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The map label for this gene is pth

Identifier: 157370226

GI number: 157370226

Start: 2172360

End: 2172950

Strand: Reverse

Name: pth

Synonym: Spro_1984

Alternate gene names: 157370226

Gene position: 2172950-2172360 (Counterclockwise)

Preceding gene: 157370228

Following gene: 157370224

Centisome position: 39.88

GC content: 55.67

Gene sequence:

>591_bases
GTGAGCAGTATTAAATTGATAGTCGGCCTGGCGAATCCGGGCGCTGAGTATGCCCAGACGCGACACAACGCCGGCGCCTG
GTACGTCGATTTACTGGCCCAGCGCCATAACCAGCAGTTGAAGGAAGAGAGCAAATTCTACGGCTACACCGCCCGCCTGA
ATTTGGCCGGTAATGACGTGCGCCTGCTGGTGCCTACCACCTTTATGAACCTCAGTGGCAAAGCCGTACTGGCGATGGCC
AATTTCTACCGTATTGAGCCGGACGAAATTCTGGTCGCGCACGACGAGCTGGATATTCCGCCGGGTGTTGCAAAAATCAA
ACTGGGTGGCGGCAACGGTGGGCACAACGGGCTGAAGGATATTCAGAGCAAGTTCGGCAATAACCCGAACTTCTATCGCT
TGCGCATCGGCATTGGCCATCCGGGCGATAAAAACAAGGTGGTGGGTTTCGTGCTCGGCAAGCCACCGGCCAGCGAGCAA
AAAATGATTGATGAAGCGATTGATGAAGCCGCACGTTGCACGGAAATTCTGCTGACCGACGGCCTGGAAAAAACCGTTCG
TCGCCTGCACAGCTTCAAAGCGCAGGCCTGA

Upstream 100 bases:

>100_bases
CGCTGACTAACGCCACGCACAGCATCAGGATTTTGTCATTCGCGGCGCAGGCAGGTAGACTAATGCCCTTTCCATTATCT
CGATCATAGCGAATCTCCCC

Downstream 100 bases:

>100_bases
TAGTGATTGCAGCGGGCATCACGCCCGCTGCCGATCCGCTTAGGTTCGCAGCTTGAAGGTTTCCTCACCGACGTTGGCAT
CGTCGGTCTGATAGCCTTCT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAQRHNQQLKEESKFYGYTARLNLAGNDVRLLVPTTFMNLSGKAVLAMA
NFYRIEPDEILVAHDELDIPPGVAKIKLGGGNGGHNGLKDIQSKFGNNPNFYRLRIGIGHPGDKNKVVGFVLGKPPASEQ
KMIDEAIDEAARCTEILLTDGLEKTVRRLHSFKAQA

Sequences:

>Translated_196_residues
MSSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAQRHNQQLKEESKFYGYTARLNLAGNDVRLLVPTTFMNLSGKAVLAMA
NFYRIEPDEILVAHDELDIPPGVAKIKLGGGNGGHNGLKDIQSKFGNNPNFYRLRIGIGHPGDKNKVVGFVLGKPPASEQ
KMIDEAIDEAARCTEILLTDGLEKTVRRLHSFKAQA
>Mature_195_residues
SSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAQRHNQQLKEESKFYGYTARLNLAGNDVRLLVPTTFMNLSGKAVLAMAN
FYRIEPDEILVAHDELDIPPGVAKIKLGGGNGGHNGLKDIQSKFGNNPNFYRLRIGIGHPGDKNKVVGFVLGKPPASEQK
MIDEAIDEAARCTEILLTDGLEKTVRRLHSFKAQA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=182, Percent_Identity=31.8681318681319, Blast_Score=84, Evalue=6e-17,
Organism=Escherichia coli, GI1787455, Length=193, Percent_Identity=81.3471502590674, Blast_Score=311, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6321983, Length=176, Percent_Identity=28.4090909090909, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_SERP5 (A8GD97)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478215.1
- ProteinModelPortal:   A8GD97
- SMR:   A8GD97
- STRING:   A8GD97
- GeneID:   5603312
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1984
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   SPRO399741:SPRO_1984-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21480; Mature: 21349

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAQRHNQQLKEESKFYGYTARLNLAGNDV
CCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCE
RLLVPTTFMNLSGKAVLAMANFYRIEPDEILVAHDELDIPPGVAKIKLGGGNGGHNGLKD
EEEEEEEEECCCCCEEEEEEHHEEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHH
IQSKFGNNPNFYRLRIGIGHPGDKNKVVGFVLGKPPASEQKMIDEAIDEAARCTEILLTD
HHHHHCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
GLEKTVRRLHSFKAQA
CHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAQRHNQQLKEESKFYGYTARLNLAGNDV
CCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCE
RLLVPTTFMNLSGKAVLAMANFYRIEPDEILVAHDELDIPPGVAKIKLGGGNGGHNGLKD
EEEEEEEEECCCCCEEEEEEHHEEECCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHH
IQSKFGNNPNFYRLRIGIGHPGDKNKVVGFVLGKPPASEQKMIDEAIDEAARCTEILLTD
HHHHHCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
GLEKTVRRLHSFKAQA
CHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA