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The map label for this gene is ggt [H]

Identifier: 157158386

GI number: 157158386

Start: 3902144

End: 3903877

Strand: Reverse

Name: ggt [H]

Synonym: EcE24377A_3924

Alternate gene names: 157158386

Gene position: 3903877-3902144 (Counterclockwise)

Preceding gene: 157157691

Following gene: 157155755

Centisome position: 78.4

GC content: 54.44

Gene sequence:

>1734_bases
ATGATAAAACCGACGTTTTTACGCCGGGTGGCCATTGCTGCTCTGCTCTCAGGAAGTTGTTTTAGCGCCGCCGCCGCGCC
TCCTGTTTCTTATGGCGTGGAGGAAGATGTCTTTCATCCAGTACGCGCGAAACAGGGGATGGTGGCGTCTGTAGATGCTA
CTGCCACTCAGGTGGGGGTGGATATCCTCAAGGAGGGCGGGAATGCCGTTGATGCTGCCGTGGCGGTGGGCTACGCGCTG
GCGGTAACGCATCCGCAGGCGGGGAATCTGGGCGGCGGTGGTTTTATGCTGATCCGCACTAAAGATGGCAACACCACTGC
TATTGATTTCCGTGAGATGGCACCCGCTAAAGCGACCCGCGATATGTTCCTTGATGATCAAGGCAACCCGGACAGCAAAA
AATCACTCACTTCGCATCTGGCCTCTGGCACGCCCGGTACGGTAGCAGGTTTCTCGCTGGCGTTGGATAAATACGGCACC
ATGCCGCTGAATAAAGTCGTGCAGCCCGCTTTTAAACTTGCACGCGATGGTTTTATCGTTAACGACGCGCTGGCTGACGA
TCTCAAAACCTACGGTAGCGAAGTGTTGCCGAATCACGAAAACAGCAAAGCTATCTTCTGGAAAGAGGGCGAACCGCTGA
AAAAGGGCGACAAGCTGGTGCAGGCGAACCTGGCAAAGAGCCTGGAGATGATTGCCGAAAACGGCCCGGACGAATTCTAC
AAAGGCACGATAGCGGAACAGATTGCCCAGGAGATGCAGAAAAACGGTGGCTTGATCACCAAAGAAGATTTAGCGGCGTA
TAAAGCGGTCGAACGCACACCGATAAGCGGCGATTATCGCGGGTATCAGGTTTACTCCATGCCACCGCCATCTTCCGGCG
GGATCCATATCGTACAAATCCTCAATATTCTGGAAAACTTCGATATGAAGAAATACGGCTTTGGCAGCGCCGATGCGATG
CAAATCATGGCAGAAGCGGAGAAATACGCCTACGCCGACCGCTCGGAATATCTTGGCGACCCGGATTTTGTCAAAGTCCC
GTGGCAGGCACTGACCAATAAAGCCTATGCCAAATCCATTGCCGATCAAATTGATATCAACAAAGCGAAGCCGTCCAGTG
AGATTCGCCCTGGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTACTCTGTAGTGGATAAAGACGGTAACGCG
GTGGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGTATTGTCGCGGGCGAGAGCGGTATTCTGCTTAATAACCA
GATGGATGATTTCTCCGCCAAACCGGGCGTACCGAACGTTTACGGGCTGGTGGGCGGTGATGCCAACGCCGTCGGGCCGA
ACAAACGCCCGCTGTCGTCGATGTCGCCGACCATTGTGGTGAAAGACGGTAAAACCTGGCTGGTTACCGGTAGCCCAGGC
GGTAGCCGGATCATCACTACAGTGCTGCAAATGGTGGTGAATAGCATCGATTATGGCATGAACGTCGCCGAAGCGACCAA
TGCGCCGCGTTTCCACCATCAGTGGTTGCCGGACGAGCTGCGTGTCGAAAAAGGGTTTAGCCCGGATACGCTCAAGCTGC
TGGAAGCAAAAGGTCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGTACACAAAGCATTATGGTTGGGCCGGACGGTGAG
TTGTACGGCGCATCCGACCCGCGCTCGGTGGATGATTTAACGGCGGGGTACTAA

Upstream 100 bases:

>100_bases
TATTCTTTAAGTTTACTCGCTTCCCGGCAAAACGATGATTAATTCAGAGTTATATACCAGGCTTAGCTGGGGTTGCCCCA
CACATAACTGGAGAATAACG

Downstream 100 bases:

>100_bases
GGTTAGCGGCCCTCTTCGTGGGAAGAGGGCTATTTTGTCAGGGCAAGCCGAAGGTAGCCTTTTTTATTTCGTAATCCTGT
AGATATTCTTCCAGCGGCTT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVGYAL
AVTHPQAGNLGGGGFMLIRTKDGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGT
MPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDEFY
KGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSADAM
QIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNA
VAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTGSPG
GSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGPDGE
LYGASDPRSVDDLTAGY

Sequences:

>Translated_577_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVGYAL
AVTHPQAGNLGGGGFMLIRTKDGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGT
MPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDEFY
KGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSADAM
QIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNA
VAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTGSPG
GSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGPDGE
LYGASDPRSVDDLTAGY
>Mature_577_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVGYAL
AVTHPQAGNLGGGGFMLIRTKDGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGT
MPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDEFY
KGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSADAM
QIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNA
VAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTGSPG
GSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGPDGE
LYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=32.0825515947467, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=32.0825515947467, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=32.0825515947467, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=32.0825515947467, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=31.4779270633397, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=30.8571428571429, Blast_Score=235, Evalue=1e-61,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.6939890710383, Blast_Score=200, Evalue=4e-51,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=28.4936479128857, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=28.4420289855072, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI153266907, Length=548, Percent_Identity=27.3722627737226, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=32.4200913242009, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=30.5936073059361, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=98.7931034482759, Blast_Score=1156, Evalue=0.0,
Organism=Caenorhabditis elegans, GI212646519, Length=573, Percent_Identity=34.3804537521815, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI72000294, Length=573, Percent_Identity=34.3804537521815, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI193208245, Length=561, Percent_Identity=32.9768270944742, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI193208247, Length=561, Percent_Identity=33.3333333333333, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=35.8717434869739, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=30.8797127468582, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.765237020316, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI72001497, Length=233, Percent_Identity=26.6094420600858, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72001495, Length=232, Percent_Identity=25.4310344827586, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=491, Percent_Identity=29.1242362525458, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45551474, Length=516, Percent_Identity=32.9457364341085, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24642670, Length=516, Percent_Identity=32.9457364341085, Blast_Score=253, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24642666, Length=516, Percent_Identity=32.9457364341085, Blast_Score=253, Evalue=4e-67,
Organism=Drosophila melanogaster, GI161077880, Length=516, Percent_Identity=32.9457364341085, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI161077878, Length=516, Percent_Identity=32.9457364341085, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=31.1068702290076, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=31.0810810810811, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=28.6751361161525, Blast_Score=193, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61563; Mature: 61563

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPTFLRRVAIAALLSGSCFSAAAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGV
CCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHHHHHH
DILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRTKDGNTTAIDFREMAPAKATR
HHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCEEEEEHHHHCCCHHHH
DMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIV
HHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEE
NDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDEFY
EHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
KGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQI
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHH
LNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSI
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHHHHH
ADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVAGES
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEECCC
GILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTGSPG
CEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCC
GSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQK
CHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHCCCE
VALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
EEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure
MIKPTFLRRVAIAALLSGSCFSAAAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGV
CCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHHHHHH
DILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRTKDGNTTAIDFREMAPAKATR
HHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCEEEEEHHHHCCCHHHH
DMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIV
HHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEE
NDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDEFY
EHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
KGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQI
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHH
LNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSI
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHHHHH
ADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVAGES
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEECCC
GILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTGSPG
CEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCC
GSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQK
CHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHCCCE
VALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
EEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]