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The map label for this gene is tdcB [H]

Identifier: 157368286

GI number: 157368286

Start: 37845

End: 38813

Strand: Reverse

Name: tdcB [H]

Synonym: Spro_0037

Alternate gene names: 157368286

Gene position: 38813-37845 (Counterclockwise)

Preceding gene: 157368287

Following gene: 157368280

Centisome position: 0.71

GC content: 56.45

Gene sequence:

>969_bases
ATGAGTCAGCTATTTGACGCGATTGTTTCCGCCCATCAGCAATTGCGCCCGCAGGTTCGCGTGACCCCGCTGGAACGCAG
CGTATTGCTGTCACAGCAGTTGGGTTGCGAGCTGTATCTGAAATGCGACCATCTGCAACCTACCGGCTCTTTTAAGTTTC
GCGGCGCCAGCAACAAGCTGCGGTTGTTAAGTGACGAGCAACGTCAACGCGGGGTAATCGCGGCTTCCAGCGGTAATCAC
GGCCAGGCGATGGCGCTGGCAGGCAAACTGACGGGAGTCAGCGTGACGGTGTATGCCCCGGAAACAGCGGCAGCGATCAA
ACTGGAAACCATCCGCGCGTTGGGCAGCGAAGTGGTGACGGTACCGGGAGATGCCCTGAAAGCGGAACAGGCGGGGGAAA
AAGCGGCGCAGGAACAGGGCAAGGTGTATGTCTCTCCCTATAACGACGAGCAGGTGATCGCCGGTCAGGGCACCTGCGGC
ATGGAGTTGGTCGAGCAGCAAGCGGATTTGGATGCAGTATTTATCGCCGTGGGTGGTGGTGGCTATATTTCAGGAATTGG
TACCGTTTTGCAGCAATTATCGCCGAAAACGCAGATTATTGCCTGCTGGCCAGAAAACTCCACCAGCATGTACAGTGCTC
TGCAGGCCGGTCATATTTATCCAGTCGAAGAGCAGGACACGCTGTCAGATGGCACCGCCGGCGGCGTTGAGCCGGGTGCG
ATCACCTTCCCACTGTGTCAGCAGGTGATTGACCGCAAAATATTGGTCAGTGAAACTGAGATCAAGCAGGCCATGCGTCA
GATTGCCGCCAGCGATCGCTGGATTATCGAAGGCGCAGCCGGGGTGGCCTTAGCCGCCGCCATCAAACTGGCACCGGAAT
TCCAGGGCAAAAAAGTGGCGGTGGTACTGTGCGGGAAAAACATTGTGCTGGAGAAATACCTCAAAGCGATCGCCGATGAA
AATCATTAA

Upstream 100 bases:

>100_bases
GCGCTTTCAAAGGAAAAAATGCCGCCGGCTACGTCGCCAAGATCCTCGGCATCGGCCGCGCCACCGTCTATAACTACCTG
AAAAATATCAAGGAGTCTGT

Downstream 100 bases:

>100_bases
CAAACGGCAGTTTCGATCGGGCCGGCGATACAGAGCGGACAGATTGTGAAGCGTATTTTAGCGCGGTTATAGCCTGCTTT
CAGGGGCGCGGTGGCGCCCC

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSQLFDAIVSAHQQLRPQVRVTPLERSVLLSQQLGCELYLKCDHLQPTGSFKFRGASNKLRLLSDEQRQRGVIAASSGNH
GQAMALAGKLTGVSVTVYAPETAAAIKLETIRALGSEVVTVPGDALKAEQAGEKAAQEQGKVYVSPYNDEQVIAGQGTCG
MELVEQQADLDAVFIAVGGGGYISGIGTVLQQLSPKTQIIACWPENSTSMYSALQAGHIYPVEEQDTLSDGTAGGVEPGA
ITFPLCQQVIDRKILVSETEIKQAMRQIAASDRWIIEGAAGVALAAAIKLAPEFQGKKVAVVLCGKNIVLEKYLKAIADE
NH

Sequences:

>Translated_322_residues
MSQLFDAIVSAHQQLRPQVRVTPLERSVLLSQQLGCELYLKCDHLQPTGSFKFRGASNKLRLLSDEQRQRGVIAASSGNH
GQAMALAGKLTGVSVTVYAPETAAAIKLETIRALGSEVVTVPGDALKAEQAGEKAAQEQGKVYVSPYNDEQVIAGQGTCG
MELVEQQADLDAVFIAVGGGGYISGIGTVLQQLSPKTQIIACWPENSTSMYSALQAGHIYPVEEQDTLSDGTAGGVEPGA
ITFPLCQQVIDRKILVSETEIKQAMRQIAASDRWIIEGAAGVALAAAIKLAPEFQGKKVAVVLCGKNIVLEKYLKAIADE
NH
>Mature_321_residues
SQLFDAIVSAHQQLRPQVRVTPLERSVLLSQQLGCELYLKCDHLQPTGSFKFRGASNKLRLLSDEQRQRGVIAASSGNHG
QAMALAGKLTGVSVTVYAPETAAAIKLETIRALGSEVVTVPGDALKAEQAGEKAAQEQGKVYVSPYNDEQVIAGQGTCGM
ELVEQQADLDAVFIAVGGGGYISGIGTVLQQLSPKTQIIACWPENSTSMYSALQAGHIYPVEEQDTLSDGTAGGVEPGAI
TFPLCQQVIDRKILVSETEIKQAMRQIAASDRWIIEGAAGVALAAAIKLAPEFQGKKVAVVLCGKNIVLEKYLKAIADEN
H

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=33.6507936507937, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI295821202, Length=304, Percent_Identity=26.6447368421053, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI295821200, Length=304, Percent_Identity=26.6447368421053, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4557415, Length=304, Percent_Identity=26.6447368421053, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI19923959, Length=331, Percent_Identity=27.4924471299094, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=33.4405144694534, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1790207, Length=291, Percent_Identity=35.3951890034364, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=23.961661341853, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71991565, Length=306, Percent_Identity=35.2941176470588, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17508781, Length=303, Percent_Identity=31.023102310231, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17537387, Length=306, Percent_Identity=33.6601307189542, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=27.2435897435897, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32566674, Length=312, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562970, Length=312, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=35.031847133758, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6320930, Length=300, Percent_Identity=35.3333333333333, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=285, Percent_Identity=25.9649122807018, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=327, Percent_Identity=27.217125382263, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21355833, Length=308, Percent_Identity=39.2857142857143, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24645328, Length=213, Percent_Identity=36.150234741784, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643623, Length=219, Percent_Identity=27.8538812785388, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20129101, Length=219, Percent_Identity=27.8538812785388, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34229; Mature: 34097

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00501 SPASE_I_1 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLFDAIVSAHQQLRPQVRVTPLERSVLLSQQLGCELYLKCDHLQPTGSFKFRGASNKL
CHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCE
RLLSDEQRQRGVIAASSGNHGQAMALAGKLTGVSVTVYAPETAAAIKLETIRALGSEVVT
EECCCHHHHCCEEEECCCCCCCEEEEEEEECCEEEEEECCCCCHHEEHHHHHHCCCCEEE
VPGDALKAEQAGEKAAQEQGKVYVSPYNDEQVIAGQGTCGMELVEQQADLDAVFIAVGGG
CCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCHHHHHHHHCCCCEEEEEECCC
GYISGIGTVLQQLSPKTQIIACWPENSTSMYSALQAGHIYPVEEQDTLSDGTAGGVEPGA
CHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCE
ITFPLCQQVIDRKILVSETEIKQAMRQIAASDRWIIEGAAGVALAAAIKLAPEFQGKKVA
EEHHHHHHHHCCCCEECHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEE
VVLCGKNIVLEKYLKAIADENH
EEEECCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQLFDAIVSAHQQLRPQVRVTPLERSVLLSQQLGCELYLKCDHLQPTGSFKFRGASNKL
HHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCE
RLLSDEQRQRGVIAASSGNHGQAMALAGKLTGVSVTVYAPETAAAIKLETIRALGSEVVT
EECCCHHHHCCEEEECCCCCCCEEEEEEEECCEEEEEECCCCCHHEEHHHHHHCCCCEEE
VPGDALKAEQAGEKAAQEQGKVYVSPYNDEQVIAGQGTCGMELVEQQADLDAVFIAVGGG
CCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCHHHHHHHHCCCCEEEEEECCC
GYISGIGTVLQQLSPKTQIIACWPENSTSMYSALQAGHIYPVEEQDTLSDGTAGGVEPGA
CHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCE
ITFPLCQQVIDRKILVSETEIKQAMRQIAASDRWIIEGAAGVALAAAIKLAPEFQGKKVA
EEHHHHHHHHCCCCEECHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEE
VVLCGKNIVLEKYLKAIADENH
EEEECCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA