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The map label for this gene is sdhB [H]

Identifier: 157369509

GI number: 157369509

Start: 1391472

End: 1392188

Strand: Direct

Name: sdhB [H]

Synonym: Spro_1266

Alternate gene names: 157369509

Gene position: 1391472-1392188 (Clockwise)

Preceding gene: 157369508

Following gene: 157369510

Centisome position: 25.54

GC content: 52.58

Gene sequence:

>717_bases
ATGAAACTCGAATTTTCAATTTATCGCTACAATCCGGATGTTGACGATGCTCCGCACATGCAGGACTACAGCCTGGAAGC
GGAAGAAGGTCGCGACATGATGTTGCTGGATGCGTTGATCCAGCTGAAAGAAAAAGATCCAAGCCTGTCGTTCCGTCGTT
CATGCCGTGAAGGCGTTTGTGGTTCCGATGGGATCAACATGAACGGTAAAAACGGCCTGGCCTGTATCACTCCGGTGTCG
TCGCTGACCAAAGGCAATAAAAAGATTGTGATCCGTCCGTTACCAGGCTTGCCGGTAGTGCGCGATCTGGTGGTCGATAT
GGGCCAGTTCTACACCCAGTATGAAAAGATCAAGCCTTTCCTGCAGAACGACGGCAAGAACCCGCCGGCGCGTGAGCACC
TGCAATCGCCGGAAGAGCGTGCCAAGCTCGATGGTCTGTACGAGTGCATTTTATGCGCTTGTTGTTCGACCTCTTGCCCG
TCATTCTGGTGGAATCCTGACAAGTTTATCGGCCCGGCTGGCCTGTTGGCGGCGTACCGCTTCCTGATTGACAGCCGTGA
CACGGAAACGGAAGAACGTTTAGACGATCTGGACGACGCTTTCAGTGTTTTCCGCTGCCATAGCATTATGAATTGTGTCA
GTGTATGCCCTAAGGGCTTGAATCCGACCCGTGCAATCGGTCATATCAAGTCTATGCTGCTGCAACGCGGCGCATAA

Upstream 100 bases:

>100_bases
CAATCGGAAAGCATGACGCGTCGTGAAGTGAACATGCAACCGAAGCTGCGCCCGGCATTCCCGCCGAAAGTGCGTTCTTA
CTAATTGCGGAGATCGATTG

Downstream 100 bases:

>100_bases
ATGGAATGAGATGCTGCGCCGGGCAGTTTCCGGCGCACATCACAAAGGAGGGAGCCTCTAAAAACTGACCCGCGGCTGCG
GCGCTAAGCAGCCTGGTTCG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKLEFSIYRYNPDVDDAPHMQDYSLEAEEGRDMMLLDALIQLKEKDPSLSFRRSCREGVCGSDGINMNGKNGLACITPVS
SLTKGNKKIVIRPLPGLPVVRDLVVDMGQFYTQYEKIKPFLQNDGKNPPAREHLQSPEERAKLDGLYECILCACCSTSCP
SFWWNPDKFIGPAGLLAAYRFLIDSRDTETEERLDDLDDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA

Sequences:

>Translated_238_residues
MKLEFSIYRYNPDVDDAPHMQDYSLEAEEGRDMMLLDALIQLKEKDPSLSFRRSCREGVCGSDGINMNGKNGLACITPVS
SLTKGNKKIVIRPLPGLPVVRDLVVDMGQFYTQYEKIKPFLQNDGKNPPAREHLQSPEERAKLDGLYECILCACCSTSCP
SFWWNPDKFIGPAGLLAAYRFLIDSRDTETEERLDDLDDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA
>Mature_238_residues
MKLEFSIYRYNPDVDDAPHMQDYSLEAEEGRDMMLLDALIQLKEKDPSLSFRRSCREGVCGSDGINMNGKNGLACITPVS
SLTKGNKKIVIRPLPGLPVVRDLVVDMGQFYTQYEKIKPFLQNDGKNPPAREHLQSPEERAKLDGLYECILCACCSTSCP
SFWWNPDKFIGPAGLLAAYRFLIDSRDTETEERLDDLDDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=233, Percent_Identity=56.2231759656652, Blast_Score=267, Evalue=8e-72,
Organism=Escherichia coli, GI1786943, Length=238, Percent_Identity=89.4957983193277, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=38.8646288209607, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=54.2735042735043, Blast_Score=255, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=52.3809523809524, Blast_Score=250, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=56.1702127659575, Blast_Score=272, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=55.1282051282051, Blast_Score=255, Evalue=1e-68,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26729; Mature: 26729

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEFSIYRYNPDVDDAPHMQDYSLEAEEGRDMMLLDALIQLKEKDPSLSFRRSCREGVC
CCEEEEEEEECCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCC
GSDGINMNGKNGLACITPVSSLTKGNKKIVIRPLPGLPVVRDLVVDMGQFYTQYEKIKPF
CCCCCCCCCCCCEEEECCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LQNDGKNPPAREHLQSPEERAKLDGLYECILCACCSTSCPSFWWNPDKFIGPAGLLAAYR
HHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHH
FLIDSRDTETEERLDDLDDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLEFSIYRYNPDVDDAPHMQDYSLEAEEGRDMMLLDALIQLKEKDPSLSFRRSCREGVC
CCEEEEEEEECCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCC
GSDGINMNGKNGLACITPVSSLTKGNKKIVIRPLPGLPVVRDLVVDMGQFYTQYEKIKPF
CCCCCCCCCCCCEEEECCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LQNDGKNPPAREHLQSPEERAKLDGLYECILCACCSTSCPSFWWNPDKFIGPAGLLAAYR
HHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHH
FLIDSRDTETEERLDDLDDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRGA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]