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The map label for this gene is arnA

Identifier: 157370396

GI number: 157370396

Start: 2352273

End: 2354255

Strand: Direct

Name: arnA

Synonym: Spro_2156

Alternate gene names: 157370396

Gene position: 2352273-2354255 (Clockwise)

Preceding gene: 157370395

Following gene: 157370397

Centisome position: 43.17

GC content: 54.82

Gene sequence:

>1983_bases
ATGAAAGCTATCGTATTTGCTTACCATGATATTGGCTGCGCTGGTCTGAAAGCGCTGACTGACGCGGGCTATGATATTCA
GGCGGTATTCACCCATACCGACGATCCTGGTGAGAACAACTTTTTCTCCTCCGTTGCCCGTGTGGGTGCCGAATTGGAGC
TGCCGGTTTATGCGCCGGAAGACGTTAACCATCCACTGTGGATCGAACGTATCCGCGAGATGCAGCCTGACATTATTTTC
TCATTCTATTACCGCAATATGCTGAGCGAAGAGCTGCTGTCACTGGCGCCAAAAGGCGGCTTCAATCTGCATGGCTCACT
GCTGCCGCATTACCGTGGTCGCGCACCGGTAAACTGGGCGCTGGTAAATGGTGAAACCGAAACCGGTGCCACGCTGCACA
AAATGGTTAAGCGTCCGGATGCCGGTGATATTGTTGGCCAGCACAAAGTGGCGATTGCCGCTAACGATACCGCGCTGACC
CTGCACAAAAAAGTGCTGGAAGCGGCACAGGCGCTGCTGAAAGAGCAACTGCCGAAGCTGAAAAACGGGACGGCCTCATT
CACCAGGCAAAATGAAGCTGAAGCCAGCTATTTTGGTCGTCGCACCGCGGCAGATGGTGAAATTCTGTGGCATAAATCAG
CGCAGGAAATCAACAACCTGGTCCGTGCCGTGACCGAACCTTACCCTGGTGCTTTCAGCTACCTTGGCCAGCGTAAACTG
ATTGTCTGGCGTGCCCGCGTGCTGGATACCCGGCATGACAAGCAACCGGGTACCGTGCTCAGTACCTCTCCGCTGATCAT
TGCCTGCGGTGAAGGCGCGCTGGAAATTGTGGCCGGCCAAAACGATGTCGGTTTGTACGTGCAAGGCAGCCGTCTGGCGC
AGGAAATGGGTATCGTCACCGACGTGCGCCTGGCCGCCAAGCCAAACGCAGTGATGAAACGCAGAACCCGCGTGCTGATC
CTCGGCGTTAACGGCTTTATCGGTAACCACCTGACCGAACGCCTGCTGCGTGATGACCGCTATGATATCTACGGTCTGGA
TATCGGTTCTGACGCCATCAGCCGTTTCCTCGGTAACCCGCGCTTCCACTTTGTGGAAGGGGATATCAGCATCCACTCCG
AGTGGATCGAGTACCACATCAAGAAATGTGACGTGATCCTGCCGCTGGTGGCGATTGCCACACCGATTGAATACACCCGC
AACCCACTGCGCGTATTCGAGCTGGATTTCGAAGAAAACCTGAAAATCGTCCGTGACTGCGTGAAATACAACAAGCGCAT
TATCTTCCCGTCCACCTCCGAGGTGTACGGCATGTGTGACGACAAGGAATTCGACGAAGACCACTCACGCCTGATTGTCG
GCCCGATCAACAAACAGCGCTGGATTTACTCGGTATCCAAGCAGTTGCTGGATCGAGTGATCTGGGCCTACGGTGCCAAA
GAAGGCTTGAAGTTCACGCTGTTCCGTCCGTTTAACTGGATGGGTCCACGTCTGGATAACCTGGATGCCGCACGTATCGG
TTCTTCTCGCGCCATTACCCAGCTGATCCTCAACCTGGTGGAAGGCTCGCCAATTAAATTGATGGACGGCGGGGCGCAAA
AACGTTGCTTCACCGACATCAATGACGGTATCGAAGCGCTGTTCCGCATTATCGAAAACCGTGATGGCCTGTGCGATGGC
CAGATCGTCAACATCGGTAACCCGACCAACGAAGCCAGTATCCGCGAGTTGGCAGAAATGCTGCTCGAAAGCTTCAACAA
CCATCCGCTGCGTGACCGTTTCCCACCCTTTGCCGGCTTCAAGGACGTTGAAAGCAGCAGCTATTACGGTAAAGGCTATC
AGGACGTTGAGCACCGCACGCCGAGCATCAAGAATGCCCGCCGCTTGCTGGATTGGCAGCCAACCATCGCCATGCAGCAA
ACCGTCGCTGATACGTTGGATTACTTCCTGCGTACGACCGTTCAGGAAGGTGACGGTGCATGA

Upstream 100 bases:

>100_bases
ACATCGGTCGCATCTATACCGACGTTCGTGCTCGTCCCCGTTATTTTGTTCAGAAAGTGGTCGGTGAACAGCCGAACCAC
AATACTCAGGAAGAAGAATA

Downstream 100 bases:

>100_bases
AGAAAGTCGGTCTGCGAGTTGACGTAGATACCTTCAGCGGCACCCGGGAAGGGGTGCCGCAGTTGCTGGAGCTGTTCGAC
AAGTACAATATTCAGGCCAG

Product: bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MKAIVFAYHDIGCAGLKALTDAGYDIQAVFTHTDDPGENNFFSSVARVGAELELPVYAPEDVNHPLWIERIREMQPDIIF
SFYYRNMLSEELLSLAPKGGFNLHGSLLPHYRGRAPVNWALVNGETETGATLHKMVKRPDAGDIVGQHKVAIAANDTALT
LHKKVLEAAQALLKEQLPKLKNGTASFTRQNEAEASYFGRRTAADGEILWHKSAQEINNLVRAVTEPYPGAFSYLGQRKL
IVWRARVLDTRHDKQPGTVLSTSPLIIACGEGALEIVAGQNDVGLYVQGSRLAQEMGIVTDVRLAAKPNAVMKRRTRVLI
LGVNGFIGNHLTERLLRDDRYDIYGLDIGSDAISRFLGNPRFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYNKRIIFPSTSEVYGMCDDKEFDEDHSRLIVGPINKQRWIYSVSKQLLDRVIWAYGAK
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLMDGGAQKRCFTDINDGIEALFRIIENRDGLCDG
QIVNIGNPTNEASIRELAEMLLESFNNHPLRDRFPPFAGFKDVESSSYYGKGYQDVEHRTPSIKNARRLLDWQPTIAMQQ
TVADTLDYFLRTTVQEGDGA

Sequences:

>Translated_660_residues
MKAIVFAYHDIGCAGLKALTDAGYDIQAVFTHTDDPGENNFFSSVARVGAELELPVYAPEDVNHPLWIERIREMQPDIIF
SFYYRNMLSEELLSLAPKGGFNLHGSLLPHYRGRAPVNWALVNGETETGATLHKMVKRPDAGDIVGQHKVAIAANDTALT
LHKKVLEAAQALLKEQLPKLKNGTASFTRQNEAEASYFGRRTAADGEILWHKSAQEINNLVRAVTEPYPGAFSYLGQRKL
IVWRARVLDTRHDKQPGTVLSTSPLIIACGEGALEIVAGQNDVGLYVQGSRLAQEMGIVTDVRLAAKPNAVMKRRTRVLI
LGVNGFIGNHLTERLLRDDRYDIYGLDIGSDAISRFLGNPRFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYNKRIIFPSTSEVYGMCDDKEFDEDHSRLIVGPINKQRWIYSVSKQLLDRVIWAYGAK
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLMDGGAQKRCFTDINDGIEALFRIIENRDGLCDG
QIVNIGNPTNEASIRELAEMLLESFNNHPLRDRFPPFAGFKDVESSSYYGKGYQDVEHRTPSIKNARRLLDWQPTIAMQQ
TVADTLDYFLRTTVQEGDGA
>Mature_660_residues
MKAIVFAYHDIGCAGLKALTDAGYDIQAVFTHTDDPGENNFFSSVARVGAELELPVYAPEDVNHPLWIERIREMQPDIIF
SFYYRNMLSEELLSLAPKGGFNLHGSLLPHYRGRAPVNWALVNGETETGATLHKMVKRPDAGDIVGQHKVAIAANDTALT
LHKKVLEAAQALLKEQLPKLKNGTASFTRQNEAEASYFGRRTAADGEILWHKSAQEINNLVRAVTEPYPGAFSYLGQRKL
IVWRARVLDTRHDKQPGTVLSTSPLIIACGEGALEIVAGQNDVGLYVQGSRLAQEMGIVTDVRLAAKPNAVMKRRTRVLI
LGVNGFIGNHLTERLLRDDRYDIYGLDIGSDAISRFLGNPRFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYNKRIIFPSTSEVYGMCDDKEFDEDHSRLIVGPINKQRWIYSVSKQLLDRVIWAYGAK
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLMDGGAQKRCFTDINDGIEALFRIIENRDGLCDG
QIVNIGNPTNEASIRELAEMLLESFNNHPLRDRFPPFAGFKDVESSSYYGKGYQDVEHRTPSIKNARRLLDWQPTIAMQQ
TVADTLDYFLRTTVQEGDGA

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily

Homologues:

Organism=Homo sapiens, GI42516563, Length=347, Percent_Identity=25.3602305475504, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI21614513, Length=243, Percent_Identity=23.8683127572016, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI238814322, Length=287, Percent_Identity=21.9512195121951, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788589, Length=653, Percent_Identity=71.5160796324655, Blast_Score=1001, Evalue=0.0,
Organism=Escherichia coli, GI1789683, Length=283, Percent_Identity=31.4487632508834, Blast_Score=136, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17539532, Length=342, Percent_Identity=25.7309941520468, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI133930964, Length=258, Percent_Identity=25.5813953488372, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=351, Percent_Identity=23.6467236467236, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21356223, Length=343, Percent_Identity=25.6559766763848, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28571984, Length=188, Percent_Identity=30.3191489361702, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550868, Length=188, Percent_Identity=30.3191489361702, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARNA_SERP5 (A8GDR7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478385.1
- ProteinModelPortal:   A8GDR7
- SMR:   A8GDR7
- STRING:   A8GDR7
- GeneID:   5605902
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2156
- eggNOG:   COG0451
- HOGENOM:   HBG298638
- OMA:   KAVVFAY
- ProtClustDB:   PRK08125
- BioCyc:   SPRO399741:SPRO_2156-MONOMER
- HAMAP:   MF_01166
- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF036506

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.13; =1.1.1.305

Molecular weight: Translated: 74191; Mature: 74191

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: ACT_SITE 104-104 ACT_SITE 434-434 ACT_SITE 619-619 BINDING 114-114 BINDING 347-347 BINDING 393-393 BINDING 398-398 BINDING 460-460 BINDING 492-492 BINDING 613-613

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVFAYHDIGCAGLKALTDAGYDIQAVFTHTDDPGENNFFSSVARVGAELELPVYAPE
CCEEEEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCC
DVNHPLWIERIREMQPDIIFSFYYRNMLSEELLSLAPKGGFNLHGSLLPHYRGRAPVNWA
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
LVNGETETGATLHKMVKRPDAGDIVGQHKVAIAANDTALTLHKKVLEAAQALLKEQLPKL
EECCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHH
KNGTASFTRQNEAEASYFGRRTAADGEILWHKSAQEINNLVRAVTEPYPGAFSYLGQRKL
CCCCCHHCCCCCHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCHHHHHCCCEE
IVWRARVLDTRHDKQPGTVLSTSPLIIACGEGALEIVAGQNDVGLYVQGSRLAQEMGIVT
EEEHHHHHCCCCCCCCCCEEECCCEEEEECCCCEEEEECCCCCEEEEECHHHHHHHCCCE
DVRLAAKPNAVMKRRTRVLILGVNGFIGNHLTERLLRDDRYDIYGLDIGSDAISRFLGNP
EEEECCCCHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCC
RFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLKIVRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYNKRIIFPSTSEVYGMCDDKEFDEDHSRLIVGPINKQRWIYSVSKQLLDRVIWAYGAK
HHHCCEEECCCCHHHEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLMDGGAQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
NDGIEALFRIIENRDGLCDGQIVNIGNPTNEASIRELAEMLLESFNNHPLRDRFPPFAGF
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCCC
KDVESSSYYGKGYQDVEHRTPSIKNARRLLDWQPTIAMQQTVADTLDYFLRTTVQEGDGA
CCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKAIVFAYHDIGCAGLKALTDAGYDIQAVFTHTDDPGENNFFSSVARVGAELELPVYAPE
CCEEEEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCC
DVNHPLWIERIREMQPDIIFSFYYRNMLSEELLSLAPKGGFNLHGSLLPHYRGRAPVNWA
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
LVNGETETGATLHKMVKRPDAGDIVGQHKVAIAANDTALTLHKKVLEAAQALLKEQLPKL
EECCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHH
KNGTASFTRQNEAEASYFGRRTAADGEILWHKSAQEINNLVRAVTEPYPGAFSYLGQRKL
CCCCCHHCCCCCHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCHHHHHCCCEE
IVWRARVLDTRHDKQPGTVLSTSPLIIACGEGALEIVAGQNDVGLYVQGSRLAQEMGIVT
EEEHHHHHCCCCCCCCCCEEECCCEEEEECCCCEEEEECCCCCEEEEECHHHHHHHCCCE
DVRLAAKPNAVMKRRTRVLILGVNGFIGNHLTERLLRDDRYDIYGLDIGSDAISRFLGNP
EEEECCCCHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCC
RFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLKIVRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYNKRIIFPSTSEVYGMCDDKEFDEDHSRLIVGPINKQRWIYSVSKQLLDRVIWAYGAK
HHHCCEEECCCCHHHEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLMDGGAQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
NDGIEALFRIIENRDGLCDGQIVNIGNPTNEASIRELAEMLLESFNNHPLRDRFPPFAGF
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCCC
KDVESSSYYGKGYQDVEHRTPSIKNARRLLDWQPTIAMQQTVADTLDYFLRTTVQEGDGA
CCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA