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The map label for this gene is pyrC

Identifier: 157370138

GI number: 157370138

Start: 2079142

End: 2080188

Strand: Reverse

Name: pyrC

Synonym: Spro_1896

Alternate gene names: 157370138

Gene position: 2080188-2079142 (Counterclockwise)

Preceding gene: 157370140

Following gene: 157370137

Centisome position: 38.18

GC content: 56.35

Gene sequence:

>1047_bases
ATGACCGCACAACCTCAAGCCCTAAAAATTCGCCGCCCTGACGACTGGCACATCCATCTGCGCGATGACGACATGCTGAA
AACGGTATTACCTTATACCAGTCAGGTCTTTGGCCGGGCGATTGTGATGCCGAACCTGGCTCTGCCAATTACTACCGTCG
CCGCGGCTTGCGCTTATCGTGACCGTATTCTGGCAGCGGTCCCTCAGGGACATGATTTCACCCCGCTGATGACCTGCTAC
CTGACCAATTCACTGGATGCAGCCGAACTGGTCAACGGGTTTGAGCAAGGCGTGTTCACCGCCGCCAAGCTGTACCCGGC
CAATGCCACTACCAATTCCAGCCACGGCGTCAGCGATGTGAAAGCCATTTACCCGCTGTTCGAGCAAATGCAGAAAATCG
GCATGCCACTGTTGATTCACGGTGAAGTGACCGATGCCGCCGTTGATATTTTCGATCGCGAGGCTCGCTTTATTGAGCAG
GTCATGGAGCCGATTCGTCAGCAGTTCCCTGAACTTAAAATCGTCTTCGAACACATCACCACCAAAGAAGCGGCGCAGTA
CGTGCAGGAAGGCAATCGTTTCCTTGGCGCGACCATCACCCCTCAGCACCTGATGTTTAACCGCAACCACATGCTGGTTG
GCGGTATCCGTCCGCACCTGTTCTGCCTGCCAATCCTGAAACGCAATATTCACCAGGACGCACTGCGCAAAGCCGTTGCC
AGCGGTTCGGATCGCTTCTTCCTCGGCACCGACTCCGCACCACATGCCAAACACCGCAAGGAATCCAGCTGCGGCTGCGC
TGGCGTATTCAACGCTCCCAATGCGATCCCGGCTTACGCCAGCGTGTTCGAGCAACTCGGTGCGCTGGATCATCTGGAAG
CCTTCTGCTCATTGAACGGCCCGCGTTTTTATGGCCTGCCGGTCAATACCGATTTCATCGAGCTGCAACGCGTAGCGACG
ACTCAGCCGGAAGAGATCGCCATGGGCAGCGAAACGGTCATTCCATTCCTGGCCGGGGAGAGTCTGAGCTGGTCGGTGAA
AGCATAA

Upstream 100 bases:

>100_bases
GCATCGCAAGCGCTTTACGCTTATCCTTACACCCCGGCGTGAATAACCCCCATTATTCGCTTTTACGTAGACCCGTTTCT
AACCGCCGGAGCCTTGCAAC

Downstream 100 bases:

>100_bases
TTATCTTTTTTTAATCCAACCTCTTGCCCCCGCGCACGGTTAACTGTATAAATATCCAGTAAATCGCTTCGGGGGCAATT
ATGCGTGTTGAAGTCACTAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTAQPQALKIRRPDDWHIHLRDDDMLKTVLPYTSQVFGRAIVMPNLALPITTVAAACAYRDRILAAVPQGHDFTPLMTCY
LTNSLDAAELVNGFEQGVFTAAKLYPANATTNSSHGVSDVKAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIEQ
VMEPIRQQFPELKIVFEHITTKEAAQYVQEGNRFLGATITPQHLMFNRNHMLVGGIRPHLFCLPILKRNIHQDALRKAVA
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPNAIPAYASVFEQLGALDHLEAFCSLNGPRFYGLPVNTDFIELQRVAT
TQPEEIAMGSETVIPFLAGESLSWSVKA

Sequences:

>Translated_348_residues
MTAQPQALKIRRPDDWHIHLRDDDMLKTVLPYTSQVFGRAIVMPNLALPITTVAAACAYRDRILAAVPQGHDFTPLMTCY
LTNSLDAAELVNGFEQGVFTAAKLYPANATTNSSHGVSDVKAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIEQ
VMEPIRQQFPELKIVFEHITTKEAAQYVQEGNRFLGATITPQHLMFNRNHMLVGGIRPHLFCLPILKRNIHQDALRKAVA
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPNAIPAYASVFEQLGALDHLEAFCSLNGPRFYGLPVNTDFIELQRVAT
TQPEEIAMGSETVIPFLAGESLSWSVKA
>Mature_347_residues
TAQPQALKIRRPDDWHIHLRDDDMLKTVLPYTSQVFGRAIVMPNLALPITTVAAACAYRDRILAAVPQGHDFTPLMTCYL
TNSLDAAELVNGFEQGVFTAAKLYPANATTNSSHGVSDVKAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIEQV
MEPIRQQFPELKIVFEHITTKEAAQYVQEGNRFLGATITPQHLMFNRNHMLVGGIRPHLFCLPILKRNIHQDALRKAVAS
GSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPNAIPAYASVFEQLGALDHLEAFCSLNGPRFYGLPVNTDFIELQRVATT
QPEEIAMGSETVIPFLAGESLSWSVKA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=347, Percent_Identity=73.7752161383285, Blast_Score=552, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=33.7078651685393, Blast_Score=168, Evalue=1e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_SERP5 (A8GD09)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478127.1
- ProteinModelPortal:   A8GD09
- SMR:   A8GD09
- STRING:   A8GD09
- GeneID:   5606386
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1896
- eggNOG:   COG0418
- HOGENOM:   HBG628648
- OMA:   KESACGC
- ProtClustDB:   PRK05451
- BioCyc:   SPRO399741:SPRO_1896-MONOMER
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 38519; Mature: 38387

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQPQALKIRRPDDWHIHLRDDDMLKTVLPYTSQVFGRAIVMPNLALPITTVAAACAYR
CCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
DRILAAVPQGHDFTPLMTCYLTNSLDAAELVNGFEQGVFTAAKLYPANATTNSSHGVSDV
HHHHEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHH
KAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIEQVMEPIRQQFPELKIVFEHIT
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TKEAAQYVQEGNRFLGATITPQHLMFNRNHMLVGGIRPHLFCLPILKRNIHQDALRKAVA
HHHHHHHHHHCCEEEECCCCHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPNAIPAYASVFEQLGALDHLEAFCSLNG
CCCCEEEEECCCCCCHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCC
PRFYGLPVNTDFIELQRVATTQPEEIAMGSETVIPFLAGESLSWSVKA
CEEEECCCCCCHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCEEEECC
>Mature Secondary Structure 
TAQPQALKIRRPDDWHIHLRDDDMLKTVLPYTSQVFGRAIVMPNLALPITTVAAACAYR
CCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
DRILAAVPQGHDFTPLMTCYLTNSLDAAELVNGFEQGVFTAAKLYPANATTNSSHGVSDV
HHHHEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHH
KAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIEQVMEPIRQQFPELKIVFEHIT
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TKEAAQYVQEGNRFLGATITPQHLMFNRNHMLVGGIRPHLFCLPILKRNIHQDALRKAVA
HHHHHHHHHHCCEEEECCCCHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
SGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPNAIPAYASVFEQLGALDHLEAFCSLNG
CCCCEEEEECCCCCCHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCC
PRFYGLPVNTDFIELQRVATTQPEEIAMGSETVIPFLAGESLSWSVKA
CEEEECCCCCCHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA