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The map label for this gene is czcR [H]

Identifier: 157369741

GI number: 157369741

Start: 1631413

End: 1632084

Strand: Direct

Name: czcR [H]

Synonym: Spro_1498

Alternate gene names: 157369741

Gene position: 1631413-1632084 (Clockwise)

Preceding gene: 157369736

Following gene: 157369742

Centisome position: 29.94

GC content: 56.7

Gene sequence:

>672_bases
ATGCGGATATTGGTAGTTGAAGACGACATCAGTACGGGTGATTACCTGAAGAAAGGGCTGGGCGAGGCCGGATACAGCGT
CGATTTGGCGCGTAACGGCACCGACGGCCTGTTTCGGGCGCTTGAGGATGCTTACGACGCCATTGTGCTCGACGTGATGC
TGCCAGGGCTGGATGGCTGGCAGATCATTGAGGTACTGCGCAAGAAAAGCGATGTGCCGATCCTGTTTCTGACCGCCCGC
GACGGGGTGCAGGATCGTATTCATGGCCTGGAGCTGGGGGCAGATGATTATTTGATCAAACCTTTTTCCTTCACTGAACT
GGTGTTGCGATTGCGCACCTTATTGCGGCGCGGCACGGTACGTGAGGCCGACCACTATGCCATTGCCGATCTGCAGCTCG
ACGTTCTGCGCCGCAAAGCGGTACGGCAGGAGCAGGTGATCCCGCTGACCAACAAAGAGTTCATGTTGTTGCATCTGTTG
GTGCGTCGTGAAGGGGAAGTGTTGTCACGCACCATGATCGCCTCGCAGGTCTGGGACATGAACTTTGACAGCGATACCAA
TGTGGTGGATGTGGCGATCAAGCGGTTGCGTGCCAAGATTGATCGGCCCTTTGACGTCAAGCTGATCCACAGCGTGCGCG
GTATCGGCTACGTTTGCGAGCCGCGTCCATGA

Upstream 100 bases:

>100_bases
AACAACAGGGACAGCACCATGTCGGTTTAATGACATTAATGTCATCAAGCATGTCTGCCGAAGCTGCTAGTATTTCCGCA
GGTGTAATGAGGTGGCGACA

Downstream 100 bases:

>100_bases
AGGCTCTGGTCCAGCGTTGGCGTGCGCTGTCGTTGACGCTGCGCAGCGCTATGCTGTTTGCGCTGGTGGCGGCGCTGGTC
GTCAGCGGTGCGGGATGGTA

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILVVEDDISTGDYLKKGLGEAGYSVDLARNGTDGLFRALEDAYDAIVLDVMLPGLDGWQIIEVLRKKSDVPILFLTAR
DGVQDRIHGLELGADDYLIKPFSFTELVLRLRTLLRRGTVREADHYAIADLQLDVLRRKAVRQEQVIPLTNKEFMLLHLL
VRREGEVLSRTMIASQVWDMNFDSDTNVVDVAIKRLRAKIDRPFDVKLIHSVRGIGYVCEPRP

Sequences:

>Translated_223_residues
MRILVVEDDISTGDYLKKGLGEAGYSVDLARNGTDGLFRALEDAYDAIVLDVMLPGLDGWQIIEVLRKKSDVPILFLTAR
DGVQDRIHGLELGADDYLIKPFSFTELVLRLRTLLRRGTVREADHYAIADLQLDVLRRKAVRQEQVIPLTNKEFMLLHLL
VRREGEVLSRTMIASQVWDMNFDSDTNVVDVAIKRLRAKIDRPFDVKLIHSVRGIGYVCEPRP
>Mature_223_residues
MRILVVEDDISTGDYLKKGLGEAGYSVDLARNGTDGLFRALEDAYDAIVLDVMLPGLDGWQIIEVLRKKSDVPILFLTAR
DGVQDRIHGLELGADDYLIKPFSFTELVLRLRTLLRRGTVREADHYAIADLQLDVLRRKAVRQEQVIPLTNKEFMLLHLL
VRREGEVLSRTMIASQVWDMNFDSDTNVVDVAIKRLRAKIDRPFDVKLIHSVRGIGYVCEPRP

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=55.8558558558559, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=51.1210762331839, Blast_Score=231, Evalue=2e-62,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=40.990990990991, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=34.0807174887892, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=35.3711790393013, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=34.703196347032, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=36.9369369369369, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=35.9090909090909, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=35.3211009174312, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=34.8017621145374, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=32, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=34.8214285714286, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.063829787234, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790437, Length=142, Percent_Identity=31.6901408450704, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=122, Percent_Identity=27.8688524590164, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25371; Mature: 25371

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDDISTGDYLKKGLGEAGYSVDLARNGTDGLFRALEDAYDAIVLDVMLPGLDGW
CEEEEEECCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
QIIEVLRKKSDVPILFLTARDGVQDRIHGLELGADDYLIKPFSFTELVLRLRTLLRRGTV
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHHCCCC
READHYAIADLQLDVLRRKAVRQEQVIPLTNKEFMLLHLLVRREGEVLSRTMIASQVWDM
CCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
NFDSDTNVVDVAIKRLRAKIDRPFDVKLIHSVRGIGYVCEPRP
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEECCCC
>Mature Secondary Structure
MRILVVEDDISTGDYLKKGLGEAGYSVDLARNGTDGLFRALEDAYDAIVLDVMLPGLDGW
CEEEEEECCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
QIIEVLRKKSDVPILFLTARDGVQDRIHGLELGADDYLIKPFSFTELVLRLRTLLRRGTV
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHHCCCC
READHYAIADLQLDVLRRKAVRQEQVIPLTNKEFMLLHLLVRREGEVLSRTMIASQVWDM
CCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
NFDSDTNVVDVAIKRLRAKIDRPFDVKLIHSVRGIGYVCEPRP
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]