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The map label for this gene is gppA

Identifier: 157368406

GI number: 157368406

Start: 176766

End: 178262

Strand: Reverse

Name: gppA

Synonym: Spro_0157

Alternate gene names: 157368406

Gene position: 178262-176766 (Counterclockwise)

Preceding gene: 157368407

Following gene: 157368404

Centisome position: 3.27

GC content: 58.98

Gene sequence:

>1497_bases
ATGCTCAGTTCCAGCGCACTTTATGCCGCTATCGACCTTGGCTCCAACAGCTTCCACATGTTGGTGGTGCGCGAGGTGGC
CGGCAGTATTCAGACTTTGGCGCGCATCAAGCGCAAGGTGCGTCTGGCTGCCGGGCTGGATCAAAACAATCTCCTGTCGC
ATGAAGCCATGCAGCGCGGCTGGCAATGCCTGAAGTTGTTCTCCGAACGCCTGCAGGACATTCCACGCGCACAGATCCGA
GTGGTCGCCACGGCTACGCTGCGTCTGGCATCCAATGCCGATGAGTTTCTGCAAACCGCAGAGCAAATTCTCGGCTGCCC
GATCCAGGTGATCAGCGGTGAAGAAGAAGCACGGCTGATCTACCACGGCGTTGCCCATACTACCGGCGGCCCGGATCAGC
GTTTAGTGGTCGATATCGGCGGCGGTAGCACCGAGCTGGTTACCGGTACCGGCGCACAGGCGGCTCAACTGTACAGCCTG
TCGATGGGTTGTGTCACCTGGCTGGAGCGGTTCTTCAGCGATCGTAATCTGGGGCAGGAGAATTTCGAGCGGGCTGAACA
GGCTGCACGTGAAATGGTGCGTCCCATCGCGCCACAGCTGCGTCAGCACGGTTGGCAAGTCTGCGTTGGTGCTTCCGGCA
CCGTTCAGGCGCTGCAGGAAATCATGGTGGCACAGGGCATGGATGAACGCATCACCCTGTCCAAACTGCGCCAATTGAAA
CAGCGCGCCATTCAGTGCGGCAAGCTGGAAGAGTTGGAAATTGAAGGGCTGACGCTGGAACGCGCACTGGTGTTCCCAAG
CGGGCTGTCGATCCTGCTGGCGATTTTCCAGGAGCTGGGCATCGAAAGCATGATGCTGGCCGGCGGCGCACTGCGCGAAG
GACTGGTCTACGGCATGTTGCATCTGCCGGTCGAACAGGACATCCGCAGCCGTACCATTCGCAACCTGCAACGACGTTAT
CTGTTGGATACCGAGCAAGCCGAGCGCGTCAGCCAATTGGCCGCCAACTTCTCGCAGCAGGTGAGCAATGAATGGCAATT
GGATGCGCGATGTCGCGAGTTATTGCACAGCGCCTGTCTGATCCACGAAATCGGCCTCAGCGTTGATTTCAAACAGGCGC
CGCAACACGCAGCCTACCTGATCCGCCATCTGGATTTACCCGGTTTCACCCCGGCGCAGAAAAAACTGCTGGCCACCCTG
CTGCAAAACCAGAGCAACACTATCGATCTGCCACTGCTGAGCCAGCAAAACGCCCTGCCGCCGCGTACGGCGCAACGTTT
ATGCCGGATTTTACGCCTGGCCATCATCTTCGCCAGCCGTCGCCGCGACGATACGCTGCCGGCGGTACGCCTGCGTGCCA
ATAATGATGATGAGCTGACGGTGATCCTGCCGCCAGGTTGGCTGGAGCAGCACCCGCTACGGGCGGAGGCGCTGGATCAG
GAAAGTCATTGGCAAAGCTATGTTCATTGGCCGTTGATACTGGAAGAACAACGTTGA

Upstream 100 bases:

>100_bases
CCTGGCACGTCCTCGCGGCGGCAACGGCCCACGCCGTAACTCCGCGCCACGTCGTGGCGGTGCGCCACGCAATAACCGTA
AACGTTCAGGCTGATAGACC

Downstream 100 bases:

>100_bases
TATGACAAGGGCGCCAATAGCGCCCTTGAGTTTGATGACAAAGTTGTCTTTGAATCCGAGATACCCGGGCCTAGCGCACC
GAGGGGCGCTCCGGCGGGCA

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MLSSSALYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDQNNLLSHEAMQRGWQCLKLFSERLQDIPRAQIR
VVATATLRLASNADEFLQTAEQILGCPIQVISGEEEARLIYHGVAHTTGGPDQRLVVDIGGGSTELVTGTGAQAAQLYSL
SMGCVTWLERFFSDRNLGQENFERAEQAAREMVRPIAPQLRQHGWQVCVGASGTVQALQEIMVAQGMDERITLSKLRQLK
QRAIQCGKLEELEIEGLTLERALVFPSGLSILLAIFQELGIESMMLAGGALREGLVYGMLHLPVEQDIRSRTIRNLQRRY
LLDTEQAERVSQLAANFSQQVSNEWQLDARCRELLHSACLIHEIGLSVDFKQAPQHAAYLIRHLDLPGFTPAQKKLLATL
LQNQSNTIDLPLLSQQNALPPRTAQRLCRILRLAIIFASRRRDDTLPAVRLRANNDDELTVILPPGWLEQHPLRAEALDQ
ESHWQSYVHWPLILEEQR

Sequences:

>Translated_498_residues
MLSSSALYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDQNNLLSHEAMQRGWQCLKLFSERLQDIPRAQIR
VVATATLRLASNADEFLQTAEQILGCPIQVISGEEEARLIYHGVAHTTGGPDQRLVVDIGGGSTELVTGTGAQAAQLYSL
SMGCVTWLERFFSDRNLGQENFERAEQAAREMVRPIAPQLRQHGWQVCVGASGTVQALQEIMVAQGMDERITLSKLRQLK
QRAIQCGKLEELEIEGLTLERALVFPSGLSILLAIFQELGIESMMLAGGALREGLVYGMLHLPVEQDIRSRTIRNLQRRY
LLDTEQAERVSQLAANFSQQVSNEWQLDARCRELLHSACLIHEIGLSVDFKQAPQHAAYLIRHLDLPGFTPAQKKLLATL
LQNQSNTIDLPLLSQQNALPPRTAQRLCRILRLAIIFASRRRDDTLPAVRLRANNDDELTVILPPGWLEQHPLRAEALDQ
ESHWQSYVHWPLILEEQR
>Mature_498_residues
MLSSSALYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDQNNLLSHEAMQRGWQCLKLFSERLQDIPRAQIR
VVATATLRLASNADEFLQTAEQILGCPIQVISGEEEARLIYHGVAHTTGGPDQRLVVDIGGGSTELVTGTGAQAAQLYSL
SMGCVTWLERFFSDRNLGQENFERAEQAAREMVRPIAPQLRQHGWQVCVGASGTVQALQEIMVAQGMDERITLSKLRQLK
QRAIQCGKLEELEIEGLTLERALVFPSGLSILLAIFQELGIESMMLAGGALREGLVYGMLHLPVEQDIRSRTIRNLQRRY
LLDTEQAERVSQLAANFSQQVSNEWQLDARCRELLHSACLIHEIGLSVDFKQAPQHAAYLIRHLDLPGFTPAQKKLLATL
LQNQSNTIDLPLLSQQNALPPRTAQRLCRILRLAIIFASRRRDDTLPAVRLRANNDDELTVILPPGWLEQHPLRAEALDQ
ESHWQSYVHWPLILEEQR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily

Homologues:

Organism=Escherichia coli, GI48994966, Length=492, Percent_Identity=77.2357723577236, Blast_Score=787, Evalue=0.0,
Organism=Escherichia coli, GI1788848, Length=502, Percent_Identity=38.6454183266932, Blast_Score=338, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6321185, Length=335, Percent_Identity=23.5820895522388, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPPA_SERP5 (A8G827)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476395.1
- ProteinModelPortal:   A8G827
- SMR:   A8G827
- STRING:   A8G827
- GeneID:   5605156
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0157
- eggNOG:   COG0248
- HOGENOM:   HBG451789
- OMA:   AMQRGWQ
- ProtClustDB:   PRK11031
- BioCyc:   SPRO399741:SPRO_0157-MONOMER
- HAMAP:   MF_01550
- InterPro:   IPR003695

Pfam domain/function: PF02541 Ppx-GppA

EC number: =3.6.1.40

Molecular weight: Translated: 55774; Mature: 55774

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSSALYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDQNNLLSHEAMQRG
CCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
WQCLKLFSERLQDIPRAQIRVVATATLRLASNADEFLQTAEQILGCPIQVISGEEEARLI
HHHHHHHHHHHHHCCHHHEEEEEHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCHHEEE
YHGVAHTTGGPDQRLVVDIGGGSTELVTGTGAQAAQLYSLSMGCVTWLERFFSDRNLGQE
EEEHHCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
NFERAEQAAREMVRPIAPQLRQHGWQVCVGASGTVQALQEIMVAQGMDERITLSKLRQLK
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIQCGKLEELEIEGLTLERALVFPSGLSILLAIFQELGIESMMLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEEEHHEECCCHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHH
HLPVEQDIRSRTIRNLQRRYLLDTEQAERVSQLAANFSQQVSNEWQLDARCRELLHSACL
HCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IHEIGLSVDFKQAPQHAAYLIRHLDLPGFTPAQKKLLATLLQNQSNTIDLPLLSQQNALP
HHHHCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
PRTAQRLCRILRLAIIFASRRRDDTLPAVRLRANNDDELTVILPPGWLEQHPLRAEALDQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHCCC
ESHWQSYVHWPLILEEQR
HHHHHHHEECCEEEECCC
>Mature Secondary Structure
MLSSSALYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDQNNLLSHEAMQRG
CCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
WQCLKLFSERLQDIPRAQIRVVATATLRLASNADEFLQTAEQILGCPIQVISGEEEARLI
HHHHHHHHHHHHHCCHHHEEEEEHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCHHEEE
YHGVAHTTGGPDQRLVVDIGGGSTELVTGTGAQAAQLYSLSMGCVTWLERFFSDRNLGQE
EEEHHCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
NFERAEQAAREMVRPIAPQLRQHGWQVCVGASGTVQALQEIMVAQGMDERITLSKLRQLK
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIQCGKLEELEIEGLTLERALVFPSGLSILLAIFQELGIESMMLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEEEHHEECCCHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHH
HLPVEQDIRSRTIRNLQRRYLLDTEQAERVSQLAANFSQQVSNEWQLDARCRELLHSACL
HCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IHEIGLSVDFKQAPQHAAYLIRHLDLPGFTPAQKKLLATLLQNQSNTIDLPLLSQQNALP
HHHHCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
PRTAQRLCRILRLAIIFASRRRDDTLPAVRLRANNDDELTVILPPGWLEQHPLRAEALDQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHCCC
ESHWQSYVHWPLILEEQR
HHHHHHHEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA