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The map label for this gene is pepD [H]

Identifier: 157369208

GI number: 157369208

Start: 1060583

End: 1062043

Strand: Reverse

Name: pepD [H]

Synonym: Spro_0963

Alternate gene names: 157369208

Gene position: 1062043-1060583 (Counterclockwise)

Preceding gene: 157369214

Following gene: 157369206

Centisome position: 19.49

GC content: 58.11

Gene sequence:

>1461_bases
GTGTCTGAATTGTCTCAACTTTCGCCACAGCCGCTGTGGGATATTTTTGCCAAAATCTGCTCTATTCCGCATCCTTCTTA
TCATGAAGAAGCGCTGGCACAGCACATCCTCGAGTGGGCCAAAGAGAAAAACCTGCACGCCGAGCGTGACCATGTAGGCA
ACATCCTGCTGCGTAAGCCGGCCACCAAAGGCATGGAAAACCGCAAGCCGGTCGCCCTGCAGGCGCACCTGGATATGGTG
CCGCAGAAAAATAACGACACCGTGCACGACTTCACCAAGGATCCGATTCAGCCGTACATCGACGGTGAGTGGATCAAGGC
GCGCGGCACCACGCTGGGTGCCGACAACGGCATCGGTATGGCCTCCGCACTGGCCGTGCTGGCCGACGACAGCGTCGAAC
ACGGCCCGCTGGAAGTGCTGTTGACCATGACCGAAGAAGCCGGTATGGACGGTGCATTTGGCCTGCAGGCTAACTGGCTG
CAAGCGGATATCCTGATCAACACCGACTCAGAAGAGGAAGGCGAGATCTACATGGGTTGCGCCGGCGGTATTGATTTCAT
CACCACCCTGCCACTGCAGCGCGAAGCCGTGCCTGCCGGTTATCAGACCCTGAAGCTGACGATCAAAGGCCTGAAAGGCG
GCCACTCTGGCGCGGATATCCACGTTGGGCTGGGCAACGCCAACAAACTGCTGGCACGCTTCCTGTTTGATCATACCGCT
GAGCTGAACCTGCGCCTGCTGGATCTGAACGGCGGTACGCTGCGCAATGCTATTCCGCGTGAAGCTTCTGCGGTAGTTGC
CGTGCCGGCCGAGAAAGCCGATGCGCTGAAAGCGCTGAGCCAGGCGTTCCTGGCTACCCTGCAAAACGAGCTGGCTGCCA
AAGAGAAGAACATTACCGTTTTGCTGGAGCCAGTCACCAGCACCTCGCAGGCGATGACCAGCGATAGCCAACAGCGTTTT
GTAGCGCTGCTCAATGGCACGCCAAACGGTGTGATCCGCATGAGCGACGCGGTGAAAGGCGTGGTGGAAACCTCACTGAA
CGTCGGCGTGGTCACCACCAGCGACAGCGAAGCAGAAATCATCTGCCTGATCCGCTCGTTGATCGACAGCGGTAAAGACT
ACGTGGTCGGCATGCTGACCGCTCTGGGTCAGTTGGCCAACGCCAAAGTGGCACCAAAAGGCGGCTACCCAGGCTGGCAG
CCGGACGCAGACTCACCGGTGATGCATCTGGTGCGCGAGATTTATCAGGATCTGTTCAACAAGACGCCGAACATCATGGT
GATCCACGCCGGTCTGGAATGCGGTCTGTTCAAAAAACCGTACCCAAACATGGATATGGTGTCGATTGGGCCAACCATCA
CCGGGCCACACTCGCCGGATGAGCAGGTGCATATCGAAAGCGTGGGGCTGTACTGGAAGTTGCTGACGGCACTGCTGAAG
GCTATCCCAGAGCGCGCGTAA

Upstream 100 bases:

>100_bases
TGATATTCTCTGGAGATCGTGCCAAAGCCGCACAGATGCCCCTAACCCTAACCGAGCGGCATTCCCGCACTGCCGAGAAT
GCTGTTACAGGAGACTTATA

Downstream 100 bases:

>100_bases
TATTACAGATGACTTAGTGATTAAACCAAGGGCGCAATACTGCATTGCGCCCTTGTTATTCCCAGGGTAGCAGCAGTTGC
CGCTCCAGTTGCGGATCCAG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSELSQLSPQPLWDIFAKICSIPHPSYHEEALAQHILEWAKEKNLHAERDHVGNILLRKPATKGMENRKPVALQAHLDMV
PQKNNDTVHDFTKDPIQPYIDGEWIKARGTTLGADNGIGMASALAVLADDSVEHGPLEVLLTMTEEAGMDGAFGLQANWL
QADILINTDSEEEGEIYMGCAGGIDFITTLPLQREAVPAGYQTLKLTIKGLKGGHSGADIHVGLGNANKLLARFLFDHTA
ELNLRLLDLNGGTLRNAIPREASAVVAVPAEKADALKALSQAFLATLQNELAAKEKNITVLLEPVTSTSQAMTSDSQQRF
VALLNGTPNGVIRMSDAVKGVVETSLNVGVVTTSDSEAEIICLIRSLIDSGKDYVVGMLTALGQLANAKVAPKGGYPGWQ
PDADSPVMHLVREIYQDLFNKTPNIMVIHAGLECGLFKKPYPNMDMVSIGPTITGPHSPDEQVHIESVGLYWKLLTALLK
AIPERA

Sequences:

>Translated_486_residues
MSELSQLSPQPLWDIFAKICSIPHPSYHEEALAQHILEWAKEKNLHAERDHVGNILLRKPATKGMENRKPVALQAHLDMV
PQKNNDTVHDFTKDPIQPYIDGEWIKARGTTLGADNGIGMASALAVLADDSVEHGPLEVLLTMTEEAGMDGAFGLQANWL
QADILINTDSEEEGEIYMGCAGGIDFITTLPLQREAVPAGYQTLKLTIKGLKGGHSGADIHVGLGNANKLLARFLFDHTA
ELNLRLLDLNGGTLRNAIPREASAVVAVPAEKADALKALSQAFLATLQNELAAKEKNITVLLEPVTSTSQAMTSDSQQRF
VALLNGTPNGVIRMSDAVKGVVETSLNVGVVTTSDSEAEIICLIRSLIDSGKDYVVGMLTALGQLANAKVAPKGGYPGWQ
PDADSPVMHLVREIYQDLFNKTPNIMVIHAGLECGLFKKPYPNMDMVSIGPTITGPHSPDEQVHIESVGLYWKLLTALLK
AIPERA
>Mature_485_residues
SELSQLSPQPLWDIFAKICSIPHPSYHEEALAQHILEWAKEKNLHAERDHVGNILLRKPATKGMENRKPVALQAHLDMVP
QKNNDTVHDFTKDPIQPYIDGEWIKARGTTLGADNGIGMASALAVLADDSVEHGPLEVLLTMTEEAGMDGAFGLQANWLQ
ADILINTDSEEEGEIYMGCAGGIDFITTLPLQREAVPAGYQTLKLTIKGLKGGHSGADIHVGLGNANKLLARFLFDHTAE
LNLRLLDLNGGTLRNAIPREASAVVAVPAEKADALKALSQAFLATLQNELAAKEKNITVLLEPVTSTSQAMTSDSQQRFV
ALLNGTPNGVIRMSDAVKGVVETSLNVGVVTTSDSEAEIICLIRSLIDSGKDYVVGMLTALGQLANAKVAPKGGYPGWQP
DADSPVMHLVREIYQDLFNKTPNIMVIHAGLECGLFKKPYPNMDMVSIGPTITGPHSPDEQVHIESVGLYWKLLTALLKA
IPERA

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=78.7628865979381, Blast_Score=800, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52512; Mature: 52381

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSQLSPQPLWDIFAKICSIPHPSYHEEALAQHILEWAKEKNLHAERDHVGNILLRKP
CCCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEECC
ATKGMENRKPVALQAHLDMVPQKNNDTVHDFTKDPIQPYIDGEWIKARGTTLGADNGIGM
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEECCCCCCCH
ASALAVLADDSVEHGPLEVLLTMTEEAGMDGAFGLQANWLQADILINTDSEEEGEIYMGC
HHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEE
AGGIDFITTLPLQREAVPAGYQTLKLTIKGLKGGHSGADIHVGLGNANKLLARFLFDHTA
CCCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCC
ELNLRLLDLNGGTLRNAIPREASAVVAVPAEKADALKALSQAFLATLQNELAAKEKNITV
CCEEEEEECCCCHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LLEPVTSTSQAMTSDSQQRFVALLNGTPNGVIRMSDAVKGVVETSLNVGVVTTSDSEAEI
EEECCCCCHHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCHH
ICLIRSLIDSGKDYVVGMLTALGQLANAKVAPKGGYPGWQPDADSPVMHLVREIYQDLFN
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
KTPNIMVIHAGLECGLFKKPYPNMDMVSIGPTITGPHSPDEQVHIESVGLYWKLLTALLK
CCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
AIPERA
HCCCCC
>Mature Secondary Structure 
SELSQLSPQPLWDIFAKICSIPHPSYHEEALAQHILEWAKEKNLHAERDHVGNILLRKP
CCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEECC
ATKGMENRKPVALQAHLDMVPQKNNDTVHDFTKDPIQPYIDGEWIKARGTTLGADNGIGM
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEECCCCCCCH
ASALAVLADDSVEHGPLEVLLTMTEEAGMDGAFGLQANWLQADILINTDSEEEGEIYMGC
HHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEE
AGGIDFITTLPLQREAVPAGYQTLKLTIKGLKGGHSGADIHVGLGNANKLLARFLFDHTA
CCCCHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCC
ELNLRLLDLNGGTLRNAIPREASAVVAVPAEKADALKALSQAFLATLQNELAAKEKNITV
CCEEEEEECCCCHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LLEPVTSTSQAMTSDSQQRFVALLNGTPNGVIRMSDAVKGVVETSLNVGVVTTSDSEAEI
EEECCCCCHHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCHH
ICLIRSLIDSGKDYVVGMLTALGQLANAKVAPKGGYPGWQPDADSPVMHLVREIYQDLFN
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
KTPNIMVIHAGLECGLFKKPYPNMDMVSIGPTITGPHSPDEQVHIESVGLYWKLLTALLK
CCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
AIPERA
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]