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The map label for this gene is uvrC

Identifier: 157370091

GI number: 157370091

Start: 2032312

End: 2034144

Strand: Direct

Name: uvrC

Synonym: Spro_1849

Alternate gene names: 157370091

Gene position: 2032312-2034144 (Clockwise)

Preceding gene: 157370090

Following gene: 157370092

Centisome position: 37.3

GC content: 53.08

Gene sequence:

>1833_bases
GTGAGTGACCGTTTTGATGCCAAAGCATTTCTAAGCACTGTAACCAGCCAGCCTGGCGTCTACCGAATGTACGACGCTAC
TGGCACGGTTATCTACGTCGGTAAAGCCAAAGATCTGAAAAAACGCCTCGCCAGTTACTTCCGCCAGCAGGTGGGAAGCC
GTAAAACTGAGACGCTGGTTAAAAATATCGCGCAAATAGACGTTACTGTTACGCACACCGAAACAGAAGCGCTATTACTG
GAACATAACTACATAAAGTTATACCAGCCGCGATATAATGTTCTTTTGCGAGACGATAAATCTTATCCGCTGATCTTCCT
CAGTGCGGACAGTCACCCGCGGCTGGCCGTGCATCGTGGTGCCAAACATGCCAAGGGGGAATACTTCGGTCCATTCCCAA
ATTCCTATGCCGTGCGTGAGACGCTGGCGCTGCTGCAGAAACTGTTCCCGATACGTCAGTGCGAGAACAGCGTATACCGC
AACCGCTCGCGCCCTTGTTTGCAGTACCAGATCGGCCGTTGCCTGGGGCCTTGTGTCGCCGGGTTGGTGAGTGAAGATGA
ATATCGTCAGCAGGTGGACTATGTGCGCCTGTTCCTGTCTGGTAAGGATCAACAGGTACTGCATCAGTTGATCGAAAGGA
TGGAAAACGCCAGCAAGGCATTGAACTTCGAAGAGGCAGCGCGGATACGCGATCAGATCCAGGCGGTACGCAGGGTGACT
GAGCGTCAGTTCGTGTCCGGTAACAGCGACGATCTGGATGTGATCGGCGTGGCATTCGAGGCCGGCATGGCCTGTCTGCA
CGTCCTGTTTATTCGCCAGGGCAAAGTGTTGGGTAGCCGCAGCTACTTCCCCAAAGTGCCAGGCGGCACCGAAATGAGCG
AAGTGGTGCAGACGTTTGTCGGTCAGTTCTATTTACAGGGTAGCCAGATGCGAACCTTGCCGGCGGAAATCCTGTTGGAT
TTCACTTTGCCGGAAAAAGAGCTGCTGGCCGAGTCGCTGTCTGAGCTGGCCGGTCGCAAAATCCAGATCCAGAGTAAACC
GCGAGGCGACCGTGCACGCTACCTTAAACTGGCGCGTACCAATGCGGCGACCGCTCTGACCACCAAGCTTTCCCAGCAGT
CGACCATTCATCAGCGACTGGCCGAATTAACCAAGGTGCTGAATCTTTCCGAGATTAACCGCATGGAATGCTTCGACATC
AGCCATACCATGGGCGAGCAAACCGTCGCTTCCTGCGTGGTGTTTGACGCTAATGGGCCGCTGCGTTCCGAGTATCGGCG
CTATAATATCACCGGCATTACGCCAGGGGATGACTATGCGGCGATGGCGCAAGTGTTGAAACGCCGCTATGGTAAGGCTC
TGGAAGAGAAAAAAATCCCCGACGTTATCTTTATTGATGGCGGTAAGGGGCAGCTTGGTATGGCGATTGACGTGTTTAAC
TCGCTGAATGTGAGCTGGGATAAAAACAAGCCCTTGCTGATCGGTATCGCCAAAGGTGCTGACCGTAAAGCCGGGTTGGA
AACACTGTTCTTTGTTCCTGAAGGTGAGGGGATTGCTTTGCCATCGGATTCACCGGCGCTGCATGTGATCCAGCACATCC
GCGATGATTCGCATAACCACGCGATCACCGGGCATCGGCAGAGAAGGGCAAAAGTAAGAAATACCAGCGCGTTGGAACTG
ATCGACGGCGTTGGGCCAAAACGGCGACAGGTGCTGTTGAAGTATATGGGTGGACTTCAACCATTATTGAACGCCAGCGT
TGAGGAAATTGCAAAAGTGCCGGGTATTTCACAAGCATTGGCAGAAAAGATCTACAATGCATTGAAACACTGA

Upstream 100 bases:

>100_bases
CGTTACCGCATGTTCAGCAAGCTGAATATCAGCGGTGATGTTGAATTGACACACCTGGCTATCCGACACGGATTGTTCAA
TGCGGAGACTTTGTTAAGCA

Downstream 100 bases:

>100_bases
GGGCAATGTAGCAACATACTCTTAATTCCCACTCCAGCCAGATAGTTACCCTAGCATTATGCAATTGAATATACCGACTT
GGCTTACTCTGTTTCGCGTA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSDRFDAKAFLSTVTSQPGVYRMYDATGTVIYVGKAKDLKKRLASYFRQQVGSRKTETLVKNIAQIDVTVTHTETEALLL
EHNYIKLYQPRYNVLLRDDKSYPLIFLSADSHPRLAVHRGAKHAKGEYFGPFPNSYAVRETLALLQKLFPIRQCENSVYR
NRSRPCLQYQIGRCLGPCVAGLVSEDEYRQQVDYVRLFLSGKDQQVLHQLIERMENASKALNFEEAARIRDQIQAVRRVT
ERQFVSGNSDDLDVIGVAFEAGMACLHVLFIRQGKVLGSRSYFPKVPGGTEMSEVVQTFVGQFYLQGSQMRTLPAEILLD
FTLPEKELLAESLSELAGRKIQIQSKPRGDRARYLKLARTNAATALTTKLSQQSTIHQRLAELTKVLNLSEINRMECFDI
SHTMGEQTVASCVVFDANGPLRSEYRRYNITGITPGDDYAAMAQVLKRRYGKALEEKKIPDVIFIDGGKGQLGMAIDVFN
SLNVSWDKNKPLLIGIAKGADRKAGLETLFFVPEGEGIALPSDSPALHVIQHIRDDSHNHAITGHRQRRAKVRNTSALEL
IDGVGPKRRQVLLKYMGGLQPLLNASVEEIAKVPGISQALAEKIYNALKH

Sequences:

>Translated_610_residues
MSDRFDAKAFLSTVTSQPGVYRMYDATGTVIYVGKAKDLKKRLASYFRQQVGSRKTETLVKNIAQIDVTVTHTETEALLL
EHNYIKLYQPRYNVLLRDDKSYPLIFLSADSHPRLAVHRGAKHAKGEYFGPFPNSYAVRETLALLQKLFPIRQCENSVYR
NRSRPCLQYQIGRCLGPCVAGLVSEDEYRQQVDYVRLFLSGKDQQVLHQLIERMENASKALNFEEAARIRDQIQAVRRVT
ERQFVSGNSDDLDVIGVAFEAGMACLHVLFIRQGKVLGSRSYFPKVPGGTEMSEVVQTFVGQFYLQGSQMRTLPAEILLD
FTLPEKELLAESLSELAGRKIQIQSKPRGDRARYLKLARTNAATALTTKLSQQSTIHQRLAELTKVLNLSEINRMECFDI
SHTMGEQTVASCVVFDANGPLRSEYRRYNITGITPGDDYAAMAQVLKRRYGKALEEKKIPDVIFIDGGKGQLGMAIDVFN
SLNVSWDKNKPLLIGIAKGADRKAGLETLFFVPEGEGIALPSDSPALHVIQHIRDDSHNHAITGHRQRRAKVRNTSALEL
IDGVGPKRRQVLLKYMGGLQPLLNASVEEIAKVPGISQALAEKIYNALKH
>Mature_609_residues
SDRFDAKAFLSTVTSQPGVYRMYDATGTVIYVGKAKDLKKRLASYFRQQVGSRKTETLVKNIAQIDVTVTHTETEALLLE
HNYIKLYQPRYNVLLRDDKSYPLIFLSADSHPRLAVHRGAKHAKGEYFGPFPNSYAVRETLALLQKLFPIRQCENSVYRN
RSRPCLQYQIGRCLGPCVAGLVSEDEYRQQVDYVRLFLSGKDQQVLHQLIERMENASKALNFEEAARIRDQIQAVRRVTE
RQFVSGNSDDLDVIGVAFEAGMACLHVLFIRQGKVLGSRSYFPKVPGGTEMSEVVQTFVGQFYLQGSQMRTLPAEILLDF
TLPEKELLAESLSELAGRKIQIQSKPRGDRARYLKLARTNAATALTTKLSQQSTIHQRLAELTKVLNLSEINRMECFDIS
HTMGEQTVASCVVFDANGPLRSEYRRYNITGITPGDDYAAMAQVLKRRYGKALEEKKIPDVIFIDGGKGQLGMAIDVFNS
LNVSWDKNKPLLIGIAKGADRKAGLETLFFVPEGEGIALPSDSPALHVIQHIRDDSHNHAITGHRQRRAKVRNTSALELI
DGVGPKRRQVLLKYMGGLQPLLNASVEEIAKVPGISQALAEKIYNALKH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=84.5901639344262, Blast_Score=1086, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_SERP5 (A8GCW2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478080.1
- ProteinModelPortal:   A8GCW2
- STRING:   A8GCW2
- GeneID:   5605811
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1849
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   SPRO399741:SPRO_1849-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68412; Mature: 68280

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRFDAKAFLSTVTSQPGVYRMYDATGTVIYVGKAKDLKKRLASYFRQQVGSRKTETLV
CCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHH
KNIAQIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADSHPRLAVHRG
HHHHHEEEEEEECCCEEEEEECCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCHHHCC
AKHAKGEYFGPFPNSYAVRETLALLQKLFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GLVSEDEYRQQVDYVRLFLSGKDQQVLHQLIERMENASKALNFEEAARIRDQIQAVRRVT
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ERQFVSGNSDDLDVIGVAFEAGMACLHVLFIRQGKVLGSRSYFPKVPGGTEMSEVVQTFV
HHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHH
GQFYLQGSQMRTLPAEILLDFTLPEKELLAESLSELAGRKIQIQSKPRGDRARYLKLART
HHHHCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHC
NAATALTTKLSQQSTIHQRLAELTKVLNLSEINRMECFDISHTMGEQTVASCVVFDANGP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHCHHHHHEEEEECCCCC
LRSEYRRYNITGITPGDDYAAMAQVLKRRYGKALEEKKIPDVIFIDGGKGQLGMAIDVFN
HHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEHHH
SLNVSWDKNKPLLIGIAKGADRKAGLETLFFVPEGEGIALPSDSPALHVIQHIRDDSHNH
CCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCCC
AITGHRQRRAKVRNTSALELIDGVGPKRRQVLLKYMGGLQPLLNASVEEIAKVPGISQAL
CCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCHHHHH
AEKIYNALKH
HHHHHHHHCC
>Mature Secondary Structure 
SDRFDAKAFLSTVTSQPGVYRMYDATGTVIYVGKAKDLKKRLASYFRQQVGSRKTETLV
CCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHH
KNIAQIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADSHPRLAVHRG
HHHHHEEEEEEECCCEEEEEECCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCHHHCC
AKHAKGEYFGPFPNSYAVRETLALLQKLFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GLVSEDEYRQQVDYVRLFLSGKDQQVLHQLIERMENASKALNFEEAARIRDQIQAVRRVT
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ERQFVSGNSDDLDVIGVAFEAGMACLHVLFIRQGKVLGSRSYFPKVPGGTEMSEVVQTFV
HHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHH
GQFYLQGSQMRTLPAEILLDFTLPEKELLAESLSELAGRKIQIQSKPRGDRARYLKLART
HHHHCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHC
NAATALTTKLSQQSTIHQRLAELTKVLNLSEINRMECFDISHTMGEQTVASCVVFDANGP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHCHHHHHEEEEECCCCC
LRSEYRRYNITGITPGDDYAAMAQVLKRRYGKALEEKKIPDVIFIDGGKGQLGMAIDVFN
HHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEHHH
SLNVSWDKNKPLLIGIAKGADRKAGLETLFFVPEGEGIALPSDSPALHVIQHIRDDSHNH
CCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCCC
AITGHRQRRAKVRNTSALELIDGVGPKRRQVLLKYMGGLQPLLNASVEEIAKVPGISQAL
CCCCCHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCHHHHH
AEKIYNALKH
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA