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The map label for this gene is hmuU [H]

Identifier: 157370406

GI number: 157370406

Start: 2363078

End: 2364082

Strand: Reverse

Name: hmuU [H]

Synonym: Spro_2166

Alternate gene names: 157370406

Gene position: 2364082-2363078 (Counterclockwise)

Preceding gene: 157370407

Following gene: 157370405

Centisome position: 43.39

GC content: 61.39

Gene sequence:

>1005_bases
ATGCGCTGCCGTACCTCTCCCCGCCTGGCGATGACCAGCCTGCTGGTACTGTTGGCACTATTGGCTTTGGGCGCGGCCAA
TATGGGGGCGCTGACGCTGTCATTCCGCACCCTGTGGCAACAGCCGTTCAGCGACACCTCCTGGCATATCTGGCTGAATA
TCCGTTTGCCGCGTGTGCTGCTGGCGGTAGTGATAGGTTGCGCGTTGGCGGTGTCCGGCGCCGTGATGCAGGGATTGTTC
CGTAATCCCTTGGCCGATCCCAGCCTGTTGGGGATCAGTAGCGGCGGCGCGCTGTTTGTCGCGCTGATTATCGTTATGCC
GCTGGCCCTGCCGCCGGTGATTGCCCTGTATGGCCACATGCTGGCGGCATTTCTCGGCAGCATGCTGGTATCGCTGTTGA
TTTACGGCATCAGCCGCAGCGGCCACGGCAGCCTGTCGCGCCTGTTGCTGGCGGGTATCGCCATTAACGCCCTGTGCATG
GCAGCGATTGGCGTGCTGTCTTACCTCAGTAATGACCAGCAACTGCGCCAGTTTTCACTGTGGATGATGGGCAGCCTGAG
CCAGTCACAATGGCCCACCCTGGCCGTTTCCGCCTCGCTGATCCTGCCGACCATCCTGCTGACACTCTTACAGGCGCGCC
GCCTGAATCTGCTGCAACTGGGAGATGAGGAGGCGCATTACCTCGGTGTGAATGTTCAGCGTGCCAAGTTACAGCTGCTG
TTGTTGAGCGCATTACTGATAGGCGCAGCGGTAGCGATGAGTGGCGTGATTGGTTTTATCGGTCTGGTGGTGCCGCATCT
GGTGCGCATGCGCCTCGGCGGCGACCACCGCTGGCTGCTGCCCTGTTCTGCACTGGGGGGAGCCTGCCTGCTGTTGGTCA
GCGATACGCTGGCACGCACGCTGGTGGCTCCGGCAGAAATGCCGGTCGGTTTGATGACCAGCCTGATCGGCGGGCCTTAT
TTCTTATGGCTGGTGATGCGCCAGCGGGAGCGCGTGGGTGGATAA

Upstream 100 bases:

>100_bases
AGCATCGCATACTGGTGGTTGACGATATGGCGCTGCTGGGCTTCGGGCTGGAAACGCCCGCCGCGCTGGCCAAGCTGCGT
CATGCGGCGGAGCAAAAGTA

Downstream 100 bases:

>100_bases
CACAGCAAGCCTGACGGCGCAGCAGTTACGTTACAGCCTGGGTTCACGGCGGCTGATCAACGATGTCTCACTGAGTATCA
ATAGCGGCGAAATGGTGGCA

Product: transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRCRTSPRLAMTSLLVLLALLALGAANMGALTLSFRTLWQQPFSDTSWHIWLNIRLPRVLLAVVIGCALAVSGAVMQGLF
RNPLADPSLLGISSGGALFVALIIVMPLALPPVIALYGHMLAAFLGSMLVSLLIYGISRSGHGSLSRLLLAGIAINALCM
AAIGVLSYLSNDQQLRQFSLWMMGSLSQSQWPTLAVSASLILPTILLTLLQARRLNLLQLGDEEAHYLGVNVQRAKLQLL
LLSALLIGAAVAMSGVIGFIGLVVPHLVRMRLGGDHRWLLPCSALGGACLLLVSDTLARTLVAPAEMPVGLMTSLIGGPY
FLWLVMRQRERVGG

Sequences:

>Translated_334_residues
MRCRTSPRLAMTSLLVLLALLALGAANMGALTLSFRTLWQQPFSDTSWHIWLNIRLPRVLLAVVIGCALAVSGAVMQGLF
RNPLADPSLLGISSGGALFVALIIVMPLALPPVIALYGHMLAAFLGSMLVSLLIYGISRSGHGSLSRLLLAGIAINALCM
AAIGVLSYLSNDQQLRQFSLWMMGSLSQSQWPTLAVSASLILPTILLTLLQARRLNLLQLGDEEAHYLGVNVQRAKLQLL
LLSALLIGAAVAMSGVIGFIGLVVPHLVRMRLGGDHRWLLPCSALGGACLLLVSDTLARTLVAPAEMPVGLMTSLIGGPY
FLWLVMRQRERVGG
>Mature_334_residues
MRCRTSPRLAMTSLLVLLALLALGAANMGALTLSFRTLWQQPFSDTSWHIWLNIRLPRVLLAVVIGCALAVSGAVMQGLF
RNPLADPSLLGISSGGALFVALIIVMPLALPPVIALYGHMLAAFLGSMLVSLLIYGISRSGHGSLSRLLLAGIAINALCM
AAIGVLSYLSNDQQLRQFSLWMMGSLSQSQWPTLAVSASLILPTILLTLLQARRLNLLQLGDEEAHYLGVNVQRAKLQLL
LLSALLIGAAVAMSGVIGFIGLVVPHLVRMRLGGDHRWLLPCSALGGACLLLVSDTLARTLVAPAEMPVGLMTSLIGGPY
FLWLVMRQRERVGG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=316, Percent_Identity=40.1898734177215, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790741, Length=279, Percent_Identity=42.2939068100358, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788004, Length=276, Percent_Identity=40.9420289855072, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786805, Length=296, Percent_Identity=38.5135135135135, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786804, Length=338, Percent_Identity=34.9112426035503, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786347, Length=279, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35670; Mature: 35670

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCRTSPRLAMTSLLVLLALLALGAANMGALTLSFRTLWQQPFSDTSWHIWLNIRLPRVL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHH
LAVVIGCALAVSGAVMQGLFRNPLADPSLLGISSGGALFVALIIVMPLALPPVIALYGHM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LAAFLGSMLVSLLIYGISRSGHGSLSRLLLAGIAINALCMAAIGVLSYLSNDQQLRQFSL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
WMMGSLSQSQWPTLAVSASLILPTILLTLLQARRLNLLQLGDEEAHYLGVNVQRAKLQLL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCHHHHHHHHH
LLSALLIGAAVAMSGVIGFIGLVVPHLVRMRLGGDHRWLLPCSALGGACLLLVSDTLART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHH
LVAPAEMPVGLMTSLIGGPYFLWLVMRQRERVGG
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRCRTSPRLAMTSLLVLLALLALGAANMGALTLSFRTLWQQPFSDTSWHIWLNIRLPRVL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHH
LAVVIGCALAVSGAVMQGLFRNPLADPSLLGISSGGALFVALIIVMPLALPPVIALYGHM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LAAFLGSMLVSLLIYGISRSGHGSLSRLLLAGIAINALCMAAIGVLSYLSNDQQLRQFSL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
WMMGSLSQSQWPTLAVSASLILPTILLTLLQARRLNLLQLGDEEAHYLGVNVQRAKLQLL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCHHHHHHHHH
LLSALLIGAAVAMSGVIGFIGLVVPHLVRMRLGGDHRWLLPCSALGGACLLLVSDTLART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHH
LVAPAEMPVGLMTSLIGGPYFLWLVMRQRERVGG
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]