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The map label for this gene is manA [H]

Identifier: 157370517

GI number: 157370517

Start: 2479245

End: 2480423

Strand: Reverse

Name: manA [H]

Synonym: Spro_2277

Alternate gene names: 157370517

Gene position: 2480423-2479245 (Counterclockwise)

Preceding gene: 157370520

Following gene: 157370516

Centisome position: 45.52

GC content: 57.93

Gene sequence:

>1179_bases
ATGCAAAAAATGACCAACGCAGTGCAAAACTATGCATGGGGCAGCCACGACGCGTTAACCCGGCTTTATGGCATCGCCAA
CCCACAAGGGCAGCCGATGGCGGAGCTGTGGATGGGCGCTCATCCGAAAAGCAGCTCCCGTGTGGCCGGTGCCGACGGTA
ATTTGCGCTCGTTGCGCGACGTGATTGATGAAGATCAGCCCAAACAACTGGGTGCCGACGTTGCCCGCCGCTTTGGTGAA
TTGCCATTCCTGTTCAAGGTGCTGTGTGCCGACCAGCCGCTGTCTATTCAGGTGCACCCAAGCAAATCGGCCGCAGAAAC
CGGTTTTGCCAAAGAAAACGCCGCCGGTATTCCCCTGGACGCGGCTGAACGCAACTATAAAGATCCTAACCACAAGCCGG
AGCTGGTGTTCGCCCTGACGCCTTTCCTGGCGATGAATGGCTTCCGCGAACTGTCCGACATTGTTTCCCTGCTGCAGCCG
ATCGCCGGAGCCCATCATGATATCGCCGCCTTCCTGCAACAGCCGGATGTCAGCCATCTGTCGTCCCTGTTTGCCAGCCT
GCTGGCGATGAGCGGCGAACAGAAATCGCTGGCGCTGGGCGTGCTGAAGGCCGCACTGAATAACCAACAGGGTGAAACCT
GGGACACGATTCGCTTTATCGCCGGTTTTTATCCGGACGACAGCGGCCTGTTCTCGCCGCTGCTGCTGAACGTGGTACAG
CTCCAACCGGGTGAAGCGATGTTCCTGTATGCCGAAACGCCGCATGCCTACCTGAAGGGCGTGGCGCTGGAAGTAATGGC
TAACTCGGACAACGTGCTGCGTGCCGGTCTGACACCTAAATTCATCGATATTCCAGAACTGTTAGCCAACCTGCAGTTCC
GTCCACAGCCGGCATCCGGCCTGCTGACTCAGCCGCAAAAGCGCGGTGACGAACTGTTCTTCCCGATCCCGGTTGAAGAC
TTCGCCTTCTCACTGCATGACCTTTCCGCCGCCCCACAGGCGCTGGCGCAAAATAGCGCGGCCATTGTGTTCTGCGTTGA
AGGTGAAGCGGTCTTAACCAAACAGGATCAGCAACTGGTGCTCAAGCCGGGTGAATCCTGCTTTATCGGCGCGTTCGAAT
CGCCGGTCAACGTCAGTGGCAGCGGCCGAATCGCCCGCGTTTATAACCTGTTGTCGTAA

Upstream 100 bases:

>100_bases
CGCTTCCACGCCACAGTTCGCGTGTAGGATAAGGCGCACAAGGTTTTTAACAGTCAGCTACTACCGCCCCTGGCGGCGAA
CGCAAAGGATGTTTATCAAG

Downstream 100 bases:

>100_bases
ACACTCGGTAAATTTCCGCAAATTGGTTGCTGAAAGAGTGGCTTACCTTCACAATTAAACGCCTGCGGGTAAACGCCTGC
CGGCGTTTTTTATTGGCCCA

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQKMTNAVQNYAWGSHDALTRLYGIANPQGQPMAELWMGAHPKSSSRVAGADGNLRSLRDVIDEDQPKQLGADVARRFGE
LPFLFKVLCADQPLSIQVHPSKSAAETGFAKENAAGIPLDAAERNYKDPNHKPELVFALTPFLAMNGFRELSDIVSLLQP
IAGAHHDIAAFLQQPDVSHLSSLFASLLAMSGEQKSLALGVLKAALNNQQGETWDTIRFIAGFYPDDSGLFSPLLLNVVQ
LQPGEAMFLYAETPHAYLKGVALEVMANSDNVLRAGLTPKFIDIPELLANLQFRPQPASGLLTQPQKRGDELFFPIPVED
FAFSLHDLSAAPQALAQNSAAIVFCVEGEAVLTKQDQQLVLKPGESCFIGAFESPVNVSGSGRIARVYNLLS

Sequences:

>Translated_392_residues
MQKMTNAVQNYAWGSHDALTRLYGIANPQGQPMAELWMGAHPKSSSRVAGADGNLRSLRDVIDEDQPKQLGADVARRFGE
LPFLFKVLCADQPLSIQVHPSKSAAETGFAKENAAGIPLDAAERNYKDPNHKPELVFALTPFLAMNGFRELSDIVSLLQP
IAGAHHDIAAFLQQPDVSHLSSLFASLLAMSGEQKSLALGVLKAALNNQQGETWDTIRFIAGFYPDDSGLFSPLLLNVVQ
LQPGEAMFLYAETPHAYLKGVALEVMANSDNVLRAGLTPKFIDIPELLANLQFRPQPASGLLTQPQKRGDELFFPIPVED
FAFSLHDLSAAPQALAQNSAAIVFCVEGEAVLTKQDQQLVLKPGESCFIGAFESPVNVSGSGRIARVYNLLS
>Mature_392_residues
MQKMTNAVQNYAWGSHDALTRLYGIANPQGQPMAELWMGAHPKSSSRVAGADGNLRSLRDVIDEDQPKQLGADVARRFGE
LPFLFKVLCADQPLSIQVHPSKSAAETGFAKENAAGIPLDAAERNYKDPNHKPELVFALTPFLAMNGFRELSDIVSLLQP
IAGAHHDIAAFLQQPDVSHLSSLFASLLAMSGEQKSLALGVLKAALNNQQGETWDTIRFIAGFYPDDSGLFSPLLLNVVQ
LQPGEAMFLYAETPHAYLKGVALEVMANSDNVLRAGLTPKFIDIPELLANLQFRPQPASGLLTQPQKRGDELFFPIPVED
FAFSLHDLSAAPQALAQNSAAIVFCVEGEAVLTKQDQQLVLKPGESCFIGAFESPVNVSGSGRIARVYNLLS

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=406, Percent_Identity=37.192118226601, Blast_Score=212, Evalue=5e-55,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=74.6803069053708, Blast_Score=598, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71997620, Length=397, Percent_Identity=31.7380352644836, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17557650, Length=421, Percent_Identity=26.3657957244656, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320839, Length=412, Percent_Identity=30.8252427184466, Blast_Score=166, Evalue=6e-42,
Organism=Drosophila melanogaster, GI21356061, Length=377, Percent_Identity=31.0344827586207, Blast_Score=151, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42461; Mature: 42461

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKMTNAVQNYAWGSHDALTRLYGIANPQGQPMAELWMGAHPKSSSRVAGADGNLRSLRD
CCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCEEECCCCCHHHHHH
VIDEDQPKQLGADVARRFGELPFLFKVLCADQPLSIQVHPSKSAAETGFAKENAAGIPLD
HHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCCCCCCCC
AAERNYKDPNHKPELVFALTPFLAMNGFRELSDIVSLLQPIAGAHHDIAAFLQQPDVSHL
HHHCCCCCCCCCCCEEEEECHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHH
SSLFASLLAMSGEQKSLALGVLKAALNNQQGETWDTIRFIAGFYPDDSGLFSPLLLNVVQ
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LQPGEAMFLYAETPHAYLKGVALEVMANSDNVLRAGLTPKFIDIPELLANLQFRPQPASG
CCCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCEECHHHHHHCCCCCCCCCCC
LLTQPQKRGDELFFPIPVEDFAFSLHDLSAAPQALAQNSAAIVFCVEGEAVLTKQDQQLV
CCCCCHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCEEE
LKPGESCFIGAFESPVNVSGSGRIARVYNLLS
ECCCCCEEEECCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MQKMTNAVQNYAWGSHDALTRLYGIANPQGQPMAELWMGAHPKSSSRVAGADGNLRSLRD
CCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCEEECCCCCHHHHHH
VIDEDQPKQLGADVARRFGELPFLFKVLCADQPLSIQVHPSKSAAETGFAKENAAGIPLD
HHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCCCCCCCC
AAERNYKDPNHKPELVFALTPFLAMNGFRELSDIVSLLQPIAGAHHDIAAFLQQPDVSHL
HHHCCCCCCCCCCCEEEEECHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHH
SSLFASLLAMSGEQKSLALGVLKAALNNQQGETWDTIRFIAGFYPDDSGLFSPLLLNVVQ
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LQPGEAMFLYAETPHAYLKGVALEVMANSDNVLRAGLTPKFIDIPELLANLQFRPQPASG
CCCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCEECHHHHHHCCCCCCCCCCC
LLTQPQKRGDELFFPIPVEDFAFSLHDLSAAPQALAQNSAAIVFCVEGEAVLTKQDQQLV
CCCCCHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCEEE
LKPGESCFIGAFESPVNVSGSGRIARVYNLLS
ECCCCCEEEECCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]