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The map label for this gene is caiC [C]

Identifier: 157368992

GI number: 157368992

Start: 832725

End: 834533

Strand: Direct

Name: caiC [C]

Synonym: Spro_0747

Alternate gene names: 157368992

Gene position: 832725-834533 (Clockwise)

Preceding gene: 157368991

Following gene: 157368993

Centisome position: 15.28

GC content: 54.56

Gene sequence:

>1809_bases
ATGATCAATAATCTGCTGCAATACCATTTAACTCACCGTATACAGCACCAAATTTCCCAGCGTGCCGATTGCACCGCTTT
TCGCCAATGGTCTCCCAGTGGCGAGAGCCAACTGACCTGGCGACAGGTCGATACGCATATCAACCGCATCGCCAGTGCGC
TGTTGGCTTTGGGTACCGACGTGCAGGAACGTATCGCGATCTTTGCCAATAACTGCATGGCCTGGTCGCTGGCGGATTTG
GCCGTGCTGCGGTTACGTGGGGTCAGCGTACCGCTGTATGCCACCAATACGCCGGCCCAGGCGGCTTTTATCATTAATGA
CGCCGATATCCGCATTTTGTTCGTTGGCGAGCAGGCTCAACTGGACGCCGCCATTGCGTTGCGCGGTGTCTGCCCTCAAC
TGATCCACATTATTGTATTTGATGATGACGCCGATCTGCGTGGCTGTGAGATAGCTCAGCACCTGAGCACCTTTGAGCGC
GCAGCCGATTTGGCGGCGTTTGAATCGCAGTTACAGCAACGCATTGCCGATTGCTGCCTGGAGGATCTGTTCACGCTGAT
TTATACCTCCGGTACCACCGGCGAACCCAAAGGGGTGATGCTGGATTACCGTAACCTGGCGGCACAGCTTTATCTGCACG
ATGGGCGGCTGACGGTAAATGAAGAAGATGTCTCTCTCAGTTTCCTGCCGATGTCGCATGTGTTCGAACGTGCCTGGAGC
TTCTTCATTATGCATTCCGGCGCGCAAAACGTGTTTTTGCCGAATACCGACTGGGTGCGCGAAGCCATGACGGCAGTACG
TCCGACGCTGATGTGTGCGGTACCGCGTTTCTACGAAAAAATCTTCAGTGCGGTGCACGAGAAAGTTGCGCGTGCACCCT
GGTTGCGTCGTGCCCTGTTCCATTGGGCGATTGTCTGTGGTGAACGCAAGTTTTTACAGGAACGTGCCGGCAAACCACTG
GGCAAGCTGTTTGATCTTTCCCACCGCTGGGCCGACAAGCTGGTGCTGAGCAAATTACGCGGCATCCTCGGTGGGCGGGT
GCGCTTCTTGCCGGCCGCCGGTGCCAAACTGGACGACAACGTCATTCTGTTTTTCCAGGCGATGGGCATTAACATCAAAT
ATGGCTATGGCATGACCGAGACCTGCGCCACCGTTTCCTGCTGGGAAGAGGGCAATTTCCGCTTTGGCTCGATTGGTAAG
CCGCTGCCGGGGATAGAGGTGCGTATTGGCGAGGAAAGCGAAATTCAGGTGCGTGGCCCGGTGGTGATGCGCGGTTATTT
CAATAAGCCGCTGGAAACCGCCGCCTCCTTTACTGCAGATGGCTGGTTGAAGACCGGCGACGCCGGTGCCATAGATGAAG
GCGGAAATCTGTTTATCACCGAGCGTCTTAAGGATCTGATGAAAACCTCCGGCGGCAAGTACATTGCCCCGCAGATGCTT
GAAGGCACGCTGGCGCAAGACCGCTTTATCGAACAGGTGGCAATCATCGCGGATGCCCGCAAATTTGTCTCCGCCTTGAT
TGTGCCCAGTTTTGAGTCGCTGGAAGAATATGCCAAGTCCATCAACCTGAAATATCAGGATCGGCTTGAACTGCTGCGCC
ATAGCCATATTCTGGAAATGTTCGAAAGCCGTCTGCGTGAGATGCAAAAAGAGTTGGCGCGGTTCGAACAGGTGAAGAAA
TTTACCCTGTTGCCGGCGGCCTTTTCGATGGAGTTGGGTGAGCTGACGCCAACGCTAAAACTGCGCCGTAAGGTGATTAT
GCAGCGCTACCAGAGTGAAATTGACTCGATGTACCAGGATAAGACTTAA

Upstream 100 bases:

>100_bases
GTAGACTGCGCGAAAAAAAGTAAACACGTGTAAGCTGAGACGCAGAGCCAGATGTCCTGCTCAACGCTAACTGTTTGATT
CATTTCAGGCTCAGGGCGCT

Downstream 100 bases:

>100_bases
TCCTGTTGCCGGGGCAGATTATCCGGTTAAAAAATCAGCATCGTTCTTGCCTGATATAGTTCTGTAATTCTCTGCCTGAC
TGAAACAATGCCTAGCCCGA

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MINNLLQYHLTHRIQHQISQRADCTAFRQWSPSGESQLTWRQVDTHINRIASALLALGTDVQERIAIFANNCMAWSLADL
AVLRLRGVSVPLYATNTPAQAAFIINDADIRILFVGEQAQLDAAIALRGVCPQLIHIIVFDDDADLRGCEIAQHLSTFER
AADLAAFESQLQQRIADCCLEDLFTLIYTSGTTGEPKGVMLDYRNLAAQLYLHDGRLTVNEEDVSLSFLPMSHVFERAWS
FFIMHSGAQNVFLPNTDWVREAMTAVRPTLMCAVPRFYEKIFSAVHEKVARAPWLRRALFHWAIVCGERKFLQERAGKPL
GKLFDLSHRWADKLVLSKLRGILGGRVRFLPAAGAKLDDNVILFFQAMGINIKYGYGMTETCATVSCWEEGNFRFGSIGK
PLPGIEVRIGEESEIQVRGPVVMRGYFNKPLETAASFTADGWLKTGDAGAIDEGGNLFITERLKDLMKTSGGKYIAPQML
EGTLAQDRFIEQVAIIADARKFVSALIVPSFESLEEYAKSINLKYQDRLELLRHSHILEMFESRLREMQKELARFEQVKK
FTLLPAAFSMELGELTPTLKLRRKVIMQRYQSEIDSMYQDKT

Sequences:

>Translated_602_residues
MINNLLQYHLTHRIQHQISQRADCTAFRQWSPSGESQLTWRQVDTHINRIASALLALGTDVQERIAIFANNCMAWSLADL
AVLRLRGVSVPLYATNTPAQAAFIINDADIRILFVGEQAQLDAAIALRGVCPQLIHIIVFDDDADLRGCEIAQHLSTFER
AADLAAFESQLQQRIADCCLEDLFTLIYTSGTTGEPKGVMLDYRNLAAQLYLHDGRLTVNEEDVSLSFLPMSHVFERAWS
FFIMHSGAQNVFLPNTDWVREAMTAVRPTLMCAVPRFYEKIFSAVHEKVARAPWLRRALFHWAIVCGERKFLQERAGKPL
GKLFDLSHRWADKLVLSKLRGILGGRVRFLPAAGAKLDDNVILFFQAMGINIKYGYGMTETCATVSCWEEGNFRFGSIGK
PLPGIEVRIGEESEIQVRGPVVMRGYFNKPLETAASFTADGWLKTGDAGAIDEGGNLFITERLKDLMKTSGGKYIAPQML
EGTLAQDRFIEQVAIIADARKFVSALIVPSFESLEEYAKSINLKYQDRLELLRHSHILEMFESRLREMQKELARFEQVKK
FTLLPAAFSMELGELTPTLKLRRKVIMQRYQSEIDSMYQDKT
>Mature_602_residues
MINNLLQYHLTHRIQHQISQRADCTAFRQWSPSGESQLTWRQVDTHINRIASALLALGTDVQERIAIFANNCMAWSLADL
AVLRLRGVSVPLYATNTPAQAAFIINDADIRILFVGEQAQLDAAIALRGVCPQLIHIIVFDDDADLRGCEIAQHLSTFER
AADLAAFESQLQQRIADCCLEDLFTLIYTSGTTGEPKGVMLDYRNLAAQLYLHDGRLTVNEEDVSLSFLPMSHVFERAWS
FFIMHSGAQNVFLPNTDWVREAMTAVRPTLMCAVPRFYEKIFSAVHEKVARAPWLRRALFHWAIVCGERKFLQERAGKPL
GKLFDLSHRWADKLVLSKLRGILGGRVRFLPAAGAKLDDNVILFFQAMGINIKYGYGMTETCATVSCWEEGNFRFGSIGK
PLPGIEVRIGEESEIQVRGPVVMRGYFNKPLETAASFTADGWLKTGDAGAIDEGGNLFITERLKDLMKTSGGKYIAPQML
EGTLAQDRFIEQVAIIADARKFVSALIVPSFESLEEYAKSINLKYQDRLELLRHSHILEMFESRLREMQKELARFEQVKK
FTLLPAAFSMELGELTPTLKLRRKVIMQRYQSEIDSMYQDKT

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794760, Length=610, Percent_Identity=30, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI42794758, Length=610, Percent_Identity=30, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI42794756, Length=610, Percent_Identity=30, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI40807491, Length=611, Percent_Identity=29.6235679214403, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI57165412, Length=618, Percent_Identity=30.5825242718447, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI57165410, Length=618, Percent_Identity=30.42071197411, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI27477105, Length=589, Percent_Identity=27.6740237691002, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI83745141, Length=606, Percent_Identity=25.5775577557756, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI42794754, Length=609, Percent_Identity=26.7651888341544, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI42794752, Length=609, Percent_Identity=26.7651888341544, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4758332, Length=604, Percent_Identity=25.6622516556291, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI12669909, Length=604, Percent_Identity=25.6622516556291, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI145693145, Length=480, Percent_Identity=25, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788107, Length=134, Percent_Identity=33.5820895522388, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789201, Length=336, Percent_Identity=24.4047619047619, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17541856, Length=593, Percent_Identity=30.185497470489, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17556552, Length=615, Percent_Identity=27.3170731707317, Blast_Score=218, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17510401, Length=602, Percent_Identity=28.0730897009967, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17553312, Length=608, Percent_Identity=27.1381578947368, Blast_Score=212, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI25147511, Length=614, Percent_Identity=26.8729641693811, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI193204819, Length=614, Percent_Identity=26.3843648208469, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17564090, Length=540, Percent_Identity=25.1851851851852, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17558820, Length=498, Percent_Identity=24.6987951807229, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559526, Length=374, Percent_Identity=28.6096256684492, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=227, Percent_Identity=32.5991189427313, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17557194, Length=488, Percent_Identity=25, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI133901848, Length=206, Percent_Identity=29.6116504854369, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=394, Percent_Identity=24.1116751269036, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=165, Percent_Identity=30.3030303030303, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324893, Length=450, Percent_Identity=26.6666666666667, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6320852, Length=612, Percent_Identity=24.0196078431373, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322182, Length=447, Percent_Identity=24.8322147651007, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6323903, Length=448, Percent_Identity=24.1071428571429, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281366413, Length=623, Percent_Identity=27.4478330658106, Blast_Score=231, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24666501, Length=623, Percent_Identity=27.4478330658106, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24666497, Length=623, Percent_Identity=27.4478330658106, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17933690, Length=627, Percent_Identity=25.6778309409888, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI19921316, Length=632, Percent_Identity=25.4746835443038, Blast_Score=186, Evalue=6e-47,
Organism=Drosophila melanogaster, GI62471681, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI62471687, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24586634, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI22026970, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI62471689, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI62471679, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI62471683, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI62471685, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24586636, Length=624, Percent_Identity=27.2435897435897, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355181, Length=477, Percent_Identity=24.3186582809224, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI18859661, Length=370, Percent_Identity=25.9459459459459, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24648260, Length=152, Percent_Identity=32.8947368421053, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24653035, Length=193, Percent_Identity=30.0518134715026, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI161076582, Length=133, Percent_Identity=33.8345864661654, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 68070; Mature: 68070

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNLLQYHLTHRIQHQISQRADCTAFRQWSPSGESQLTWRQVDTHINRIASALLALGTD
CCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
VQERIAIFANNCMAWSLADLAVLRLRGVSVPLYATNTPAQAAFIINDADIRILFVGEQAQ
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEEEECCHHH
LDAAIALRGVCPQLIHIIVFDDDADLRGCEIAQHLSTFERAADLAAFESQLQQRIADCCL
HHHHHHHHHCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDLFTLIYTSGTTGEPKGVMLDYRNLAAQLYLHDGRLTVNEEDVSLSFLPMSHVFERAWS
HHHHHHHCCCCCCCCCCCEEEEHHHHEEEEEEECCEEEECCCCCEEEEECHHHHHHHHHH
FFIMHSGAQNVFLPNTDWVREAMTAVRPTLMCAVPRFYEKIFSAVHEKVARAPWLRRALF
HHEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
HWAIVCGERKFLQERAGKPLGKLFDLSHRWADKLVLSKLRGILGGRVRFLPAAGAKLDDN
HHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
VILFFQAMGINIKYGYGMTETCATVSCWEEGNFRFGSIGKPLPGIEVRIGEESEIQVRGP
EEEEEEEECCEEEECCCCHHHHHEEEEECCCCEEECCCCCCCCCCEEEECCCCCEEEECC
VVMRGYFNKPLETAASFTADGWLKTGDAGAIDEGGNLFITERLKDLMKTSGGKYIAPQML
EEEECCCCCCHHHHHCCCCCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECHHHH
EGTLAQDRFIEQVAIIADARKFVSALIVPSFESLEEYAKSINLKYQDRLELLRHSHILEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FESRLREMQKELARFEQVKKFTLLPAAFSMELGELTPTLKLRRKVIMQRYQSEIDSMYQD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
KT
CC
>Mature Secondary Structure
MINNLLQYHLTHRIQHQISQRADCTAFRQWSPSGESQLTWRQVDTHINRIASALLALGTD
CCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
VQERIAIFANNCMAWSLADLAVLRLRGVSVPLYATNTPAQAAFIINDADIRILFVGEQAQ
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEEEECCHHH
LDAAIALRGVCPQLIHIIVFDDDADLRGCEIAQHLSTFERAADLAAFESQLQQRIADCCL
HHHHHHHHHCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDLFTLIYTSGTTGEPKGVMLDYRNLAAQLYLHDGRLTVNEEDVSLSFLPMSHVFERAWS
HHHHHHHCCCCCCCCCCCEEEEHHHHEEEEEEECCEEEECCCCCEEEEECHHHHHHHHHH
FFIMHSGAQNVFLPNTDWVREAMTAVRPTLMCAVPRFYEKIFSAVHEKVARAPWLRRALF
HHEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
HWAIVCGERKFLQERAGKPLGKLFDLSHRWADKLVLSKLRGILGGRVRFLPAAGAKLDDN
HHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
VILFFQAMGINIKYGYGMTETCATVSCWEEGNFRFGSIGKPLPGIEVRIGEESEIQVRGP
EEEEEEEECCEEEECCCCHHHHHEEEEECCCCEEECCCCCCCCCCEEEECCCCCEEEECC
VVMRGYFNKPLETAASFTADGWLKTGDAGAIDEGGNLFITERLKDLMKTSGGKYIAPQML
EEEECCCCCCHHHHHCCCCCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECHHHH
EGTLAQDRFIEQVAIIADARKFVSALIVPSFESLEEYAKSINLKYQDRLELLRHSHILEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FESRLREMQKELARFEQVKKFTLLPAAFSMELGELTPTLKLRRKVIMQRYQSEIDSMYQD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
KT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]