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The map label for this gene is lip2 [H]

Identifier: 157368620

GI number: 157368620

Start: 420594

End: 421613

Strand: Reverse

Name: lip2 [H]

Synonym: Spro_0373

Alternate gene names: 157368620

Gene position: 421613-420594 (Counterclockwise)

Preceding gene: 157368626

Following gene: 157368610

Centisome position: 7.74

GC content: 53.63

Gene sequence:

>1020_bases
ATGAAAACCGTATCAGCTGTCCTGACTTCTGCTCTTTTCACATCCGCCACCGCCGTGGCTTCCGAACAACCAGTCAACCT
TCCTGCTCCCACAGCCGGAGTGCAGGCATTTCTTAACGTACTGAACTCCGGTAGCGGCAAACCTATGGAACAACTGACCC
CGCAGGAAGCCCGTCAGGTACTGATTGGTGCACAGAAGGGCGTTACGCTGCCATCTGCGCAGGTTTCAGAAAAAATCATT
ACGGTGAACGGGCAACCAATAAAACTGAAAATCGTGAAACCGGACAACACAGCCGGCACACTTCCTGTGTTCATGTTCTT
CCATGGTGGTGGCTGGGTACTGGGAGATTTCCCGACTCATGAACGTCTCATCCGGGACCTGGTTCGCTCATCCGGCGCTG
CTGCGGTATATGTGGATTACACTCCGTCACCGGAGGCCCACTTCCCTGTCGCGATTCACCAGGCGTATGAGGCAACTAAG
TGGGTGGCTGAACACGGTCAGGAAATTGGCGTGGATGGCAGCCGTCTGGGCCTGGTCGGTAACAGCGTCGGCGGGAATAT
GGTGGCCTCTGTGGCGCTGCAGGCTAAACAGTTTAACGGACCGAAGATCCGTTATAACGTAATGCTGTGGCCAGTAACTG
ATGCGAATTTTGACAATGCATCCTACAACCGCTACGAAAACGGCTATTTCCTTACGAAAAACATGATGGAATGGTTCTGG
GATAACTACACCACTAACGCGTCAGACCGTAATAATATTCTAGCTTCGCCACTGCGGGCCACCACGGAACAGCTGAAAGG
GTTCCCGCAAACCTTAATCCAGACAGCGGAACTGGATGTTCTACGCGACGAAGGTGAAGCGTTCGGCCGCAAGCTGGATG
CCGCCGGCGTACCTGTGACAGTGACACGCTACAACGGTATGATCCATGACTATGGGCTGCTGAACCCGTTAAGTCAGGAG
CCCACCGTCAAAACTGCGCTGGAGCAGGCGGCTTCAGCATTGCATGAGCATCTGAAATAA

Upstream 100 bases:

>100_bases
AGAATATTGCGTGCAAGTATTATTCATGCAATATAAATGCCGGGAACAACCGGCGCTCAACTGAATAATACAATCAACAT
ACATCTAACGAGGCTTAATC

Downstream 100 bases:

>100_bases
TATTCGTATAGTTTTCAAACAGCGCGGCCAGAGGTCACGCTGCTTTGTATGAGTCTGGTTTGCACCTGTGCTAATTCCAG
GCGAGAAAGTCTTAGTCAAC

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKTVSAVLTSALFTSATAVASEQPVNLPAPTAGVQAFLNVLNSGSGKPMEQLTPQEARQVLIGAQKGVTLPSAQVSEKII
TVNGQPIKLKIVKPDNTAGTLPVFMFFHGGGWVLGDFPTHERLIRDLVRSSGAAAVYVDYTPSPEAHFPVAIHQAYEATK
WVAEHGQEIGVDGSRLGLVGNSVGGNMVASVALQAKQFNGPKIRYNVMLWPVTDANFDNASYNRYENGYFLTKNMMEWFW
DNYTTNASDRNNILASPLRATTEQLKGFPQTLIQTAELDVLRDEGEAFGRKLDAAGVPVTVTRYNGMIHDYGLLNPLSQE
PTVKTALEQAASALHEHLK

Sequences:

>Translated_339_residues
MKTVSAVLTSALFTSATAVASEQPVNLPAPTAGVQAFLNVLNSGSGKPMEQLTPQEARQVLIGAQKGVTLPSAQVSEKII
TVNGQPIKLKIVKPDNTAGTLPVFMFFHGGGWVLGDFPTHERLIRDLVRSSGAAAVYVDYTPSPEAHFPVAIHQAYEATK
WVAEHGQEIGVDGSRLGLVGNSVGGNMVASVALQAKQFNGPKIRYNVMLWPVTDANFDNASYNRYENGYFLTKNMMEWFW
DNYTTNASDRNNILASPLRATTEQLKGFPQTLIQTAELDVLRDEGEAFGRKLDAAGVPVTVTRYNGMIHDYGLLNPLSQE
PTVKTALEQAASALHEHLK
>Mature_339_residues
MKTVSAVLTSALFTSATAVASEQPVNLPAPTAGVQAFLNVLNSGSGKPMEQLTPQEARQVLIGAQKGVTLPSAQVSEKII
TVNGQPIKLKIVKPDNTAGTLPVFMFFHGGGWVLGDFPTHERLIRDLVRSSGAAAVYVDYTPSPEAHFPVAIHQAYEATK
WVAEHGQEIGVDGSRLGLVGNSVGGNMVASVALQAKQFNGPKIRYNVMLWPVTDANFDNASYNRYENGYFLTKNMMEWFW
DNYTTNASDRNNILASPLRATTEQLKGFPQTLIQTAELDVLRDEGEAFGRKLDAAGVPVTVTRYNGMIHDYGLLNPLSQE
PTVKTALEQAASALHEHLK

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=136, Percent_Identity=31.6176470588235, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI68299767, Length=276, Percent_Identity=24.6376811594203, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI68051721, Length=152, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786682, Length=230, Percent_Identity=28.695652173913, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17567059, Length=304, Percent_Identity=25.3289473684211, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=166, Percent_Identity=29.5180722891566, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 36782; Mature: 36782

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVSAVLTSALFTSATAVASEQPVNLPAPTAGVQAFLNVLNSGSGKPMEQLTPQEARQV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LIGAQKGVTLPSAQVSEKIITVNGQPIKLKIVKPDNTAGTLPVFMFFHGGGWVLGDFPTH
HHCCCCCCCCCCHHHCCEEEEECCCEEEEEEECCCCCCCCCEEEEEEECCCEEECCCCCH
ERLIRDLVRSSGAAAVYVDYTPSPEAHFPVAIHQAYEATKWVAEHGQEIGVDGSRLGLVG
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
NSVGGNMVASVALQAKQFNGPKIRYNVMLWPVTDANFDNASYNRYENGYFLTKNMMEWFW
CCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHH
DNYTTNASDRNNILASPLRATTEQLKGFPQTLIQTAELDVLRDEGEAFGRKLDAAGVPVT
CCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCEE
VTRYNGMIHDYGLLNPLSQEPTVKTALEQAASALHEHLK
EEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTVSAVLTSALFTSATAVASEQPVNLPAPTAGVQAFLNVLNSGSGKPMEQLTPQEARQV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LIGAQKGVTLPSAQVSEKIITVNGQPIKLKIVKPDNTAGTLPVFMFFHGGGWVLGDFPTH
HHCCCCCCCCCCHHHCCEEEEECCCEEEEEEECCCCCCCCCEEEEEEECCCEEECCCCCH
ERLIRDLVRSSGAAAVYVDYTPSPEAHFPVAIHQAYEATKWVAEHGQEIGVDGSRLGLVG
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
NSVGGNMVASVALQAKQFNGPKIRYNVMLWPVTDANFDNASYNRYENGYFLTKNMMEWFW
CCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHH
DNYTTNASDRNNILASPLRATTEQLKGFPQTLIQTAELDVLRDEGEAFGRKLDAAGVPVT
CCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCEE
VTRYNGMIHDYGLLNPLSQEPTVKTALEQAASALHEHLK
EEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]