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The map label for this gene is hemR [H]

Identifier: 157370409

GI number: 157370409

Start: 2366007

End: 2368091

Strand: Reverse

Name: hemR [H]

Synonym: Spro_2169

Alternate gene names: 157370409

Gene position: 2368091-2366007 (Counterclockwise)

Preceding gene: 157370410

Following gene: 157370408

Centisome position: 43.46

GC content: 58.08

Gene sequence:

>2085_bases
ATGCCTCTGATCTATTCCACCCGGCTGCGTTTATCCGCATTGAGTCTGGCGATTGCCTGTACTCTGCCGACGGTGACTTT
TGCACAAACCAGCGAAACCCCTTCTTCTTCCTCGGCGACGGCACCGGTTAAAAAGGACAAAGCCAGCGACGAAACCATGA
CGGTAGCCGCCACCGGCAATGCGCGCAGCAGCTTTGAAGCGCCGATGATGGTCACGGTGATCGAGGCCGATACGCCGCAA
AGCCAAACCGCCACCAGCGCCGGCGATATGCTGCGCCGCGTGCCGGGCATTACCGTCAATGGCACCGGTCGCAGTAATGG
CCAGGACGTTTTCATGCGTGGCTATGGTAAAAATGGCGTGCTGACGCTGGTGGATGGCATCCGTCAGGGTACCGATACCG
GCCACCTTGGTGCCACCTTCCTCGATCCGGCACTGGTGAAACGCATCGAAGTCGTGCGCGGCCCTTCCGCCCTGCTGTAT
GGCAGCGGCGCACTGGGCGGCGTAATTGCTTATGAAACCGTAGATGCCGCCGATCTGCTGTTGCCCGGCCATAATAGTGG
CTACCGGGTGTATGGCACCGCCGGCAGCGGCGACCACAGCCTCGGCATGGGGGCCAGCACCTACGGCAGAACCGACAATC
TCGACGGCCTGCTGTCATTTGGCACCCGCGACGTCGGCAATCTGCGTCAGGGCAACGGCTTCGATGCACCCAATGATGAA
ACCATCAGCAATCTGCTGGCCAAGGGGACCTGGACGCTCGATGAGAATCAGTCATTGAGCGGCGACCTGCGCTACTACAA
CAACCGGGCGCAAGAGCCGAAAAACCCGCAGGAATCGGCCAGCAGCAGCGGTAACCAGATGACCGACCGCTCGACCATTC
AACGCGACGGCCAGCTTGGCTACAAACTGAAGCCTGTGGGTCAGGATTGGCTCGACGCCGAAGCCAAAATCTATTACTCC
GAAGTGGAGATCAACGCCCACACCAACGGCAGTGAAGATGAAGCGCGCAAGCAAACCACTCGCGGTGCCAAACTCGAAAA
CCGCAGCCGTTTGTTTGCCGATACCTTCGCCTCTCACTTATTGACCTACGGCAGCGAAGCTTACAAGCAGGAGCAAACAC
CGGGTGGCGCGACAGAAAGCTTCCCACAGGCGAAAATCAACTTTGCTTCCGGCTGGTTGCAGGACGAAATTACCCTGCGC
GACCTGCCGGTCACCCTGCTTGCCGGGACGCGTTACGATAACTACAAGGGTTCCAGCGACGGTTACGCCGATGTTGACGC
CGACAAGTGGTCATCGCGCGGTGCCGTTACAGTGACGCCAACCGACTGGTTAATGCTGTTCGGTTCTTATTCGCAGGCTT
TCCGCGCCCCGACAATGGGAGAGATGTACAACGATTCCAAGCACTTCTCTATCCCCATGGGGCCGACCACCATTACCAAC
AACTGGGTGCCTAACCCGAACCTGAAGCCGGAAACCAATGCCACCCAGGAATACGGTTTCGGGCTACGCTTTGACGATTT
GCTACTGGCTGATGACAGCCTGCAATTCAAAGCCAGCTACTTTGATACCAAAGCCCGCGACTACATCACCACGGATGTCA
CCATGGAGCTGGGTCGTGGCCCTCGTGGCCCTTATTGCATCAGCTGCACCACTTTCTCGACCAATATCGACCGTGCAAAA
ATTTGGGGCTGGGACGCAACGCTGAGCTATAAAACCGCCATTTTTGGCTGGGACCTGGCGTACAACCGCACTCGTGGCAA
GAACGAAAGCAGCGGCGAATGGCTAAACAGCATCAATCCGGACACGGTAACCAGCACGCTGGATATTCCACTGGGTGAAA
CCGGCCTGTCCACCGGCTGGGTGGCCACTGTGGCCCAACGAGCCACCCGCGTAGAAACCGGCACCGCAGAACAAGGCGGC
TACGGCGTCAACGATTTTTACCTGAGCTATAAAGGCCGCGAACGCCTGCAGGGCGTGACCACCACGGTGGTGCTGGGCAA
CGCCTTTGATAAAGAATATTACTCGCCACAGGGCATACCGCAGGACGGGCGTAATGCCAAACTGCTGGTCAGCTATCAGT
GGTAA

Upstream 100 bases:

>100_bases
CAAATAATTCCCATCCCTTAACGCCAGCCACCCAGATCCTTTTTGATCCAGGCAGCCAGCAAATCTATTGATATGTTTAA
AACATACGGAGAGTTGCGAC

Downstream 100 bases:

>100_bases
CGTTTTAAATCCGGCGGGCATGAAGATTGCCCGCCGCTTGATTCACACACAGGAGAACCCGCAATGAGCAATACCCTATA
TGCACGCTACCAGCAGGCAA

Product: TonB-dependent heme/hemoglobin receptor family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 694; Mature: 693

Protein sequence:

>694_residues
MPLIYSTRLRLSALSLAIACTLPTVTFAQTSETPSSSSATAPVKKDKASDETMTVAATGNARSSFEAPMMVTVIEADTPQ
SQTATSAGDMLRRVPGITVNGTGRSNGQDVFMRGYGKNGVLTLVDGIRQGTDTGHLGATFLDPALVKRIEVVRGPSALLY
GSGALGGVIAYETVDAADLLLPGHNSGYRVYGTAGSGDHSLGMGASTYGRTDNLDGLLSFGTRDVGNLRQGNGFDAPNDE
TISNLLAKGTWTLDENQSLSGDLRYYNNRAQEPKNPQESASSSGNQMTDRSTIQRDGQLGYKLKPVGQDWLDAEAKIYYS
EVEINAHTNGSEDEARKQTTRGAKLENRSRLFADTFASHLLTYGSEAYKQEQTPGGATESFPQAKINFASGWLQDEITLR
DLPVTLLAGTRYDNYKGSSDGYADVDADKWSSRGAVTVTPTDWLMLFGSYSQAFRAPTMGEMYNDSKHFSIPMGPTTITN
NWVPNPNLKPETNATQEYGFGLRFDDLLLADDSLQFKASYFDTKARDYITTDVTMELGRGPRGPYCISCTTFSTNIDRAK
IWGWDATLSYKTAIFGWDLAYNRTRGKNESSGEWLNSINPDTVTSTLDIPLGETGLSTGWVATVAQRATRVETGTAEQGG
YGVNDFYLSYKGRERLQGVTTTVVLGNAFDKEYYSPQGIPQDGRNAKLLVSYQW

Sequences:

>Translated_694_residues
MPLIYSTRLRLSALSLAIACTLPTVTFAQTSETPSSSSATAPVKKDKASDETMTVAATGNARSSFEAPMMVTVIEADTPQ
SQTATSAGDMLRRVPGITVNGTGRSNGQDVFMRGYGKNGVLTLVDGIRQGTDTGHLGATFLDPALVKRIEVVRGPSALLY
GSGALGGVIAYETVDAADLLLPGHNSGYRVYGTAGSGDHSLGMGASTYGRTDNLDGLLSFGTRDVGNLRQGNGFDAPNDE
TISNLLAKGTWTLDENQSLSGDLRYYNNRAQEPKNPQESASSSGNQMTDRSTIQRDGQLGYKLKPVGQDWLDAEAKIYYS
EVEINAHTNGSEDEARKQTTRGAKLENRSRLFADTFASHLLTYGSEAYKQEQTPGGATESFPQAKINFASGWLQDEITLR
DLPVTLLAGTRYDNYKGSSDGYADVDADKWSSRGAVTVTPTDWLMLFGSYSQAFRAPTMGEMYNDSKHFSIPMGPTTITN
NWVPNPNLKPETNATQEYGFGLRFDDLLLADDSLQFKASYFDTKARDYITTDVTMELGRGPRGPYCISCTTFSTNIDRAK
IWGWDATLSYKTAIFGWDLAYNRTRGKNESSGEWLNSINPDTVTSTLDIPLGETGLSTGWVATVAQRATRVETGTAEQGG
YGVNDFYLSYKGRERLQGVTTTVVLGNAFDKEYYSPQGIPQDGRNAKLLVSYQW
>Mature_693_residues
PLIYSTRLRLSALSLAIACTLPTVTFAQTSETPSSSSATAPVKKDKASDETMTVAATGNARSSFEAPMMVTVIEADTPQS
QTATSAGDMLRRVPGITVNGTGRSNGQDVFMRGYGKNGVLTLVDGIRQGTDTGHLGATFLDPALVKRIEVVRGPSALLYG
SGALGGVIAYETVDAADLLLPGHNSGYRVYGTAGSGDHSLGMGASTYGRTDNLDGLLSFGTRDVGNLRQGNGFDAPNDET
ISNLLAKGTWTLDENQSLSGDLRYYNNRAQEPKNPQESASSSGNQMTDRSTIQRDGQLGYKLKPVGQDWLDAEAKIYYSE
VEINAHTNGSEDEARKQTTRGAKLENRSRLFADTFASHLLTYGSEAYKQEQTPGGATESFPQAKINFASGWLQDEITLRD
LPVTLLAGTRYDNYKGSSDGYADVDADKWSSRGAVTVTPTDWLMLFGSYSQAFRAPTMGEMYNDSKHFSIPMGPTTITNN
WVPNPNLKPETNATQEYGFGLRFDDLLLADDSLQFKASYFDTKARDYITTDVTMELGRGPRGPYCISCTTFSTNIDRAKI
WGWDATLSYKTAIFGWDLAYNRTRGKNESSGEWLNSINPDTVTSTLDIPLGETGLSTGWVATVAQRATRVETGTAEQGGY
GVNDFYLSYKGRERLQGVTTTVVLGNAFDKEYYSPQGIPQDGRNAKLLVSYQW

Specific function: This protein is involved in the initial step of iron uptake by binding hemin, an iron chelatin siderophore that allows the bacteria to extract iron from the environment [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=604, Percent_Identity=24.1721854304636, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786798, Length=171, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790405, Length=143, Percent_Identity=37.0629370629371, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR011276
- InterPro:   IPR010949 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 75365; Mature: 75234

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIYSTRLRLSALSLAIACTLPTVTFAQTSETPSSSSATAPVKKDKASDETMTVAATGN
CCCEEECCHHHHHHEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
ARSSFEAPMMVTVIEADTPQSQTATSAGDMLRRVPGITVNGTGRSNGQDVFMRGYGKNGV
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCC
LTLVDGIRQGTDTGHLGATFLDPALVKRIEVVRGPSALLYGSGALGGVIAYETVDAADLL
EEEEHHHHCCCCCCCCCHHHHCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCHHHEE
LPGHNSGYRVYGTAGSGDHSLGMGASTYGRTDNLDGLLSFGTRDVGNLRQGNGFDAPNDE
ECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHH
TISNLLAKGTWTLDENQSLSGDLRYYNNRAQEPKNPQESASSSGNQMTDRSTIQRDGQLG
HHHHHHHCCCEEECCCCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCCCC
YKLKPVGQDWLDAEAKIYYSEVEINAHTNGSEDEARKQTTRGAKLENRSRLFADTFASHL
EEEEECCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LTYGSEAYKQEQTPGGATESFPQAKINFASGWLQDEITLRDLPVTLLAGTRYDNYKGSSD
HHHCHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCC
GYADVDADKWSSRGAVTVTPTDWLMLFGSYSQAFRAPTMGEMYNDSKHFSIPMGPTTITN
CCCCCCCCCCCCCCEEEECCHHHEEEECCHHHHHCCCCCHHHCCCCCEEEECCCCCEECC
NWVPNPNLKPETNATQEYGFGLRFDDLLLADDSLQFKASYFDTKARDYITTDVTMELGRG
CCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCEEEEECCCCCCCCEEEEEEEEEECCC
PRGPYCISCTTFSTNIDRAKIWGWDATLSYKTAIFGWDLAYNRTRGKNESSGEWLNSINP
CCCCEEEEEEEEECCCCCEEEECCCCEEEEEEEEEEEEEEECCCCCCCCCCCHHHHCCCC
DTVTSTLDIPLGETGLSTGWVATVAQRATRVETGTAEQGGYGVNDFYLSYKGRERLQGVT
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHCCEE
TTVVLGNAFDKEYYSPQGIPQDGRNAKLLVSYQW
EEEEECCCCCHHHCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
PLIYSTRLRLSALSLAIACTLPTVTFAQTSETPSSSSATAPVKKDKASDETMTVAATGN
CCEEECCHHHHHHEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
ARSSFEAPMMVTVIEADTPQSQTATSAGDMLRRVPGITVNGTGRSNGQDVFMRGYGKNGV
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCC
LTLVDGIRQGTDTGHLGATFLDPALVKRIEVVRGPSALLYGSGALGGVIAYETVDAADLL
EEEEHHHHCCCCCCCCCHHHHCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCHHHEE
LPGHNSGYRVYGTAGSGDHSLGMGASTYGRTDNLDGLLSFGTRDVGNLRQGNGFDAPNDE
ECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHH
TISNLLAKGTWTLDENQSLSGDLRYYNNRAQEPKNPQESASSSGNQMTDRSTIQRDGQLG
HHHHHHHCCCEEECCCCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCCCC
YKLKPVGQDWLDAEAKIYYSEVEINAHTNGSEDEARKQTTRGAKLENRSRLFADTFASHL
EEEEECCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LTYGSEAYKQEQTPGGATESFPQAKINFASGWLQDEITLRDLPVTLLAGTRYDNYKGSSD
HHHCHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCC
GYADVDADKWSSRGAVTVTPTDWLMLFGSYSQAFRAPTMGEMYNDSKHFSIPMGPTTITN
CCCCCCCCCCCCCCEEEECCHHHEEEECCHHHHHCCCCCHHHCCCCCEEEECCCCCEECC
NWVPNPNLKPETNATQEYGFGLRFDDLLLADDSLQFKASYFDTKARDYITTDVTMELGRG
CCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCEEEEECCCCCCCCEEEEEEEEEECCC
PRGPYCISCTTFSTNIDRAKIWGWDATLSYKTAIFGWDLAYNRTRGKNESSGEWLNSINP
CCCCEEEEEEEEECCCCCEEEECCCCEEEEEEEEEEEEEEECCCCCCCCCCCHHHHCCCC
DTVTSTLDIPLGETGLSTGWVATVAQRATRVETGTAEQGGYGVNDFYLSYKGRERLQGVT
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHCCEE
TTVVLGNAFDKEYYSPQGIPQDGRNAKLLVSYQW
EEEEECCCCCHHHCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1425573 [H]