGGTGCAGGAAGCTCACCACCATCGACGCGGCGACGCGGATGGCGCACTGGCGCAGGCGTTGCATCGCATTCAGGGCGA
GCTGCACGTCGGTGGCCAGGAACATTTTTATCTGGAGACCCAGATTGCCTCGGTGCTGCCGGCTGAGGACGGCGGCATGC
TGGTGTATTCATCGACCCAGAACCCCACCGAAATCCAAAAGTTGGTGGCCTCGGTGCTTAATTTACCGATGCACAAGGTG
ACTATCGACACGCGGCGCATGGGCGGCGGCTTTGGCGGCAAAGAGACTCAGGCCGCCGGCCCGGCGTGCCTGTGTGCGGT
GGTGGCACACCTTACCGGGCGGCCGGTCAAAATGCGGTTGAACCGCCGCGACGACATGCTGATCACCGGCAAACGCCACC
CGTTTTATATTCAGTATGACGTCGGTTTTGACGACAGCGGTCTGTTGAATGGGGTGAAAATCACCCTGGCCGGTAACTGC
GGCTACTCGCTCGATCTCTCCGGTTCTATCGTTGATCGCGCCATGTTCCATGCTGATAACGCCTATTTCCTGCAGGATGT
ACTGATAACCGGCCACCGCTGTAAAACCCATATCGCCTCCAATACGGCCTATCGTGGCTTTGGCGGGCCACAGGGCATGA
TGGCGATCGAGCAGATCATGGACCACATCGCGCGCTATCTGGCGCTCGATCCGCTGGCGGTGCGTAAAACCAATTACTAC
GGTAAAGATCAGCGCAACATCACCCATTACCATCAGCCGGTGGAACAGAATCTGCTGCAAGAGATCACCGCCGAACTGGA
GCGCAGTGCGGATTATCAGGCGCGGCGTCAGGCTATCCGGCAGTTCAACGCACAAAACCCAATCCTGAAGAAGGGGCTGG
CGCTGACGCCGGTCAAATTCGGTATCTCCTTTACCGCCGGCTTCCTCAATCAGGCGGGGGCGCTGGTACTGATTTACACC
GACGGCAGCATTCAACTCAACCACGGCGGTACCGAGATGGGCCAGGGGTTGAACACCAAGGTGGCGCAGATTGTCGCCGA
AGTATTTCAGGTGGAAATAGAGCGTATCCAGATCACCGCCACCGATACCGGTAAAGTGCCGAACACCTCGCCGACGGCGG
CATCCTCCGGCACCGACCTGAACGGCAAGGCGGCGGAGAATGCGGCTTTGACCATCAAACAGCGATTGACTGACATGCTG
GCCAGGCAGCATCAGGTTAGCGCTGAGCAGATCCTCTTCAACAATGGGCAGGTCAGGGTGGGTGAACGCTATTTCAGCTT
CGAACAGGTGGTAGAACAGGCCTATTTCAATCAAATCTCACTTGCCAGTACCGGTTACTACCGCACACCGAAGATCTTTT
ACGATCGCGACAAGGCCAGCGGCCATCCTTTCTATTACTTTGCCTACGGCGCGGCTTGCGCAGAGGTGTTAATTGATACG
CTGACCGGCGAATACAAACTGCTGCGCGCCGACATTCTGCACGACGTGGGCGACTCGCTGAACCCGGCAATCGACATCGG
TCAGGTGGAGGGCGGTTTTGTGCAGGGCATGGGCTGGCTGACCAGCGAGGAGTTGGTGTGGGACCAACAGGGCAGGCTGC
TGACTAACGGCCCGGCCAGCTACAAAATACCGGCGATTGGTGACGTTCCTGCGGATCTGCGCGTTACGCTGCTGGAGAAC
CGCAAAAACCCCGAGGACACGGTATTTCATTCCAAAGCGGTGGGCGAGCCACCGTTTATGTTGGGCATCTCGGTCTGGTG
TGCCATCAAGGATGCGGTGGCCAGTCTGGCGGACTACCGTCTGCAGCCCAATATTGACGCACCGGCCACGCCGGAGCGGG
TGCTGTGGGGAGTACAGCAGATGCTTTCAAGTGACATTGTCACTAAATTGGCACGGGAGAACGGCGATGGATGA

Upstream 100 bases:

>100_bases
CGTGCCAGCAGCGCTTATCGCCTGTTGGTGGCGCAGAATCTGTTGCGTCGCTATTTCATTGCGCTGACTGAGCCACAGCT
GGCGATCGAGGTGACGGCTT

Downstream 100 bases:

>100_bases
GTGGATTGAGGCACTGGCCGATCTGCGACGGCGCGGAGAACCCTGCGTACTGGTGACGCTGGTGGATGAGCTGGGCTCCA
CGCCGCGTAATCGTGGCACC

Product: xanthine dehydrogenase molybdopterin binding subunit

Products: urate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MSNSKRTEYTQQQLAERFRQPLPSGVGRSRKHESADKHVSGEAQYIDDRLEFPNQLHLAAKLSEKAHARIEKLDLSACYD
FPGVVRVITWQDVPGELDIAPLTYGDPLLAKDVVEYVGQVIAVVAAEDPEIAWRAAQAIKVSYQELPAQLDVTQSLREGF
VVQEAHHHRRGDADGALAQALHRIQGELHVGGQEHFYLETQIASVLPAEDGGMLVYSSTQNPTEIQKLVASVLNLPMHKV
TIDTRRMGGGFGGKETQAAGPACLCAVVAHLTGRPVKMRLNRRDDMLITGKRHPFYIQYDVGFDDSGLLNGVKITLAGNC
GYSLDLSGSIVDRAMFHADNAYFLQDVLITGHRCKTHIASNTAYRGFGGPQGMMAIEQIMDHIARYLALDPLAVRKTNYY
GKDQRNITHYHQPVEQNLLQEITAELERSADYQARRQAIRQFNAQNPILKKGLALTPVKFGISFTAGFLNQAGALVLIYT
DGSIQLNHGGTEMGQGLNTKVAQIVAEVFQVEIERIQITATDTGKVPNTSPTAASSGTDLNGKAAENAALTIKQRLTDML
ARQHQVSAEQILFNNGQVRVGERYFSFEQVVEQAYFNQISLASTGYYRTPKIFYDRDKASGHPFYYFAYGAACAEVLIDT
LTGEYKLLRADILHDVGDSLNPAIDIGQVEGGFVQGMGWLTSEELVWDQQGRLLTNGPASYKIPAIGDVPADLRVTLLEN
RKNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRLQPNIDAPATPERVLWGVQQMLSSDIVTKLARENGDG

Sequences:

>Translated_797_residues
MSNSKRTEYTQQQLAERFRQPLPSGVGRSRKHESADKHVSGEAQYIDDRLEFPNQLHLAAKLSEKAHARIEKLDLSACYD
FPGVVRVITWQDVPGELDIAPLTYGDPLLAKDVVEYVGQVIAVVAAEDPEIAWRAAQAIKVSYQELPAQLDVTQSLREGF
VVQEAHHHRRGDADGALAQALHRIQGELHVGGQEHFYLETQIASVLPAEDGGMLVYSSTQNPTEIQKLVASVLNLPMHKV
TIDTRRMGGGFGGKETQAAGPACLCAVVAHLTGRPVKMRLNRRDDMLITGKRHPFYIQYDVGFDDSGLLNGVKITLAGNC
GYSLDLSGSIVDRAMFHADNAYFLQDVLITGHRCKTHIASNTAYRGFGGPQGMMAIEQIMDHIARYLALDPLAVRKTNYY
GKDQRNITHYHQPVEQNLLQEITAELERSADYQARRQAIRQFNAQNPILKKGLALTPVKFGISFTAGFLNQAGALVLIYT
DGSIQLNHGGTEMGQGLNTKVAQIVAEVFQVEIERIQITATDTGKVPNTSPTAASSGTDLNGKAAENAALTIKQRLTDML
ARQHQVSAEQILFNNGQVRVGERYFSFEQVVEQAYFNQISLASTGYYRTPKIFYDRDKASGHPFYYFAYGAACAEVLIDT
LTGEYKLLRADILHDVGDSLNPAIDIGQVEGGFVQGMGWLTSEELVWDQQGRLLTNGPASYKIPAIGDVPADLRVTLLEN
RKNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRLQPNIDAPATPERVLWGVQQMLSSDIVTKLARENGDG
>Mature_796_residues
SNSKRTEYTQQQLAERFRQPLPSGVGRSRKHESADKHVSGEAQYIDDRLEFPNQLHLAAKLSEKAHARIEKLDLSACYDF
PGVVRVITWQDVPGELDIAPLTYGDPLLAKDVVEYVGQVIAVVAAEDPEIAWRAAQAIKVSYQELPAQLDVTQSLREGFV
VQEAHHHRRGDADGALAQALHRIQGELHVGGQEHFYLETQIASVLPAEDGGMLVYSSTQNPTEIQKLVASVLNLPMHKVT
IDTRRMGGGFGGKETQAAGPACLCAVVAHLTGRPVKMRLNRRDDMLITGKRHPFYIQYDVGFDDSGLLNGVKITLAGNCG
YSLDLSGSIVDRAMFHADNAYFLQDVLITGHRCKTHIASNTAYRGFGGPQGMMAIEQIMDHIARYLALDPLAVRKTNYYG
KDQRNITHYHQPVEQNLLQEITAELERSADYQARRQAIRQFNAQNPILKKGLALTPVKFGISFTAGFLNQAGALVLIYTD
GSIQLNHGGTEMGQGLNTKVAQIVAEVFQVEIERIQITATDTGKVPNTSPTAASSGTDLNGKAAENAALTIKQRLTDMLA
RQHQVSAEQILFNNGQVRVGERYFSFEQVVEQAYFNQISLASTGYYRTPKIFYDRDKASGHPFYYFAYGAACAEVLIDTL
TGEYKLLRADILHDVGDSLNPAIDIGQVEGGFVQGMGWLTSEELVWDQQGRLLTNGPASYKIPAIGDVPADLRVTLLENR
KNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRLQPNIDAPATPERVLWGVQQMLSSDIVTKLARENGDG

Specific function: Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=768, Percent_Identity=43.4895833333333, Blast_Score=632, Evalue=0.0,
Organism=Homo sapiens, GI71773480, Length=778, Percent_Identity=38.0462724935733, Blast_Score=501, Evalue=1e-141,
Organism=Escherichia coli, GI1789246, Length=854, Percent_Identity=26.9320843091335, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1789230, Length=764, Percent_Identity=25.7853403141361, Blast_Score=215, Evalue=1e-56,
Organism=Escherichia coli, GI1786478, Length=761, Percent_Identity=25.4927726675427, Blast_Score=125, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17540638, Length=800, Percent_Identity=39.75, Blast_Score=545, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17539860, Length=780, Percent_Identity=32.9487179487179, Blast_Score=374, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI32566215, Length=748, Percent_Identity=32.2192513368984, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17737937, Length=780, Percent_Identity=40.2564102564103, Blast_Score=577, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24647193, Length=798, Percent_Identity=30.952380952381, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24647199, Length=757, Percent_Identity=30.5151915455746, Blast_Score=316, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24647201, Length=756, Percent_Identity=29.3650793650794, Blast_Score=295, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24647195, Length=808, Percent_Identity=29.5792079207921, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24647197, Length=759, Percent_Identity=30.0395256916996, Blast_Score=285, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR001041
- InterPro:   IPR017699 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2; PF01799 Fer2_2 [H]

EC number: 1.17.1.4

Molecular weight: Translated: 87773; Mature: 87642

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSKRTEYTQQQLAERFRQPLPSGVGRSRKHESADKHVSGEAQYIDDRLEFPNQLHLAA
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCHHHHHH
KLSEKAHARIEKLDLSACYDFPGVVRVITWQDVPGELDIAPLTYGDPLLAKDVVEYVGQV
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHH
IAVVAAEDPEIAWRAAQAIKVSYQELPAQLDVTQSLREGFVVQEAHHHRRGDADGALAQA
HEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEHHHHHHCCCCCCHHHHHH
LHRIQGELHVGGQEHFYLETQIASVLPAEDGGMLVYSSTQNPTEIQKLVASVLNLPMHKV
HHHHCCCEEECCCCEEEEEEHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEE
TIDTRRMGGGFGGKETQAAGPACLCAVVAHLTGRPVKMRLNRRDDMLITGKRHPFYIQYD
EEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCEEEEEE
VGFDDSGLLNGVKITLAGNCGYSLDLSGSIVDRAMFHADNAYFLQDVLITGHRCKTHIAS
CCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCC
NTAYRGFGGPQGMMAIEQIMDHIARYLALDPLAVRKTNYYGKDQRNITHYHQPVEQNLLQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCCHHHHCHHHHHHHH
EITAELERSADYQARRQAIRQFNAQNPILKKGLALTPVKFGISFTAGFLNQAGALVLIYT
HHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCEECEEHHCHHHHHHHHCCCCCEEEEEE
DGSIQLNHGGTEMGQGLNTKVAQIVAEVFQVEIERIQITATDTGKVPNTSPTAASSGTDL
CCEEEECCCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCC
NGKAAENAALTIKQRLTDMLARQHQVSAEQILFNNGQVRVGERYFSFEQVVEQAYFNQIS
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHEECCCCEEECHHHHHHHHHHHHHHHCCEE
LASTGYYRTPKIFYDRDKASGHPFYYFAYGAACAEVLIDTLTGEYKLLRADILHDVGDSL
ECCCCCCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
NPAIDIGQVEGGFVQGMGWLTSEELVWDQQGRLLTNGPASYKIPAIGDVPADLRVTLLEN
CCCEEECCCCCCCEECCCCCCCCHHEECCCCCEEECCCCCEECCCCCCCCCCEEEEEECC
RKNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRLQPNIDAPATPERVLWGVQQ
CCCCCHHHEEHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
MLSSDIVTKLARENGDG
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSKRTEYTQQQLAERFRQPLPSGVGRSRKHESADKHVSGEAQYIDDRLEFPNQLHLAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCHHHHHH
KLSEKAHARIEKLDLSACYDFPGVVRVITWQDVPGELDIAPLTYGDPLLAKDVVEYVGQV
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHH
IAVVAAEDPEIAWRAAQAIKVSYQELPAQLDVTQSLREGFVVQEAHHHRRGDADGALAQA
HEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEHHHHHHCCCCCCHHHHHH
LHRIQGELHVGGQEHFYLETQIASVLPAEDGGMLVYSSTQNPTEIQKLVASVLNLPMHKV
HHHHCCCEEECCCCEEEEEEHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEE
TIDTRRMGGGFGGKETQAAGPACLCAVVAHLTGRPVKMRLNRRDDMLITGKRHPFYIQYD
EEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCEEEEEE
VGFDDSGLLNGVKITLAGNCGYSLDLSGSIVDRAMFHADNAYFLQDVLITGHRCKTHIAS
CCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCC
NTAYRGFGGPQGMMAIEQIMDHIARYLALDPLAVRKTNYYGKDQRNITHYHQPVEQNLLQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCCHHHHCHHHHHHHH
EITAELERSADYQARRQAIRQFNAQNPILKKGLALTPVKFGISFTAGFLNQAGALVLIYT
HHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCEECEEHHCHHHHHHHHCCCCCEEEEEE
DGSIQLNHGGTEMGQGLNTKVAQIVAEVFQVEIERIQITATDTGKVPNTSPTAASSGTDL
CCEEEECCCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCC
NGKAAENAALTIKQRLTDMLARQHQVSAEQILFNNGQVRVGERYFSFEQVVEQAYFNQIS
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHEECCCCEEECHHHHHHHHHHHHHHHCCEE
LASTGYYRTPKIFYDRDKASGHPFYYFAYGAACAEVLIDTLTGEYKLLRADILHDVGDSL
ECCCCCCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
NPAIDIGQVEGGFVQGMGWLTSEELVWDQQGRLLTNGPASYKIPAIGDVPADLRVTLLEN
CCCEEECCCCCCCEECCCCCCCCHHEECCCCCEEECCCCCEECCCCCCCCCCEEEEEECC
RKNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRLQPNIDAPATPERVLWGVQQ
CCCCCHHHEEHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
MLSSDIVTKLARENGDG
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthine; NAD+; H2O

Specific reaction: xanthine + NAD+ + H2O = urate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]