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The map label for this gene is guaC

Identifier: 157369020

GI number: 157369020

Start: 863949

End: 864992

Strand: Direct

Name: guaC

Synonym: Spro_0775

Alternate gene names: 157369020

Gene position: 863949-864992 (Clockwise)

Preceding gene: 157369016

Following gene: 157369025

Centisome position: 15.86

GC content: 54.69

Gene sequence:

>1044_bases
ATGCGTATTGAAGAAGATTTGAAGTTAGGCTTTAAAGATGTGCTGATTCGCCCTAAGCGCTCCACGCTGAAAAGCCGTTC
AGAAGTTGAACTGGAGCGTCAGTTTACCTTCAAACATTCTGGCCTGAGCTGGTCCGGCGTGCCGATTATCGCCGCCAACA
TGGACTCAGTCGGCACCTTCAGCATGGCAGAGGCCCTGGCTTCCTTCGACGTACTCACCGCCGTACACAAACACTACACC
CTTGAACAATGGGCCGCATTTGTGCAGCGCGTACCGGCATCGGTGCTGCGCCACGTTATGGTTTCAACCGGCACTTCAGA
AGCTGATTTTGTGAAGATGCAGCAAATTCTGGCCTTGTCGCCGGGGTTGAAGTTTATCTGTATCGACGTCGCCAACGGTT
ACTCAGAGCATTTTGTCGCCTTCTTGCAGAAAGCGCGTGAAGCCTGCCCGAACCATGTGATCTGTGCCGGTAACGTAGTC
ACTGGTGAAATGGTTGAAGAGTTGATCCTCTCCGGTGCCGATATCGTCAAAGTGGGTATTGGTCCTGGGTCAGTCTGCAC
CACCCGAGTGAAAACCGGTGTGGGTTATCCGCAGCTGTCTGCGGTGATCGAGTGTGCCGATGCGGCACACGGCCTTGGCG
GTCAGATCGTCAGTGATGGCGGTTGTTCGGTACCGGGTGATGTAGCTAAAGCCTTTGGTGGCGGCGCAGATTTTGTCATG
CTGGGTGGCATGCTGGCCGGTCATGACGAGTGCGAAGGCACAGTAGTGGAAGAGAACGGCGAGAAATTCATGCTGTTCTA
CGGTATGAGTTCCGAATCGGCGATGAAACGTCACGTCGGTGGTGTTGCCCAGTACCGTGCGGCAGAAGGCAAAACCGTCA
AACTGCCACTGCGTGGCGAGGTTGAGTTTACCGTCCGTGATATCCTGGGTGGCCTGCGCTCCGCCTGTACTTATGTCGGT
GCGGAACGTCTGAAAGAGCTGACCAAACGCACCACCTTTATCCGCGTAGCGGAGCAGGAAAACCGCGTATTCGGCAGTAA
CTAA

Upstream 100 bases:

>100_bases
GCGCGTATGATAGCGTCACTGGAACTGGCATTAATCTACCGTCGCCTTTCAAGACATTGCGTTCTGCGATCCGTCGCCAT
AAACCAGGAAATCATAAGTC

Downstream 100 bases:

>100_bases
TCCGGCTCGCTTCAACCTGACCAAACCTTGGGCGCAGTTCAGTGCTGCACTCAAGGTTTTCCAGAACTTACCCCAAAACA
TTCCCCAACTGGAATATCGG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSEVELERQFTFKHSGLSWSGVPIIAANMDSVGTFSMAEALASFDVLTAVHKHYT
LEQWAAFVQRVPASVLRHVMVSTGTSEADFVKMQQILALSPGLKFICIDVANGYSEHFVAFLQKAREACPNHVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGTVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGEVEFTVRDILGGLRSACTYVG
AERLKELTKRTTFIRVAEQENRVFGSN

Sequences:

>Translated_347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSEVELERQFTFKHSGLSWSGVPIIAANMDSVGTFSMAEALASFDVLTAVHKHYT
LEQWAAFVQRVPASVLRHVMVSTGTSEADFVKMQQILALSPGLKFICIDVANGYSEHFVAFLQKAREACPNHVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGTVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGEVEFTVRDILGGLRSACTYVG
AERLKELTKRTTFIRVAEQENRVFGSN
>Mature_347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSEVELERQFTFKHSGLSWSGVPIIAANMDSVGTFSMAEALASFDVLTAVHKHYT
LEQWAAFVQRVPASVLRHVMVSTGTSEADFVKMQQILALSPGLKFICIDVANGYSEHFVAFLQKAREACPNHVICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
LGGMLAGHDECEGTVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGEVEFTVRDILGGLRSACTYVG
AERLKELTKRTTFIRVAEQENRVFGSN

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily

Homologues:

Organism=Homo sapiens, GI50541954, Length=342, Percent_Identity=68.4210526315789, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI50541952, Length=342, Percent_Identity=68.4210526315789, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI50541948, Length=342, Percent_Identity=68.4210526315789, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI50541956, Length=342, Percent_Identity=68.4210526315789, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI156104880, Length=343, Percent_Identity=66.7638483965015, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI66933016, Length=233, Percent_Identity=28.755364806867, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI217035150, Length=233, Percent_Identity=30.0429184549356, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI217035148, Length=233, Percent_Identity=30.0429184549356, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI217035146, Length=233, Percent_Identity=30.0429184549356, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI217035152, Length=233, Percent_Identity=30.0429184549356, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI156616279, Length=233, Percent_Identity=30.0429184549356, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI34328930, Length=233, Percent_Identity=30.0429184549356, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI34328928, Length=233, Percent_Identity=30.0429184549356, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786293, Length=346, Percent_Identity=85.5491329479769, Blast_Score=614, Evalue=1e-177,
Organism=Escherichia coli, GI1788855, Length=226, Percent_Identity=34.5132743362832, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=63.5568513119534, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71994385, Length=218, Percent_Identity=31.1926605504587, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71994389, Length=169, Percent_Identity=36.094674556213, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=31.063829787234, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=30.8016877637131, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6323464, Length=235, Percent_Identity=30.2127659574468, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=35, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641071, Length=235, Percent_Identity=30.6382978723404, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24641073, Length=235, Percent_Identity=30.6382978723404, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28571163, Length=237, Percent_Identity=29.957805907173, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): GUAC_SERP5 (A8G9U1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477009.1
- ProteinModelPortal:   A8G9U1
- SMR:   A8G9U1
- STRING:   A8G9U1
- GeneID:   5604325
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0775
- eggNOG:   COG0516
- HOGENOM:   HBG298985
- OMA:   FRNSKQM
- ProtClustDB:   PRK05096
- BioCyc:   SPRO399741:SPRO_0775-MONOMER
- HAMAP:   MF_00596
- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000235
- TIGRFAMs:   TIGR01305

Pfam domain/function: PF00478 IMPDH

EC number: =1.7.1.7

Molecular weight: Translated: 37301; Mature: 37301

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 186-186

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEEDLKLGFKDVLIRPKRSTLKSRSEVELERQFTFKHSGLSWSGVPIIAANMDSVGTF
CCCCHHHHCCHHHHEECCCHHHHCCHHHHHHHHHEEEEECCCCCCCCEEEEECCCCCCHH
SMAEALASFDVLTAVHKHYTLEQWAAFVQRVPASVLRHVMVSTGTSEADFVKMQQILALS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
PGLKFICIDVANGYSEHFVAFLQKAREACPNHVICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHDECEGTVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGE
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VEFTVRDILGGLRSACTYVGAERLKELTKRTTFIRVAEQENRVFGSN
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure
MRIEEDLKLGFKDVLIRPKRSTLKSRSEVELERQFTFKHSGLSWSGVPIIAANMDSVGTF
CCCCHHHHCCHHHHEECCCHHHHCCHHHHHHHHHEEEEECCCCCCCCEEEEECCCCCCHH
SMAEALASFDVLTAVHKHYTLEQWAAFVQRVPASVLRHVMVSTGTSEADFVKMQQILALS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
PGLKFICIDVANGYSEHFVAFLQKAREACPNHVICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHDECEGTVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGE
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VEFTVRDILGGLRSACTYVGAERLKELTKRTTFIRVAEQENRVFGSN
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA