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The map label for this gene is mhpR [H]

Identifier: 157158422

GI number: 157158422

Start: 402181

End: 403128

Strand: Reverse

Name: mhpR [H]

Synonym: EcE24377A_0370

Alternate gene names: 157158422

Gene position: 403128-402181 (Counterclockwise)

Preceding gene: 157157121

Following gene: 157155643

Centisome position: 8.1

GC content: 53.59

Gene sequence:

>948_bases
ATGATTTTTTATTGTGCGCTCAGTATAGGAAGGGTATTTTCGGCTACAATCAAAACATGCCCGAATGTGCACCAGGTGCA
CAACGTTGTTTTAACTATAGAAATGTCAATTAATATGCAGAACAATGAGCAGACGGAATACAAAACCGTGCGCGGCTTAA
CCCGCGGTCTAATGTTATTAAATATGTTAAATAAACTTGATGGCGGTGCCAGCGTCGGGCTGCTGGCGGAACTCAGCGGC
CTGCATCGCACCACTGTGCGGCGACTGCTGGAGACGCTGCAGGAAGAGGGATATGTCCGCCGTAGCCCCTCCGATGATAG
TTTTCGACTGACCATCAAAGTGCGGCAATTAAGCGAAGGATTTCGTGACGAACAGTGGATTTCTGCACTGGCGGCCCCGC
TGCTGGGCGATCTGTTGCGCGAAGTGGTATGGCCAACAGATGTGTCCACCCTGGATGTTGATGCAATGGTGGTACGCGAA
ACCACCCACCGTTTCAGCCGCTTATCCTTTCACCGGGCAATGGTCGGGCGACGTTTACCGCTCCTGAAAACCGCCTCGGG
CCTGACCTGGCTGGCCTTTTGCCCGGAACAAGAACGCAAGGAATTAATCGAAATGTTAGCCGCCCGCCCCGGTGATGACT
ATCAACTGGCACGAGAACCGTTAAAGCTGCAAGCCATTCTGGCGCGCGCGCGCAAAGAGGGTTACGGACAGAACTACCGC
GGCTGGGATCAGGAGGAGAAGATTGCCTCTATCGCCGTACCGCTGCGCAGTGAACAACGGGTGATTGGCTGTCTGAATCT
GGTGTATATGGCGAGCGCAATGACCATTGAACAGGCAGCGGAAAAGCATCTTCCGGCGCTACAACGGGTAGCAAAACAGA
TCGAAGAAGGGGTTGAATCGCAGGCTATTCTGGTGGCCGGACGGCGAAGCGGCGTGCATTTACGTTGA

Upstream 100 bases:

>100_bases
GATGTCAGGGTGTTGTATTGCCATTTCAGTACCTCACGACTCGGACAAAATGCCGTTGCGCGCACAGTACAGCGCAACTT
ATTTTGTTAAAAACATGTAA

Downstream 100 bases:

>100_bases
CACCATCGAATGGCGCAAAACCTTTCGTGGTATGGCATGATAGCGCCCGGAAGAGAGTCAATTCAGGGTGGTGAATGTGA
AACCAGTAACGCTATACGAT

Product: DNA-binding transcriptional activator MhpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSG
LHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRE
TTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLAARPGDDYQLAREPLKLQAILARARKEGYGQNYR
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGVHLR

Sequences:

>Translated_315_residues
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSG
LHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRE
TTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLAARPGDDYQLAREPLKLQAILARARKEGYGQNYR
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGVHLR
>Mature_315_residues
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLLNMLNKLDGGASVGLLAELSG
LHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEGFRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRE
TTHRFSRLSFHRAMVGRRLPLLKTASGLTWLAFCPEQERKELIEMLAARPGDDYQLAREPLKLQAILARARKEGYGQNYR
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVESQAILVAGRRSGVHLR

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=277, Percent_Identity=98.5559566787004, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1789999, Length=143, Percent_Identity=32.1678321678322, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786468, Length=226, Percent_Identity=27.4336283185841, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082359, Length=202, Percent_Identity=27.7227722772277, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 35521; Mature: 35521

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLL
CEEEEEEHHHHHHHHHHHHCCCHHHHCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
NMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEEHHHCC
FRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LLKTASGLTWLAFCPEQERKELIEMLAARPGDDYQLAREPLKLQAILARARKEGYGQNYR
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVES
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
QAILVAGRRSGVHLR
CEEEEEECCCCCCCC
>Mature Secondary Structure
MIFYCALSIGRVFSATIKTCPNVHQVHNVVLTIEMSINMQNNEQTEYKTVRGLTRGLMLL
CEEEEEEHHHHHHHHHHHHCCCHHHHCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
NMLNKLDGGASVGLLAELSGLHRTTVRRLLETLQEEGYVRRSPSDDSFRLTIKVRQLSEG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEEHHHCC
FRDEQWISALAAPLLGDLLREVVWPTDVSTLDVDAMVVRETTHRFSRLSFHRAMVGRRLP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LLKTASGLTWLAFCPEQERKELIEMLAARPGDDYQLAREPLKLQAILARARKEGYGQNYR
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GWDQEEKIASIAVPLRSEQRVIGCLNLVYMASAMTIEQAAEKHLPALQRVAKQIEEGVES
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
QAILVAGRRSGVHLR
CEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]