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The map label for this gene is uvrY [H]

Identifier: 157370090

GI number: 157370090

Start: 2031663

End: 2032319

Strand: Direct

Name: uvrY [H]

Synonym: Spro_1848

Alternate gene names: 157370090

Gene position: 2031663-2032319 (Clockwise)

Preceding gene: 157370088

Following gene: 157370091

Centisome position: 37.29

GC content: 51.6

Gene sequence:

>657_bases
TTGATTAGCGTTCTTCTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTTGAAGATATCAAAGGTAT
AAAAGTTGTCGGGGAGGCCCAATGCGGTGAAGACGCCGTGAAATGGTGCCGTGGCAATGCTGTAGATATCGTTCTTATGG
ATATGAACATGCCGGGTATTGGCGGGCTGGAAGCCACGCGCAAAATTGTACGTTATGCGCCCGACGTTAAAGTCATCATG
CTGACTATCCATACTGAAAATCCATTGCCGGCCAAGGTGATGCAGGCGGGTGCTGCAGGTTATCTGAGCAAGGGCGCGGC
GCCACAGGATGTGGTGAATGCCATTCGCGCCGTGCAGGCCGGGCAGCGCTATATCGCGTCCGATATTGCCCAACAGATGG
CATTGAGCCAATTGGAGCCGCAGACGGAAACGCCGTTTAGCTGCCTGTCTGAGCGCGAGCTGCAGATTATGCTGATGATC
ACTAAAGGCAAAAAGGTTAACGAGATCTCGGAACAACTGAGTCTCAGCCCCAAAACGGTGAACAGTTATCGTTACCGCAT
GTTCAGCAAGCTGAATATCAGCGGTGATGTTGAATTGACACACCTGGCTATCCGACACGGATTGTTCAATGCGGAGACTT
TGTTAAGCAGTGAGTGA

Upstream 100 bases:

>100_bases
TAAGTATTAATCTGTGTTCATTCTTGGCTGAAAAACAAGTAATATCTCTGCCTATAACAGAGGCTGATTGCGTTACTCCC
TTCTTTTTGGAGATTTTTCC

Downstream 100 bases:

>100_bases
CCGTTTTGATGCCAAAGCATTTCTAAGCACTGTAACCAGCCAGCCTGGCGTCTACCGAATGTACGACGCTACTGGCACGG
TTATCTACGTCGGTAAAGCC

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRGNAVDIVLMDMNMPGIGGLEATRKIVRYAPDVKVIM
LTIHTENPLPAKVMQAGAAGYLSKGAAPQDVVNAIRAVQAGQRYIASDIAQQMALSQLEPQTETPFSCLSERELQIMLMI
TKGKKVNEISEQLSLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLLSSE

Sequences:

>Translated_218_residues
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRGNAVDIVLMDMNMPGIGGLEATRKIVRYAPDVKVIM
LTIHTENPLPAKVMQAGAAGYLSKGAAPQDVVNAIRAVQAGQRYIASDIAQQMALSQLEPQTETPFSCLSERELQIMLMI
TKGKKVNEISEQLSLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLLSSE
>Mature_218_residues
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRGNAVDIVLMDMNMPGIGGLEATRKIVRYAPDVKVIM
LTIHTENPLPAKVMQAGAAGYLSKGAAPQDVVNAIRAVQAGQRYIASDIAQQMALSQLEPQTETPFSCLSERELQIMLMI
TKGKKVNEISEQLSLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLLSSE

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=87.5576036866359, Blast_Score=393, Evalue=1e-111,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=35, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=31.7073170731707, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=26.865671641791, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=27.1844660194175, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=26.6009852216749, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1787473, Length=185, Percent_Identity=29.1891891891892, Blast_Score=81, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23948; Mature: 23948

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRGNAVDIVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCC
GGLEATRKIVRYAPDVKVIMLTIHTENPLPAKVMQAGAAGYLSKGAAPQDVVNAIRAVQA
CCHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHH
GQRYIASDIAQQMALSQLEPQTETPFSCLSERELQIMLMITKGKKVNEISEQLSLSPKTV
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCHH
NSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLLSSE
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MISVLLVDDHELVRAGIRRILEDIKGIKVVGEAQCGEDAVKWCRGNAVDIVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCC
GGLEATRKIVRYAPDVKVIMLTIHTENPLPAKVMQAGAAGYLSKGAAPQDVVNAIRAVQA
CCHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHH
GQRYIASDIAQQMALSQLEPQTETPFSCLSERELQIMLMITKGKKVNEISEQLSLSPKTV
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCHH
NSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLLSSE
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]