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The map label for this gene is pyrD

Identifier: 157369983

GI number: 157369983

Start: 1917112

End: 1918122

Strand: Direct

Name: pyrD

Synonym: Spro_1740

Alternate gene names: 157369983

Gene position: 1917112-1918122 (Clockwise)

Preceding gene: 157369977

Following gene: 157369984

Centisome position: 35.18

GC content: 49.75

Gene sequence:

>1011_bases
ATGTACTACCCCCTCATCAGAAAAGCGTTGTTCCAGCTCGATCCCGAGCGTGCGCACGAATTGACTTTTCAACAGCTTCG
CCGTGTCACCGGTACCCCGTTAGAATTCCTTATTCGTCAGTCTGTGCCGACTAAACCGGTAAGCTGCATGGGGCTCTCTT
TTAAAAACCCATTGGGCTTGGCTGCCGGTCTGGATAAAGACGGCGAGTGTATCGATGCGTTTGGCGCTATGGGTTTTGGT
TTTGTCGAAGTCGGCACCGTGACGCCGCGCCCGCAGTCGGGCAATGACAAACCGCGCCTGTTCCGTATTGTGGAAGCCGA
AGGCCTGATCAACCGCATGGGCTTTAATAACCAGGGTGTGGATAATCTGGTTGAAAACGTTAAGAAATCCCATTTCGGCG
GTATTCTGGGGATTAATATCGGCAAGAATAAAGACACCCCGGTTGAGCAAGGAAAAGACGATTATCTAATCTGCATGGAT
AAAGTTTATCCGTATGCCGGTTATATCGCGATTAACATTTCGTCACCTAATACCCCAGGATTACGATCCTTACAGTATGG
CGAAGCGTTGGACGATCTGCTGGCTGCGATTAAAAATAAGCAGCAGGAATTACATGAGCGTCATCACAAATATGTACCGG
TAGCAGTAAAGATCGCACCGGATCTTTCTGAAGAAGAATTGATCCAAATAGCCGACAGCCTGGTGCGTCATAATATAGAT
GGCGTGATCGCGACCAATACCACGCTGGATCGTAAATTGATCCAGGGGCTGAATTATTGTGAGCAAATGGGGGGCCTGAG
TGGTCGTCCGCTGCAGGCGAGCAGCACCGAAGTGATCCGTCGTTTGTCACTTGAGCTGCAAGGGCGCTTGCCGATTATCG
GCGTTGGCGGAATTGATTCCCTGATGGCGGCGCGGGAAAAAATGGCGGCAGGGGCTTCACTGGTGCAAATTTATTCCGGA
TTTATCTTCAAGGGTCCACGCCTGATTAAAGATATCGTTAACTACATCTAA

Upstream 100 bases:

>100_bases
TTGCGTAAAAAACGCTTTTTTTGCTTTTAATCAATTCCAATTGGTCAGGGGATACCGGATAATACGCCCCCGGTTTGCAA
CCGGGAAATCAGGAGAGTAC

Downstream 100 bases:

>100_bases
TATTTTTCCTTTCATTTTCCGCCGGGGGTTTATTTATTCCCCCGGCTCGTCTATATTTTGTCCACTAGCATAAATATCGT
TCGCGGAATTATCCGATGTT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MYYPLIRKALFQLDPERAHELTFQQLRRVTGTPLEFLIRQSVPTKPVSCMGLSFKNPLGLAAGLDKDGECIDAFGAMGFG
FVEVGTVTPRPQSGNDKPRLFRIVEAEGLINRMGFNNQGVDNLVENVKKSHFGGILGINIGKNKDTPVEQGKDDYLICMD
KVYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKNKQQELHERHHKYVPVAVKIAPDLSEEELIQIADSLVRHNID
GVIATNTTLDRKLIQGLNYCEQMGGLSGRPLQASSTEVIRRLSLELQGRLPIIGVGGIDSLMAAREKMAAGASLVQIYSG
FIFKGPRLIKDIVNYI

Sequences:

>Translated_336_residues
MYYPLIRKALFQLDPERAHELTFQQLRRVTGTPLEFLIRQSVPTKPVSCMGLSFKNPLGLAAGLDKDGECIDAFGAMGFG
FVEVGTVTPRPQSGNDKPRLFRIVEAEGLINRMGFNNQGVDNLVENVKKSHFGGILGINIGKNKDTPVEQGKDDYLICMD
KVYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKNKQQELHERHHKYVPVAVKIAPDLSEEELIQIADSLVRHNID
GVIATNTTLDRKLIQGLNYCEQMGGLSGRPLQASSTEVIRRLSLELQGRLPIIGVGGIDSLMAAREKMAAGASLVQIYSG
FIFKGPRLIKDIVNYI
>Mature_336_residues
MYYPLIRKALFQLDPERAHELTFQQLRRVTGTPLEFLIRQSVPTKPVSCMGLSFKNPLGLAAGLDKDGECIDAFGAMGFG
FVEVGTVTPRPQSGNDKPRLFRIVEAEGLINRMGFNNQGVDNLVENVKKSHFGGILGINIGKNKDTPVEQGKDDYLICMD
KVYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKNKQQELHERHHKYVPVAVKIAPDLSEEELIQIADSLVRHNID
GVIATNTTLDRKLIQGLNYCEQMGGLSGRPLQASSTEVIRRLSLELQGRLPIIGVGGIDSLMAAREKMAAGASLVQIYSG
FIFKGPRLIKDIVNYI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=44.1441441441441, Blast_Score=235, Evalue=5e-62,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=84.2261904761905, Blast_Score=599, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17509475, Length=304, Percent_Identity=44.078947368421, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI281361352, Length=340, Percent_Identity=39.4117647058824, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17137316, Length=340, Percent_Identity=39.4117647058824, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_SERP5 (A8GCK4)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477972.1
- ProteinModelPortal:   A8GCK4
- SMR:   A8GCK4
- STRING:   A8GCK4
- GeneID:   5604739
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1740
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- BioCyc:   SPRO399741:SPRO_1740-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36993; Mature: 36993

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYPLIRKALFQLDPERAHELTFQQLRRVTGTPLEFLIRQSVPTKPVSCMGLSFKNPLGL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEECCCCCCCCCH
AAGLDKDGECIDAFGAMGFGFVEVGTVTPRPQSGNDKPRLFRIVEAEGLINRMGFNNQGV
HCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCH
DNLVENVKKSHFGGILGINIGKNKDTPVEQGKDDYLICMDKVYPYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCC
LRSLQYGEALDDLLAAIKNKQQELHERHHKYVPVAVKIAPDLSEEELIQIADSLVRHNID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIATNTTLDRKLIQGLNYCEQMGGLSGRPLQASSTEVIRRLSLELQGRLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHH
LMAAREKMAAGASLVQIYSGFIFKGPRLIKDIVNYI
HHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHC
>Mature Secondary Structure
MYYPLIRKALFQLDPERAHELTFQQLRRVTGTPLEFLIRQSVPTKPVSCMGLSFKNPLGL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEECCCCCCCCCH
AAGLDKDGECIDAFGAMGFGFVEVGTVTPRPQSGNDKPRLFRIVEAEGLINRMGFNNQGV
HCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCH
DNLVENVKKSHFGGILGINIGKNKDTPVEQGKDDYLICMDKVYPYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCC
LRSLQYGEALDDLLAAIKNKQQELHERHHKYVPVAVKIAPDLSEEELIQIADSLVRHNID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIATNTTLDRKLIQGLNYCEQMGGLSGRPLQASSTEVIRRLSLELQGRLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHH
LMAAREKMAAGASLVQIYSGFIFKGPRLIKDIVNYI
HHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA