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The map label for this gene is ampC [H]

Identifier: 157370513

GI number: 157370513

Start: 2474186

End: 2475322

Strand: Direct

Name: ampC [H]

Synonym: Spro_2273

Alternate gene names: 157370513

Gene position: 2474186-2475322 (Clockwise)

Preceding gene: 157370511

Following gene: 157370515

Centisome position: 45.41

GC content: 56.73

Gene sequence:

>1137_bases
ATGACCAAAATAAATCGCCTGGCGGCCGCGTTGTTGGCCGCAATGATCCTGCCGGCAGGCCATGCCGCCGACAAAGCCGA
GATTGACGCCATTATTCAGCCGCTGATGCAAAAATACGGCGTGCCGGGCATGGCCATCGCCGTGTCGGTGGACGGGAAAC
AGCAGTTTTATGATTATGGTGTGGCGTCCAAACAGACCGGCAAGCCGATCACCAACCAGACCCTGTTTGAAGTGGGCTCA
TTGAGCAAAACCTTCACCGCCACGCTGGCGGCCTATGCGCAAAATGAGGGCAAACTGTCGTTCGCCGAACCGGCCAGCCA
TTACCTGTCTGAGCTGCGTGGCAGTGCATTTGACCGTGTCAGCCTGCTGAACCTGGCGACACACACCTCCGGCTTGCCGC
TGTTTGTCCCGGACGAAGTGACCAATGACGCGCAATTGATGGCGTATTACAAAAACTGGCAGCCACCACATGCCGTGGGG
AGTTATCGGGTTTATTCCAACCTGGGTATTGGCATGCTGGGGATGATCACCGCCAAAAGCCTGAACCAGCCCTTTGCGCA
GGCGATGGAAAAACAGCTGCTGCCGGCTTTGGGCATGAACCACAGCTACGTTAATGTTCCGGCTGCGCAGATGGATAATT
ACGCGCAGGGCTACAACAAGAAAGACCAACCGGTGCGAGTCACCCCCGGCCCGTTGGACGCAGAATCCTACGGCATCAAA
TCCAATGCCGAGGATCTGATCCGTTACCTTGAAGCCAACATGCAGGTGGCCAAGGTGGGGGATAAGTGGCGCAAGGCACT
GGCAGCTACCCATACCGGTTATTACCGGGCCGGGGTGTTCACCCAGGATCTGATGTGGGAAAGCTACGCTTATCCGGAAA
AGTTGACGACGCTGACGGAAGGCAACAACGCCGGGATGATCATGAACGGCACTCCGGCCACCGCCATCACGCCACCGAAG
CAGGAACAGGGCGCTGCCTGGTACAATAAAACCGGATCGACCGGTGGCTTCTCCACCTACGCGGTATTCATCCCATCGAA
GAAAATTGCCGTGGTGATGCTGGCCAACAAATGGTTCCCGAACGACGATCGGGTTGCGGCCACCTACCAGTTGATACAGG
CGCTGGATAAACGTTAA

Upstream 100 bases:

>100_bases
TCAGAAAAGGAATAACACCATCATCCAAGGATATCTTCGCGTCGACAGGCAATAAAATCTTTTGCCATCGGCCGATACCC
TGCAAACCAAGAGCTTTCAC

Downstream 100 bases:

>100_bases
TTAATGGCCTCTCAGGACGCTGTAATGGCGTCCTGAGACGATGACTGGTGCGCCCGCTTTTCCCGCATAAAATCAACAAA
TACCCGCAGCTTGAGCGGCA

Product: beta-lactamase

Products: NA

Alternate protein names: Cephalosporinase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTKINRLAAALLAAMILPAGHAADKAEIDAIIQPLMQKYGVPGMAIAVSVDGKQQFYDYGVASKQTGKPITNQTLFEVGS
LSKTFTATLAAYAQNEGKLSFAEPASHYLSELRGSAFDRVSLLNLATHTSGLPLFVPDEVTNDAQLMAYYKNWQPPHAVG
SYRVYSNLGIGMLGMITAKSLNQPFAQAMEKQLLPALGMNHSYVNVPAAQMDNYAQGYNKKDQPVRVTPGPLDAESYGIK
SNAEDLIRYLEANMQVAKVGDKWRKALAATHTGYYRAGVFTQDLMWESYAYPEKLTTLTEGNNAGMIMNGTPATAITPPK
QEQGAAWYNKTGSTGGFSTYAVFIPSKKIAVVMLANKWFPNDDRVAATYQLIQALDKR

Sequences:

>Translated_378_residues
MTKINRLAAALLAAMILPAGHAADKAEIDAIIQPLMQKYGVPGMAIAVSVDGKQQFYDYGVASKQTGKPITNQTLFEVGS
LSKTFTATLAAYAQNEGKLSFAEPASHYLSELRGSAFDRVSLLNLATHTSGLPLFVPDEVTNDAQLMAYYKNWQPPHAVG
SYRVYSNLGIGMLGMITAKSLNQPFAQAMEKQLLPALGMNHSYVNVPAAQMDNYAQGYNKKDQPVRVTPGPLDAESYGIK
SNAEDLIRYLEANMQVAKVGDKWRKALAATHTGYYRAGVFTQDLMWESYAYPEKLTTLTEGNNAGMIMNGTPATAITPPK
QEQGAAWYNKTGSTGGFSTYAVFIPSKKIAVVMLANKWFPNDDRVAATYQLIQALDKR
>Mature_377_residues
TKINRLAAALLAAMILPAGHAADKAEIDAIIQPLMQKYGVPGMAIAVSVDGKQQFYDYGVASKQTGKPITNQTLFEVGSL
SKTFTATLAAYAQNEGKLSFAEPASHYLSELRGSAFDRVSLLNLATHTSGLPLFVPDEVTNDAQLMAYYKNWQPPHAVGS
YRVYSNLGIGMLGMITAKSLNQPFAQAMEKQLLPALGMNHSYVNVPAAQMDNYAQGYNKKDQPVRVTPGPLDAESYGIKS
NAEDLIRYLEANMQVAKVGDKWRKALAATHTGYYRAGVFTQDLMWESYAYPEKLTTLTEGNNAGMIMNGTPATAITPPKQ
EQGAAWYNKTGSTGGFSTYAVFIPSKKIAVVMLANKWFPNDDRVAATYQLIQALDKR

Specific function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-C beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=350, Percent_Identity=39.7142857142857, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI1786574, Length=379, Percent_Identity=24.5382585751979, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=250, Percent_Identity=24, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001586
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 41203; Mature: 41072

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00336 BETA_LACTAMASE_C

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKINRLAAALLAAMILPAGHAADKAEIDAIIQPLMQKYGVPGMAIAVSVDGKQQFYDYG
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHCC
VASKQTGKPITNQTLFEVGSLSKTFTATLAAYAQNEGKLSFAEPASHYLSELRGSAFDRV
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCHHHHH
SLLNLATHTSGLPLFVPDEVTNDAQLMAYYKNWQPPHAVGSYRVYSNLGIGMLGMITAKS
HHHHHHHCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHH
LNQPFAQAMEKQLLPALGMNHSYVNVPAAQMDNYAQGYNKKDQPVRVTPGPLDAESYGIK
CCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCC
SNAEDLIRYLEANMQVAKVGDKWRKALAATHTGYYRAGVFTQDLMWESYAYPEKLTTLTE
CCHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCHHHHEEEC
GNNAGMIMNGTPATAITPPKQEQGAAWYNKTGSTGGFSTYAVFIPSKKIAVVMLANKWFP
CCCCCEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCC
NDDRVAATYQLIQALDKR
CCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKINRLAAALLAAMILPAGHAADKAEIDAIIQPLMQKYGVPGMAIAVSVDGKQQFYDYG
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHCC
VASKQTGKPITNQTLFEVGSLSKTFTATLAAYAQNEGKLSFAEPASHYLSELRGSAFDRV
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCHHHHH
SLLNLATHTSGLPLFVPDEVTNDAQLMAYYKNWQPPHAVGSYRVYSNLGIGMLGMITAKS
HHHHHHHCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHH
LNQPFAQAMEKQLLPALGMNHSYVNVPAAQMDNYAQGYNKKDQPVRVTPGPLDAESYGIK
CCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCC
SNAEDLIRYLEANMQVAKVGDKWRKALAATHTGYYRAGVFTQDLMWESYAYPEKLTTLTE
CCHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCHHHHEEEC
GNNAGMIMNGTPATAITPPKQEQGAAWYNKTGSTGGFSTYAVFIPSKKIAVVMLANKWFP
CCCCCEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCC
NDDRVAATYQLIQALDKR
CCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2227364 [H]