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The map label for this gene is fabH

Identifier: 157370146

GI number: 157370146

Start: 2088136

End: 2089089

Strand: Direct

Name: fabH

Synonym: Spro_1904

Alternate gene names: 157370146

Gene position: 2088136-2089089 (Clockwise)

Preceding gene: 157370145

Following gene: 157370147

Centisome position: 38.32

GC content: 56.92

Gene sequence:

>954_bases
ATGTATACAAAGATTCTCGGTACGGGGAGTTATTTACCCGTACAAGTGCGCACCAACGCTGACCTTGAAAAAATGGTGGA
TACCTCTGACGAGTGGATCGTCTCACGTACGGGTATCCGTGAACGCCGTATTGCCGCTGCTGATGAAACAGTTGCGACGA
TGGGTTTCCACGCTGCTGAAAAAGCGCTGGAAATGGCAGGTGTGGCTAAAGAAGACATCGGGCTGATCGTTGTGGCTACC
ACCACCTCGACCCACGCATTTCCAAGTTCTGCCTGCCAGGTGCAGCAGATGCTGGGCATCAAAGACTGTGCGGCATTCGA
TCTGGCTGCGGCCTGTGCCGGTTTCACCTATGCGTTGAGCGTCGCCGATCAGTATGTTAAAAACGGCGCGGTGAAGCATG
CTCTGGTGATCGGCGCAGACGTGTTGTCACGCACGCTGGATCCGGAAGATCGCGGCACTATCATTCTGTTTGGTGATGGC
GCAGGCGCGGTGCTGTTGGGGGCTTCTGAAGAGCCGGGCATTTTGTCGACCCATCTGCACGCCGACGGCAGCTACGGCGG
TTTGTTGACCTTGCCGTTCAAGGATCGTCAGGATCAGGACAAGCCGGCCTATGTCACCATGGCGGGTAATGAAGTCTTCA
AGGTTGCGGTTACCGAACTGGCTCACATCGTTGATGAAACGCTGCAGGCCAATAATCTGGATCGCAGCGCGCTGGACTGG
CTGGTGCCGCACCAGGCCAATTTGCGTATTATCAGCGCGACGGCGAAAAAATTGGGTATGGGGATGGATAAAGTGGTAGT
GACGCTCGATCGTCACGGTAACACCTCTGCCGCCTCGGTCCCTGCAGCGCTCGACGAAGCGGTGCGTGATGGGCGGATCC
AACGCGGCCAACTGGTGCTGCTGGAAGCCTTTGGCGGCGGCTTTACCTGGGGCTCGGCGCTGGTTCGTTTCTGA

Upstream 100 bases:

>100_bases
AGTGGCAATCGAACAGGCTGTGCAGGCGGTGCAGCGGCAAGTCCCTGACAGGATTGCTGCGCGCCTTGAAGCTGTATTAC
CTAAGAGTGACTGATCGTAC

Downstream 100 bases:

>100_bases
TATAACAGGAAGAAAAAATGACGCAATTTGCTTTTGTTTTTCCAGGCCAGGGTTCACAGACTCTGGGCATGCTGGCCGAT
TTGGCCACTCAATATCCGAT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MYTKILGTGSYLPVQVRTNADLEKMVDTSDEWIVSRTGIRERRIAAADETVATMGFHAAEKALEMAGVAKEDIGLIVVAT
TTSTHAFPSSACQVQQMLGIKDCAAFDLAAACAGFTYALSVADQYVKNGAVKHALVIGADVLSRTLDPEDRGTIILFGDG
AGAVLLGASEEPGILSTHLHADGSYGGLLTLPFKDRQDQDKPAYVTMAGNEVFKVAVTELAHIVDETLQANNLDRSALDW
LVPHQANLRIISATAKKLGMGMDKVVVTLDRHGNTSAASVPAALDEAVRDGRIQRGQLVLLEAFGGGFTWGSALVRF

Sequences:

>Translated_317_residues
MYTKILGTGSYLPVQVRTNADLEKMVDTSDEWIVSRTGIRERRIAAADETVATMGFHAAEKALEMAGVAKEDIGLIVVAT
TTSTHAFPSSACQVQQMLGIKDCAAFDLAAACAGFTYALSVADQYVKNGAVKHALVIGADVLSRTLDPEDRGTIILFGDG
AGAVLLGASEEPGILSTHLHADGSYGGLLTLPFKDRQDQDKPAYVTMAGNEVFKVAVTELAHIVDETLQANNLDRSALDW
LVPHQANLRIISATAKKLGMGMDKVVVTLDRHGNTSAASVPAALDEAVRDGRIQRGQLVLLEAFGGGFTWGSALVRF
>Mature_317_residues
MYTKILGTGSYLPVQVRTNADLEKMVDTSDEWIVSRTGIRERRIAAADETVATMGFHAAEKALEMAGVAKEDIGLIVVAT
TTSTHAFPSSACQVQQMLGIKDCAAFDLAAACAGFTYALSVADQYVKNGAVKHALVIGADVLSRTLDPEDRGTIILFGDG
AGAVLLGASEEPGILSTHLHADGSYGGLLTLPFKDRQDQDKPAYVTMAGNEVFKVAVTELAHIVDETLQANNLDRSALDW
LVPHQANLRIISATAKKLGMGMDKVVVTLDRHGNTSAASVPAALDEAVRDGRIQRGQLVLLEAFGGGFTWGSALVRF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=82.9652996845426, Blast_Score=546, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_SERP5 (A8GD17)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478135.1
- ProteinModelPortal:   A8GD17
- SMR:   A8GD17
- STRING:   A8GD17
- GeneID:   5606429
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1904
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   YLPAQVR
- ProtClustDB:   PRK09352
- BioCyc:   SPRO399741:SPRO_1904-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33657; Mature: 33657

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 244-244 ACT_SITE 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTKILGTGSYLPVQVRTNADLEKMVDTSDEWIVSRTGIRERRIAAADETVATMGFHAAE
CCEEEEECCCEEEEEEECCCCHHHHHCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHH
KALEMAGVAKEDIGLIVVATTTSTHAFPSSACQVQQMLGIKDCAAFDLAAACAGFTYALS
HHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VADQYVKNGAVKHALVIGADVLSRTLDPEDRGTIILFGDGAGAVLLGASEEPGILSTHLH
HHHHHHHCCCHHHHEEEEHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ADGSYGGLLTLPFKDRQDQDKPAYVTMAGNEVFKVAVTELAHIVDETLQANNLDRSALDW
CCCCCCCEEEECCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHH
LVPHQANLRIISATAKKLGMGMDKVVVTLDRHGNTSAASVPAALDEAVRDGRIQRGQLVL
HCCCCCCEEEEEECHHHHCCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCEEE
LEAFGGGFTWGSALVRF
EEECCCCCCHHHHHHCC
>Mature Secondary Structure
MYTKILGTGSYLPVQVRTNADLEKMVDTSDEWIVSRTGIRERRIAAADETVATMGFHAAE
CCEEEEECCCEEEEEEECCCCHHHHHCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHH
KALEMAGVAKEDIGLIVVATTTSTHAFPSSACQVQQMLGIKDCAAFDLAAACAGFTYALS
HHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VADQYVKNGAVKHALVIGADVLSRTLDPEDRGTIILFGDGAGAVLLGASEEPGILSTHLH
HHHHHHHCCCHHHHEEEEHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ADGSYGGLLTLPFKDRQDQDKPAYVTMAGNEVFKVAVTELAHIVDETLQANNLDRSALDW
CCCCCCCEEEECCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHH
LVPHQANLRIISATAKKLGMGMDKVVVTLDRHGNTSAASVPAALDEAVRDGRIQRGQLVL
HCCCCCCEEEEEECHHHHCCCCCCEEEEEECCCCCCHHHCCHHHHHHHHCCCCCCCCEEE
LEAFGGGFTWGSALVRF
EEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA