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The map label for this gene is zitB [H]

Identifier: 157369527

GI number: 157369527

Start: 1411353

End: 1412303

Strand: Reverse

Name: zitB [H]

Synonym: Spro_1284

Alternate gene names: 157369527

Gene position: 1412303-1411353 (Counterclockwise)

Preceding gene: 157369528

Following gene: 157369505

Centisome position: 25.92

GC content: 57.1

Gene sequence:

>951_bases
ATGTCGGACGCCCCACACGTACACCAGCCAAAAGACAGTAATAGTAAACGCCTACTGACCGCTTTTTTAGTCACCGCGGT
CTTTATGGTCGCCGAAGTGGCCGGCGGGTTAATTTCAGGTTCACTGGCGCTGCTGGCGGATGCCGGCCATATGCTCACCG
ACGCCGCCGCGCTGCTGGTGGCCTTGATGGCCGTCCACTTCTCACAGCGTAAGCCCAATGCGCGCCACACCTTCGGTTAT
CTGCGTCTGACCACCCTGGCGGCCTTCCTCAACGCCGCCGCGCTGTTGGTGATCGTGGTATTCATCCTGTGGGAGGCGAT
ACGGCGTTTCTTCGAGCCACAGCCGGTGATGGGTACGCCAATGCTGATTATCGCCATAGCGGGGCTGCTGGCCAACCTGT
TCGCCTTCTGGTTACTGCACCGGGGCAGCGAAGAGAAAAATATCAATGTGCGCGCTGCCGCATTGCATGTGCTGGGTGAT
TTACTGGGGTCGGTGGGTGCCATCGCCGCCGCCATTGTGATCCTTACCACTGGCTGGACGCCGATTGACCCGATATTGTC
AGTGCTGGTGTCTTGTCTGGTGATACGCAGCGCCTGGCGACTGCTGAAAGAGAGTTTCCACGAGCTGCTGGAGGGCACGC
CGCAGGAGGTGGACATCAACAAGTTGCAAAAGGACCTGTGCCTGAATATTCCGGAAGTACGCAATATTCATCACGTCCAT
GTGTGGCAGATTGGTGAACAAAAGTTGATGACGCTGCATGCGCAGGTGATACCGCCGCACGACCATGATGGCCTGCTGCG
CCGTATTCAGGCCTATCTGCTGGAGCACTATCGGATTGGTCACGTAACCATTCAGATGGAATATCAGCACTGTGATACAC
CCGACTGTGGGATTAACCGGGCCCCCGAGCCGAGTGACCACTCACATTCACATGTGGGACATCATCACTAG

Upstream 100 bases:

>100_bases
CCTATACTGAATTGAGTACGTTAGTGGAACAGATCCTGATAGAACTGGATAATCTGGTCAGCACTGACGAGTCGTATTTT
GCTATGGATAAGGAAGAATA

Downstream 100 bases:

>100_bases
AATCCACTGGGGCGCCTTATTCGGCGCCCCAGTTATGTTATGGTGCAGAAGATAATGGCCGCGATTGATTGTTGCCGGCG
CTTTTGATCCACAGCCAGGA

Product: zinc transporter ZitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSDAPHVHQPKDSNSKRLLTAFLVTAVFMVAEVAGGLISGSLALLADAGHMLTDAAALLVALMAVHFSQRKPNARHTFGY
LRLTTLAAFLNAAALLVIVVFILWEAIRRFFEPQPVMGTPMLIIAIAGLLANLFAFWLLHRGSEEKNINVRAAALHVLGD
LLGSVGAIAAAIVILTTGWTPIDPILSVLVSCLVIRSAWRLLKESFHELLEGTPQEVDINKLQKDLCLNIPEVRNIHHVH
VWQIGEQKLMTLHAQVIPPHDHDGLLRRIQAYLLEHYRIGHVTIQMEYQHCDTPDCGINRAPEPSDHSHSHVGHHH

Sequences:

>Translated_316_residues
MSDAPHVHQPKDSNSKRLLTAFLVTAVFMVAEVAGGLISGSLALLADAGHMLTDAAALLVALMAVHFSQRKPNARHTFGY
LRLTTLAAFLNAAALLVIVVFILWEAIRRFFEPQPVMGTPMLIIAIAGLLANLFAFWLLHRGSEEKNINVRAAALHVLGD
LLGSVGAIAAAIVILTTGWTPIDPILSVLVSCLVIRSAWRLLKESFHELLEGTPQEVDINKLQKDLCLNIPEVRNIHHVH
VWQIGEQKLMTLHAQVIPPHDHDGLLRRIQAYLLEHYRIGHVTIQMEYQHCDTPDCGINRAPEPSDHSHSHVGHHH
>Mature_315_residues
SDAPHVHQPKDSNSKRLLTAFLVTAVFMVAEVAGGLISGSLALLADAGHMLTDAAALLVALMAVHFSQRKPNARHTFGYL
RLTTLAAFLNAAALLVIVVFILWEAIRRFFEPQPVMGTPMLIIAIAGLLANLFAFWLLHRGSEEKNINVRAAALHVLGDL
LGSVGAIAAAIVILTTGWTPIDPILSVLVSCLVIRSAWRLLKESFHELLEGTPQEVDINKLQKDLCLNIPEVRNIHHVHV
WQIGEQKLMTLHAQVIPPHDHDGLLRRIQAYLLEHYRIGHVTIQMEYQHCDTPDCGINRAPEPSDHSHSHVGHHH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=315, Percent_Identity=29.2063492063492, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI21359890, Length=318, Percent_Identity=29.874213836478, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI289803013, Length=296, Percent_Identity=30.7432432432432, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI289803009, Length=296, Percent_Identity=30.7432432432432, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI289803007, Length=296, Percent_Identity=30.7432432432432, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI289803003, Length=296, Percent_Identity=30.7432432432432, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI64762489, Length=296, Percent_Identity=30.7432432432432, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI21361112, Length=307, Percent_Identity=29.6416938110749, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI20070323, Length=338, Percent_Identity=25.4437869822485, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI14210520, Length=230, Percent_Identity=26.9565217391304, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=40.7692307692308, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI52351208, Length=160, Percent_Identity=30, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=29.4573643410853, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=29.4573643410853, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786966, Length=292, Percent_Identity=69.1780821917808, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1790349, Length=223, Percent_Identity=23.7668161434978, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193210990, Length=330, Percent_Identity=31.5151515151515, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17555794, Length=317, Percent_Identity=30.2839116719243, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=317, Percent_Identity=29.6529968454259, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32564488, Length=303, Percent_Identity=30.03300330033, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17550440, Length=126, Percent_Identity=31.7460317460317, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17550442, Length=126, Percent_Identity=31.7460317460317, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324892, Length=136, Percent_Identity=37.5, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=126, Percent_Identity=38.0952380952381, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320411, Length=179, Percent_Identity=34.0782122905028, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656728, Length=341, Percent_Identity=28.7390029325513, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24656724, Length=341, Percent_Identity=28.7390029325513, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24656720, Length=341, Percent_Identity=28.7390029325513, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24656715, Length=341, Percent_Identity=28.7390029325513, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21357035, Length=341, Percent_Identity=28.7390029325513, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24583858, Length=338, Percent_Identity=25.4437869822485, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=34.6938775510204, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=34.6938775510204, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=34.6938775510204, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=34.6938775510204, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24645863, Length=127, Percent_Identity=34.6456692913386, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24584409, Length=119, Percent_Identity=33.6134453781513, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574430, Length=119, Percent_Identity=33.6134453781513, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34926; Mature: 34795

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAPHVHQPKDSNSKRLLTAFLVTAVFMVAEVAGGLISGSLALLADAGHMLTDAAALLV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHH
ALMAVHFSQRKPNARHTFGYLRLTTLAAFLNAAALLVIVVFILWEAIRRFFEPQPVMGTP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
MLIIAIAGLLANLFAFWLLHRGSEEKNINVRAAALHVLGDLLGSVGAIAAAIVILTTGWT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIDPILSVLVSCLVIRSAWRLLKESFHELLEGTPQEVDINKLQKDLCLNIPEVRNIHHVH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCEEE
VWQIGEQKLMTLHAQVIPPHDHDGLLRRIQAYLLEHYRIGHVTIQMEYQHCDTPDCGINR
EEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
APEPSDHSHSHVGHHH
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDAPHVHQPKDSNSKRLLTAFLVTAVFMVAEVAGGLISGSLALLADAGHMLTDAAALLV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHH
ALMAVHFSQRKPNARHTFGYLRLTTLAAFLNAAALLVIVVFILWEAIRRFFEPQPVMGTP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
MLIIAIAGLLANLFAFWLLHRGSEEKNINVRAAALHVLGDLLGSVGAIAAAIVILTTGWT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIDPILSVLVSCLVIRSAWRLLKESFHELLEGTPQEVDINKLQKDLCLNIPEVRNIHHVH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCEEE
VWQIGEQKLMTLHAQVIPPHDHDGLLRRIQAYLLEHYRIGHVTIQMEYQHCDTPDCGINR
EEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
APEPSDHSHSHVGHHH
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]