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The map label for this gene is bioA [H]

Identifier: 157369553

GI number: 157369553

Start: 1438698

End: 1439990

Strand: Reverse

Name: bioA [H]

Synonym: Spro_1310

Alternate gene names: 157369553

Gene position: 1439990-1438698 (Counterclockwise)

Preceding gene: 157369558

Following gene: 157369551

Centisome position: 26.43

GC content: 60.48

Gene sequence:

>1293_bases
ATGATTTGGTTTACAAGCATGTCTATCACTGCCTCTGACCTTGAGTTCGACCAACGCCATATCTGGCACCCGTACACTTC
CATGAGCCACCCGCTGCCCTGTTATCCGGTAGAAGCCGCCAGCGGCGTTGAGCTGCAGCTGGCCGACGGTCGGCGACTGA
TTGACGGCATGTCCTCCTGGTGGGCGGCAATTCACGGATACAACCACCCGCAGCTGAACCAGGCCGCCACGCAACAGTTG
GAAAAAATGTCGCACGTGATGTTCGGCGGCATTACCCATCCTGCGGCCATTGCCCTGTGCCGCCGTCTGGTGGCAATGAC
ACCGGAGGCGCTGCAATGCGTATTCCTGGCGGATTCCGGCTCGGTGGCGGTAGAGGTGTCGCTGAAGATGGCGCTGCAAT
ACTGGCAGGCTCGCGGGGAAAGGCGACAACGCATTCTGACCCTGCGGCACGGCTATCACGGCGATACCTTTGGCGCGATG
TCGGTGTGCGATCCGGACAATTCGATGCACAGCCTTTATCAGGGTTATCTGGCGCCGCACCTGTTCGCTACCGCGCCGCA
GTGCGGTTTCGACCAGGTCTGGGATGAAAATGATATTGCGCCGTTCGCCGCGCTGCTGGAGCAGCATGCCGGAGAAGTGG
CTGCGGTGATCCTGGAGCCGGTAGTCCAGGGCGCAGGCGGCATGCGCATCTACCACCCGACCTATCTCAAGCGGGTGCGT
GAGCTGTGCGATCGTCATCAGGTGCTGCTGATCGCCGACGAGATCGCCACCGGTTTCGGTCGCACTGGCAAGCTGTTTGC
CTGTGAACATGCCGACGTGGTGCCGGATATTCTGTGTCTGGGCAAGGCGCTGACCGGTGGCTATATGACGCTATCCGCCA
CCCTGACCACGCGCCACGTGGCGGAAACCATCAGCAACGGGGCCGCCGGCTGCTTTATGCACGGACCAACCTTTATGGGC
AACCCGCTGGCCTGTGCGGTGGCCAACGCCAGCCTGTCGCTGTTGGCGGAAAACCACTGGCAGCAGCAGGTCGCCGCTAT
CGAAAGCCAACTGAAACAGCAGTTATTACCGCTGAAGGCGCTGCCAAAAGTGGCGGATGTGAGAGTGCTGGGGGCGATTG
GCGTAGTAGAAATGCGCGAGTCGGTGGATGTGGCGCAGCTACAGCGTGGCTTTGTCGAGCGCGGCGTGTGGATCCGGCCC
TTCGGCAAACTGATTTATTTGATGCCGCCGTATATTATTGAACCTGAACAGCTCAGCCGTTTGACCGCCGCCGTAGCGGC
CGCAGTAGAGTAA

Upstream 100 bases:

>100_bases
CCCACTGTCCAGTGAATGCGATCGGCCATCACGGCGTCTCCAAAATGAAAAAAGTGTCGTCAGTTTAGATATTGTGGATA
TACTGTCAACCATTACGAAT

Downstream 100 bases:

>100_bases
TTGCTTACCAATGCTGGTCCAGATAACGGGCCAGCCACACCAGGCACCCCACCCACAGCAAAATGATCATCACCGCCGCC
ATCCGGCCGGTTGGATTATC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MIWFTSMSITASDLEFDQRHIWHPYTSMSHPLPCYPVEAASGVELQLADGRRLIDGMSSWWAAIHGYNHPQLNQAATQQL
EKMSHVMFGGITHPAAIALCRRLVAMTPEALQCVFLADSGSVAVEVSLKMALQYWQARGERRQRILTLRHGYHGDTFGAM
SVCDPDNSMHSLYQGYLAPHLFATAPQCGFDQVWDENDIAPFAALLEQHAGEVAAVILEPVVQGAGGMRIYHPTYLKRVR
ELCDRHQVLLIADEIATGFGRTGKLFACEHADVVPDILCLGKALTGGYMTLSATLTTRHVAETISNGAAGCFMHGPTFMG
NPLACAVANASLSLLAENHWQQQVAAIESQLKQQLLPLKALPKVADVRVLGAIGVVEMRESVDVAQLQRGFVERGVWIRP
FGKLIYLMPPYIIEPEQLSRLTAAVAAAVE

Sequences:

>Translated_430_residues
MIWFTSMSITASDLEFDQRHIWHPYTSMSHPLPCYPVEAASGVELQLADGRRLIDGMSSWWAAIHGYNHPQLNQAATQQL
EKMSHVMFGGITHPAAIALCRRLVAMTPEALQCVFLADSGSVAVEVSLKMALQYWQARGERRQRILTLRHGYHGDTFGAM
SVCDPDNSMHSLYQGYLAPHLFATAPQCGFDQVWDENDIAPFAALLEQHAGEVAAVILEPVVQGAGGMRIYHPTYLKRVR
ELCDRHQVLLIADEIATGFGRTGKLFACEHADVVPDILCLGKALTGGYMTLSATLTTRHVAETISNGAAGCFMHGPTFMG
NPLACAVANASLSLLAENHWQQQVAAIESQLKQQLLPLKALPKVADVRVLGAIGVVEMRESVDVAQLQRGFVERGVWIRP
FGKLIYLMPPYIIEPEQLSRLTAAVAAAVE
>Mature_430_residues
MIWFTSMSITASDLEFDQRHIWHPYTSMSHPLPCYPVEAASGVELQLADGRRLIDGMSSWWAAIHGYNHPQLNQAATQQL
EKMSHVMFGGITHPAAIALCRRLVAMTPEALQCVFLADSGSVAVEVSLKMALQYWQARGERRQRILTLRHGYHGDTFGAM
SVCDPDNSMHSLYQGYLAPHLFATAPQCGFDQVWDENDIAPFAALLEQHAGEVAAVILEPVVQGAGGMRIYHPTYLKRVR
ELCDRHQVLLIADEIATGFGRTGKLFACEHADVVPDILCLGKALTGGYMTLSATLTTRHVAETISNGAAGCFMHGPTFMG
NPLACAVANASLSLLAENHWQQQVAAIESQLKQQLLPLKALPKVADVRVLGAIGVVEMRESVDVAQLQRGFVERGVWIRP
FGKLIYLMPPYIIEPEQLSRLTAAVAAAVE

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=423, Percent_Identity=30.4964539007092, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI284507298, Length=308, Percent_Identity=33.1168831168831, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI13994255, Length=374, Percent_Identity=28.6096256684492, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI226442709, Length=322, Percent_Identity=27.3291925465839, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI37574042, Length=322, Percent_Identity=27.3291925465839, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI226442705, Length=314, Percent_Identity=27.0700636942675, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI24119277, Length=365, Percent_Identity=27.3972602739726, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786991, Length=422, Percent_Identity=74.4075829383886, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI145693181, Length=296, Percent_Identity=37.8378378378378, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789016, Length=387, Percent_Identity=29.1989664082687, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789759, Length=391, Percent_Identity=30.9462915601023, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1788044, Length=306, Percent_Identity=34.3137254901961, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1787560, Length=433, Percent_Identity=27.0207852193995, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786349, Length=390, Percent_Identity=27.9487179487179, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=430, Percent_Identity=28.8372093023256, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25144274, Length=221, Percent_Identity=37.10407239819, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=360, Percent_Identity=28.8888888888889, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=341, Percent_Identity=25.5131964809384, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=451, Percent_Identity=48.3370288248337, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=29.6551724137931, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6324432, Length=393, Percent_Identity=28.498727735369, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6321456, Length=321, Percent_Identity=23.98753894081, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21357415, Length=398, Percent_Identity=30.4020100502513, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI28574759, Length=364, Percent_Identity=30.4945054945055, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161085790, Length=364, Percent_Identity=30.4945054945055, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356575, Length=347, Percent_Identity=26.5129682997118, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47179; Mature: 47179

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWFTSMSITASDLEFDQRHIWHPYTSMSHPLPCYPVEAASGVELQLADGRRLIDGMSSW
CEEEEEECEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHH
WAAIHGYNHPQLNQAATQQLEKMSHVMFGGITHPAAIALCRRLVAMTPEALQCVFLADSG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCC
SVAVEVSLKMALQYWQARGERRQRILTLRHGYHGDTFGAMSVCDPDNSMHSLYQGYLAPH
CEEEEHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
LFATAPQCGFDQVWDENDIAPFAALLEQHAGEVAAVILEPVVQGAGGMRIYHPTYLKRVR
HHHCCCCCCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECHHHHHHHH
ELCDRHQVLLIADEIATGFGRTGKLFACEHADVVPDILCLGKALTGGYMTLSATLTTRHV
HHHCCCCEEEEEHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHH
AETISNGAAGCFMHGPTFMGNPLACAVANASLSLLAENHWQQQVAAIESQLKQQLLPLKA
HHHHCCCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LPKVADVRVLGAIGVVEMRESVDVAQLQRGFVERGVWIRPFGKLIYLMPPYIIEPEQLSR
CCCHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCEEEECCCCEECHHHHHH
LTAAVAAAVE
HHHHHHHHCC
>Mature Secondary Structure
MIWFTSMSITASDLEFDQRHIWHPYTSMSHPLPCYPVEAASGVELQLADGRRLIDGMSSW
CEEEEEECEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHH
WAAIHGYNHPQLNQAATQQLEKMSHVMFGGITHPAAIALCRRLVAMTPEALQCVFLADSG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCC
SVAVEVSLKMALQYWQARGERRQRILTLRHGYHGDTFGAMSVCDPDNSMHSLYQGYLAPH
CEEEEHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
LFATAPQCGFDQVWDENDIAPFAALLEQHAGEVAAVILEPVVQGAGGMRIYHPTYLKRVR
HHHCCCCCCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECHHHHHHHH
ELCDRHQVLLIADEIATGFGRTGKLFACEHADVVPDILCLGKALTGGYMTLSATLTTRHV
HHHCCCCEEEEEHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHH
AETISNGAAGCFMHGPTFMGNPLACAVANASLSLLAENHWQQQVAAIESQLKQQLLPLKA
HHHHCCCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LPKVADVRVLGAIGVVEMRESVDVAQLQRGFVERGVWIRPFGKLIYLMPPYIIEPEQLSR
CCCHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCEEEECCCCEECHHHHHH
LTAAVAAAVE
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]