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The map label for this gene is msrA

Identifier: 157368705

GI number: 157368705

Start: 506868

End: 507509

Strand: Reverse

Name: msrA

Synonym: Spro_0458

Alternate gene names: 157368705

Gene position: 507509-506868 (Counterclockwise)

Preceding gene: 157368709

Following gene: 157368704

Centisome position: 9.31

GC content: 58.26

Gene sequence:

>642_bases
GTGGTGCCATTTTTTGATAAAACACAAACTGTCGACCAGGCAAACGCATTACCTGGCCGCACCACTCCCATGCCGGTTGC
CACGCTTAACGTGGTCACCGATCACTCAATGACCCAAGTGCCGGACGGCCTGGAAGTAGCGATCTTCGCCATGGGGTGTT
TCTGGGGAGTGGAACGCCTGTTCTGGCAGCAGCAAGGGGTTTACAGCACCGCAGCAGGCTACAGCGGTGGCTATACGCCA
AACCCGACCTACCGCGAAGTATGCAGCGGCCAAACGGGCCACACGGAAGTGGTACGAGTGGTATTCGATCCGAAAATCAT
CAGCTACAAACAGTTGCTGCAGGTATTCTGGGAGAACCACGATCCGGCGCAGGGCATGCGTCAGGGCGGCGACGTCGGTA
CCCAGTATCGCTCGGCGATTTATACGCTGACGCCGGAGCAGCAGACCGAAGCGGAAAGCAGCCTGCAGCGTTTCCAACAG
GCGATGGAGCAGGCCGGCGATAAACGCGCCATCACCACCGAGGTCGCACCGGCCCTGCCGTTCTACTATGCCGAGGACGA
CCACCAGCAGTACCTGTACAAAAACCCTGAAGGATACTGTGGTCTGGGTGGTATCGGTGTTTGCTTGCCACCACAGGGCT
AA

Upstream 100 bases:

>100_bases
ATAATCTCAATATGTAGCTTATTGTGGGCAAAGTTGCGGCTAGATACAACTTAACTGCCGCCTCTTGGGCCAATTCTTAC
TGTGACAACAGGAGTCAACC

Downstream 100 bases:

>100_bases
GCCGCAGGTTGGAGGTAATTTTTTAACCGCTGGCGGCCCCGGTAGGGCTGCTGCTATACTGTGCGGGCCGGATCATCGGC
CCGATAACCTTCTTTCTGGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MVPFFDKTQTVDQANALPGRTTPMPVATLNVVTDHSMTQVPDGLEVAIFAMGCFWGVERLFWQQQGVYSTAAGYSGGYTP
NPTYREVCSGQTGHTEVVRVVFDPKIISYKQLLQVFWENHDPAQGMRQGGDVGTQYRSAIYTLTPEQQTEAESSLQRFQQ
AMEQAGDKRAITTEVAPALPFYYAEDDHQQYLYKNPEGYCGLGGIGVCLPPQG

Sequences:

>Translated_213_residues
MVPFFDKTQTVDQANALPGRTTPMPVATLNVVTDHSMTQVPDGLEVAIFAMGCFWGVERLFWQQQGVYSTAAGYSGGYTP
NPTYREVCSGQTGHTEVVRVVFDPKIISYKQLLQVFWENHDPAQGMRQGGDVGTQYRSAIYTLTPEQQTEAESSLQRFQQ
AMEQAGDKRAITTEVAPALPFYYAEDDHQQYLYKNPEGYCGLGGIGVCLPPQG
>Mature_213_residues
MVPFFDKTQTVDQANALPGRTTPMPVATLNVVTDHSMTQVPDGLEVAIFAMGCFWGVERLFWQQQGVYSTAAGYSGGYTP
NPTYREVCSGQTGHTEVVRVVFDPKIISYKQLLQVFWENHDPAQGMRQGGDVGTQYRSAIYTLTPEQQTEAESSLQRFQQ
AMEQAGDKRAITTEVAPALPFYYAEDDHQQYLYKNPEGYCGLGGIGVCLPPQG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=204, Percent_Identity=54.9019607843137, Blast_Score=231, Evalue=3e-61,
Organism=Homo sapiens, GI208609995, Length=181, Percent_Identity=56.9060773480663, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI208609993, Length=204, Percent_Identity=41.1764705882353, Blast_Score=147, Evalue=6e-36,
Organism=Escherichia coli, GI1790665, Length=210, Percent_Identity=76.6666666666667, Blast_Score=327, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17533973, Length=154, Percent_Identity=38.3116883116883, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=169, Percent_Identity=32.5443786982249, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=40, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=39.7163120567376, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=38.6206896551724, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_SERP5 (A8G8X6)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476694.1
- ProteinModelPortal:   A8G8X6
- SMR:   A8G8X6
- STRING:   A8G8X6
- GeneID:   5603268
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0458
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   SAIYCTT
- ProtClustDB:   PRK00058
- BioCyc:   SPRO399741:SPRO_0458-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23590; Mature: 23590

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: ACT_SITE 53-53

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPFFDKTQTVDQANALPGRTTPMPVATLNVVTDHSMTQVPDGLEVAIFAMGCFWGVERL
CCCCCCCCCCHHHHCCCCCCCCCCCEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHH
FWQQQGVYSTAAGYSGGYTPNPTYREVCSGQTGHTEVVRVVFDPKIISYKQLLQVFWENH
HHHHCCCEECCCCCCCCCCCCCCHHHHHCCCCCCHHEEEEEECCCHHHHHHHHHHHHCCC
DPAQGMRQGGDVGTQYRSAIYTLTPEQQTEAESSLQRFQQAMEQAGDKRAITTEVAPALP
CHHHHHHCCCCCCHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCC
FYYAEDDHQQYLYKNPEGYCGLGGIGVCLPPQG
EEECCCCCHHHHHCCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure
MVPFFDKTQTVDQANALPGRTTPMPVATLNVVTDHSMTQVPDGLEVAIFAMGCFWGVERL
CCCCCCCCCCHHHHCCCCCCCCCCCEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHH
FWQQQGVYSTAAGYSGGYTPNPTYREVCSGQTGHTEVVRVVFDPKIISYKQLLQVFWENH
HHHHCCCEECCCCCCCCCCCCCCHHHHHCCCCCCHHEEEEEECCCHHHHHHHHHHHHCCC
DPAQGMRQGGDVGTQYRSAIYTLTPEQQTEAESSLQRFQQAMEQAGDKRAITTEVAPALP
CHHHHHHCCCCCCHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCC
FYYAEDDHQQYLYKNPEGYCGLGGIGVCLPPQG
EEECCCCCHHHHHCCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA