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The map label for this gene is hutC [H]

Identifier: 157370320

GI number: 157370320

Start: 2271788

End: 2272543

Strand: Reverse

Name: hutC [H]

Synonym: Spro_2078

Alternate gene names: 157370320

Gene position: 2272543-2271788 (Counterclockwise)

Preceding gene: 157370324

Following gene: 157370319

Centisome position: 41.71

GC content: 61.11

Gene sequence:

>756_bases
TTGGTTGATCAACAGACCGTGCTGCAACTGGCTGCTGCCATGAGCGATACCCCCGCCCCGATCTATCAACGGGTCAAGCA
GGCGATCGTAAACCAAATCCGTGCCGGCCACTGGTTACCGCACCAACGCGTCCCCTCGGAAAGTGAACTGGTGGCCGAGC
TTGGCGTCAGTCGCATGACCATCAACCGTGCGCTGCGCGAACTGACCACCGAAGGTTTCCTGATCCGCATGCAGGGCGTG
GGGACCTTTGTCGCCGAAGCCAAAGCGCACACCGCCCTGCTGGAAGTGCATAACATCGCCGACGAAATCGCCGCCCGTGG
CCACCGCCACAGCAGCAAAATCCTGCAGCTAAAGGCCCGTCCGGCCAGTGAAGAAGAAGCGCTGGCGCTAGGCATTCAAC
CCGGCCAGCAGCTGTTCTATTCGCAAATCGTGCATTATGAAAACGACCTGCCGGTGCAGGTGGAAGACCGCTGCGTCAAT
CCTTTGATCGCCCCCGACTACATGCTGCAGGATTTCGATCGCGTCACGCCTTATATCTACCTGACGCAGGCCGCCCCGCT
GACCGCAGGCGAGCACATCGTGGAAGCCGTGGTGCCAACCCACCAGGAGCGCGAACTGCTGCAACTGGAAGACCACGAAC
CCGGCCTGCTGATCCATCGCCGCACCTGGTCCGGCAAAACCGTGGTGACCTCGGCGCGCCTGCTGTACCCCGGCAGCCGC
TATCAACTGTTTGGCCGTTTCACCAGCGAAGTCTGA

Upstream 100 bases:

>100_bases
TTGCTGTGGCGAACCGGCCCTTAGTTGTATATACATATACATACGCCGACACCAACAGTAAACTGGTGTTATTATTTTTT
TATTTGACGAGGTTAACGTC

Downstream 100 bases:

>100_bases
CCCCGGCGGGTGCTGCTTTGGCACCCGTCCTTCCACAACGATCACATCCCGATAACAAATTTTTATCCCGCCTCTTGTGA
CAACTCAATGAATGCGCTAG

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MVDQQTVLQLAAAMSDTPAPIYQRVKQAIVNQIRAGHWLPHQRVPSESELVAELGVSRMTINRALRELTTEGFLIRMQGV
GTFVAEAKAHTALLEVHNIADEIAARGHRHSSKILQLKARPASEEEALALGIQPGQQLFYSQIVHYENDLPVQVEDRCVN
PLIAPDYMLQDFDRVTPYIYLTQAAPLTAGEHIVEAVVPTHQERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSR
YQLFGRFTSEV

Sequences:

>Translated_251_residues
MVDQQTVLQLAAAMSDTPAPIYQRVKQAIVNQIRAGHWLPHQRVPSESELVAELGVSRMTINRALRELTTEGFLIRMQGV
GTFVAEAKAHTALLEVHNIADEIAARGHRHSSKILQLKARPASEEEALALGIQPGQQLFYSQIVHYENDLPVQVEDRCVN
PLIAPDYMLQDFDRVTPYIYLTQAAPLTAGEHIVEAVVPTHQERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSR
YQLFGRFTSEV
>Mature_251_residues
MVDQQTVLQLAAAMSDTPAPIYQRVKQAIVNQIRAGHWLPHQRVPSESELVAELGVSRMTINRALRELTTEGFLIRMQGV
GTFVAEAKAHTALLEVHNIADEIAARGHRHSSKILQLKARPASEEEALALGIQPGQQLFYSQIVHYENDLPVQVEDRCVN
PLIAPDYMLQDFDRVTPYIYLTQAAPLTAGEHIVEAVVPTHQERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSR
YQLFGRFTSEV

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=199, Percent_Identity=25.6281407035176, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082252, Length=150, Percent_Identity=30.6666666666667, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790118, Length=207, Percent_Identity=23.1884057971014, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788418, Length=161, Percent_Identity=24.223602484472, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28197; Mature: 28197

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQQTVLQLAAAMSDTPAPIYQRVKQAIVNQIRAGHWLPHQRVPSESELVAELGVSRMT
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHH
INRALRELTTEGFLIRMQGVGTFVAEAKAHTALLEVHNIADEIAARGHRHSSKILQLKAR
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PASEEEALALGIQPGQQLFYSQIVHYENDLPVQVEDRCVNPLIAPDYMLQDFDRVTPYIY
CCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCHHHHHHHHHHCCCEEE
LTQAAPLTAGEHIVEAVVPTHQERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSR
EECCCCCCHHHHHHHHHCCCCCCCHHHEECCCCCCEEEEEECCCCCEEEEEHEEECCCCH
YQLFGRFTSEV
HEEEEEHHCCC
>Mature Secondary Structure
MVDQQTVLQLAAAMSDTPAPIYQRVKQAIVNQIRAGHWLPHQRVPSESELVAELGVSRMT
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCHHHHH
INRALRELTTEGFLIRMQGVGTFVAEAKAHTALLEVHNIADEIAARGHRHSSKILQLKAR
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PASEEEALALGIQPGQQLFYSQIVHYENDLPVQVEDRCVNPLIAPDYMLQDFDRVTPYIY
CCCCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCHHHHHHHHHHCCCEEE
LTQAAPLTAGEHIVEAVVPTHQERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSR
EECCCCCCHHHHHHHHHCCCCCCCHHHEECCCCCCEEEEEECCCCCEEEEEHEEECCCCH
YQLFGRFTSEV
HEEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]