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The map label for this gene is fruR [H]

Identifier: 157368995

GI number: 157368995

Start: 837280

End: 838284

Strand: Direct

Name: fruR [H]

Synonym: Spro_0750

Alternate gene names: 157368995

Gene position: 837280-838284 (Clockwise)

Preceding gene: 157368994

Following gene: 157368997

Centisome position: 15.37

GC content: 58.51

Gene sequence:

>1005_bases
GTGAAACTGGATGAAATCGCGCGTCTCGCAGGCGTTTCGCGCACCACGGCCAGTTATGTCATCAACGGCAAGGCGAAGCA
GTATCGTGTCAGCGATAAAACCGTCGAAAAAGTGATGGCCGTGGTCAGGGAGCACAACTATCACCCGAATGCCGTCGCGG
CAGGGCTGCGCGCCGGGCGAACTCGTTCAATCGGTCTGGTGATACCGGATCTGGAAAACACCAGCTATACCCGCATCGCC
AATTATCTGGAGCGTCAGGCCCGTCAACGCGGTTACCAGCTGTTGATTGCCTGTTCGGAAGATCAGCCGGATAACGAAAT
GCGCTGTATTGAGCATCTGCTGCAACGCCAGGTCGACGCGTTAATCGTTTCTACCGCCTTGCCGCCGGAGCATCCGTTCT
ATCAGCGCTGGGCCAATGATCCGCTGCCAATTATCGCACTGGATCGGGCGCTGGATCGCGAGCATTTCATCAGTGTGGTC
GGGGCCGACCAAGAGGATTCCTTCGCACTGGCGCAGGAGCTTCGTACCTTCCCGGCAGAGTCGGTACTGTATCTGGGAGC
GTTGCCGGAGCTTTCCGTCAGCTTCCTGCGTGAGCAGGGTTTCCGCGAAGCCTGGCAGGATGACGAACGACCTGTCGATT
ATCTGTATGCCAACAGCTATGAGCGTGAGGCGGCCGGCGTGTTGTTTGCCGAATGGCTGAAAACCCATCCTATGCCCCAG
GCGCTGTTCACTACCTCATTCTCTTTGTTGCAAGGGGTGATGGATGTGACGCTGAAGCAACGTGGCCGTTTGCCGACCGA
TCTGGCCATCGCCACCTTCGGCGATCACGAGCTGTTGGACTTCCTTGAGTGTCCGGTTCTGGCGGTCGCTCAGCGCCACC
GTGACGTGGCCGAGCGGGTGCTTGAACTGGTACTGGCCAGCCTGGATGAGCCGCGTAAACCCAAGCCGGGTCTGACGCGT
ATCCGTCGTAATTTGTTCCGCCGCGGCAGCCTTAGCCGGAAGTAA

Upstream 100 bases:

>100_bases
CTGTTAGATCGCAGAGGCTGGATTGAATAACCGCACAGGATGCGATGGTTAATCCGAGCATGGTTTTCACTTCTATTTTC
AGCGTCATTAAGGGGTTAAC

Downstream 100 bases:

>100_bases
ACCCAAACAGGAGCGCCCCGTTGCGCTCCTGCTTCACACGTAGCCCGCCACCCTGAACAACCTTCTGCAGTATTCCAGAA
AATAGCCATACACCACGCCC

Product: DNA-binding transcriptional regulator FruR

Products: NA

Alternate protein names: Catabolite repressor/activator [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDALIVSTALPPEHPFYQRWANDPLPIIALDRALDREHFISVV
GADQEDSFALAQELRTFPAESVLYLGALPELSVSFLREQGFREAWQDDERPVDYLYANSYEREAAGVLFAEWLKTHPMPQ
ALFTTSFSLLQGVMDVTLKQRGRLPTDLAIATFGDHELLDFLECPVLAVAQRHRDVAERVLELVLASLDEPRKPKPGLTR
IRRNLFRRGSLSRK

Sequences:

>Translated_334_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDALIVSTALPPEHPFYQRWANDPLPIIALDRALDREHFISVV
GADQEDSFALAQELRTFPAESVLYLGALPELSVSFLREQGFREAWQDDERPVDYLYANSYEREAAGVLFAEWLKTHPMPQ
ALFTTSFSLLQGVMDVTLKQRGRLPTDLAIATFGDHELLDFLECPVLAVAQRHRDVAERVLELVLASLDEPRKPKPGLTR
IRRNLFRRGSLSRK
>Mature_334_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDALIVSTALPPEHPFYQRWANDPLPIIALDRALDREHFISVV
GADQEDSFALAQELRTFPAESVLYLGALPELSVSFLREQGFREAWQDDERPVDYLYANSYEREAAGVLFAEWLKTHPMPQ
ALFTTSFSLLQGVMDVTLKQRGRLPTDLAIATFGDHELLDFLECPVLAVAQRHRDVAERVLELVLASLDEPRKPKPGLTR
IRRNLFRRGSLSRK

Specific function: Represses some operons but activates others. It is implicated in the regulation of a large number of operons encoding enzymes which comprise central pathways of carbon metabolism. Binds D-fructose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786268, Length=333, Percent_Identity=89.4894894894895, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1790194, Length=339, Percent_Identity=28.6135693215339, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787580, Length=289, Percent_Identity=22.8373702422145, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787948, Length=335, Percent_Identity=21.7910447761194, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789068, Length=276, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790369, Length=306, Percent_Identity=22.8758169934641, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789202, Length=128, Percent_Identity=32.8125, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788474, Length=278, Percent_Identity=24.8201438848921, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790715, Length=124, Percent_Identity=30.6451612903226, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012781
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37951; Mature: 37951

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGR
CCHHHHHHHHCCCHHHHHHEECCCCCEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LIVSTALPPEHPFYQRWANDPLPIIALDRALDREHFISVVGADQEDSFALAQELRTFPAE
HHHHCCCCCCCCHHHHHCCCCCCEEEHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHCCHH
SVLYLGALPELSVSFLREQGFREAWQDDERPVDYLYANSYEREAAGVLFAEWLKTHPMPQ
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCH
ALFTTSFSLLQGVMDVTLKQRGRLPTDLAIATFGDHELLDFLECPVLAVAQRHRDVAERV
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHH
LELVLASLDEPRKPKPGLTRIRRNLFRRGSLSRK
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGR
CCHHHHHHHHCCCHHHHHHEECCCCCEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LIVSTALPPEHPFYQRWANDPLPIIALDRALDREHFISVVGADQEDSFALAQELRTFPAE
HHHHCCCCCCCCHHHHHCCCCCCEEEHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHCCHH
SVLYLGALPELSVSFLREQGFREAWQDDERPVDYLYANSYEREAAGVLFAEWLKTHPMPQ
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCH
ALFTTSFSLLQGVMDVTLKQRGRLPTDLAIATFGDHELLDFLECPVLAVAQRHRDVAERV
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHH
LELVLASLDEPRKPKPGLTRIRRNLFRRGSLSRK
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]