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The map label for this gene is selA

Identifier: 157368339

GI number: 157368339

Start: 94027

End: 95418

Strand: Direct

Name: selA

Synonym: Spro_0090

Alternate gene names: 157368339

Gene position: 94027-95418 (Clockwise)

Preceding gene: 157368338

Following gene: 157368340

Centisome position: 1.73

GC content: 62.5

Gene sequence:

>1392_bases
ATGAGCACTGAATCCCAGCATCTTTACAGCCAGTTACCCGCCATTGACCGCCTGCTGCGCGATCCCGCTATCGAACCGCT
GGTGGCGCAGCATGGCCAGACGCTGATTAGCGAGCTACTGCGCCAACTGCAATTACAGGCGCGTGAAACCATTAAACAGC
ATCAACGGCTGCCTGACTGGTGTGCCGACTGGCCGCAGGCGCTTGGCGCCAGGCTGGCACAACAGCAGCGCCCGTCGTTG
GCCCCGGTATTCAATCTAAGCGGTACCGTGTTGCACACCAATCTCGGCCGGGCTCTGCTGGCGCAACCGGCGATAGAGGC
GGTGACGCGTTCGATGGGCGCGGCGGTGACGCTGGAATACGATCTCGATGGCGCCGGGCGTGGGCATCGCGATCGCGCCG
TTGCGGATTTACTGTGCCAACTGACCGGCGCGGAAGACGCCTGTATCGTCAATAACAATGCGGCCGCGGTATTGCTGATG
CTGGCGGCGATCGCCCCCGGCAAGCAAGTGGTGGTGTCGCGCGGTGAGCTGGTGGAAATTGGCGGCGCGTTCCGTATTCC
CGACGTGATGCGTCAGGCGGGCTGCCAGTTGGTCGAAGTAGGCACCACCAACCGCACCCATCTGAAAGACTACCGTAACG
CGATTAACGATCAGACCGGGTTGTTGATGAAGGTGCATACCAGCAACTACAGCATTCAGGGCTTTACCGCCGCGGTGGAC
GAAGCCGAGCTGGCGCAGCTGGGTGCCGAACACGGCCTGCCGACCGCCACCGATCTGGGCAGCGGCTCGCTGATTGATAT
GGCGCAGTACGGCCTGCCGGCCGAACCTATGCCGCAGCGACTGCTGGCTGCCGGTGTTGATCTGGTGACCTTCTCCGGTG
ACAAACTGTTGGGCGGCCCACAGGCCGGCATCATCGTCGGTAAAAAGGCGCTGATTGCCAGGTTGCAGCAGCATCCTTTA
AAGCGTGCGCTGCGCGTCGGCAAACTGACGCTGGCGGCGCTGGAGGCCACCTTACGGCTCTATCAACAACCCGAACTGCT
GGGGCAACAGTTGCCGACGCTGCGGCTGCTGACACGTCCACAACAGGCGATGCAGGCTGCCGCCGAGCGACTGTTACAGG
TGCTGACGCCGCAGTTTACCGGGCATTTCCAGTTGCGTGCCGAGCCGTGCTGGTCGCAGATCGGTAGCGGTTCATTGCCG
GTGGATCGGCTACCCAGCTATGCATTGACCTTTACGCCGCAGGACGGCCGTGGCGCAACGCTGGAAGCGTTGGCGGAACG
CTGGCGCGCTCTGCCGCAGCCGGTGATTGGCCGCATTAACGACGGCAGGCTGTGGCTGGATCTACGCTGTCTGGAGCAGG
AAGACGCATTGATTGAGGCGCTGAGCGCATGA

Upstream 100 bases:

>100_bases
CCGCGAAAGCTTTGCCCGCACCTCGCCTCCCTGATGTCTCCCACCCCGCAACTGCGGGGTTCTGCTTTATGCCGAGACCA
CACAATAAAACCGAGCGACC

Downstream 100 bases:

>100_bases
TTATCGCTACCGCCGGTCATGTCGATCATGGCAAAACCACCCTGCTGCAGGCGATCACCGGGATTAACGCCGATCGCCTG
CCGGAGGAGAAACGCCGCGG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSTESQHLYSQLPAIDRLLRDPAIEPLVAQHGQTLISELLRQLQLQARETIKQHQRLPDWCADWPQALGARLAQQQRPSL
APVFNLSGTVLHTNLGRALLAQPAIEAVTRSMGAAVTLEYDLDGAGRGHRDRAVADLLCQLTGAEDACIVNNNAAAVLLM
LAAIAPGKQVVVSRGELVEIGGAFRIPDVMRQAGCQLVEVGTTNRTHLKDYRNAINDQTGLLMKVHTSNYSIQGFTAAVD
EAELAQLGAEHGLPTATDLGSGSLIDMAQYGLPAEPMPQRLLAAGVDLVTFSGDKLLGGPQAGIIVGKKALIARLQQHPL
KRALRVGKLTLAALEATLRLYQQPELLGQQLPTLRLLTRPQQAMQAAAERLLQVLTPQFTGHFQLRAEPCWSQIGSGSLP
VDRLPSYALTFTPQDGRGATLEALAERWRALPQPVIGRINDGRLWLDLRCLEQEDALIEALSA

Sequences:

>Translated_463_residues
MSTESQHLYSQLPAIDRLLRDPAIEPLVAQHGQTLISELLRQLQLQARETIKQHQRLPDWCADWPQALGARLAQQQRPSL
APVFNLSGTVLHTNLGRALLAQPAIEAVTRSMGAAVTLEYDLDGAGRGHRDRAVADLLCQLTGAEDACIVNNNAAAVLLM
LAAIAPGKQVVVSRGELVEIGGAFRIPDVMRQAGCQLVEVGTTNRTHLKDYRNAINDQTGLLMKVHTSNYSIQGFTAAVD
EAELAQLGAEHGLPTATDLGSGSLIDMAQYGLPAEPMPQRLLAAGVDLVTFSGDKLLGGPQAGIIVGKKALIARLQQHPL
KRALRVGKLTLAALEATLRLYQQPELLGQQLPTLRLLTRPQQAMQAAAERLLQVLTPQFTGHFQLRAEPCWSQIGSGSLP
VDRLPSYALTFTPQDGRGATLEALAERWRALPQPVIGRINDGRLWLDLRCLEQEDALIEALSA
>Mature_462_residues
STESQHLYSQLPAIDRLLRDPAIEPLVAQHGQTLISELLRQLQLQARETIKQHQRLPDWCADWPQALGARLAQQQRPSLA
PVFNLSGTVLHTNLGRALLAQPAIEAVTRSMGAAVTLEYDLDGAGRGHRDRAVADLLCQLTGAEDACIVNNNAAAVLLML
AAIAPGKQVVVSRGELVEIGGAFRIPDVMRQAGCQLVEVGTTNRTHLKDYRNAINDQTGLLMKVHTSNYSIQGFTAAVDE
AELAQLGAEHGLPTATDLGSGSLIDMAQYGLPAEPMPQRLLAAGVDLVTFSGDKLLGGPQAGIIVGKKALIARLQQHPLK
RALRVGKLTLAALEATLRLYQQPELLGQQLPTLRLLTRPQQAMQAAAERLLQVLTPQFTGHFQLRAEPCWSQIGSGSLPV
DRLPSYALTFTPQDGRGATLEALAERWRALPQPVIGRINDGRLWLDLRCLEQEDALIEALSA

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=461, Percent_Identity=69.8481561822126, Blast_Score=617, Evalue=1e-178,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_SERP5 (A8G7W0)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476328.1
- ProteinModelPortal:   A8G7W0
- STRING:   A8G7W0
- GeneID:   5606985
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0090
- eggNOG:   COG1921
- HOGENOM:   HBG564950
- OMA:   KRGDRDD
- ProtClustDB:   PRK04311
- BioCyc:   SPRO399741:SPRO_0090-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 50166; Mature: 50035

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTESQHLYSQLPAIDRLLRDPAIEPLVAQHGQTLISELLRQLQLQARETIKQHQRLPDW
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
CADWPQALGARLAQQQRPSLAPVFNLSGTVLHTNLGRALLAQPAIEAVTRSMGAAVTLEY
HHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEE
DLDGAGRGHRDRAVADLLCQLTGAEDACIVNNNAAAVLLMLAAIAPGKQVVVSRGELVEI
ECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCEEEE
GGAFRIPDVMRQAGCQLVEVGTTNRTHLKDYRNAINDQTGLLMKVHTSNYSIQGFTAAVD
CCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCEEECCHHHHCC
EAELAQLGAEHGLPTATDLGSGSLIDMAQYGLPAEPMPQRLLAAGVDLVTFSGDKLLGGP
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHCCCCEEEECCCCCCCCC
QAGIIVGKKALIARLQQHPLKRALRVGKLTLAALEATLRLYQQPELLGQQLPTLRLLTRP
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHCCH
QQAMQAAAERLLQVLTPQFTGHFQLRAEPCWSQIGSGSLPVDRLPSYALTFTPQDGRGAT
HHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCCCCHHHCCCEEEEECCCCCCCCH
LEALAERWRALPQPVIGRINDGRLWLDLRCLEQEDALIEALSA
HHHHHHHHHHCCCHHHCCCCCCEEEEEEEECCHHHHHHHHHCC
>Mature Secondary Structure 
STESQHLYSQLPAIDRLLRDPAIEPLVAQHGQTLISELLRQLQLQARETIKQHQRLPDW
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
CADWPQALGARLAQQQRPSLAPVFNLSGTVLHTNLGRALLAQPAIEAVTRSMGAAVTLEY
HHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEE
DLDGAGRGHRDRAVADLLCQLTGAEDACIVNNNAAAVLLMLAAIAPGKQVVVSRGELVEI
ECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCEEEE
GGAFRIPDVMRQAGCQLVEVGTTNRTHLKDYRNAINDQTGLLMKVHTSNYSIQGFTAAVD
CCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCEEECCHHHHCC
EAELAQLGAEHGLPTATDLGSGSLIDMAQYGLPAEPMPQRLLAAGVDLVTFSGDKLLGGP
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHCCCCEEEECCCCCCCCC
QAGIIVGKKALIARLQQHPLKRALRVGKLTLAALEATLRLYQQPELLGQQLPTLRLLTRP
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHCCH
QQAMQAAAERLLQVLTPQFTGHFQLRAEPCWSQIGSGSLPVDRLPSYALTFTPQDGRGAT
HHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCCCCHHHCCCEEEEECCCCCCCCH
LEALAERWRALPQPVIGRINDGRLWLDLRCLEQEDALIEALSA
HHHHHHHHHHCCCHHHCCCCCCEEEEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA