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The map label for this gene is metR [H]

Identifier: 157368490

GI number: 157368490

Start: 269766

End: 270716

Strand: Reverse

Name: metR [H]

Synonym: Spro_0241

Alternate gene names: 157368490

Gene position: 270716-269766 (Counterclockwise)

Preceding gene: 157368492

Following gene: 157368488

Centisome position: 4.97

GC content: 58.68

Gene sequence:

>951_bases
ATGATCGAACTGAAACACTTACGGACGCTGCAGGCTCTGCGCAATACCGGTTCGCTGGCGGCCGCGGCTGCCCAACTCCA
TCAGACGCAGTCTGCTCTTTCGCATCAGTTCAGCGATCTGGAGCAGCGCCTGGGCTTCAAGCTGTTCGTTCGTAAAAGCC
AACCGCTGCGCTTTACCGCGCAGGGAGAGATCCTGTTACAGCTGGCAGAGCAGGTTCTGCCGCAAATTCAGCAGGCATTG
CAAACGTGCCACGAACCGCATCAGGCCACGCTGCGTATCGCCATTGAATGCCACAGCTGTATTCAATGGCTGACACCGGC
GCTGGATAACTTCCGTCAGAGTTGGCCGCAGGTGGTGATGGACTTTAAGTCCGGCGTCACCTTTGATCCGCAACCGGCCT
TACAGCAAGGCGAGCTGGATCTGGTGCTGACTTCCGATATTCTGCCGCGCAGCGGTCTGCATTATTCACCGATGTTTGAT
TTTGAAGTGCGACTGGTGCTGGCGCCGGATCACCCGTTGGCCAGCAAACTGCACATTGAACCCGAAGATTTGATCGATGA
AACGCTGATGATTTATCCGGTACAGCGTCAACGGCTGGATATCTGGCGTCATTTCCTGCAGCCGGCGGGCATCAGCCCGG
CGCTGAAAAACGTCGATAACACCCTGCTACTGATCCAGATGGTGTCGGCGCGGATGGGGATTGCGGCGTTACCGCATTGG
GTGGTGGAGAGTTTTGAGCGCCAGGGGTTGGTGGTGACCAAAACCCTGGGCGATGGCCTGTGGAGCCGTCTGTATGCCGC
AGTTCGCGATGGTGAGCAGCGTCAGGCGGTAACCGAAGCCTTTATCCGTTCGGCACGCCAGCACGCCTGCAATCATCTGC
CGTTCGTCCGGGACGCCGCCCGCCCAAGCGCCGGTGTTGCCAGCGTCAAACCGCTGGCCTCGCAACCCTGA

Upstream 100 bases:

>100_bases
TATTCCCCATTTAGCCGTCCAGATGTTTACACATCCATAATCCGCAGGTACTGTATTAACCACAAGCGCAATTTATTCAC
TGTCACTGTGAAGGACTCTC

Downstream 100 bases:

>100_bases
CGACCAGGGCTGCCTGCGCTTGGGCAGCCCGGTTTATTTACTGATTATTTTGGGTGCCACCCAACGGCGATGTACCCACA
GCGAAGCAACAATCACCGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MIELKHLRTLQALRNTGSLAAAAAQLHQTQSALSHQFSDLEQRLGFKLFVRKSQPLRFTAQGEILLQLAEQVLPQIQQAL
QTCHEPHQATLRIAIECHSCIQWLTPALDNFRQSWPQVVMDFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFD
FEVRLVLAPDHPLASKLHIEPEDLIDETLMIYPVQRQRLDIWRHFLQPAGISPALKNVDNTLLLIQMVSARMGIAALPHW
VVESFERQGLVVTKTLGDGLWSRLYAAVRDGEQRQAVTEAFIRSARQHACNHLPFVRDAARPSAGVASVKPLASQP

Sequences:

>Translated_316_residues
MIELKHLRTLQALRNTGSLAAAAAQLHQTQSALSHQFSDLEQRLGFKLFVRKSQPLRFTAQGEILLQLAEQVLPQIQQAL
QTCHEPHQATLRIAIECHSCIQWLTPALDNFRQSWPQVVMDFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFD
FEVRLVLAPDHPLASKLHIEPEDLIDETLMIYPVQRQRLDIWRHFLQPAGISPALKNVDNTLLLIQMVSARMGIAALPHW
VVESFERQGLVVTKTLGDGLWSRLYAAVRDGEQRQAVTEAFIRSARQHACNHLPFVRDAARPSAGVASVKPLASQP
>Mature_316_residues
MIELKHLRTLQALRNTGSLAAAAAQLHQTQSALSHQFSDLEQRLGFKLFVRKSQPLRFTAQGEILLQLAEQVLPQIQQAL
QTCHEPHQATLRIAIECHSCIQWLTPALDNFRQSWPQVVMDFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFD
FEVRLVLAPDHPLASKLHIEPEDLIDETLMIYPVQRQRLDIWRHFLQPAGISPALKNVDNTLLLIQMVSARMGIAALPHW
VVESFERQGLVVTKTLGDGLWSRLYAAVRDGEQRQAVTEAFIRSARQHACNHLPFVRDAARPSAGVASVKPLASQP

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=311, Percent_Identity=84.887459807074, Blast_Score=552, Evalue=1e-159,
Organism=Escherichia coli, GI1788887, Length=285, Percent_Identity=27.3684210526316, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082024, Length=269, Percent_Identity=28.996282527881, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI157672245, Length=239, Percent_Identity=25.5230125523013, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787879, Length=254, Percent_Identity=27.5590551181102, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87081904, Length=177, Percent_Identity=29.9435028248588, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786401, Length=160, Percent_Identity=27.5, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786448, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789204, Length=264, Percent_Identity=26.5151515151515, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787530, Length=224, Percent_Identity=25.4464285714286, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789506, Length=181, Percent_Identity=23.7569060773481, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788706, Length=170, Percent_Identity=26.4705882352941, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=251, Percent_Identity=21.9123505976096, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789492, Length=264, Percent_Identity=27.6515151515151, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI145693105, Length=240, Percent_Identity=22.0833333333333, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35492; Mature: 35492

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELKHLRTLQALRNTGSLAAAAAQLHQTQSALSHQFSDLEQRLGFKLFVRKSQPLRFTA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEC
QGEILLQLAEQVLPQIQQALQTCHEPHQATLRIAIECHSCIQWLTPALDNFRQSWPQVVM
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFDFEVRLVLAPDHPLASKLHIE
HHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEECCC
PEDLIDETLMIYPVQRQRLDIWRHFLQPAGISPALKNVDNTLLLIQMVSARMGIAALPHW
HHHHHCCHHEEECCHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VVESFERQGLVVTKTLGDGLWSRLYAAVRDGEQRQAVTEAFIRSARQHACNHLPFVRDAA
HHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
RPSAGVASVKPLASQP
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIELKHLRTLQALRNTGSLAAAAAQLHQTQSALSHQFSDLEQRLGFKLFVRKSQPLRFTA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEC
QGEILLQLAEQVLPQIQQALQTCHEPHQATLRIAIECHSCIQWLTPALDNFRQSWPQVVM
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFKSGVTFDPQPALQQGELDLVLTSDILPRSGLHYSPMFDFEVRLVLAPDHPLASKLHIE
HHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEECCC
PEDLIDETLMIYPVQRQRLDIWRHFLQPAGISPALKNVDNTLLLIQMVSARMGIAALPHW
HHHHHCCHHEEECCHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VVESFERQGLVVTKTLGDGLWSRLYAAVRDGEQRQAVTEAFIRSARQHACNHLPFVRDAA
HHHHHHHCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
RPSAGVASVKPLASQP
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]