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The map label for this gene is 157370377

Identifier: 157370377

GI number: 157370377

Start: 2331597

End: 2333378

Strand: Direct

Name: 157370377

Synonym: Spro_2137

Alternate gene names: NA

Gene position: 2331597-2333378 (Clockwise)

Preceding gene: 157370376

Following gene: 157370378

Centisome position: 42.79

GC content: 57.74

Gene sequence:

>1782_bases
ATGGCAACGGTAATGAAAAAAGTAGACGCGGTGATCGTCGGCTTCGGCTGGGTGGGCGCCATTATGGCCAAAGAATTGAC
CGAGGCCGGGCTGAACGTGGTGGCGCTGGAACGCGGCCCGATGCGCGATACCTATCCGGATGGTTCCTACCCGCAGGTGA
TCGACGAACTGACCTATAACATTCGCCGCAAACTGTTCCAGGATTTGTCAAAAAGCACCGTGACCATTCGTCATAATACC
AGCCAGACGGCGGTGCCTTACCGTCAGTTGGCGGCGTTCTTGCCGGGTACCGGCGTGGGTGGCGCAGGCCTGCACTGGTC
TGGCGTGCATTTCCGGGTCGATCCGATTGAATTGCGCATGCGCAGTCACTACGAAGAACGTTACGGCAAGAGTTTTATCC
CGAAAGACATGACCATTCAGGATTTCGGTGTCAGCTACGCCGAGCTGGAGCCGTTCTTCGACAAAGCGGAAAAAGTGTTC
GGCACTTCCGGCACCGCCTGGACCATCAAAGGCCAGAAAGTGGGCCAAAAGGGCGGTAACCCGTTTGCCGGTGACCGTTC
CGATGACTTCCCGTTGCCGGCGCAGAAAAATACTTTCTCCGCCCAGATGTTCGAGAAAGCCGCGCGAGACGTGGGATACC
ATCCTTATAACCTGCCTTCTGCCAACACCTCGGATTCCTATACCAACCCGTATGGCGCGCAGATGGGGCCGTGCAACTTC
TGCGGTTTCTGTAGCGGTTACGCCTGCTATATGTATTCCAAAGCCTCGCCGAACGTCAATATTCTGCCGGCACTGCGCAT
GGAGAAACGCTTCGAGCTGCGCACCAACGCCAACGTGTTGAAAGTGAACCTGACCGCCGACAAGTCTCGTGCGACCGGTG
TGAATTACATTGATGCGCAGGGCCGTGAAGTTGAGCAACCGGCCGAACTGGTGATCCTGGGCGCGTTCCAGTTCCACAAC
GTCCACCTGATGCTGCTGTCCGGCATCGGCAAACCTTACGATCCGGTGACCGGCGAAGGGGTGGTTGGGCGTAACTTCGC
CTATCAGAACATGACCACCATCAAGGCGTTCTTCGACAAGGACGTGTTCACTAACCCGTTCATCGGCGCCGGCGGTAACG
GTGTGGGTGTGGACGACTTCAACGCCGACAACTTTGACCATGCCGAGGCAGGCTTTGTTGGCGGTTCGCCGTTCTGGGTC
AACCAGGCGGGCACCAAACCGATCTCCGGCTTGCCAACCCCTCCGGGTACCCCGGCCTGGGGCAGTAAGTGGAAAGCGGC
GGTGGCAGATGCCTATACCCATCATGTCTCGATGGATGCCCACGGCGCGCACCAGTCTTATCGCAGCAACTATCTGGATC
TCGATCCTACCTATAAGAACGTGTTCGGCCAGCCGCTGCTGCGCATGACGTTCGACTGGCAGGAAAACGACGTCAAGATG
TCGCAATTTATGTACGAGAAAATGGCGCCGATCGCCAAGGCCATGAACCCGAAACTGATCTCCGGCAGCCCAAAAAATGC
CGACAGCCATTTCGATACCACCAGCTACCAAACCACCCATATGAACGGCGGTGCGGTGATGGGCGAAGATCCGAACACCA
GCGCGGTGAACCGCTATCTGCAGAGCTGGGACGTGCATAACGTGTTCTCGATCGGCGCGTCGGCCTTCCCGCAGGGGCTG
GGTTACAACCCGACCGGCACCGTGGCCGCGTTGGCTTACTGGTCTGCACGCGCTATTCGCGAGCAGTATCTGAAAAACCC
AGGCCCTTTGGTGCAGGCATAA

Upstream 100 bases:

>100_bases
TTAATTTTCCGGGCGCACGCGCCGACTTTATGGACTGGGTTGAGCGAGGGGAACGTTATCCCTTACCCCCGGTATCAATT
CGTGGGGAGAGGGGGTAACA

Downstream 100 bases:

>100_bases
GGACGGCGACTGATGAAAGCATTTGTTCCCGCACTGGTTCTCAGTGCACTGAGTTTCTCCGTCTGGGCGCAGGACGCCAC
GGTCAGCAGCGAGTTGATCA

Product: gluconate 2-dehydrogenase

Products: NA

Alternate protein names: GA 2-DH dehydrogenase subunit; GADH dehydrogenase subunit [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MATVMKKVDAVIVGFGWVGAIMAKELTEAGLNVVALERGPMRDTYPDGSYPQVIDELTYNIRRKLFQDLSKSTVTIRHNT
SQTAVPYRQLAAFLPGTGVGGAGLHWSGVHFRVDPIELRMRSHYEERYGKSFIPKDMTIQDFGVSYAELEPFFDKAEKVF
GTSGTAWTIKGQKVGQKGGNPFAGDRSDDFPLPAQKNTFSAQMFEKAARDVGYHPYNLPSANTSDSYTNPYGAQMGPCNF
CGFCSGYACYMYSKASPNVNILPALRMEKRFELRTNANVLKVNLTADKSRATGVNYIDAQGREVEQPAELVILGAFQFHN
VHLMLLSGIGKPYDPVTGEGVVGRNFAYQNMTTIKAFFDKDVFTNPFIGAGGNGVGVDDFNADNFDHAEAGFVGGSPFWV
NQAGTKPISGLPTPPGTPAWGSKWKAAVADAYTHHVSMDAHGAHQSYRSNYLDLDPTYKNVFGQPLLRMTFDWQENDVKM
SQFMYEKMAPIAKAMNPKLISGSPKNADSHFDTTSYQTTHMNGGAVMGEDPNTSAVNRYLQSWDVHNVFSIGASAFPQGL
GYNPTGTVAALAYWSARAIREQYLKNPGPLVQA

Sequences:

>Translated_593_residues
MATVMKKVDAVIVGFGWVGAIMAKELTEAGLNVVALERGPMRDTYPDGSYPQVIDELTYNIRRKLFQDLSKSTVTIRHNT
SQTAVPYRQLAAFLPGTGVGGAGLHWSGVHFRVDPIELRMRSHYEERYGKSFIPKDMTIQDFGVSYAELEPFFDKAEKVF
GTSGTAWTIKGQKVGQKGGNPFAGDRSDDFPLPAQKNTFSAQMFEKAARDVGYHPYNLPSANTSDSYTNPYGAQMGPCNF
CGFCSGYACYMYSKASPNVNILPALRMEKRFELRTNANVLKVNLTADKSRATGVNYIDAQGREVEQPAELVILGAFQFHN
VHLMLLSGIGKPYDPVTGEGVVGRNFAYQNMTTIKAFFDKDVFTNPFIGAGGNGVGVDDFNADNFDHAEAGFVGGSPFWV
NQAGTKPISGLPTPPGTPAWGSKWKAAVADAYTHHVSMDAHGAHQSYRSNYLDLDPTYKNVFGQPLLRMTFDWQENDVKM
SQFMYEKMAPIAKAMNPKLISGSPKNADSHFDTTSYQTTHMNGGAVMGEDPNTSAVNRYLQSWDVHNVFSIGASAFPQGL
GYNPTGTVAALAYWSARAIREQYLKNPGPLVQA
>Mature_592_residues
ATVMKKVDAVIVGFGWVGAIMAKELTEAGLNVVALERGPMRDTYPDGSYPQVIDELTYNIRRKLFQDLSKSTVTIRHNTS
QTAVPYRQLAAFLPGTGVGGAGLHWSGVHFRVDPIELRMRSHYEERYGKSFIPKDMTIQDFGVSYAELEPFFDKAEKVFG
TSGTAWTIKGQKVGQKGGNPFAGDRSDDFPLPAQKNTFSAQMFEKAARDVGYHPYNLPSANTSDSYTNPYGAQMGPCNFC
GFCSGYACYMYSKASPNVNILPALRMEKRFELRTNANVLKVNLTADKSRATGVNYIDAQGREVEQPAELVILGAFQFHNV
HLMLLSGIGKPYDPVTGEGVVGRNFAYQNMTTIKAFFDKDVFTNPFIGAGGNGVGVDDFNADNFDHAEAGFVGGSPFWVN
QAGTKPISGLPTPPGTPAWGSKWKAAVADAYTHHVSMDAHGAHQSYRSNYLDLDPTYKNVFGQPLLRMTFDWQENDVKMS
QFMYEKMAPIAKAMNPKLISGSPKNADSHFDTTSYQTTHMNGGAVMGEDPNTSAVNRYLQSWDVHNVFSIGASAFPQGLG
YNPTGTVAALAYWSARAIREQYLKNPGPLVQA

Specific function: Part of the heterotrimer that catalyzes the conversion of D-gluconate to 2-dehydro-D-gluconate. This subunit functions as the dehydrogenase [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.3 [H]

Molecular weight: Translated: 65068; Mature: 64937

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVMKKVDAVIVGFGWVGAIMAKELTEAGLNVVALERGPMRDTYPDGSYPQVIDELTYN
CCHHHHHHCEEEECHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
IRRKLFQDLSKSTVTIRHNTSQTAVPYRQLAAFLPGTGVGGAGLHWSGVHFRVDPIELRM
HHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCEECCEEEEECHHHHHH
RSHYEERYGKSFIPKDMTIQDFGVSYAELEPFFDKAEKVFGTSGTAWTIKGQKVGQKGGN
HHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCCCC
PFAGDRSDDFPLPAQKNTFSAQMFEKAARDVGYHPYNLPSANTSDSYTNPYGAQMGPCNF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
CGFCSGYACYMYSKASPNVNILPALRMEKRFELRTNANVLKVNLTADKSRATGVNYIDAQ
HHHHCCEEEEEEECCCCCCEEEECHHCCHHHEEECCCEEEEEEEECCCCCCCCCCEECCC
GREVEQPAELVILGAFQFHNVHLMLLSGIGKPYDPVTGEGVVGRNFAYQNMTTIKAFFDK
CCCCCCCCEEEEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHCC
DVFTNPFIGAGGNGVGVDDFNADNFDHAEAGFVGGSPFWVNQAGTKPISGLPTPPGTPAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
GSKWKAAVADAYTHHVSMDAHGAHQSYRSNYLDLDPTYKNVFGQPLLRMTFDWQENDVKM
CCCHHHHHHHHHHHEEECCCCCCHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCHHH
SQFMYEKMAPIAKAMNPKLISGSPKNADSHFDTTSYQTTHMNGGAVMGEDPNTSAVNRYL
HHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHH
QSWDVHNVFSIGASAFPQGLGYNPTGTVAALAYWSARAIREQYLKNPGPLVQA
HHCCCHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATVMKKVDAVIVGFGWVGAIMAKELTEAGLNVVALERGPMRDTYPDGSYPQVIDELTYN
CHHHHHHCEEEECHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
IRRKLFQDLSKSTVTIRHNTSQTAVPYRQLAAFLPGTGVGGAGLHWSGVHFRVDPIELRM
HHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCEECCEEEEECHHHHHH
RSHYEERYGKSFIPKDMTIQDFGVSYAELEPFFDKAEKVFGTSGTAWTIKGQKVGQKGGN
HHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCCCC
PFAGDRSDDFPLPAQKNTFSAQMFEKAARDVGYHPYNLPSANTSDSYTNPYGAQMGPCNF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
CGFCSGYACYMYSKASPNVNILPALRMEKRFELRTNANVLKVNLTADKSRATGVNYIDAQ
HHHHCCEEEEEEECCCCCCEEEECHHCCHHHEEECCCEEEEEEEECCCCCCCCCCEECCC
GREVEQPAELVILGAFQFHNVHLMLLSGIGKPYDPVTGEGVVGRNFAYQNMTTIKAFFDK
CCCCCCCCEEEEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHCC
DVFTNPFIGAGGNGVGVDDFNADNFDHAEAGFVGGSPFWVNQAGTKPISGLPTPPGTPAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
GSKWKAAVADAYTHHVSMDAHGAHQSYRSNYLDLDPTYKNVFGQPLLRMTFDWQENDVKM
CCCHHHHHHHHHHHEEECCCCCCHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCHHH
SQFMYEKMAPIAKAMNPKLISGSPKNADSHFDTTSYQTTHMNGGAVMGEDPNTSAVNRYL
HHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHH
QSWDVHNVFSIGASAFPQGLGYNPTGTVAALAYWSARAIREQYLKNPGPLVQA
HHCCCHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9352901 [H]