Click here to switch to the map view.

The map label for this gene is aaeR [H]

Identifier: 157370446

GI number: 157370446

Start: 2407753

End: 2408664

Strand: Direct

Name: aaeR [H]

Synonym: Spro_2206

Alternate gene names: 157370446

Gene position: 2407753-2408664 (Clockwise)

Preceding gene: 157370441

Following gene: 157370447

Centisome position: 44.19

GC content: 60.64

Gene sequence:

>912_bases
ATGGCGGTTTTCGCTACCGTGGTGGCGGAAGGATCCTTTGCCGGCGCGGCCCGGCGGCTGGGCATGACGCCATCGGCGGT
CAGCCAGCATATGCGTTCGTTGGAAAAAGCGCTCGGTGTGCCGTTGTTACATCGTTCTACACGACGGTTGGCGCTGACCG
AGGCAGGGGCGGCATTTCACCCCGGCTGCGAGGCAATGCTGTTTCAGGCGCAGCAGGCTGAACAACGGCTGGCCGAGTTG
CGTGACACTCTGGTGGGGGAGTTGCGTATCGCTACGACCATTGGCATCGGCGGCCGTCCGCTCGCAGAGGCGCTGGCACC
GCTGCTGCAGGCGCATCCCAAACTGACTCTGCGGGTGTTGGCGGACGATCGAATCGTCGACATGATCGAACAACGGATCG
ACATTGCACTGCGGGTCAATCGTCAACTGGCCGATGCCAATATGATTGCTCACCCACTGGCCGAATGGCCAATGGTGCTG
TGTGCCGCTCCGCGCTACCTTAGCCAGTACGGGGTGCCGGAAGCGCCGCAGGACCTGGTGCAGCATCGCTGGATCTCGGG
CGCTTTCAGCGGGGCGCATCTGGATTTGCATCATCAGGGCGGTCAGCAGCTAAAATTACGTCTGGCGGAAGGGCAGATCG
TCAGTGACAGCATGACCGTGATGCGCGGCTTCACTCGCAGCGGCCTGGGGATTTCGATTCAACCGCTGTATGAAATAGAG
GATGAATTGCAGCGCGGTGAACTGATCCAACTGATGCCTGAATGGCGACCGGCCCCGCTGCGGCTGCACGCGCTGACGCT
AGAACGGGCAATGCCGGAGAAAAATCGTCAGGCGCTGCGTTATTTACGCGACTATTTTCACCGACATGCCGAAAAGTCAC
TTGCCAGCGGCGCCGATGGCGTCTTCAATTAG

Upstream 100 bases:

>100_bases
GCGTATCTACAATGTAGTACTTAACAATAGGGTTGATTAGTGCCATATTCATGCTTTCTTGAGTAAGTAAAACTTCATAA
TCGTGGATAAACTGAATCGA

Downstream 100 bases:

>100_bases
CAAGAGAACGCAGGAGGACGTGTGGCGCAGCAGCTCGAGTTTTTTGATATCCCCAGCCCGTGTCGCGGCATTTGTCAGGC
CGACGATCGCGGCTTTTGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MAVFATVVAEGSFAGAARRLGMTPSAVSQHMRSLEKALGVPLLHRSTRRLALTEAGAAFHPGCEAMLFQAQQAEQRLAEL
RDTLVGELRIATTIGIGGRPLAEALAPLLQAHPKLTLRVLADDRIVDMIEQRIDIALRVNRQLADANMIAHPLAEWPMVL
CAAPRYLSQYGVPEAPQDLVQHRWISGAFSGAHLDLHHQGGQQLKLRLAEGQIVSDSMTVMRGFTRSGLGISIQPLYEIE
DELQRGELIQLMPEWRPAPLRLHALTLERAMPEKNRQALRYLRDYFHRHAEKSLASGADGVFN

Sequences:

>Translated_303_residues
MAVFATVVAEGSFAGAARRLGMTPSAVSQHMRSLEKALGVPLLHRSTRRLALTEAGAAFHPGCEAMLFQAQQAEQRLAEL
RDTLVGELRIATTIGIGGRPLAEALAPLLQAHPKLTLRVLADDRIVDMIEQRIDIALRVNRQLADANMIAHPLAEWPMVL
CAAPRYLSQYGVPEAPQDLVQHRWISGAFSGAHLDLHHQGGQQLKLRLAEGQIVSDSMTVMRGFTRSGLGISIQPLYEIE
DELQRGELIQLMPEWRPAPLRLHALTLERAMPEKNRQALRYLRDYFHRHAEKSLASGADGVFN
>Mature_302_residues
AVFATVVAEGSFAGAARRLGMTPSAVSQHMRSLEKALGVPLLHRSTRRLALTEAGAAFHPGCEAMLFQAQQAEQRLAELR
DTLVGELRIATTIGIGGRPLAEALAPLLQAHPKLTLRVLADDRIVDMIEQRIDIALRVNRQLADANMIAHPLAEWPMVLC
AAPRYLSQYGVPEAPQDLVQHRWISGAFSGAHLDLHHQGGQQLKLRLAEGQIVSDSMTVMRGFTRSGLGISIQPLYEIED
ELQRGELIQLMPEWRPAPLRLHALTLERAMPEKNRQALRYLRDYFHRHAEKSLASGADGVFN

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=289, Percent_Identity=37.0242214532872, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1786401, Length=254, Percent_Identity=34.251968503937, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI87081978, Length=297, Percent_Identity=30.6397306397306, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789440, Length=260, Percent_Identity=30.3846153846154, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI145693193, Length=274, Percent_Identity=29.1970802919708, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787589, Length=261, Percent_Identity=29.1187739463602, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787128, Length=257, Percent_Identity=26.8482490272374, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788481, Length=257, Percent_Identity=29.5719844357977, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789173, Length=253, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI157672245, Length=128, Percent_Identity=32.03125, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33541; Mature: 33410

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVFATVVAEGSFAGAARRLGMTPSAVSQHMRSLEKALGVPLLHRSTRRLALTEAGAAFH
CCEEEEEHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHEEEECCCCCCC
PGCEAMLFQAQQAEQRLAELRDTLVGELRIATTIGIGGRPLAEALAPLLQAHPKLTLRVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCEEEEEE
ADDRIVDMIEQRIDIALRVNRQLADANMIAHPLAEWPMVLCAAPRYLSQYGVPEAPQDLV
CCHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHH
QHRWISGAFSGAHLDLHHQGGQQLKLRLAEGQIVSDSMTVMRGFTRSGLGISIQPLYEIE
HHHHHHCCCCCCEEEEECCCCCEEEEEECCCEEEHHHHHHHHHHHCCCCCEEECHHHHHH
DELQRGELIQLMPEWRPAPLRLHALTLERAMPEKNRQALRYLRDYFHRHAEKSLASGADG
HHHCCCCCEECCCCCCCCCEEEHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VFN
CCC
>Mature Secondary Structure 
AVFATVVAEGSFAGAARRLGMTPSAVSQHMRSLEKALGVPLLHRSTRRLALTEAGAAFH
CEEEEEHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHEEEECCCCCCC
PGCEAMLFQAQQAEQRLAELRDTLVGELRIATTIGIGGRPLAEALAPLLQAHPKLTLRVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCEEEEEE
ADDRIVDMIEQRIDIALRVNRQLADANMIAHPLAEWPMVLCAAPRYLSQYGVPEAPQDLV
CCHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHH
QHRWISGAFSGAHLDLHHQGGQQLKLRLAEGQIVSDSMTVMRGFTRSGLGISIQPLYEIE
HHHHHHCCCCCCEEEEECCCCCEEEEEECCCEEEHHHHHHHHHHHCCCCCEEECHHHHHH
DELQRGELIQLMPEWRPAPLRLHALTLERAMPEKNRQALRYLRDYFHRHAEKSLASGADG
HHHCCCCCEECCCCCCCCCEEEHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VFN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]