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The map label for this gene is pgm [H]

Identifier: 157369484

GI number: 157369484

Start: 1365339

End: 1366982

Strand: Direct

Name: pgm [H]

Synonym: Spro_1241

Alternate gene names: 157369484

Gene position: 1365339-1366982 (Clockwise)

Preceding gene: 157369483

Following gene: 157369485

Centisome position: 25.06

GC content: 57.54

Gene sequence:

>1644_bases
ATGGCGAATAATCCACGTGCCGGGCAACCGGCTCAGCAAAGCGATTTGATCAACGTAGCCCAGCTGACGTCGCAGTACTA
TGTACTGCAACCTGAAGCTGGCAATGCAGCACACGCGGTGAAGTTCGGGACTTCGGGCCATCGCGGCAGCGCTCTGCGTC
ATAGCTTTAATGAAAACCATATTCTCGCTATTGCGCAGGCGATTGCGGAAGTCCGCCATCAGCAAGGGGTGACCGGCCCA
TGCTACGTGGGCAAAGACACTCATGCGCTGTCCGAGCCTGCCTTTATTTCTGTACTGGAAGTGTTGACCGCCAATGGCGT
CGATGTTGTCGTGCAGGAAAATAACGGCTTCACGCCAACCCCTGCGGTATCCCATGCCATTTTGTGCCATAACCGCAACG
GTGGGGCATTGGCCGACGGCATCGTTATTACCCCGTCTCACAATCCCCCGGAAGACGGTGGCATCAAATATAACCCGACC
AACGGCGGCCCGGCCGACACCAATCTGACCTCGGTGATTGAAAAGCGCGCCAATGAACTGCTGTCTTTGCAGCTGCAAGG
CGTTCAGCGTCAGTCATTGGACAAGGCCTGGAACAGCGGCCGCGTGCACGCACAAGATCTGGTGCAGCCGTACGTCGAAG
GGTTGGTGGATATTGTCGATATGCCTGCTATCCAGCGTGCCGGCCTGAAGTTGGGCGTCGATCCGCTTGGCGGTTCCGGC
ATTGCCTACTGGCAGCGTATTGCCGAGCATTACAAGCTGGATCTGACGCTGGTGAACGACTCTATCGATCAGACCTTCCG
CTTTATGCACCTGGACCACGACGGCGTGATCCGCATGGACTGTTCTTCAGTGCCGGCGATGGGGGGGTTGCTGGCGCTGC
GTGACAAGTTCGATCTGGCGTTCGCCAACGACCCGGATTACGACCGCCACGGCATTGTTACGCCGAAGGGCCTGATGAAC
CCGAACCATTATCTGGCGGTGTCCATCAACTACCTGTTCCAGCATCGTCCACAGTGGGGCGCCGATGTGGCGGTGGGCAA
AACGCTGGTTTCCAGTGCAATGATTGACCGCGTGGTCGCCTCTCTGGGCCGTAAACTGGTGGAAGTGCCAGTGGGCTTCA
AATGGTTTGTCGATGGCTTGTACGATGGCAGCCTGGGCTTTGGTGGCGAAGAGAGCGCTGGGGCATCCTTCCTGCGTTTC
AACGGCAAACCTTGGTCTACCGATAAAGACGGCATGATTATGTGTCTGTTGGCGGCGGAAATCACCGCAGTCACCGGTGA
AAACCCACAAAATCACTACGAAGATCTGGCCAAACGCTTTGGCGCACCGAGCTACAACCGCATTCAGGCGCCGGCAACCT
CAGCGCAGAAAGCCGCGTTGTCCAAGCTGTCACCGGAAATGGTCAAGGCCGATACTCTGGCGGGTGATCCGATCACCGCA
CGTCTGACCGCAGCACCGGGCAACGGCGCACCCATTGGCGGCCTGAAAGTGATGACTGACAATGGCTGGTTCGCAGCGCG
TCCTTCCGGTACCGAAGAGGCTTACAAGATTTATTGTGAGAGCTTCCTGGGGGCCGAACATCGCGAAAAGATCGAGCACG
AAGCGGTCGAAATCGTCAGCGCAGTGCTGGCTTCCGCCAAGTAA

Upstream 100 bases:

>100_bases
GAAAAAGTTTGCGGTACTATCTAATTTAGCGAACAGCCCGTCATGGTGGCCGTGAGCGACATATTGCCAGGCCGCAGGAC
AGGGATAGGGAGATATGTCG

Downstream 100 bases:

>100_bases
GTTTTCCCCACTTCCGATGAAAGCGCTGTTTTTACAGCGCTTTTTTTATGCATGCAATTTAGATATATCTATTTTACGAA
CAGCGCTTGCGCATTTAGAT

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MANNPRAGQPAQQSDLINVAQLTSQYYVLQPEAGNAAHAVKFGTSGHRGSALRHSFNENHILAIAQAIAEVRHQQGVTGP
CYVGKDTHALSEPAFISVLEVLTANGVDVVVQENNGFTPTPAVSHAILCHNRNGGALADGIVITPSHNPPEDGGIKYNPT
NGGPADTNLTSVIEKRANELLSLQLQGVQRQSLDKAWNSGRVHAQDLVQPYVEGLVDIVDMPAIQRAGLKLGVDPLGGSG
IAYWQRIAEHYKLDLTLVNDSIDQTFRFMHLDHDGVIRMDCSSVPAMGGLLALRDKFDLAFANDPDYDRHGIVTPKGLMN
PNHYLAVSINYLFQHRPQWGADVAVGKTLVSSAMIDRVVASLGRKLVEVPVGFKWFVDGLYDGSLGFGGEESAGASFLRF
NGKPWSTDKDGMIMCLLAAEITAVTGENPQNHYEDLAKRFGAPSYNRIQAPATSAQKAALSKLSPEMVKADTLAGDPITA
RLTAAPGNGAPIGGLKVMTDNGWFAARPSGTEEAYKIYCESFLGAEHREKIEHEAVEIVSAVLASAK

Sequences:

>Translated_547_residues
MANNPRAGQPAQQSDLINVAQLTSQYYVLQPEAGNAAHAVKFGTSGHRGSALRHSFNENHILAIAQAIAEVRHQQGVTGP
CYVGKDTHALSEPAFISVLEVLTANGVDVVVQENNGFTPTPAVSHAILCHNRNGGALADGIVITPSHNPPEDGGIKYNPT
NGGPADTNLTSVIEKRANELLSLQLQGVQRQSLDKAWNSGRVHAQDLVQPYVEGLVDIVDMPAIQRAGLKLGVDPLGGSG
IAYWQRIAEHYKLDLTLVNDSIDQTFRFMHLDHDGVIRMDCSSVPAMGGLLALRDKFDLAFANDPDYDRHGIVTPKGLMN
PNHYLAVSINYLFQHRPQWGADVAVGKTLVSSAMIDRVVASLGRKLVEVPVGFKWFVDGLYDGSLGFGGEESAGASFLRF
NGKPWSTDKDGMIMCLLAAEITAVTGENPQNHYEDLAKRFGAPSYNRIQAPATSAQKAALSKLSPEMVKADTLAGDPITA
RLTAAPGNGAPIGGLKVMTDNGWFAARPSGTEEAYKIYCESFLGAEHREKIEHEAVEIVSAVLASAK
>Mature_546_residues
ANNPRAGQPAQQSDLINVAQLTSQYYVLQPEAGNAAHAVKFGTSGHRGSALRHSFNENHILAIAQAIAEVRHQQGVTGPC
YVGKDTHALSEPAFISVLEVLTANGVDVVVQENNGFTPTPAVSHAILCHNRNGGALADGIVITPSHNPPEDGGIKYNPTN
GGPADTNLTSVIEKRANELLSLQLQGVQRQSLDKAWNSGRVHAQDLVQPYVEGLVDIVDMPAIQRAGLKLGVDPLGGSGI
AYWQRIAEHYKLDLTLVNDSIDQTFRFMHLDHDGVIRMDCSSVPAMGGLLALRDKFDLAFANDPDYDRHGIVTPKGLMNP
NHYLAVSINYLFQHRPQWGADVAVGKTLVSSAMIDRVVASLGRKLVEVPVGFKWFVDGLYDGSLGFGGEESAGASFLRFN
GKPWSTDKDGMIMCLLAAEITAVTGENPQNHYEDLAKRFGAPSYNRIQAPATSAQKAALSKLSPEMVKADTLAGDPITAR
LTAAPGNGAPIGGLKVMTDNGWFAARPSGTEEAYKIYCESFLGAEHREKIEHEAVEIVSAVLASAK

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=448, Percent_Identity=27.0089285714286, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI21361621, Length=445, Percent_Identity=26.9662921348315, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI133922562, Length=419, Percent_Identity=26.9689737470167, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786904, Length=546, Percent_Identity=84.6153846153846, Blast_Score=938, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323752, Length=456, Percent_Identity=26.9736842105263, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322722, Length=422, Percent_Identity=27.9620853080569, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17864244, Length=453, Percent_Identity=27.5938189845475, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 58681; Mature: 58550

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNPRAGQPAQQSDLINVAQLTSQYYVLQPEAGNAAHAVKFGTSGHRGSALRHSFNENH
CCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHCCCCCH
ILAIAQAIAEVRHQQGVTGPCYVGKDTHALSEPAFISVLEVLTANGVDVVVQENNGFTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCC
PAVSHAILCHNRNGGALADGIVITPSHNPPEDGGIKYNPTNGGPADTNLTSVIEKRANEL
HHHCEEEEEECCCCCEEECCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LSLQLQGVQRQSLDKAWNSGRVHAQDLVQPYVEGLVDIVDMPAIQRAGLKLGVDPLGGSG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCCCH
IAYWQRIAEHYKLDLTLVNDSIDQTFRFMHLDHDGVIRMDCSSVPAMGGLLALRDKFDLA
HHHHHHHHHHHEEEEEEECCCHHHHEEEEEECCCCEEEECCCCCCCCCCCEEEECCCCEE
FANDPDYDRHGIVTPKGLMNPNHYLAVSINYLFQHRPQWGADVAVGKTLVSSAMIDRVVA
ECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SLGRKLVEVPVGFKWFVDGLYDGSLGFGGEESAGASFLRFNGKPWSTDKDGMIMCLLAAE
HHHHHHHHCCCCCEEHECCEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEHH
ITAVTGENPQNHYEDLAKRFGAPSYNRIQAPATSAQKAALSKLSPEMVKADTLAGDPITA
HHEECCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHCCCCCCEEE
RLTAAPGNGAPIGGLKVMTDNGWFAARPSGTEEAYKIYCESFLGAEHREKIEHEAVEIVS
EEEECCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AVLASAK
HHHHCCC
>Mature Secondary Structure 
ANNPRAGQPAQQSDLINVAQLTSQYYVLQPEAGNAAHAVKFGTSGHRGSALRHSFNENH
CCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHCCCCCH
ILAIAQAIAEVRHQQGVTGPCYVGKDTHALSEPAFISVLEVLTANGVDVVVQENNGFTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCC
PAVSHAILCHNRNGGALADGIVITPSHNPPEDGGIKYNPTNGGPADTNLTSVIEKRANEL
HHHCEEEEEECCCCCEEECCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LSLQLQGVQRQSLDKAWNSGRVHAQDLVQPYVEGLVDIVDMPAIQRAGLKLGVDPLGGSG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCCCH
IAYWQRIAEHYKLDLTLVNDSIDQTFRFMHLDHDGVIRMDCSSVPAMGGLLALRDKFDLA
HHHHHHHHHHHEEEEEEECCCHHHHEEEEEECCCCEEEECCCCCCCCCCCEEEECCCCEE
FANDPDYDRHGIVTPKGLMNPNHYLAVSINYLFQHRPQWGADVAVGKTLVSSAMIDRVVA
ECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SLGRKLVEVPVGFKWFVDGLYDGSLGFGGEESAGASFLRFNGKPWSTDKDGMIMCLLAAE
HHHHHHHHCCCCCEEHECCEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEHH
ITAVTGENPQNHYEDLAKRFGAPSYNRIQAPATSAQKAALSKLSPEMVKADTLAGDPITA
HHEECCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHCCCCCCEEE
RLTAAPGNGAPIGGLKVMTDNGWFAARPSGTEEAYKIYCESFLGAEHREKIEHEAVEIVS
EEEECCCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AVLASAK
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]