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The map label for this gene is wecA [H]

Identifier: 157368410

GI number: 157368410

Start: 182166

End: 183248

Strand: Direct

Name: wecA [H]

Synonym: Spro_0161

Alternate gene names: 157368410

Gene position: 182166-183248 (Clockwise)

Preceding gene: 157368409

Following gene: 157368411

Centisome position: 3.34

GC content: 51.62

Gene sequence:

>1083_bases
ATGAGTACTGAAATTCTATTTGTTTTCCTGTTTTCTTTGGCTTTTCTCTTTGTTGCCCGTAAAGCAGCAAAACGTATTGG
TCTGGTTGATAAACCTAATTACCGTAAACGCCATCAGGGGCTGATCCCTCTGGTCGGAGGTATTTCTGTTTATGCCGGGC
TGTGCTTCGCCTTTCTTATCTCTGACCAAACGATTGCGCATGGCAAACTCTACCTCGCTTGCGCGGGGATATTAGTGTTC
GTTGGTGCTCTTGACGATCGTTTCGATATCAGCGTGAAAATTCGTGCGCTGGTTCAGGCACTGGTCGGCATCGCGATGAT
GGTTTTCGCCGGGCTTTACCTGCGCAGTTTGGGTCATGTGCTGGGCGATTGGGAAATGCTGCTGGGGCCGTTTGGCTACC
TGGTTACGCTGTTTGCCGTTTGGGCAGCCATCAACGCTTTTAACATGGTTGACGGTATTGATGGCCTGCTGGGTGGGCTG
TCGTGCGTGTCTTTCGGTGCGCTGGGCGTGTTGTTGTACCTGAGCGGTCATTCTGACCTGGCCTTCTGGTGCTTCGCAAT
GATTGCCGCCATCGTTCCTTATATTCTGCTTAACCTCGGCATTCTTGGCCGCCGGTATAAAGTGTTTATGGGGGATGCCG
GTAGCACGCTGATCGGTTTCACCGCCATTTGGCTATTGGTGCAAAGTTCGCAGGGCAAAGCTCACTCCATCAATCCGGTT
ACCGCGTTGTGGATTATTGCCATCCCGCTGATGGACATGATTGCGATCATGTACCGCCGTTTACGTAAAGGGATGAGCCC
TTTCTCTCCAGACCGCCAACACATTCACCATTTGATTATGCGCGCAGGCTTTACGCCACGGCAGGCTTTCGTGTTGATTA
CCCTGGCGGCAGCCTTGCTGGCGGCTATCGGCGTGCTTGGCGAGCGCCTTACTTTTATCCCTGAATGGGTAATGTTGGCA
TTATTCTTGCTTGCCTTCTTCTTGTACGGCTACTGCATTAAACGCGCCTGGCGTGTTGCACGTTACATTAAGCGTATCAA
GCGTCGTCTGCGGCGTTCGAACGGCAATAAGCAAGTATCTTAA

Upstream 100 bases:

>100_bases
AAATGACTGAAAGGTAGCGGGATACCATGGCGCAACCTGTCGCCCGTGTTAAGCTGCCTTATCTTCTACAGAGATCTTGT
TAACTGTGAACTTACTCACT

Downstream 100 bases:

>100_bases
CCAGAGGCTTTTGGGCAGTGATGAATCCAGAAACAAGGTCTGACAAGAATATCCCGGCGGTGGATAACGAACTCGATATC
CGCGGCCTGTGCTGCACCCT

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSTEILFVFLFSLAFLFVARKAAKRIGLVDKPNYRKRHQGLIPLVGGISVYAGLCFAFLISDQTIAHGKLYLACAGILVF
VGALDDRFDISVKIRALVQALVGIAMMVFAGLYLRSLGHVLGDWEMLLGPFGYLVTLFAVWAAINAFNMVDGIDGLLGGL
SCVSFGALGVLLYLSGHSDLAFWCFAMIAAIVPYILLNLGILGRRYKVFMGDAGSTLIGFTAIWLLVQSSQGKAHSINPV
TALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTPRQAFVLITLAAALLAAIGVLGERLTFIPEWVMLA
LFLLAFFLYGYCIKRAWRVARYIKRIKRRLRRSNGNKQVS

Sequences:

>Translated_360_residues
MSTEILFVFLFSLAFLFVARKAAKRIGLVDKPNYRKRHQGLIPLVGGISVYAGLCFAFLISDQTIAHGKLYLACAGILVF
VGALDDRFDISVKIRALVQALVGIAMMVFAGLYLRSLGHVLGDWEMLLGPFGYLVTLFAVWAAINAFNMVDGIDGLLGGL
SCVSFGALGVLLYLSGHSDLAFWCFAMIAAIVPYILLNLGILGRRYKVFMGDAGSTLIGFTAIWLLVQSSQGKAHSINPV
TALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTPRQAFVLITLAAALLAAIGVLGERLTFIPEWVMLA
LFLLAFFLYGYCIKRAWRVARYIKRIKRRLRRSNGNKQVS
>Mature_359_residues
STEILFVFLFSLAFLFVARKAAKRIGLVDKPNYRKRHQGLIPLVGGISVYAGLCFAFLISDQTIAHGKLYLACAGILVFV
GALDDRFDISVKIRALVQALVGIAMMVFAGLYLRSLGHVLGDWEMLLGPFGYLVTLFAVWAAINAFNMVDGIDGLLGGLS
CVSFGALGVLLYLSGHSDLAFWCFAMIAAIVPYILLNLGILGRRYKVFMGDAGSTLIGFTAIWLLVQSSQGKAHSINPVT
ALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTPRQAFVLITLAAALLAAIGVLGERLTFIPEWVMLAL
FLLAFFLYGYCIKRAWRVARYIKRIKRRLRRSNGNKQVS

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=344, Percent_Identity=79.0697674418605, Blast_Score=523, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 39898; Mature: 39766

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEILFVFLFSLAFLFVARKAAKRIGLVDKPNYRKRHQGLIPLVGGISVYAGLCFAFLI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
SDQTIAHGKLYLACAGILVFVGALDDRFDISVKIRALVQALVGIAMMVFAGLYLRSLGHV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDWEMLLGPFGYLVTLFAVWAAINAFNMVDGIDGLLGGLSCVSFGALGVLLYLSGHSDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AFWCFAMIAAIVPYILLNLGILGRRYKVFMGDAGSTLIGFTAIWLLVQSSQGKAHSINPV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHH
TALWIIAIPLMDMIAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTPRQAFVLITLAAALL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AAIGVLGERLTFIPEWVMLALFLLAFFLYGYCIKRAWRVARYIKRIKRRLRRSNGNKQVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STEILFVFLFSLAFLFVARKAAKRIGLVDKPNYRKRHQGLIPLVGGISVYAGLCFAFLI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]