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The map label for this gene is atpB

Identifier: 157368251

GI number: 157368251

Start: 969

End: 1790

Strand: Direct

Name: atpB

Synonym: Spro_0002

Alternate gene names: 157368251

Gene position: 969-1790 (Clockwise)

Preceding gene: 157368250

Following gene: 157368252

Centisome position: 0.02

GC content: 48.3

Gene sequence:

>822_bases
ATGTCTGCATCTGGAGAAAATGGGACTGCAAAGGACTATATCAGCCACCATCTGAATAACCTTCAGTTGGATCTGCGTAC
TTTTCAGTTAGTTGAACCACACTCTGGTACCCCGACATTCTGGACGTTGAACATTGACTCATTGTTCTTCTCTGTGGTGT
TGGGCGCGCTGTTCTTGTTTATCTTCAAGAAAGTAGCCAATACAGCCACCAGCGGTGTACCGGGGAAACTTCAAACTGCC
GTCGAACTTATCATGGGCTTCGTCGACAGTAGCGTTCGTGATATGTATCACGGCAAGAGCAAGGTTATTGCTCCGCTGGC
GCTGACCGTGTTTGTCTGGGTATTCCTGATGAACATGATGGATCTGCTGCCAATCGATCTGCTGCCGTTTATTGGCGAGC
ATGTGTTTGGTTTGCCGGCACTGCGTGTCGTCCCTACCGCAGACGTGAGTATTACACTGTCGATGGCGTTGGGCGTATTT
ATCCTGATTCTGTTCTATAGCATCAAAATGAAAGGCGTTGGTGGGTTCGTTAAAGAGTTAACCATGCAGCCGTTCAACCA
TCCGTTATTCATTCCAATCAACCTGATTCTTGAAGGTGTCAGCCTGCTGTCCAAGCCTGTTTCACTGGGCCTGCGACTGT
TCGGCAACATGTATGCGGGTGAGTTGATCTTCATCCTGATTGCCGGTTTGTTGCCGTGGTGGTCACAGTGGCTTCTGAAT
GTGCCTTGGGCTATTTTCCACATCCTGATCATTACGCTTCAAGCCTTTATTTTCATGGTTCTGACGATTGTCTATCTCTC
GATGGCATCTGAAGAGCACTGA

Upstream 100 bases:

>100_bases
TACCGCTTGGCCTGACCTATTTAGCGGTGTTAGTGGTGCAGATAGTGGCACCGGCCGTGATTAACAGTTACCGAACTTAA
CTAAAAGGGTAAGAGGCATC

Downstream 100 bases:

>100_bases
TTTTCTTAAAACACTTGTACTTTTAAACTGAAACAAACTGGAGACTGTCATGGAAAACCTGAGTATGGATCTGCTGTACA
TGGCTGCCGCTGTGATGATG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSASGENGTAKDYISHHLNNLQLDLRTFQLVEPHSGTPTFWTLNIDSLFFSVVLGALFLFIFKKVANTATSGVPGKLQTA
VELIMGFVDSSVRDMYHGKSKVIAPLALTVFVWVFLMNMMDLLPIDLLPFIGEHVFGLPALRVVPTADVSITLSMALGVF
ILILFYSIKMKGVGGFVKELTMQPFNHPLFIPINLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLN
VPWAIFHILIITLQAFIFMVLTIVYLSMASEEH

Sequences:

>Translated_273_residues
MSASGENGTAKDYISHHLNNLQLDLRTFQLVEPHSGTPTFWTLNIDSLFFSVVLGALFLFIFKKVANTATSGVPGKLQTA
VELIMGFVDSSVRDMYHGKSKVIAPLALTVFVWVFLMNMMDLLPIDLLPFIGEHVFGLPALRVVPTADVSITLSMALGVF
ILILFYSIKMKGVGGFVKELTMQPFNHPLFIPINLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLN
VPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
>Mature_272_residues
SASGENGTAKDYISHHLNNLQLDLRTFQLVEPHSGTPTFWTLNIDSLFFSVVLGALFLFIFKKVANTATSGVPGKLQTAV
ELIMGFVDSSVRDMYHGKSKVIAPLALTVFVWVFLMNMMDLLPIDLLPFIGEHVFGLPALRVVPTADVSITLSMALGVFI
LILFYSIKMKGVGGFVKELTMQPFNHPLFIPINLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLNV
PWAIFHILIITLQAFIFMVLTIVYLSMASEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=270, Percent_Identity=83.3333333333333, Blast_Score=444, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_SERP5 (A8G7M2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476240.1
- ProteinModelPortal:   A8G7M2
- SMR:   A8G7M2
- STRING:   A8G7M2
- GeneID:   5604877
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0002
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   LPWWSQF
- ProtClustDB:   PRK05815
- BioCyc:   SPRO399741:SPRO_0002-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 30372; Mature: 30241

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2011a408)-; HASH(0x2111d038)-; HASH(0x201dc99c)-; HASH(0x201e276c)-; HASH(0x201730dc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASGENGTAKDYISHHLNNLQLDLRTFQLVEPHSGTPTFWTLNIDSLFFSVVLGALFLF
CCCCCCCCCHHHHHHHHHCCHHHHHHHHEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHH
IFKKVANTATSGVPGKLQTAVELIMGFVDSSVRDMYHGKSKVIAPLALTVFVWVFLMNMM
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DLLPIDLLPFIGEHVFGLPALRVVPTADVSITLSMALGVFILILFYSIKMKGVGGFVKEL
HHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TMQPFNHPLFIPINLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLN
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
SASGENGTAKDYISHHLNNLQLDLRTFQLVEPHSGTPTFWTLNIDSLFFSVVLGALFLF
CCCCCCCCHHHHHHHHHCCHHHHHHHHEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHH
IFKKVANTATSGVPGKLQTAVELIMGFVDSSVRDMYHGKSKVIAPLALTVFVWVFLMNMM
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DLLPIDLLPFIGEHVFGLPALRVVPTADVSITLSMALGVFILILFYSIKMKGVGGFVKEL
HHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TMQPFNHPLFIPINLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWLLN
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA