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The map label for this gene is fbaA [H]

Identifier: 157370495

GI number: 157370495

Start: 2456148

End: 2456990

Strand: Reverse

Name: fbaA [H]

Synonym: Spro_2255

Alternate gene names: 157370495

Gene position: 2456990-2456148 (Counterclockwise)

Preceding gene: 157370496

Following gene: 157370494

Centisome position: 45.09

GC content: 56.35

Gene sequence:

>843_bases
ATGAAACTCTATAACTTCAACGAGCTGTTGTCCGTAGCCAAAGCCCGTGATTTCAAGGCAATAGGTTCGTTCAATCTCCA
CTGTCTGGAGATGCTGCCGGCCTTTTTCAAAGCGGCCAGGGACACCCACAGCCCGCTGATGATCCAGATTTCAACCGGCA
CCGCCGAGTATCTGGGCTACAAACTGCTGGTTGATTCGGTACGCTCACTGGCAGAGAGTGAAGATGTGCCCACCTGCCTG
CATCTGGATCACTGCTCGGATATCGCCTCCATCGTCACCGCGATCGACGCCGGTTTCAGTTCGGTGATGTACGACGGTTC
TCACCTGGAAATGGACGAAAACATCGCCAATACCCGCAAGGTGATCGACATTGCACGCCAGCGCAACGTTTCGGTTGAGG
CCGAATTGGGCGCTATCGGCGGCTCGGAGGACGGCAAAGCGGTGGCGGAAGAAGACATCACCTTTACCACGGTGGAAGAC
GCCAAACGCTTTGTCGAAGCAACCGGGGTCGACATGTTGGCCGTCTCGGTCGGCACCGTTCACGGCATGTACACCGGTAA
GGCACATATCCAGCATCAGCGGCTGGCGGAAATCACCGCGGCCACCCGTACCCCACTGGTCCTGCACGGCGGCACCGGAG
TCAGCGATGAGGACATGCGACGAGCAGTGGCAGGCGGCATTGAAAAGGTCAATGTGGGCACCGAGATGAACGTGCAATGG
GTCGGCCGCTGCATGCAAACATTCGAAAAGGGCAAGGTGAATGACAGCGTGCGCAAATTCCTGATCCCGGCCAATAATGC
CGTCACCCAAGTATTAACGGAAAAGATCGGCCTGTTTAGATAA

Upstream 100 bases:

>100_bases
CAGGGTAACTGGCTGTTCATCGCTCTGTTCATCATCTTCGTCACGCTGATTGCGTGGTTTGTTAACGGTAAATCAACCAA
GCACCATGAGGAAAAAGTCC

Downstream 100 bases:

>100_bases
TCACTGCCCCGTTTTCTTTTTAATATAACCCTACAACCCTGGTGCCCCGGCGCCCGTCGGGGCTGGAGAATACTATGCTT
AATTTTATGAAATTACAGCG

Product: ketose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKLYNFNELLSVAKARDFKAIGSFNLHCLEMLPAFFKAARDTHSPLMIQISTGTAEYLGYKLLVDSVRSLAESEDVPTCL
HLDHCSDIASIVTAIDAGFSSVMYDGSHLEMDENIANTRKVIDIARQRNVSVEAELGAIGGSEDGKAVAEEDITFTTVED
AKRFVEATGVDMLAVSVGTVHGMYTGKAHIQHQRLAEITAATRTPLVLHGGTGVSDEDMRRAVAGGIEKVNVGTEMNVQW
VGRCMQTFEKGKVNDSVRKFLIPANNAVTQVLTEKIGLFR

Sequences:

>Translated_280_residues
MKLYNFNELLSVAKARDFKAIGSFNLHCLEMLPAFFKAARDTHSPLMIQISTGTAEYLGYKLLVDSVRSLAESEDVPTCL
HLDHCSDIASIVTAIDAGFSSVMYDGSHLEMDENIANTRKVIDIARQRNVSVEAELGAIGGSEDGKAVAEEDITFTTVED
AKRFVEATGVDMLAVSVGTVHGMYTGKAHIQHQRLAEITAATRTPLVLHGGTGVSDEDMRRAVAGGIEKVNVGTEMNVQW
VGRCMQTFEKGKVNDSVRKFLIPANNAVTQVLTEKIGLFR
>Mature_280_residues
MKLYNFNELLSVAKARDFKAIGSFNLHCLEMLPAFFKAARDTHSPLMIQISTGTAEYLGYKLLVDSVRSLAESEDVPTCL
HLDHCSDIASIVTAIDAGFSSVMYDGSHLEMDENIANTRKVIDIARQRNVSVEAELGAIGGSEDGKAVAEEDITFTTVED
AKRFVEATGVDMLAVSVGTVHGMYTGKAHIQHQRLAEITAATRTPLVLHGGTGVSDEDMRRAVAGGIEKVNVGTEMNVQW
VGRCMQTFEKGKVNDSVRKFLIPANNAVTQVLTEKIGLFR

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=278, Percent_Identity=35.2517985611511, Blast_Score=180, Evalue=9e-47,
Organism=Escherichia coli, GI87082041, Length=279, Percent_Identity=34.7670250896057, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788072, Length=220, Percent_Identity=35, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789293, Length=278, Percent_Identity=26.2589928057554, Blast_Score=78, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322790, Length=277, Percent_Identity=27.0758122743682, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30480; Mature: 30480

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNFNELLSVAKARDFKAIGSFNLHCLEMLPAFFKAARDTHSPLMIQISTGTAEYLGY
CCCCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
KLLVDSVRSLAESEDVPTCLHLDHCSDIASIVTAIDAGFSSVMYDGSHLEMDENIANTRK
HHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCHHHHHHHH
VIDIARQRNVSVEAELGAIGGSEDGKAVAEEDITFTTVEDAKRFVEATGVDMLAVSVGTV
HHHHHHHCCCCEEEEECCCCCCCCCCCHHHCCCEEEEHHHHHHHHHHCCCHHEEEHHHHH
HGMYTGKAHIQHQRLAEITAATRTPLVLHGGTGVSDEDMRRAVAGGIEKVNVGTEMNVQW
HEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHH
VGRCMQTFEKGKVNDSVRKFLIPANNAVTQVLTEKIGLFR
HHHHHHHHHCCCCCHHHHHEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLYNFNELLSVAKARDFKAIGSFNLHCLEMLPAFFKAARDTHSPLMIQISTGTAEYLGY
CCCCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
KLLVDSVRSLAESEDVPTCLHLDHCSDIASIVTAIDAGFSSVMYDGSHLEMDENIANTRK
HHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCHHHHHHHH
VIDIARQRNVSVEAELGAIGGSEDGKAVAEEDITFTTVEDAKRFVEATGVDMLAVSVGTV
HHHHHHHCCCCEEEEECCCCCCCCCCCHHHCCCEEEEHHHHHHHHHHCCCHHEEEHHHHH
HGMYTGKAHIQHQRLAEITAATRTPLVLHGGTGVSDEDMRRAVAGGIEKVNVGTEMNVQW
HEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCHHH
VGRCMQTFEKGKVNDSVRKFLIPANNAVTQVLTEKIGLFR
HHHHHHHHHCCCCCHHHHHEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]