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The map label for this gene is upp [H]

Identifier: 157369938

GI number: 157369938

Start: 1856773

End: 1857423

Strand: Direct

Name: upp [H]

Synonym: Spro_1695

Alternate gene names: 157369938

Gene position: 1856773-1857423 (Clockwise)

Preceding gene: 157369937

Following gene: 157369939

Centisome position: 34.08

GC content: 49.46

Gene sequence:

>651_bases
ATGAAACTTTCTAATATTCATCTGCTAGCCCCAAGTCATTATCTTACTTATTTACACACCCAAATCCGTAATAAGCAGGC
GGAGCACGCCTGCTTCGAATATTATAGCGATCAACTGTTGCGCCAACTGCTGGTGCAGGTTGCCGCCTTACTGCCGTATG
AAAAAAATGAGGTGATTACGCCCATTGGCGAAACCTATGCGGGGCTAAAACTTGCCCGCGGTATTTGCGGCGTTTCGGTT
ATCCGTGCCGGGGAAAGTTTTGAGGGCGAGTATCGCAGAATGTTTAGCGGCCAGCCGATAGGCAAAATACTTATTCAACG
CAATCCGCAAAGCAAGCTACCAAAATACTTCTACTCACATTTTCCCGACGATATTGCCGAACGCGCCGTGTTGTTATTTG
AACCTATGCTGGCCACGGGCGGTTCGCTGATCATGGCAATCGAAACTCTGTTGGAGCAAGGCGTGCCGCTGGAAAATATC
TATGTTGTTAATGTATTGGCATCGCCGGTGGGGGTCGAACGTTTGTTTGCCCGTTTCCCTGACATCCAACTGGTGACCTC
ATCCATTGAACAGGGACTCTCGGATCAGGCCTTTATGAAACCGGGGATCGGCGACTTTGGTGACCGATATTTTGGTACCC
GGCACGGGTAA

Upstream 100 bases:

>100_bases
CAGACTGACTTTTATTTTTAATCGATATAAGCCTTCCTTTCACCTAACCCGGTGAAGGGCGGTGCTTATGCATCCATTAC
TCTGTTAAAAGAACAAGGTT

Downstream 100 bases:

>100_bases
TTAAACTCTACAAAGGAAAAAAACATGCCGCACGTGAAAATTCAGCACTTTCCGCAGGTACTTTCCCAAACTGCCAAGAA
TGCACTGGCAGAGGAGATAA

Product: phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKLSNIHLLAPSHYLTYLHTQIRNKQAEHACFEYYSDQLLRQLLVQVAALLPYEKNEVITPIGETYAGLKLARGICGVSV
IRAGESFEGEYRRMFSGQPIGKILIQRNPQSKLPKYFYSHFPDDIAERAVLLFEPMLATGGSLIMAIETLLEQGVPLENI
YVVNVLASPVGVERLFARFPDIQLVTSSIEQGLSDQAFMKPGIGDFGDRYFGTRHG

Sequences:

>Translated_216_residues
MKLSNIHLLAPSHYLTYLHTQIRNKQAEHACFEYYSDQLLRQLLVQVAALLPYEKNEVITPIGETYAGLKLARGICGVSV
IRAGESFEGEYRRMFSGQPIGKILIQRNPQSKLPKYFYSHFPDDIAERAVLLFEPMLATGGSLIMAIETLLEQGVPLENI
YVVNVLASPVGVERLFARFPDIQLVTSSIEQGLSDQAFMKPGIGDFGDRYFGTRHG
>Mature_216_residues
MKLSNIHLLAPSHYLTYLHTQIRNKQAEHACFEYYSDQLLRQLLVQVAALLPYEKNEVITPIGETYAGLKLARGICGVSV
IRAGESFEGEYRRMFSGQPIGKILIQRNPQSKLPKYFYSHFPDDIAERAVLLFEPMLATGGSLIMAIETLLEQGVPLENI
YVVNVLASPVGVERLFARFPDIQLVTSSIEQGLSDQAFMKPGIGDFGDRYFGTRHG

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI57863312, Length=197, Percent_Identity=37.0558375634518, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI301129207, Length=197, Percent_Identity=37.0558375634518, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI21450816, Length=210, Percent_Identity=34.7619047619048, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI87082118, Length=187, Percent_Identity=31.5508021390374, Blast_Score=93, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539892, Length=209, Percent_Identity=31.5789473684211, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17539894, Length=209, Percent_Identity=31.5789473684211, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17506069, Length=188, Percent_Identity=35.1063829787234, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17506071, Length=165, Percent_Identity=36.3636363636364, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321920, Length=209, Percent_Identity=44.4976076555024, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324339, Length=213, Percent_Identity=30.5164319248826, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28573516, Length=210, Percent_Identity=38.5714285714286, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28573514, Length=210, Percent_Identity=38.5714285714286, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28573512, Length=210, Percent_Identity=38.5714285714286, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45550449, Length=210, Percent_Identity=38.5714285714286, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21358379, Length=210, Percent_Identity=34.2857142857143, Blast_Score=138, Evalue=3e-33,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24222; Mature: 24222

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSNIHLLAPSHYLTYLHTQIRNKQAEHACFEYYSDQLLRQLLVQVAALLPYEKNEVIT
CCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
PIGETYAGLKLARGICGVSVIRAGESFEGEYRRMFSGQPIGKILIQRNPQSKLPKYFYSH
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHC
FPDDIAERAVLLFEPMLATGGSLIMAIETLLEQGVPLENIYVVNVLASPVGVERLFARFP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCHHHHHHHCC
DIQLVTSSIEQGLSDQAFMKPGIGDFGDRYFGTRHG
CHHHHHHHHHCCCCCHHHHCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MKLSNIHLLAPSHYLTYLHTQIRNKQAEHACFEYYSDQLLRQLLVQVAALLPYEKNEVIT
CCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
PIGETYAGLKLARGICGVSVIRAGESFEGEYRRMFSGQPIGKILIQRNPQSKLPKYFYSH
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHC
FPDDIAERAVLLFEPMLATGGSLIMAIETLLEQGVPLENIYVVNVLASPVGVERLFARFP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCHHHHHHHCC
DIQLVTSSIEQGLSDQAFMKPGIGDFGDRYFGTRHG
CHHHHHHHHHCCCCCHHHHCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]