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The map label for this gene is clpB [H]

Identifier: 157369131

GI number: 157369131

Start: 980289

End: 982862

Strand: Direct

Name: clpB [H]

Synonym: Spro_0886

Alternate gene names: 157369131

Gene position: 980289-982862 (Clockwise)

Preceding gene: 157369130

Following gene: 157369133

Centisome position: 17.99

GC content: 54.82

Gene sequence:

>2574_bases
ATGCGTCTGGATCGTCTTACTAACAAATTCCAGCTTGCCCTCGCCGATGCCCAATCTTTAGCCCTTGGGCGCGACAACCA
GTTTATTGAACCGTTACATCTGATGAGCGCTCTGCTCAATCAGGACGGGGGCACGGTTCGTCCACTCTTAACTTCTGCCG
GTATCGATGCAGGGCGCGTGCGCACTGAAATCGAGCAGGCACTGTCTCGTCAGCCTCAAGTCGAAGGTACCGGTGGTGAC
GTTCAACCGTCCCATGAACTGGTGCGTGTCCTTAACCTGTGTGACAAGCTGGCGCAAAAGCGGGCGGACAAATTCATTTC
TTCCGAACTCTTTGTACTGGCGGTGCTTGAGGATCGTGGAACATTGACCGATCTGTTGAAAGCGGCCGGTGCGACAACCG
ATAAAATCAGCAAGGCTATTGAGCAAATGCGAGGTGGAGACAGCGTGGAAGAGCAGGGTGCTGAAGACCAACGTCAGGCA
TTGAAGAAATACACTATTGATCTGACCGAACGTGCCGAGCAGGGCAAGCTTGACCCGGTTATCGGCCGTGACGAAGAGAT
CCGTCGCACCATTCAGGTGCTGCAACGTCGTACCAAAAACAACCCGGTGTTGATCGGCGAGCCTGGCGTGGGTAAAACCG
CCATCGTCGAAGGTTTGGCGCAACGCATCATTAATGGTGAAGTCCCGGAAGGCTTAAAGCATAAACGAGTGCTGTCCCTC
GATATGGGGGCGCTGATTGCCGGGGCCAAGTACCGCGGTGAGTTTGAAGAGCGTCTGAAAGCGGTGCTGAGCGATCTGTC
CAAACAGGAAGGCAGCGTCATTCTGTTTATTGATGAACTGCACACTATGGTTGGCGCGGGTAAAGCCGATGGCGCAATGG
ATGCCGGCAATATGTTGAAACCGGCGCTGGCGCGTGGGGAACTGCACTGCGTCGGTGCCACCACGCTGGACGAATATCGC
CAGTATATAGAGAAGGACGCGGCGCTCGAACGTCGTTTCCAGAAAGTCTATGTGGCGGAACCCAGCGTTGAAGACACCAT
CGCTATCCTGCGAGGCCTGAAAGAACGTTATGAACTGCATCACCATGTGCAGATCACTGACCCGGCGATTGTTGCGGCAG
CGACCTTGTCACACCGCTATATCTCCGATCGTCAATTGCCGGATAAGGCTATTGACCTGATCGATGAGGCGGCGTCCAGC
ATCCGTATGCAGATGGACTCCAAGCCGGAATCGCTCGATCGTCTGGAGCGCCGCATTATTCAGCTTAAGCTGGAGCAACA
GGCGCTGAGTAAAGAGTCGGACGACGCCAGCAAGAAACGTCTGGAAATGCTTAGCGGTGAGCTGGAGCAGAAAGAGCGTG
AATATTCAGAGCTTGAAGAAGAGTGGAAAGCGGAAAAAGCCTCACTCTCCGGTACGCAGAATATCAAAGCGGAACTTGAG
CAGGCCAAGATAACCCTGGAGCAGGCACGTCGCGTCGGCGATCTGGGGCGGATGTCGGAACTGCAGTACGGCAAGATCCC
AGAGTTGGAAAAACAGCTTGCTGCCGCCACGCTGGCCGAAGGCAAAACCATGAAGCTGTTGCGTAACCGGGTGACCGACG
CAGAAATTGCCGAAGTGTTGGCGCGAGCTACCGGTATTCCTGTTGCCAGAATGCTGGAAGGCGAGCGTGACAAGCTGTTG
CGCCTGGAGCAGGAGCTGCATTCTCGGGTGATTGGCCAGGATGAAGCCGTGAGCGCGGTATCTAACGCCATTCGCCGTAG
CCGAGCTGGGCTTTCAGATCCAAACCGTCCAATCGGTTCGTTCCTGTTCCTCGGTCCGACCGGGGTGGGGAAAACCGAAC
TCTGTAAGGCGCTGGCCTCGTTCCTGTTCGACAGTGACGATGCCATGGTGCGTATCGATATGTCCGAGTTTATGGAAAAA
CATTCGGTATCGCGGCTGGTGGGTGCGCCTCCGGGCTATGTCGGGTATGAAGAGGGCGGTTATCTGACCGAGGCGGTACG
TCGTCGACCTTATTCAGTGATCCTGCTGGATGAAGTTGAGAAGGCGCACCCGGATGTATTCAACATTCTGCTGCAGGTCC
TGGACGATGGGCGGCTGACCGATGGTCAGGGACGTACCGTTGATTTCCGTAATACCGTGGTGATCATGACTTCTAACCTG
GGGTCCGATCTGATCCAGGAACACTTCGGTCAGATGAACTACGCGCAGATGAAGGAATCGGTGATGGAAATGGTCACGCA
TCATTTCCGTCCGGAATTCATCAACCGTATAGATGAGGTGGTAGTGTTCCACCCACTCGGCCAGAAACACATTGCCGAGA
TCGCCAAGATTCAGTTGGCGCGTCTGTACAAACGTCTGGAAGAGCGTGGTTACGAAGTCACTATGACCGAACCGGCGTTG
GAGCTACTGGGTAAAACTGGTTTCGACCCTGTGTATGGTGCGCGTCCATTGAAACGCGCTATCCAGCAGGAGATCGAAAA
CCCATTGGCGCAGCAAATCCTTTCCGGCAAGTTGATTCCGGGCAAACTGGTGACGCTGGATGTGGAAGACGAGCACATCG
TCGCTAAACAGTAA

Upstream 100 bases:

>100_bases
TGATGTAGTACCGAAAATATACAGTCGAAATAACCTTGAATTTTTGAGGGATGACCTCATTTAATCTCCAGTAGCAATTT
CGACCCATCTTGGAGGTGTT

Downstream 100 bases:

>100_bases
CGGCTATCTATAGTCATTGCGATAAAAGGGAGCGGGCGACCGCTCCCTTTTCTTTATCTGTTTTCATTGCTCTTAGAGAG
TTTTCTGGGCTAACGGCCTT

Product: protein disaggregation chaperone

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 857; Mature: 857

Protein sequence:

>857_residues
MRLDRLTNKFQLALADAQSLALGRDNQFIEPLHLMSALLNQDGGTVRPLLTSAGIDAGRVRTEIEQALSRQPQVEGTGGD
VQPSHELVRVLNLCDKLAQKRADKFISSELFVLAVLEDRGTLTDLLKAAGATTDKISKAIEQMRGGDSVEEQGAEDQRQA
LKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKHKRVLSL
DMGALIAGAKYRGEFEERLKAVLSDLSKQEGSVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVYVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASS
IRMQMDSKPESLDRLERRIIQLKLEQQALSKESDDASKKRLEMLSGELEQKEREYSELEEEWKAEKASLSGTQNIKAELE
QAKITLEQARRVGDLGRMSELQYGKIPELEKQLAAATLAEGKTMKLLRNRVTDAEIAEVLARATGIPVARMLEGERDKLL
RLEQELHSRVIGQDEAVSAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDSDDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQEHFGQMNYAQMKESVMEMVTHHFRPEFINRIDEVVVFHPLGQKHIAEIAKIQLARLYKRLEERGYEVTMTEPAL
ELLGKTGFDPVYGARPLKRAIQQEIENPLAQQILSGKLIPGKLVTLDVEDEHIVAKQ

Sequences:

>Translated_857_residues
MRLDRLTNKFQLALADAQSLALGRDNQFIEPLHLMSALLNQDGGTVRPLLTSAGIDAGRVRTEIEQALSRQPQVEGTGGD
VQPSHELVRVLNLCDKLAQKRADKFISSELFVLAVLEDRGTLTDLLKAAGATTDKISKAIEQMRGGDSVEEQGAEDQRQA
LKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKHKRVLSL
DMGALIAGAKYRGEFEERLKAVLSDLSKQEGSVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVYVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASS
IRMQMDSKPESLDRLERRIIQLKLEQQALSKESDDASKKRLEMLSGELEQKEREYSELEEEWKAEKASLSGTQNIKAELE
QAKITLEQARRVGDLGRMSELQYGKIPELEKQLAAATLAEGKTMKLLRNRVTDAEIAEVLARATGIPVARMLEGERDKLL
RLEQELHSRVIGQDEAVSAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDSDDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQEHFGQMNYAQMKESVMEMVTHHFRPEFINRIDEVVVFHPLGQKHIAEIAKIQLARLYKRLEERGYEVTMTEPAL
ELLGKTGFDPVYGARPLKRAIQQEIENPLAQQILSGKLIPGKLVTLDVEDEHIVAKQ
>Mature_857_residues
MRLDRLTNKFQLALADAQSLALGRDNQFIEPLHLMSALLNQDGGTVRPLLTSAGIDAGRVRTEIEQALSRQPQVEGTGGD
VQPSHELVRVLNLCDKLAQKRADKFISSELFVLAVLEDRGTLTDLLKAAGATTDKISKAIEQMRGGDSVEEQGAEDQRQA
LKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKHKRVLSL
DMGALIAGAKYRGEFEERLKAVLSDLSKQEGSVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVYVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASS
IRMQMDSKPESLDRLERRIIQLKLEQQALSKESDDASKKRLEMLSGELEQKEREYSELEEEWKAEKASLSGTQNIKAELE
QAKITLEQARRVGDLGRMSELQYGKIPELEKQLAAATLAEGKTMKLLRNRVTDAEIAEVLARATGIPVARMLEGERDKLL
RLEQELHSRVIGQDEAVSAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALASFLFDSDDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQEHFGQMNYAQMKESVMEMVTHHFRPEFINRIDEVVVFHPLGQKHIAEIAKIQLARLYKRLEERGYEVTMTEPAL
ELLGKTGFDPVYGARPLKRAIQQEIENPLAQQILSGKLIPGKLVTLDVEDEHIVAKQ

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=37.1069182389937, Blast_Score=217, Evalue=3e-56,
Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=87.3978996499417, Blast_Score=1536, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=421, Percent_Identity=39.4299287410926, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6320464, Length=705, Percent_Identity=53.6170212765957, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=838, Percent_Identity=43.3174224343675, Blast_Score=686, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95459; Mature: 95459

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDRLTNKFQLALADAQSLALGRDNQFIEPLHLMSALLNQDGGTVRPLLTSAGIDAGRV
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHH
RTEIEQALSRQPQVEGTGGDVQPSHELVRVLNLCDKLAQKRADKFISSELFVLAVLEDRG
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
TLTDLLKAAGATTDKISKAIEQMRGGDSVEEQGAEDQRQALKKYTIDLTERAEQGKLDPV
HHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKHKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHEE
DMGALIAGAKYRGEFEERLKAVLSDLSKQEGSVILFIDELHTMVGAGKADGAMDAGNMLK
CHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCVGATTLDEYRQYIEKDAALERRFQKVYVAEPSVEDTIAILRGLKERYELH
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HHVQITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASSIRMQMDSKPESLDRLERRII
HCEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QLKLEQQALSKESDDASKKRLEMLSGELEQKEREYSELEEEWKAEKASLSGTQNIKAELE
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QAKITLEQARRVGDLGRMSELQYGKIPELEKQLAAATLAEGKTMKLLRNRVTDAEIAEVL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
ARATGIPVARMLEGERDKLLRLEQELHSRVIGQDEAVSAVSNAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALASFLFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
HHHHHHHHCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSDLIQEHFGQMNYAQMKESVMEMVTHHFRPEFINRIDEVVVFHPLGQKHIAEIAKIQLA
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
RLYKRLEERGYEVTMTEPALELLGKTGFDPVYGARPLKRAIQQEIENPLAQQILSGKLIP
HHHHHHHHCCCEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GKLVTLDVEDEHIVAKQ
CEEEEEECCCCCCCCCC
>Mature Secondary Structure
MRLDRLTNKFQLALADAQSLALGRDNQFIEPLHLMSALLNQDGGTVRPLLTSAGIDAGRV
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHH
RTEIEQALSRQPQVEGTGGDVQPSHELVRVLNLCDKLAQKRADKFISSELFVLAVLEDRG
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
TLTDLLKAAGATTDKISKAIEQMRGGDSVEEQGAEDQRQALKKYTIDLTERAEQGKLDPV
HHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKHKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHEE
DMGALIAGAKYRGEFEERLKAVLSDLSKQEGSVILFIDELHTMVGAGKADGAMDAGNMLK
CHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCVGATTLDEYRQYIEKDAALERRFQKVYVAEPSVEDTIAILRGLKERYELH
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HHVQITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASSIRMQMDSKPESLDRLERRII
HCEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QLKLEQQALSKESDDASKKRLEMLSGELEQKEREYSELEEEWKAEKASLSGTQNIKAELE
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QAKITLEQARRVGDLGRMSELQYGKIPELEKQLAAATLAEGKTMKLLRNRVTDAEIAEVL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
ARATGIPVARMLEGERDKLLRLEQELHSRVIGQDEAVSAVSNAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALASFLFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
HHHHHHHHCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSDLIQEHFGQMNYAQMKESVMEMVTHHFRPEFINRIDEVVVFHPLGQKHIAEIAKIQLA
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
RLYKRLEERGYEVTMTEPALELLGKTGFDPVYGARPLKRAIQQEIENPLAQQILSGKLIP
HHHHHHHHCCCEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GKLVTLDVEDEHIVAKQ
CEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]