Click here to switch to the map view.

The map label for this gene is folE [H]

Identifier: 157369803

GI number: 157369803

Start: 1699830

End: 1700495

Strand: Direct

Name: folE [H]

Synonym: Spro_1560

Alternate gene names: 157369803

Gene position: 1699830-1700495 (Clockwise)

Preceding gene: 157369802

Following gene: 157369804

Centisome position: 31.2

GC content: 53.9

Gene sequence:

>666_bases
ATGACATCATTAAGTAAAGAAGCTGTTCTGGTTCATGCGGCGCTCGAAGAGCGTGGCCTGGAAACCCCGTTGCGTGGTGA
AGTGCTGGATCGCGAGACGCGCAAGCGCCGTATTAAAGAGCACATGACGGAAATCATGCAGCTGCTTAATCTCGATCTAT
CCGACGATAGCCTGGCGGAAACCCCGCATCGCATTGCCAAGATGTATGTCGATGAAATTTTCTCCGGCCTGGACTACGCG
AATTTCCCAAAAATTACCGTCATCGAAAACAAGATGAAGGTAGATGAAATGGTGACGGTGCGCGACATTACCCTGACCAG
CACCTGTGAACACCATTTCGTGACAATCGACGGTAAAGCGACCGTGGCCTACATTCCGAAAGATGCGGTGATCGGCCTGT
CGAAAATCAACCGTATCGTGCAATTTTTCTCCCAGCGCCCACAGGTGCAGGAGCGTCTGACTCAACAGATCCTGGTGGCA
TTGCAAACCCTGCTGGGCACCAATAACGTGGCAGTATCGATTGATGCGGTCCATTATTGTGTTAAGGCGCGCGGTATCCG
CGACGCGACCAGCGCCACCACCACCACCTCGCTGGGTGGGCTGTTCAAGTCCAGCCAGAACACCCGTCAGGAATTCCTGC
GTGCGGTGCGACATCACCAGGGGTGA

Upstream 100 bases:

>100_bases
AGCAATGACGGAAACCTCTGCCGTCAGGAGAGTATGCAATTCACCAGTCTGCTCGGTAAAGCAGCCGGATTGGCGAGTTC
AGGTCCGTTGGAGAGATGAA

Downstream 100 bases:

>100_bases
TGCGGGGTTAACGAATAAGAACAGGCGCCTGCGGGCGCCTTTTTAATGGCCGGAATACAGCGATAAAATAATGAGCAACC
CTTCGACCACACCGCTGCCG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTSLSKEAVLVHAALEERGLETPLRGEVLDRETRKRRIKEHMTEIMQLLNLDLSDDSLAETPHRIAKMYVDEIFSGLDYA
NFPKITVIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDAVIGLSKINRIVQFFSQRPQVQERLTQQILVA
LQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHQG

Sequences:

>Translated_221_residues
MTSLSKEAVLVHAALEERGLETPLRGEVLDRETRKRRIKEHMTEIMQLLNLDLSDDSLAETPHRIAKMYVDEIFSGLDYA
NFPKITVIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDAVIGLSKINRIVQFFSQRPQVQERLTQQILVA
LQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHQG
>Mature_220_residues
TSLSKEAVLVHAALEERGLETPLRGEVLDRETRKRRIKEHMTEIMQLLNLDLSDDSLAETPHRIAKMYVDEIFSGLDYAN
FPKITVIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDAVIGLSKINRIVQFFSQRPQVQERLTQQILVAL
QTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHQG

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=123, Percent_Identity=46.3414634146341, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI4503949, Length=123, Percent_Identity=46.3414634146341, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI66932970, Length=82, Percent_Identity=51.219512195122, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI66932972, Length=82, Percent_Identity=51.219512195122, Blast_Score=88, Evalue=6e-18,
Organism=Escherichia coli, GI1788476, Length=222, Percent_Identity=89.6396396396396, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17560486, Length=220, Percent_Identity=36.3636363636364, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=40.6593406593407, Blast_Score=125, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24656796, Length=122, Percent_Identity=46.7213114754098, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24656791, Length=122, Percent_Identity=46.7213114754098, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24656782, Length=122, Percent_Identity=46.7213114754098, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 24874; Mature: 24743

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLSKEAVLVHAALEERGLETPLRGEVLDRETRKRRIKEHMTEIMQLLNLDLSDDSLAE
CCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TPHRIAKMYVDEIFSGLDYANFPKITVIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKA
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHEEEEECCCCCEEEEECCCE
TVAYIPKDAVIGLSKINRIVQFFSQRPQVQERLTQQILVALQTLLGTNNVAVSIDAVHYC
EEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
VKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHQG
HHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSLSKEAVLVHAALEERGLETPLRGEVLDRETRKRRIKEHMTEIMQLLNLDLSDDSLAE
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TPHRIAKMYVDEIFSGLDYANFPKITVIENKMKVDEMVTVRDITLTSTCEHHFVTIDGKA
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHEEEEECCCCCEEEEECCCE
TVAYIPKDAVIGLSKINRIVQFFSQRPQVQERLTQQILVALQTLLGTNNVAVSIDAVHYC
EEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
VKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHQG
HHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA