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The map label for this gene is czcS [H]

Identifier: 157369742

GI number: 157369742

Start: 1632081

End: 1633505

Strand: Direct

Name: czcS [H]

Synonym: Spro_1499

Alternate gene names: 157369742

Gene position: 1632081-1633505 (Clockwise)

Preceding gene: 157369741

Following gene: 157369743

Centisome position: 29.95

GC content: 58.95

Gene sequence:

>1425_bases
ATGAAGGCTCTGGTCCAGCGTTGGCGTGCGCTGTCGTTGACGCTGCGCAGCGCTATGCTGTTTGCGCTGGTGGCGGCGCT
GGTCGTCAGCGGTGCGGGATGGTACCTGTACGACGCAATGCGTCAGGAGATGACCCTCCGCAGCGATTTGCAGGTCACCG
GCCGGGTGGAGTATTACCGTAATTTACTGAGCCGGCGTTTTCCGCTCGAGCGGCTGATGGCGAACACCGGCCTGTTTGAA
AATATGCTGGGGAACGAGCAGGACGTGCTGATTTTTCAGCAACCGGGGCAAAAGCCGTTAATCAACGTTAACCCGGCCAG
GCTGAGCCTGCCGCCGATGATCCCGACGCCGGTTGGCACGCCGCAGCGGTTGAGTGCGGTACAGAGCGGGCAGACGGCGC
AAGGCGTGCCATTGCGAGCGGTCTCGGCGCTGGTCAGACTGGAGGACGGCAACCTGCTGCAGATCTCGGCGGCCCATGTG
ATGTTCAATGAACAGAAGATGCTGGCGCGTTATCTTTGGCGAATTGTCGCCGCGGTGATAGTGGCGTTTGTCCTGATTGC
ATTGCTGGGTTATTGGGTGATGCGCCGTGGCTTACAGCCATTATGGCGCATGGCAGCGCAGGCGGCGGTGATCACACCGA
ATACGCTGTCGACTCGCCTGAGCGAGCAGGGGGCGCCGAAGGAATTGCAGCAACTGACTCGTTCGTTTAATGCCATGCTC
GATCGCCTGAACGAAGGCTATCAACGGCTGACGCAGTTTTCCGCCGATCTGGCGCACGAGATCCGCACTCCGGTGGGCGC
GTTAATGGGGCAATGTCAGGTGGCGCTGTATCAGTCACGCAGCGTGGAGGAGTATGAAACCCTGTTGTCGAACAACATGG
ATGAACTGGAACGCATTTCGCGCATGGTAGAAAATATTCTGTTTCTGGCGCGTGCCGGCGAAGGGCAAGCGGTGCTGAAC
GTCAGTCGCCTTGATATGGCGCAAGAGCTGCAACGGGTGGCGGATTATTTTGAAGGCCTGGCGGAAGAGCGCGGTATTAC
GCTGGTTTGCGCAGGCAGAGGGCAATTGCTGGCGGATGCCATGTTGTTCCAACGTGCACTGAGCAATCTGGTGGCCAATG
CGGTGCGTTATGCCGATGAGAACAGCCAGATATTACTCCAGACCCTCACTCAGCAGACTGGGGAAGTGGTTGTACAGGTG
GTTAATCAGGGGCCGGCTATTGCTCCAGCCCATCTTGATAAGTTGTTTGACCGTTTCTACCGCGCGGATGCTGCCCGCAG
TTCCGGCAGCCATGCCAGCGGGCTGGGATTGGCGATCGTCCGCGCAATCATGACGCTGCACGGCGGTGTCACTCGTGCCC
ACTGCTCCGGAGGGAATAACTCCGCCCGGATCACCTTTAGCCTGATCTTTCCCGCCGCAGATTAA

Upstream 100 bases:

>100_bases
ATGTGGCGATCAAGCGGTTGCGTGCCAAGATTGATCGGCCCTTTGACGTCAAGCTGATCCACAGCGTGCGCGGTATCGGC
TACGTTTGCGAGCCGCGTCC

Downstream 100 bases:

>100_bases
TTTAATCCCGCCGTTTGAGACTAATCTTTGCATCACTAATATAGTGACGCAGGGTATTATTGGCGCAAATGTATTCGTAA
CCATTTACTTTCATTTTCCC

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKALVQRWRALSLTLRSAMLFALVAALVVSGAGWYLYDAMRQEMTLRSDLQVTGRVEYYRNLLSRRFPLERLMANTGLFE
NMLGNEQDVLIFQQPGQKPLINVNPARLSLPPMIPTPVGTPQRLSAVQSGQTAQGVPLRAVSALVRLEDGNLLQISAAHV
MFNEQKMLARYLWRIVAAVIVAFVLIALLGYWVMRRGLQPLWRMAAQAAVITPNTLSTRLSEQGAPKELQQLTRSFNAML
DRLNEGYQRLTQFSADLAHEIRTPVGALMGQCQVALYQSRSVEEYETLLSNNMDELERISRMVENILFLARAGEGQAVLN
VSRLDMAQELQRVADYFEGLAEERGITLVCAGRGQLLADAMLFQRALSNLVANAVRYADENSQILLQTLTQQTGEVVVQV
VNQGPAIAPAHLDKLFDRFYRADAARSSGSHASGLGLAIVRAIMTLHGGVTRAHCSGGNNSARITFSLIFPAAD

Sequences:

>Translated_474_residues
MKALVQRWRALSLTLRSAMLFALVAALVVSGAGWYLYDAMRQEMTLRSDLQVTGRVEYYRNLLSRRFPLERLMANTGLFE
NMLGNEQDVLIFQQPGQKPLINVNPARLSLPPMIPTPVGTPQRLSAVQSGQTAQGVPLRAVSALVRLEDGNLLQISAAHV
MFNEQKMLARYLWRIVAAVIVAFVLIALLGYWVMRRGLQPLWRMAAQAAVITPNTLSTRLSEQGAPKELQQLTRSFNAML
DRLNEGYQRLTQFSADLAHEIRTPVGALMGQCQVALYQSRSVEEYETLLSNNMDELERISRMVENILFLARAGEGQAVLN
VSRLDMAQELQRVADYFEGLAEERGITLVCAGRGQLLADAMLFQRALSNLVANAVRYADENSQILLQTLTQQTGEVVVQV
VNQGPAIAPAHLDKLFDRFYRADAARSSGSHASGLGLAIVRAIMTLHGGVTRAHCSGGNNSARITFSLIFPAAD
>Mature_474_residues
MKALVQRWRALSLTLRSAMLFALVAALVVSGAGWYLYDAMRQEMTLRSDLQVTGRVEYYRNLLSRRFPLERLMANTGLFE
NMLGNEQDVLIFQQPGQKPLINVNPARLSLPPMIPTPVGTPQRLSAVQSGQTAQGVPLRAVSALVRLEDGNLLQISAAHV
MFNEQKMLARYLWRIVAAVIVAFVLIALLGYWVMRRGLQPLWRMAAQAAVITPNTLSTRLSEQGAPKELQQLTRSFNAML
DRLNEGYQRLTQFSADLAHEIRTPVGALMGQCQVALYQSRSVEEYETLLSNNMDELERISRMVENILFLARAGEGQAVLN
VSRLDMAQELQRVADYFEGLAEERGITLVCAGRGQLLADAMLFQRALSNLVANAVRYADENSQILLQTLTQQTGEVVVQV
VNQGPAIAPAHLDKLFDRFYRADAARSSGSHASGLGLAIVRAIMTLHGGVTRAHCSGGNNSARITFSLIFPAAD

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=460, Percent_Identity=31.5217391304348, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1786783, Length=279, Percent_Identity=41.2186379928315, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1790346, Length=240, Percent_Identity=30.8333333333333, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=26.2773722627737, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787894, Length=301, Percent_Identity=27.906976744186, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=28.4697508896797, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=28.5087719298246, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789403, Length=297, Percent_Identity=27.6094276094276, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790551, Length=295, Percent_Identity=27.1186440677966, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789808, Length=272, Percent_Identity=27.9411764705882, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=29.6296296296296, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=23.3480176211454, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=284, Percent_Identity=23.5915492957746, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=26.5217391304348, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=23.9130434782609, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52394; Mature: 52394

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVQRWRALSLTLRSAMLFALVAALVVSGAGWYLYDAMRQEMTLRSDLQVTGRVEYYR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
NLLSRRFPLERLMANTGLFENMLGNEQDVLIFQQPGQKPLINVNPARLSLPPMIPTPVGT
HHHHHCCCHHHHHHHCCHHHHHCCCCCCEEEEECCCCCCCEECCCCCEECCCCCCCCCCC
PQRLSAVQSGQTAQGVPLRAVSALVRLEDGNLLQISAAHVMFNEQKMLARYLWRIVAAVI
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
VAFVLIALLGYWVMRRGLQPLWRMAAQAAVITPNTLSTRLSEQGAPKELQQLTRSFNAML
HHHHHHHHHHHHHHHHCHHHHHHHHHCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHH
DRLNEGYQRLTQFSADLAHEIRTPVGALMGQCQVALYQSRSVEEYETLLSNNMDELERIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
RMVENILFLARAGEGQAVLNVSRLDMAQELQRVADYFEGLAEERGITLVCAGRGQLLADA
HHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHH
MLFQRALSNLVANAVRYADENSQILLQTLTQQTGEVVVQVVNQGPAIAPAHLDKLFDRFY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RADAARSSGSHASGLGLAIVRAIMTLHGGVTRAHCSGGNNSARITFSLIFPAAD
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCC
>Mature Secondary Structure
MKALVQRWRALSLTLRSAMLFALVAALVVSGAGWYLYDAMRQEMTLRSDLQVTGRVEYYR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
NLLSRRFPLERLMANTGLFENMLGNEQDVLIFQQPGQKPLINVNPARLSLPPMIPTPVGT
HHHHHCCCHHHHHHHCCHHHHHCCCCCCEEEEECCCCCCCEECCCCCEECCCCCCCCCCC
PQRLSAVQSGQTAQGVPLRAVSALVRLEDGNLLQISAAHVMFNEQKMLARYLWRIVAAVI
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
VAFVLIALLGYWVMRRGLQPLWRMAAQAAVITPNTLSTRLSEQGAPKELQQLTRSFNAML
HHHHHHHHHHHHHHHHCHHHHHHHHHCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHH
DRLNEGYQRLTQFSADLAHEIRTPVGALMGQCQVALYQSRSVEEYETLLSNNMDELERIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
RMVENILFLARAGEGQAVLNVSRLDMAQELQRVADYFEGLAEERGITLVCAGRGQLLADA
HHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHH
MLFQRALSNLVANAVRYADENSQILLQTLTQQTGEVVVQVVNQGPAIAPAHLDKLFDRFY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RADAARSSGSHASGLGLAIVRAIMTLHGGVTRAHCSGGNNSARITFSLIFPAAD
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]